pyruvic acid has been researched along with Cardiomegaly in 17 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cardiac hypertrophy was also evident by a 49% increase in whole cell capacitance of isolated left ventricular myocytes (P < 0." | 1.30 | Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction. ( Patel, KP; Rozanski, GJ; Xu, Z; Zhang, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Ni, J | 1 |
| Zhang, H | 1 |
| Wang, X | 2 |
| Liu, Z | 1 |
| Nie, T | 1 |
| Li, L | 1 |
| Su, J | 1 |
| Zhu, Y | 1 |
| Ma, C | 1 |
| Huang, Y | 1 |
| Mao, J | 1 |
| Gao, X | 1 |
| Fan, G | 1 |
| Fernandez-Caggiano, M | 1 |
| Kamynina, A | 1 |
| Francois, AA | 1 |
| Prysyazhna, O | 1 |
| Eykyn, TR | 1 |
| Krasemann, S | 1 |
| Crespo-Leiro, MG | 1 |
| Vieites, MG | 1 |
| Bianchi, K | 1 |
| Morales, V | 1 |
| Domenech, N | 1 |
| Eaton, P | 1 |
| Zhang, Y | 1 |
| Taufalele, PV | 1 |
| Cochran, JD | 1 |
| Robillard-Frayne, I | 1 |
| Marx, JM | 1 |
| Soto, J | 1 |
| Rauckhorst, AJ | 1 |
| Tayyari, F | 1 |
| Pewa, AD | 1 |
| Gray, LR | 1 |
| Teesch, LM | 1 |
| Puchalska, P | 1 |
| Funari, TR | 1 |
| McGlauflin, R | 1 |
| Zimmerman, K | 1 |
| Kutschke, WJ | 1 |
| Cassier, T | 1 |
| Hitchcock, S | 1 |
| Lin, K | 1 |
| Kato, KM | 1 |
| Stueve, JL | 1 |
| Haff, L | 1 |
| Weiss, RM | 1 |
| Cox, JE | 2 |
| Rutter, J | 2 |
| Taylor, EB | 1 |
| Crawford, PA | 1 |
| Lewandowski, ED | 3 |
| Des Rosiers, C | 1 |
| Abel, ED | 1 |
| Cluntun, AA | 1 |
| Badolia, R | 1 |
| Lettlova, S | 1 |
| Parnell, KM | 1 |
| Shankar, TS | 1 |
| Diakos, NA | 1 |
| Olson, KA | 1 |
| Taleb, I | 1 |
| Tatum, SM | 1 |
| Berg, JA | 1 |
| Cunningham, CN | 1 |
| Van Ry, T | 1 |
| Bott, AJ | 1 |
| Krokidi, AT | 1 |
| Fogarty, S | 1 |
| Skedros, S | 1 |
| Swiatek, WI | 1 |
| Yu, X | 1 |
| Luo, B | 1 |
| Merx, S | 1 |
| Navankasattusas, S | 1 |
| Ducker, GS | 1 |
| Holland, WL | 1 |
| McKellar, SH | 1 |
| Drakos, SG | 1 |
| Chambers, KT | 1 |
| Cooper, MA | 1 |
| Swearingen, AR | 1 |
| Brookheart, RT | 1 |
| Schweitzer, GG | 1 |
| Weinheimer, CJ | 1 |
| Kovacs, A | 1 |
| Koves, TR | 1 |
| Muoio, DM | 1 |
| McCommis, KS | 1 |
| Finck, BN | 1 |
| Lahey, R | 1 |
| Carley, AN | 1 |
| Glass, CE | 1 |
| Accola, KD | 1 |
| Silvestry, S | 1 |
| O'Donnell, JM | 2 |
| Pound, KM | 1 |
| Sorokina, N | 1 |
| Ballal, K | 1 |
| Berkich, DA | 1 |
| Fasano, M | 1 |
| Lanoue, KF | 1 |
| Taegtmeyer, H | 1 |
| Sack, MN | 1 |
| Leong, HS | 1 |
| Brownsey, RW | 1 |
| Kulpa, JE | 1 |
| Allard, MF | 1 |
| BOZHKO, AP | 1 |
| WAKO, H | 1 |
| Morgan, HE | 1 |
| Kira, Y | 1 |
| Gordon, EE | 1 |
| Rozanski, GJ | 1 |
| Xu, Z | 1 |
| Zhang, K | 1 |
| Patel, KP | 1 |
| Rubio-Gozalbo, ME | 1 |
| Smeitink, JA | 1 |
| Ruitenbeek, W | 1 |
| Ter Laak, H | 1 |
| Mullaart, RA | 1 |
| Schuelke, M | 1 |
| Mariman, EC | 1 |
| Sengers, RC | 1 |
| Gabreëls, FJ | 1 |
| Ngai, SM | 1 |
| Way, MM | 1 |
| Chan, H | 1 |
| Tsui, SK | 1 |
| Lee, CY | 1 |
| Fung, KP | 1 |
| Giordano, G | 1 |
| Corradi, D | 1 |
| D'Adda, T | 1 |
| Melissari, M | 1 |
| Whitmer, JT | 1 |
1 review available for pyruvic acid and Cardiomegaly
| Article | Year |
|---|---|
Glycolysis and pyruvate oxidation in cardiac hypertrophy--why so unbalanced?
