pyruvic acid has been researched along with Chemical and Drug Induced Liver Injury in 14 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| "The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group)." | 3.69 | Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. ( Kawai, Y; Noguchi, M, 1996) |
| "Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent." | 1.38 | Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients. ( Hashimoto, T; Kobayashi, A; Kondo, K; Kuno, H; Shoda, T; Sugai, S; Suzuki, Y; Takahashi, A; Toyoda, K; Yamada, N, 2012) |
| " There was even a toxic response form the mixture at concentrations where the chemicals alone yielded no such response." | 1.27 | Assessment of the toxicity of chemical mixtures with isolated rat hepatocytes: cadmium and chloroform. ( Stacey, NH, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Komulainen, T | 1 |
| Lodge, T | 1 |
| Hinttala, R | 1 |
| Bolszak, M | 1 |
| Pietilä, M | 1 |
| Koivunen, P | 1 |
| Hakkola, J | 1 |
| Poulton, J | 1 |
| Morten, KJ | 1 |
| Uusimaa, J | 1 |
| Toropova, AA | 1 |
| Nikolaev, SM | 1 |
| Razuvaeva, YG | 1 |
| Fedorov, AV | 1 |
| Sambueva, ZG | 1 |
| Ubeeva, IP | 1 |
| Josan, S | 1 |
| Billingsley, K | 1 |
| Orduna, J | 1 |
| Park, JM | 1 |
| Luong, R | 1 |
| Yu, L | 1 |
| Hurd, R | 1 |
| Pfefferbaum, A | 1 |
| Spielman, D | 1 |
| Mayer, D | 1 |
| Andersson, U | 1 |
| Lindberg, J | 1 |
| Wang, S | 1 |
| Balasubramanian, R | 1 |
| Marcusson-Ståhl, M | 1 |
| Hannula, M | 1 |
| Zeng, C | 1 |
| Juhasz, PJ | 1 |
| Kolmert, J | 1 |
| Bäckström, J | 1 |
| Nord, L | 1 |
| Nilsson, K | 1 |
| Martin, S | 1 |
| Glinghammar, B | 1 |
| Cederbrant, K | 1 |
| Schuppe-Koistinen, I | 1 |
| Kondo, K | 1 |
| Yamada, N | 1 |
| Suzuki, Y | 1 |
| Toyoda, K | 1 |
| Hashimoto, T | 1 |
| Takahashi, A | 1 |
| Kobayashi, A | 1 |
| Shoda, T | 1 |
| Kuno, H | 1 |
| Sugai, S | 1 |
| Mori, M | 1 |
| Yamagata, T | 1 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| Shiriaeva, AP | 1 |
| Baĭdiuk, EV | 1 |
| Arkad'eva, AV | 1 |
| Okovityĭ, SV | 1 |
| Morozov, VI | 1 |
| Sakuta, GA | 1 |
| Santone, KS | 1 |
| Acosta, D | 1 |
| Bruckner, JV | 1 |
| Record, CO | 1 |
| Chase, RA | 1 |
| Williams, R | 1 |
| Appleton, D | 1 |
| Noguchi, M | 1 |
| Kawai, Y | 1 |
| Badr, MZ | 1 |
| Takagi, D | 1 |
| Takeyama, N | 1 |
| Tanaka, T | 1 |
| Turnbull, DM | 1 |
| Dick, DJ | 1 |
| Wilson, L | 1 |
| Sherratt, HS | 1 |
| Alberti, KG | 1 |
| Stacey, NH | 1 |
1 trial available for pyruvic acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
13 other studies available for pyruvic acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.
Topics: Adenosine Triphosphate; Anticonvulsants; Cell Death; Cell Proliferation; Cell Respiration; Chemical | 2015 |
[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis].
Topics: Adenosine Triphosphate; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Dru | 2014 |
Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-(13)C]pyruvate.
Topics: Alanine; Animals; Carbon Tetrachloride; Carbon-13 Magnetic Resonance Spectroscopy; Chemical and Drug | 2015 |
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran.
Topics: Adenosine Triphosphate; Alanine Transaminase; Azetidines; Benzylamines; Biomarkers; Blood Proteins; | 2009 |
Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antipyretics; Blood Glucose; | 2012 |
[Hepatocyte mitochondrion respiratory chain in rats with experimental toxic hepatitis].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochromes c; Dinitrophenols | 2007 |
Cadmium toxicity in primary cultures of rat hepatocytes.
Topics: Animals; Cadmium; Chemical and Drug Induced Liver Injury; L-Lactate Dehydrogenase; Lactates; Lactic | 1982 |
Disturbances of lactate metabolism in patients with liver damage due to paracetamol overdose.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Viral, Human; Human | 1981 |
Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice.
Topics: Anesthesia; Anesthesia Recovery Period; Animals; Brain Chemistry; Carcinogens; Chemical and Drug Ind | 1996 |
Effects of the anti-AIDS drug dideoxyinosine on hepatic glycolysis in the perfused rat liver: role of intracellular calcium stores.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Calcium; Chemical and Drug Induced Li | 1991 |
Biochemical effects of acute stress on energy metabolism in liver damaged rats.
Topics: Acetyl Coenzyme A; Animals; Chemical and Drug Induced Liver Injury; Cyclic AMP; Cyclic GMP; Energy M | 1987 |
Valproate causes metabolic disturbance in normal man.
Topics: Acetoacetates; Administration, Oral; Blood Glucose; Chemical and Drug Induced Liver Injury; Humans; | 1986 |
Assessment of the toxicity of chemical mixtures with isolated rat hepatocytes: cadmium and chloroform.
Topics: Animals; Aspartate Aminotransferases; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Chl | 1987 |