pyruvic acid has been researched along with Cataract in 17 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of pyruvate on the progress of galactose cataract has been studied." | 7.68 | Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992) |
| "Cataract was induced by maintaining young rats on a diet containing 30% galactose." | 3.72 | Ophthalmoscopic and morphogenetic changes in rat lens induced by galactose: attenuation by pyruvate. ( Hegde, KR; Kalakonda, S; Varma, SD, 2004) |
| "Studies show that the pyruvate treatment decreased the extent of several biochemical changes known to be associated with cataract formation, such as the elevation in the levels of glycated proteins, sorbitol, lipid peroxidation (MDA) and inhibition of the cation pump." | 3.70 | Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. ( Ali, AH; Devamanoharan, PS; Henein, M; Varma, SD; Zhao, W, 2000) |
| "The effect of pyruvate on the progress of galactose cataract has been studied." | 3.68 | Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992) |
| "The cataracts were then extracted either by routine extracapsular extraction or by phacoemulsification, both followed by intraocular lens implantation." | 2.74 | Possibility of topical antioxidant treatment of cataracts: corneal penetration of pyruvate in humans. ( Chandra, P; Hegde, KR; Varma, SD, 2009) |
| "Cataract is one of the major causes of blindness throughout the world." | 2.43 | [Risk factors in cataract]. ( Popescu, L; Vîrgolici, B, 2006) |
| "Cataract is one of the major causes of age-dependent visual impairment and blindness." | 2.38 | Scientific basis for medical therapy of cataracts by antioxidants. ( Varma, SD, 1991) |
| "Cataracts have also been observed in human beings treated with hyperbaric oxygen for different afflictions." | 1.27 | Ascorbic acid and the eye lens. ( Richards, RD; Varma, SD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chandra, P | 1 |
| Hegde, KR | 6 |
| Varma, SD | 14 |
| Mohanty, I | 1 |
| Joshi, S | 1 |
| Trivedi, D | 1 |
| Srivastava, S | 1 |
| Tandon, R | 1 |
| Gupta, SK | 1 |
| Kalakonda, S | 1 |
| Kovtun, S | 2 |
| Vîrgolici, B | 1 |
| Popescu, L | 1 |
| Ramachandran, S | 2 |
| Devamanoharan, PS | 6 |
| Morris, SM | 1 |
| Ali, AH | 3 |
| Beyer-Mears, A | 1 |
| Diecke, FP | 1 |
| Mistry, K | 1 |
| Ellison, C | 1 |
| Cruz, E | 1 |
| Zhao, W | 3 |
| Rutzen, AR | 1 |
| Henein, M | 3 |
| Richards, RD | 1 |
2 reviews available for pyruvic acid and Cataract
| Article | Year |
|---|---|
[Risk factors in cataract].
Topics: Adrenal Cortex Hormones; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Cataract; | 2006 |
Scientific basis for medical therapy of cataracts by antioxidants.
Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Carotenoids; Cataract; Humans; Lipid Metabolism | 1991 |
1 trial available for pyruvic acid and Cataract
| Article | Year |
|---|---|
Possibility of topical antioxidant treatment of cataracts: corneal penetration of pyruvate in humans.
Topics: Adolescent; Adult; Aged; Antioxidants; Aqueous Humor; Cataract; Cataract Extraction; Cornea; Humans; | 2009 |
14 other studies available for pyruvic acid and Cataract
| Article | Year |
|---|---|
Pyruvate modulates antioxidant status of cultured human lens epithelial cells under hypergalactosemic conditions.
Topics: Antioxidants; Cataract; Cells, Cultured; Epithelial Cells; Galactosemias; Glutathione; Humans; Lens | 2002 |
Ophthalmoscopic and morphogenetic changes in rat lens induced by galactose: attenuation by pyruvate.
Topics: Animals; Cataract; Cell Differentiation; Cell Movement; Diet; Galactitol; Galactose; Lens, Crystalli | 2004 |
Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate.
Topics: Animals; Apoptosis; Cataract; Cell Differentiation; Cell Movement; Diabetes Complications; Diabetes | 2004 |
Prevention of cataract by pyruvate in experimentally diabetic mice.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Glycosylation; Lens, Crystalline; Mice; Mice, In | 2005 |
Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate.
Topics: Animals; Cataract; Culture Media; Disease Models, Animal; Lens, Crystalline; Mice; Oxidative Stress; | 2006 |
Induction of ultraviolet cataracts in vitro: prevention by pyruvate.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aqueous Humor; Biological Transport, Active; Cataract | 2007 |
Prevention of oxidative damage to rat lens by pyruvate in vitro: possible attenuation in vivo.
Topics: Adenosine Triphosphate; Animals; Cataract; Crystallins; Electrophoresis, Polyacrylamide Gel; Glutath | 1995 |
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract.
Topics: Animals; Biological Transport; Carbohydrates; Cataract; Culture Media; Culture Techniques; Diabetes | 1997 |
Fructose induced deactivation of glucose-6-phosphate dehydrogenase activity and its prevention by pyruvate: implications in cataract prevention.
Topics: Animals; Catalase; Cataract; Cytochrome c Group; Diabetes Complications; Dose-Response Relationship, | 1998 |
Attenuation of galactose-induced cataract by pyruvate.
Topics: Adenosine Triphosphate; Animals; Aqueous Humor; Cataract; Diet; Galactose; Galactosemias; Glycoprote | 1999 |
Fructose-mediated damage to lens alpha-crystallin: prevention by pyruvate.
Topics: Animals; Antioxidants; Catalase; Cataract; Cattle; Crystallins; Diabetes Complications; Diabetes Mel | 2000 |
Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cataract; Crystallins; Diabetes Mellitus, Experimental | 2000 |
Prevention of galactose cataract by pyruvate.
Topics: Adenosine Triphosphate; Animals; Cataract; Crystallins; Diet; Disease Models, Animal; Galactitol; Ga | 1992 |
Ascorbic acid and the eye lens.
Topics: Animals; Aqueous Humor; Ascorbic Acid; Cataract; Free Radicals; Glucose; Humans; Hyperbaric Oxygenat | 1988 |