pyruvic acid has been researched along with Carcinogenesis in 10 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import." | 1.56 | Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. ( Bensard, CL; Berg, JA; Bott, AJ; Cluntun, A; Dove, KK; Ducker, GS; Earl, CS; Evason, KJ; Fogarty, S; Krah, NM; Lettlova, S; Murtaugh, LC; Namnath, DF; Nowinski, SM; Olson, KA; Panic, V; Rutter, J; Schell, JC; Tanner, JM; Tantin, D; Thummel, CS; Vázquez-Arreguín, K; Villanueva, CJ; Wei, P; Wisidagama, DR, 2020) |
| "Furthermore, LDHA/PDHA1 changes in HNSCC cells resulted in a broad metabolic reprogramming while intracellular molecules including polyunsaturated fatty acids and nitrogen metabolism related metabolites underlie the malignant changes." | 1.51 | Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. ( Chang, CW; Chen, HM; Chen, TY; Chen, YF; Chia, HY; Chou, CY; Chuang, LT; Hsieh, YT; Huang, JM; Huang, PC; Kuo, TY; Li, WC; Liu, CJ; Lo, JF, 2019) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsieh, YT | 2 |
| Tu, HF | 1 |
| Yang, MH | 1 |
| Chen, YF | 2 |
| Lan, XY | 1 |
| Huang, CL | 1 |
| Chen, HM | 2 |
| Li, WC | 2 |
| Tompkins, SC | 1 |
| Sheldon, RD | 1 |
| Rauckhorst, AJ | 1 |
| Noterman, MF | 1 |
| Solst, SR | 1 |
| Buchanan, JL | 1 |
| Mapuskar, KA | 1 |
| Pewa, AD | 1 |
| Gray, LR | 1 |
| Oonthonpan, L | 1 |
| Sharma, A | 1 |
| Scerbo, DA | 1 |
| Dupuy, AJ | 1 |
| Spitz, DR | 1 |
| Taylor, EB | 1 |
| Bensard, CL | 1 |
| Wisidagama, DR | 1 |
| Olson, KA | 2 |
| Berg, JA | 1 |
| Krah, NM | 1 |
| Schell, JC | 1 |
| Nowinski, SM | 1 |
| Fogarty, S | 1 |
| Bott, AJ | 1 |
| Wei, P | 1 |
| Dove, KK | 1 |
| Tanner, JM | 1 |
| Panic, V | 1 |
| Cluntun, A | 1 |
| Lettlova, S | 1 |
| Earl, CS | 1 |
| Namnath, DF | 1 |
| Vázquez-Arreguín, K | 1 |
| Villanueva, CJ | 1 |
| Tantin, D | 1 |
| Murtaugh, LC | 1 |
| Evason, KJ | 1 |
| Ducker, GS | 1 |
| Thummel, CS | 1 |
| Rutter, J | 2 |
| Sandoval, IT | 1 |
| Delacruz, RG | 1 |
| Miller, BN | 1 |
| Hill, S | 1 |
| Gabriel, AE | 1 |
| Boyd, K | 1 |
| Satterfield, C | 1 |
| Van Remmen, H | 1 |
| Jones, DA | 1 |
| Zhang, M | 1 |
| Pan, Y | 1 |
| Tang, D | 1 |
| Dorfman, RG | 1 |
| Xu, L | 1 |
| Zhou, Q | 1 |
| Zhou, L | 1 |
| Wang, Y | 1 |
| Li, Y | 1 |
| Yin, Y | 1 |
| Kong, B | 1 |
| Friess, H | 1 |
| Zhao, S | 1 |
| Wu, JL | 1 |
| Wang, L | 1 |
| Zou, X | 1 |
| Chen, TY | 1 |
| Huang, JM | 1 |
| Liu, CJ | 1 |
| Chuang, LT | 1 |
| Huang, PC | 1 |
| Kuo, TY | 1 |
| Chia, HY | 1 |
| Chou, CY | 1 |
| Chang, CW | 1 |
| Lo, JF | 1 |
| Xie, H | 1 |
| Hanai, J | 1 |
| Ren, JG | 1 |
| Kats, L | 1 |
| Burgess, K | 1 |
| Bhargava, P | 1 |
| Signoretti, S | 1 |
| Billiard, J | 1 |
| Duffy, KJ | 1 |
| Grant, A | 1 |
| Wang, X | 1 |
| Lorkiewicz, PK | 1 |
| Schatzman, S | 1 |
| Bousamra, M | 1 |
| Lane, AN | 1 |
| Higashi, RM | 1 |
| Fan, TW | 1 |
| Pandolfi, PP | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Li, W | 1 |
| Zhang, C | 1 |
| Jackson, K | 1 |
| Shen, X | 1 |
| Jin, R | 1 |
| Li, G | 1 |
| Kevil, CG | 1 |
| Gu, X | 1 |
| Shi, R | 1 |
| Zhao, Y | 1 |
| Ma, X | 1 |
| Deng, J | 1 |
| Cao, N | 1 |
| Guo, Z | 1 |
| Zheng, Y | 1 |
| Geng, S | 1 |
| Meng, M | 1 |
| Lin, H | 1 |
| Duan, Y | 1 |
| Du, G | 1 |
| Chan, LN | 1 |
| Chen, Z | 1 |
| Braas, D | 1 |
| Lee, JW | 1 |
| Xiao, G | 1 |
| Geng, H | 1 |
| Cosgun, KN | 1 |
| Hurtz, C | 1 |
| Shojaee, S | 1 |
| Cazzaniga, V | 1 |
| Schjerven, H | 1 |
| Ernst, T | 1 |
| Hochhaus, A | 1 |
| Kornblau, SM | 1 |
| Konopleva, M | 1 |
| Pufall, MA | 1 |
| Cazzaniga, G | 1 |
| Liu, GJ | 1 |
| Milne, TA | 1 |
| Koeffler, HP | 1 |
| Ross, TS | 1 |
| Sánchez-García, I | 1 |
| Borkhardt, A | 1 |
| Yamamoto, KR | 1 |
| Dickins, RA | 1 |
| Graeber, TG | 1 |
| Müschen, M | 1 |
10 other studies available for pyruvic acid and Carcinogenesis
| Article | Year |
|---|---|
Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors.
Topics: Adenosine Triphosphate; Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; DNA-Binding P | 2021 |
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Citric Acid Cycle; | 2019 |
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Topics: Adenoma; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Drosophila; | 2020 |
A metabolic switch controls intestinal differentiation downstream of
Topics: Adenomatous Polyposis Coli Protein; Animals; Carcinogenesis; Gene Expression Regulation; Humans; Int | 2017 |
Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis.
Topics: Animals; Apoptosis; Bile Duct Neoplasms; Carcinogenesis; Carrier Proteins; Cell Line, Tumor; Cell Pr | 2019 |
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Heterografts; Humans; L-L | 2019 |
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Topics: Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
UCP2 knockout suppresses mouse skin carcinogenesis.
Topics: Adenosine Triphosphate; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Chromatography, High Pres | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Metabolic gatekeeper function of B-lymphoid transcription factors.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals | 2017 |