pyruvic acid has been researched along with Cell Transformation, Neoplastic in 12 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import." | 1.56 | Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. ( Bensard, CL; Berg, JA; Bott, AJ; Cluntun, A; Dove, KK; Ducker, GS; Earl, CS; Evason, KJ; Fogarty, S; Krah, NM; Lettlova, S; Murtaugh, LC; Namnath, DF; Nowinski, SM; Olson, KA; Panic, V; Rutter, J; Schell, JC; Tanner, JM; Tantin, D; Thummel, CS; Vázquez-Arreguín, K; Villanueva, CJ; Wei, P; Wisidagama, DR, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, J | 1 |
| Quan, M | 1 |
| Xie, D | 1 |
| Gao, Y | 1 |
| Guha, S | 1 |
| Fallon, MB | 1 |
| Chen, J | 1 |
| Xie, K | 1 |
| Bensard, CL | 1 |
| Wisidagama, DR | 1 |
| Olson, KA | 1 |
| Berg, JA | 1 |
| Krah, NM | 1 |
| Schell, JC | 1 |
| Nowinski, SM | 1 |
| Fogarty, S | 1 |
| Bott, AJ | 1 |
| Wei, P | 1 |
| Dove, KK | 1 |
| Tanner, JM | 1 |
| Panic, V | 1 |
| Cluntun, A | 1 |
| Lettlova, S | 1 |
| Earl, CS | 1 |
| Namnath, DF | 1 |
| Vázquez-Arreguín, K | 1 |
| Villanueva, CJ | 1 |
| Tantin, D | 1 |
| Murtaugh, LC | 1 |
| Evason, KJ | 1 |
| Ducker, GS | 1 |
| Thummel, CS | 1 |
| Rutter, J | 1 |
| Gándara, L | 1 |
| Durrieu, L | 1 |
| Behrensen, C | 1 |
| Wappner, P | 1 |
| Chen, AP | 1 |
| Chu, W | 1 |
| Gu, YP | 1 |
| Cunningham, CH | 1 |
| Cunnhingham, CH | 1 |
| Xie, H | 1 |
| Hanai, J | 1 |
| Ren, JG | 1 |
| Kats, L | 1 |
| Burgess, K | 1 |
| Bhargava, P | 1 |
| Signoretti, S | 1 |
| Billiard, J | 1 |
| Duffy, KJ | 1 |
| Grant, A | 1 |
| Wang, X | 1 |
| Lorkiewicz, PK | 1 |
| Schatzman, S | 1 |
| Bousamra, M | 1 |
| Lane, AN | 1 |
| Higashi, RM | 1 |
| Fan, TW | 1 |
| Pandolfi, PP | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Cardaci, S | 1 |
| Zheng, L | 1 |
| MacKay, G | 1 |
| van den Broek, NJ | 1 |
| MacKenzie, ED | 1 |
| Nixon, C | 1 |
| Stevenson, D | 1 |
| Tumanov, S | 1 |
| Bulusu, V | 1 |
| Kamphorst, JJ | 1 |
| Vazquez, A | 1 |
| Fleming, S | 1 |
| Schiavi, F | 1 |
| Kalna, G | 1 |
| Blyth, K | 1 |
| Strathdee, D | 1 |
| Gottlieb, E | 1 |
| Walker, CM | 1 |
| Chen, Y | 2 |
| Lai, SY | 1 |
| Bankson, JA | 1 |
| Yang, D | 1 |
| Wang, MT | 1 |
| Tang, Y | 1 |
| Jiang, H | 1 |
| Jones, TT | 1 |
| Rao, K | 1 |
| Brewer, GJ | 1 |
| Singh, KK | 1 |
| Nie, D | 1 |
| Wittwer, JA | 1 |
| Robbins, D | 1 |
| Wang, F | 1 |
| Codarin, S | 1 |
| Shen, X | 1 |
| Kevil, CG | 1 |
| Huang, TT | 1 |
| Van Remmen, H | 1 |
| Richardson, A | 1 |
| Zhao, Y | 1 |
| Chang, I | 1 |
| Cho, N | 1 |
| Koh, JY | 1 |
| Lee, MS | 1 |
| Sens, DA | 1 |
| Hochstadt, B | 1 |
| Amos, H | 1 |
| McKeehan, WL | 1 |
12 other studies available for pyruvic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expres | 2020 |
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Topics: Adenoma; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Drosophila; | 2020 |
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drosophila melanogas | 2019 |
Probing early tumor response to radiation therapy using hyperpolarized [1-¹³C]pyruvate in MDA-MB-231 xenografts.
Topics: Animals; Apoptosis; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cell Transformation, N | 2013 |
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Topics: Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Carcinoma, Renal Cell; Cell Line, Transformed; Cell Prolif | 2015 |
A novel perfused Bloch-McConnell simulator for analyzing the accuracy of dynamic hyperpolarized MRS.
Topics: Animals; Cell Transformation, Neoplastic; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Models | 2016 |
Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L).
Topics: Adenosine Triphosphate; Animals; Antimycin A; Cell Transformation, Neoplastic; Electron Transport; E | 2010 |
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Topics: Animals; Cell Respiration; Cell Transformation, Neoplastic; Humans; Malates; Mice; Mice, Inbred C57B | 2011 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell | 2003 |
Effects of pyruvate on the growth of normal and transformed hamster embryo fibroblasts.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cric | 1982 |
Control of normal and transformed cell proliferation by growth factor-nutrient interactions.
Topics: Animals; Calcium; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cul | 1984 |