pyruvic acid has been researched along with Complex IV Deficiency in 18 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes demonstrated only minor changes in redox state and in the behavior of the mitochondrial respiratory chain." | 3.68 | The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia. ( Capaldi, R; Chow, W; Glerum, DM; Lightowlers, R; Petrova-Benedict, R; Robinson, BH, 1990) |
| "Focal COX deficiency was found in 14 (93%) of 15 patients and in nine (60%) of 15 controls." | 1.31 | Impaired redox status and cytochrome c oxidase deficiency in patients with polymyalgia rheumatica. ( Authier, FJ; Chariot, P; Chevalier, X; Drogou, I; Gherardi, R; Yerroum, M, 2001) |
| "Here, we report on cytochrome c oxidase deficiency in the liver but not in the skeletal muscle of a 5-month-old girl who presented hepatic failure in early infancy." | 1.29 | Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure. ( Cerrone, R; Chretien, D; Edery, P; Fabre, M; Gérard, B; Munnich, A; Rabier, D; Rambaud, C; Rötig, A; Saudubray, JM, 1994) |
| "To elucidate the etiology of Leigh syndrome, biochemical analyses and mitochondrial DNA analyses were performed on cultured lymphoblastoid cells from 20 patients with the clinical characteristics of this disorder." | 1.29 | [Defects of pyruvate metabolism in cultured lymphoblastoid cells of 20 patients with Leigh syndrome]. ( Ito, M; Kimura, S; Kuroda, Y; Matsuda, J; Naito, E; Osaka, H; Saijo, T; Yokota, I, 1996) |
| "Amniocytes with an established cytochrome c oxidase deficiency were also investigated." | 1.28 | Prenatal diagnosis of systemic disorders of the respiratory chain in cultured amniocytes and chorionic villus fibroblasts by studying the formation of lactate and pyruvate from glucose. ( Bakkeren, JA; Feller, N; Ruitenbeek, W; Ruiter, J; Sengers, RC; Trijbels, JM; Wanders, RJ; Wijburg, FA, 1992) |
| "The presentation and clinical course of cytochrome c oxidase deficiency are highly variable and the diagnosis of cytochrome c oxidase deficiency should be considered in all patients with lactic acidosis or subacute necrotizing encephalomyelopathy." | 1.28 | Variable presentation of cytochrome c oxidase deficiency. ( Cunniff, C; Keppler, K, 1992) |
| "Two new patients with Leigh's syndrome (subacute necrotizing encephalomyelopathy) due to deficiency of cytochrome c oxidase are presented and their data are compared with those of the four Leigh's syndrome patients previously reported with this deficiency." | 1.27 | Cytochrome c oxidase deficiency in subacute necrotizing encephalomyelopathy. ( Arts, WF; Fernandes, J; Loonen, MC; Luyt-Houwen, IE; Przyrembel, H; Scholte, HR; Trijbels, JM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 12 (66.67) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prick, MJ | 1 |
| Gabreëls, FJ | 2 |
| Trijbels, JM | 4 |
| Janssen, AJ | 1 |
| le Coultre, R | 1 |
| van Dam, K | 1 |
| Jaspar, HH | 1 |
| Ebels, EJ | 1 |
| Op de Coul, AA | 1 |
| Edery, P | 1 |
| Gérard, B | 1 |
| Chretien, D | 1 |
| Rötig, A | 1 |
| Cerrone, R | 1 |
| Rabier, D | 1 |
| Rambaud, C | 1 |
| Fabre, M | 1 |
| Saudubray, JM | 1 |
| Munnich, A | 1 |
| Caruso, U | 1 |
| Adami, A | 1 |
| Bertini, E | 1 |
| Burlina, AB | 1 |
| Carnevale, F | 1 |
| Cerone, R | 1 |
| Dionisi-Vici, C | 1 |
| Giordano, G | 1 |
| Leuzzi, E | 1 |
| Parenti, G | 1 |
| Savasta, S | 1 |
| Uziel, G | 1 |
| Zeviani, M | 2 |
| Bakker, HD | 1 |
| Van den Bogert, C | 1 |
| Drewes, JG | 1 |
| Barth, PG | 1 |
| Scholte, HR | 4 |
| Wanders, RJ | 4 |
| Ruitenbeek, W | 4 |
| Naito, E | 1 |
| Ito, M | 1 |
| Yokota, I | 1 |
| Saijo, T | 1 |
| Matsuda, J | 1 |
| Osaka, H | 1 |
| Kimura, S | 1 |
| Kuroda, Y | 1 |
| Rubio-Gozalbo, ME | 1 |
| Smeitink, JA | 1 |
| Ter Laak, H | 1 |
| Mullaart, RA | 1 |
| Schuelke, M | 1 |
| Mariman, EC | 1 |
| Sengers, RC | 3 |
| Murakami, N | 1 |
| Sakuta, R | 1 |
| Chariot, P | 1 |
| Chevalier, X | 1 |
| Yerroum, M | 1 |
| Drogou, I | 1 |
| Authier, FJ | 1 |
| Gherardi, R | 1 |
| Wijburg, FA | 3 |
| Ruiter, J | 1 |
| Bakkeren, JA | 1 |
| Feller, N | 3 |
| Keppler, K | 1 |
| Cunniff, C | 1 |
| Beyenburg, S | 1 |
| von Wersebe, O | 1 |
| Zierz, S | 1 |
| Trounce, I | 1 |
| Byrne, E | 1 |
| Marzuki, S | 1 |
| Dennett, X | 1 |
| Sudoyo, H | 1 |
| Mastaglia, F | 1 |
| Berkovic, SF | 1 |
| Sunohara, N | 1 |
| Przyrembel, H | 3 |
| Robinson, BH | 1 |
| Glerum, DM | 1 |
| Chow, W | 1 |
| Petrova-Benedict, R | 1 |
| Lightowlers, R | 1 |
| Capaldi, R | 1 |
| DiMauro, S | 1 |
| Bonilla, E | 1 |
| Servidei, S | 1 |
| DeVivo, DC | 1 |
| Schon, EA | 1 |
| Arts, WF | 1 |
| Loonen, MC | 1 |
| Fernandes, J | 1 |
| Luyt-Houwen, IE | 1 |
3 reviews available for pyruvic acid and Complex IV Deficiency
| Article | Year |
|---|---|
Respiratory-chain and pyruvate metabolism defects: Italian collaborative survey on 72 patients.
