pyruvic acid has been researched along with Critical Illness in 12 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ethyl pyruvate has demonstrated anti-inflammatory actions and improved hyperpermeability and bacterial translocation due to endotoxemia and is of benefit in animal models of sepsis and septic shock." | 4.83 | Is pyruvate an endogenous anti-inflammatory molecule? ( Das, UN, 2006) |
| "We enrolled 105 patients with septic shock hospitalized in the mixed intensive care unit of a tertiary hospital." | 1.39 | Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study. ( Armaganidis, A; Dimopoulou, I; Ilias, I; Kopterides, P; Nikitas, N; Theodorakopoulou, M; Vassiliadi, DA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Levitt, DG | 1 |
| Levitt, JE | 1 |
| Levitt, MD | 1 |
| Hu, S | 1 |
| Dai, YL | 1 |
| Gao, MJ | 1 |
| Wang, XN | 1 |
| Wang, HB | 1 |
| Dou, YQ | 1 |
| Bai, XD | 1 |
| Zhou, FQ | 1 |
| Nikitas, N | 1 |
| Kopterides, P | 1 |
| Ilias, I | 1 |
| Theodorakopoulou, M | 1 |
| Vassiliadi, DA | 1 |
| Armaganidis, A | 1 |
| Dimopoulou, I | 1 |
| Maddison, L | 1 |
| Karjagin, J | 1 |
| Tenhunen, J | 1 |
| Kirsimägi, U | 1 |
| Starkopf, J | 1 |
| Marcoux, J | 1 |
| McArthur, DA | 1 |
| Miller, C | 1 |
| Glenn, TC | 1 |
| Villablanca, P | 1 |
| Martin, NA | 1 |
| Hovda, DA | 1 |
| Alger, JR | 1 |
| Vespa, PM | 2 |
| Hillered, L | 1 |
| Enblad, P | 1 |
| Stein, NR | 1 |
| McArthur, DL | 1 |
| Etchepare, M | 1 |
| Peerdeman, SM | 1 |
| Girbes, AR | 1 |
| Vandertop, WP | 1 |
| Contaldo, C | 1 |
| Plock, J | 1 |
| Sakai, H | 1 |
| Takeoka, S | 1 |
| Tsuchida, E | 1 |
| Leunig, M | 1 |
| Banic, A | 1 |
| Erni, D | 1 |
| Das, UN | 1 |
| Verdant, CL | 1 |
| Chierego, M | 1 |
| De Moor, V | 1 |
| Chamlou, R | 1 |
| Creteur, J | 1 |
| de Dieu Mutijima, J | 1 |
| Loi, P | 1 |
| Gelin, M | 1 |
| Gullo, A | 1 |
| Vincent, JL | 1 |
| De Backer, D | 1 |
| Rooyackers, OE | 1 |
| Gijsen, AP | 1 |
| Saris, WH | 1 |
| Soeters, PB | 1 |
| Wagenmakers, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peritoneal/Serum Lactate Ratio in Relaparotomy[NCT01161849] | 60 participants (Anticipated) | Observational | 2010-08-31 | Completed | |||
| Feasibility of Microdialysis by Laparoscopy[NCT01786694] | Phase 3 | 11 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvic acid and Critical Illness
| Article | Year |
|---|---|
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
Is pyruvate an endogenous anti-inflammatory molecule?
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Critical Illness; Cytokines; Disease | 2006 |
1 trial available for pyruvic acid and Critical Illness
| Article | Year |
|---|---|
Moderate intra-abdominal hypertension leads to anaerobic metabolism in the rectus abdominis muscle tissue of critically ill patients: a prospective observational study.
Topics: Adult; Anaerobiosis; Critical Illness; Female; Glutamic Acid; Humans; Intra-Abdominal Hypertension; | 2014 |
9 other studies available for pyruvic acid and Critical Illness
| Article | Year |
|---|---|
Pyruvate as a novel carrier of hydroxyethyl starch 130/0.4 may protect kidney in rats subjected to severe burns.
Topics: Acute Kidney Injury; Animals; Burns; Critical Illness; Disease Models, Animal; Drug Carriers; Fluid | 2018 |
Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study.
Topics: Adipose Tissue; Aged; Critical Illness; Female; Humans; Intensive Care Units; Lactic Acid; Male; Mic | 2013 |
Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury.
Topics: Adolescent; Adult; Atrophy; Biomarkers; Brain Diseases; Brain Injuries; Chronic Disease; Cohort Stud | 2008 |
Nonischemic energy metabolic crisis in acute brain injury.
Topics: Biomarkers; Brain Injuries; Critical Care; Critical Illness; Energy Metabolism; Female; Glasgow Coma | 2008 |
Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation.
Topics: Adult; Blood Pressure; Brain; Brain Diseases, Metabolic; Brain Injuries; Cardiopulmonary Resuscitati | 2012 |
Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis.
Topics: Adolescent; Aged; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Critical Care; Criti | 2002 |
New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.
Topics: Animals; Blood Substitutes; Carbohydrate Metabolism; Cattle; Cricetinae; Critical Illness; Disease M | 2005 |
Prediction of postoperative complications after urgent laparotomy by intraperitoneal microdialysis: A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Lactic Acid; Laparotomy; Male; Mic | 2006 |
Prediction of postoperative complications after urgent laparotomy by intraperitoneal microdialysis: A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Lactic Acid; Laparotomy; Male; Mic | 2006 |
Prediction of postoperative complications after urgent laparotomy by intraperitoneal microdialysis: A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Lactic Acid; Laparotomy; Male; Mic | 2006 |
Prediction of postoperative complications after urgent laparotomy by intraperitoneal microdialysis: A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Lactic Acid; Laparotomy; Male; Mic | 2006 |
Derangement in aerobic and anaerobic energy metabolism in skeletal muscle of critically ill and recovering rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Creatine; Critical Illness; Energy Metabolism; | 1996 |