Topics: Animals; Cardiomegaly; Glucose; Glycolysis; Humans; Oxidation-Reduction; Pyruvate Dehydrogenase Comp | 2003 |
16 other studies available for pyruvic acid and Cardiomegaly
| Article | Year |
|---|---|
Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Dihydrolipoamide Dehydrogenase; Glucose; Mice; Pyruvate Dehydrogenase Complex | 2022 |
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy.
Topics: Angiotensin II; Animals; Anion Transport Proteins; Cardiomegaly; Cell Proliferation; Citric Acid Cyc | 2020 |
Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Topics: Adaptation, Physiological; Animals; Anion Transport Proteins; Cardiomegaly; Cardiomyopathy, Dilated; | 2020 |
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.
Topics: Animals; Anion Transport Proteins; Cardiomegaly; Heart Failure; Heart-Assist Devices; Humans; Lactic | 2021 |
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Topics: Animals; Cardiolipins; Cardiomegaly; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Digly | 2021 |
Enhanced Redox State and Efficiency of Glucose Oxidation With miR Based Suppression of Maladaptive NADPH-Dependent Malic Enzyme 1 Expression in Hypertrophied Hearts.
Topics: Aged; Animals; Cardiomegaly; Glucose; Glutathione; Humans; Malate Dehydrogenase; Male; MicroRNAs; Mi | 2018 |
Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.
Topics: Animals; Cardiomegaly; Citric Acid Cycle; Dichloroacetic Acid; Humans; Ketone Oxidoreductases; Malat | 2009 |
Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.
Topics: Animals; Cardiomegaly; Citric Acid Cycle; Dichloroacetic Acid; Humans; Ketone Oxidoreductases; Malat | 2009 |
[CONTENT OF GLYCOGEN, LACTIC AND PYRUVIC ACID IN THE MYOCARDIUM IN COMPENSATORY HYPERFUNCTION].
Topics: Animals; Carbohydrate Metabolism; Cardiomegaly; Glycogen; Heart Failure; Lactates; Metabolism; Myoca | 1963 |
Pyruvic acid and heart enlarging; and acetaldehyde, preliminary report.
Topics: Acetaldehyde; Beriberi; Cardiomegaly; Heart; Pyruvates; Pyruvic Acid | 1951 |
Aortic pressure, substrate utilization and protein synthesis.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Energy Metabolism; Glucose; Heart; Heart Arrest, Induc | 1984 |
Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction.
Topics: Animals; Cardiomegaly; Cells, Cultured; Coronary Vessels; Dichloroacetic Acid; Evoked Potentials; He | 1998 |
Spinal muscular atrophy-like picture, cardiomyopathy, and cytochrome c oxidase deficiency.
Topics: Blotting, Western; Cardiomegaly; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Huma | 1999 |
In silico studies of energy metabolism of normal and diseased heart.
Topics: Cardiomegaly; Cardiomyopathies; Computational Biology; Energy Metabolism; Expressed Sequence Tags; G | 2000 |
[An autopsy case of neonatal lactic acidosis].
Topics: Acidosis, Lactic; Atrophy; Autopsy; Body Fluids; Brain; Cardiomegaly; Epilepsy, Generalized; Fatal O | 2001 |
Energy metabolism and mechanical function in perfused hearts of Syrian hamsters with dilated or hypertrophic cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiomegaly; Carnitine; Coenzyme A; Coronary Circu | 1986 |