Topics: Cytochrome-c Oxidase Deficiency; Electron Transport; Humans; Italy; Metabolism, Inborn Errors; Pyruv | 1996 |
[Pure mitochondrial myopathy].
Topics: Child; Cytochrome-c Oxidase Deficiency; Electron Transport Complex I; Electron Transport Complex II; | 2001 |
Mitochondrial myopathies.
Topics: Adenosine Triphosphatases; Biological Transport; Carnitine; Citric Acid Cycle; Cytochrome-c Oxidase | 1987 |
15 other studies available for pyruvic acid and Complex IV Deficiency
| Article | Year |
|---|---|
Progressive poliodystrophy (Alpers' disease) with a defect in cytochrome aa3 in muscle: a report of two unrelated patients.
Topics: Atrophy; Brain; Child; Child, Preschool; Cytochrome a Group; Cytochrome-c Oxidase Deficiency; Cytoch | 1983 |
Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure.
Topics: Cytochrome-c Oxidase Deficiency; Female; Humans; Infant; Lactates; Lactic Acid; Liver; Liver Failure | 1994 |
Progressive generalized brain atrophy and infantile spasms associated with cytochrome c oxidase deficiency.
Topics: Acidosis; Atrophy; Brain; Cytochrome-c Oxidase Deficiency; Humans; Infant, Newborn; Lactates; Lactic | 1996 |
[Defects of pyruvate metabolism in cultured lymphoblastoid cells of 20 patients with Leigh syndrome].
Topics: Biomarkers; Cells, Cultured; Cytochrome-c Oxidase Deficiency; DNA, Mitochondrial; Female; Humans; In | 1996 |
Spinal muscular atrophy-like picture, cardiomyopathy, and cytochrome c oxidase deficiency.
Topics: Blotting, Western; Cardiomegaly; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Huma | 1999 |
Impaired redox status and cytochrome c oxidase deficiency in patients with polymyalgia rheumatica.
Topics: Aged; Aged, 80 and over; Biopsy; Case-Control Studies; Cytochrome-c Oxidase Deficiency; Female; Huma | 2001 |
Prenatal diagnosis of systemic disorders of the respiratory chain in cultured amniocytes and chorionic villus fibroblasts by studying the formation of lactate and pyruvate from glucose.
Topics: Amnion; Cells, Cultured; Chorionic Villi; Cytochrome-c Oxidase Deficiency; Female; Fibroblasts; Gluc | 1992 |
Variable presentation of cytochrome c oxidase deficiency.
Topics: Cytochrome-c Oxidase Deficiency; Female; Humans; Infant, Newborn; Lactates; Lactic Acid; Male; Metab | 1992 |
[Delayed manifestation of mitochondrial myopathy--complex I and IV deficiency of the mitochondrial respiratory chain with progressive paresis].
Topics: Biopsy; Cytochrome-c Oxidase Deficiency; Electromyography; Humans; Lactates; Lactic Acid; Male; Midd | 1991 |
Functional respiratory chain studies in subjects with chronic progressive external ophthalmoplegia and large heteroplasmic mitochondrial DNA deletions.
Topics: Adult; Chromosome Deletion; Cytochrome-c Oxidase Deficiency; DNA, Mitochondrial; Electron Transport; | 1991 |
[Leigh's syndrome].
Topics: Brain Diseases, Metabolic; Cytochrome-c Oxidase Deficiency; Electron Transport; Electron Transport C | 1990 |
Detection of respiratory chain dysfunction by measuring lactate and pyruvate production in cultured fibroblasts.
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Child, Preschool; Cytochrome-c Oxidase Defici | 1990 |
The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia.
Topics: Acidosis, Lactic; Brain Diseases; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Hum | 1990 |
Studies on the formation of lactate and pyruvate from glucose in cultured skin fibroblasts: implications for detection of respiratory chain defects.
Topics: Cells, Cultured; Child, Preschool; Cytochrome-c Oxidase Deficiency; Electron Transport; Electron Tra | 1989 |
Cytochrome c oxidase deficiency in subacute necrotizing encephalomyelopathy.
Topics: Brain; Brain Diseases, Metabolic; Child; Child, Preschool; Cytochrome-c Oxidase Deficiency; Electron | 1987 |