pyruvic acid has been researched along with Brain Neoplasms in 28 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyruvic acid has a critical role in energy metabolism and a capability to nonenzymatically decarboxylate H2O2 into H2O." | 5.32 | Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. ( Mazzio, EA; Soliman, KF, 2003) |
| "To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model." | 3.77 | Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. ( Bok, R; James, CD; Nelson, SJ; Ozawa, T; Park, I; Phillips, JJ; Ronen, SM; Vigneron, DB, 2011) |
| " Dosing was based on haplotype variation in glutathione transferase zeta 1/maleylacetoacetate isomerase (GSTZ1/MAAI), which participates in DCA and tyrosine catabolism." | 2.79 | Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors. ( Coats, BS; Dunbar, EM; Forder, JR; Langaee, T; Lew, A; Shroads, AL; Shuster, JJ; Stacpoole, PW; Wagner, DA, 2014) |
| "Metabolic imaging of brain tumors using (13)C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-(13)C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clinical trials in multiple centers." | 1.43 | Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. ( Blough, MD; Cairncross, JG; Chaumeil, MM; Chesnelong, C; Eriksson, P; Luchman, HA; Najac, C; Radoul, M; Ronen, SM; Viswanath, P, 2016) |
| "Pyruvic acid has a critical role in energy metabolism and a capability to nonenzymatically decarboxylate H2O2 into H2O." | 1.32 | Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. ( Mazzio, EA; Soliman, KF, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 14 (50.00) | 24.3611 |
| 2020's | 7 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, H | 1 |
| Hosoi, Y | 1 |
| Ishikawa, K | 1 |
| Yoshitake, J | 1 |
| Shibata, T | 1 |
| Uchida, K | 1 |
| Hashizume, H | 1 |
| Mizuno, M | 1 |
| Okazaki, Y | 1 |
| Toyokuni, S | 1 |
| Nakamura, K | 1 |
| Kajiyama, H | 1 |
| Kikkawa, F | 1 |
| Hori, M | 1 |
| Hong, D | 1 |
| Batsios, G | 2 |
| Viswanath, P | 3 |
| Gillespie, AM | 2 |
| Vaidya, M | 1 |
| Larson, PEZ | 5 |
| Ronen, SM | 4 |
| Gondáš, E | 1 |
| Kráľová Trančíková, A | 1 |
| Dibdiaková, K | 1 |
| Galanda, T | 1 |
| Hatok, J | 1 |
| Račay, P | 1 |
| Dobrota, D | 1 |
| Murín, R | 1 |
| Mukherjee, J | 1 |
| Luchman, HA | 2 |
| Phillips, JJ | 2 |
| Costello, JF | 1 |
| Pieper, RO | 1 |
| Qi, Q | 1 |
| Fox, MS | 1 |
| Lim, H | 2 |
| Bartha, R | 1 |
| Scholl, TJ | 2 |
| Hoffman, L | 1 |
| Lee, TY | 1 |
| Thiessen, JD | 1 |
| Mishkovsky, M | 1 |
| Gusyatiner, O | 1 |
| Lanz, B | 1 |
| Cudalbu, C | 1 |
| Vassallo, I | 1 |
| Hamou, MF | 1 |
| Bloch, J | 1 |
| Comment, A | 1 |
| Gruetter, R | 1 |
| Hegi, ME | 1 |
| Park, I | 5 |
| Gordon, JW | 3 |
| Carvajal, L | 3 |
| Chen, HY | 4 |
| Bok, R | 4 |
| Van Criekinge, M | 3 |
| Ferrone, M | 2 |
| Slater, JB | 3 |
| Xu, D | 4 |
| Kurhanewicz, J | 2 |
| Vigneron, DB | 5 |
| Chang, S | 3 |
| Nelson, SJ | 4 |
| Lupo, JM | 1 |
| Miller, JJ | 1 |
| Grist, JT | 1 |
| Serres, S | 1 |
| Larkin, JR | 1 |
| Lau, AZ | 1 |
| Ray, K | 1 |
| Fisher, KR | 1 |
| Hansen, E | 1 |
| Tougaard, RS | 1 |
| Nielsen, PM | 1 |
| Lindhardt, J | 1 |
| Laustsen, C | 1 |
| Gallagher, FA | 1 |
| Tyler, DJ | 1 |
| Sibson, N | 1 |
| Autry, A | 2 |
| Mammoli, D | 3 |
| Milshteyn, E | 1 |
| Li, Y | 3 |
| Aggarwal, R | 1 |
| Nelson, S | 1 |
| Autry, AW | 1 |
| Mareyam, A | 1 |
| Vareth, M | 1 |
| Chang, SM | 1 |
| Wald, LL | 1 |
| Gordon, J | 1 |
| Chung, B | 1 |
| Shin, P | 1 |
| Crane, J | 1 |
| Michel, KA | 1 |
| Zieliński, R | 1 |
| Walker, CM | 1 |
| Le Roux, L | 1 |
| Priebe, W | 1 |
| Bankson, JA | 1 |
| Schellingerhout, D | 1 |
| Dunbar, EM | 1 |
| Coats, BS | 1 |
| Shroads, AL | 1 |
| Langaee, T | 1 |
| Lew, A | 1 |
| Forder, JR | 1 |
| Shuster, JJ | 1 |
| Wagner, DA | 1 |
| Stacpoole, PW | 1 |
| Thind, K | 1 |
| Martinez-Santiesteban, FM | 1 |
| Park, JM | 2 |
| Josan, S | 2 |
| Jang, T | 2 |
