pyruvic acid has been researched along with Charcot-Marie-Tooth Disease in 3 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Charcot-Marie-Tooth Disease: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylene blue was used to stimulate the rate of pyruvate oxidation in two different assay systems of pyruvate dehydrogenase activity in cultured human fibroblasts to determine if such partial defects, if present, could be detected in a stimulated assay system." | 1.27 | Normal pyruvate oxidation in Friedreich ataxia and Charcot-Marie-Tooth disease fibroblasts. ( Wilson, WG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahenk, Z | 1 |
| Yalvac, ME | 1 |
| Amornvit, J | 1 |
| Arnold, WD | 1 |
| Chen, L | 1 |
| Shontz, KM | 1 |
| Lewis, S | 1 |
| Pich, S | 1 |
| Bach, D | 1 |
| Briones, P | 1 |
| Liesa, M | 1 |
| Camps, M | 1 |
| Testar, X | 1 |
| Palacín, M | 1 |
| Zorzano, A | 1 |
| Wilson, WG | 1 |
3 other studies available for pyruvic acid and Charcot-Marie-Tooth Disease
| Article | Year |
|---|---|
Efficacy of exogenous pyruvate in Trembler
Topics: Animals; Axons; Charcot-Marie-Tooth Disease; Disease Models, Animal; Mice; Myelin Proteins; Myelin S | 2018 |
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system.
Topics: Base Sequence; Charcot-Marie-Tooth Disease; DNA Primers; Fatty Acids; Glucose; GTP Phosphohydrolases | 2005 |
Normal pyruvate oxidation in Friedreich ataxia and Charcot-Marie-Tooth disease fibroblasts.
Topics: Cell Line; Charcot-Marie-Tooth Disease; Female; Fibroblasts; Friedreich Ataxia; Humans; Male; Methyl | 1985 |