| Merchant, M | 2 |
| Watkins, R | 1 |
| Hurd, RE | 2 |
| Recht, LD | 1 |
| Mayer, D | 2 |
| Spielman, DM | 2 |
| Chaumeil, MM | 1 |
| Radoul, M | 1 |
| Najac, C | 1 |
| Eriksson, P | 1 |
| Blough, MD | 1 |
| Chesnelong, C | 1 |
| Cairncross, JG | 1 |
| Joe, E | 1 |
| Lee, H | 1 |
| Lee, J | 1 |
| Yang, S | 1 |
| Choi, YS | 1 |
| Wang, E | 1 |
| Song, HT | 1 |
| Kim, DH | 1 |
| Lindvall, P | 1 |
| Roslin, M | 1 |
| Bergenheim, AT | 1 |
| Rodrigues, TB | 1 |
| López-Larrubia, P | 1 |
| Cerdán, S | 1 |
| Day, SE | 1 |
| Kettunen, MI | 1 |
| Cherukuri, MK | 1 |
| Mitchell, JB | 1 |
| Lizak, MJ | 1 |
| Morris, HD | 1 |
| Matsumoto, S | 1 |
| Koretsky, AP | 1 |
| Brindle, KM | 1 |
| Ozawa, T | 1 |
| James, CD | 1 |
| Yen, YF | 1 |
| Recht, L | 1 |
| Mazzio, EA | 1 |
| Soliman, KF | 1 |
| Jagtap, JC | 1 |
| Chandele, A | 1 |
| Chopde, BA | 1 |
| Shastry, P | 1 |
| Darbin, O | 1 |
| Lonjon, M | 1 |
| Quentien, MH | 1 |
| Michiels, JF | 1 |
| Grellier, P | 1 |
| Negrin, J | 1 |
| Rostain, JC | 1 |
| Risso, JJ | 1 |
| Alhonen-Hongisto, L | 1 |
| Levin, VA | 1 |
| Marton, LJ | 1 |
| Hara, T | 1 |
| Iio, M | 1 |
| Izuchi, R | 1 |
| Tsukiyama, T | 1 |
| Yokoi, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Phase 3 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:[NCT02616484] | Phase 3 | 34 participants (Actual) | Interventional | 2020-07-14 | Active, not recruiting | ||
| Phase 1, Open-Label, Single-Arm, Clinical and Metabolomics Study of Dichloroacetate (DCA) in Adults With Recurrent Malignant Brain Tumors[NCT01111097] | Phase 1 | 15 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pyruvic acid and Brain Neoplasms
| Article | Year |
|---|---|
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Topics: Acetone; Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Brai | 2014 |
27 other studies available for pyruvic acid and Brain Neoplasms
| Article | Year |
|---|---|
Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified.
Topics: Brain Neoplasms; Cell Death; Cell Line, Tumor; Formates; Glioblastoma; Glyoxylates; Humans; Plasma G | 2021 |
Acquisition and quantification pipeline for in vivo hyperpolarized
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Kinetics; Magnetic Resonance Spectroscopy; Pyruvic Acid; | 2022 |
Immunodetection of Pyruvate Carboxylase Expression in Human Astrocytomas, Glioblastomas, Oligodendrogliomas, and Meningiomas.
Topics: Astrocytoma; Brain Neoplasms; Glioblastoma; Humans; Meningeal Neoplasms; Meningioma; Oligodendroglio | 2023 |
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng | 2021 |
Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Fluorodeoxyglucose F18; Glioma; Glucose; Gl | 2021 |
Hyperpolarized
Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma | 2021 |
Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.
Topics: Adult; Brain; Brain Neoplasms; Carbon Isotopes; Equipment Design; Feasibility Studies; Female; Human | 2018 |
Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Disease Models, | 2019 |
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain Neoplasms; Carbon Isotopes; Cell Line, Tum | 2018 |
Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.
Topics: Artifacts; Bicarbonates; Brain; Brain Neoplasms; Calibration; Carbon Isotopes; Carbon-13 Magnetic Re | 2019 |
Comparison between 8- and 32-channel phased-array receive coils for in vivo hyperpolarized
Topics: Brain; Brain Neoplasms; Equipment Design; Humans; Image Interpretation, Computer-Assisted; Magnetic | 2019 |
Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.
Topics: Brain; Brain Neoplasms; Carbon Isotopes; Echo-Planar Imaging; Humans; Image Interpretation, Computer | 2020 |
Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; | 2019 |
Construction and evaluation of a switch-tuned (13) C - (1) H birdcage radiofrequency coil for imaging the metabolism of hyperpolarized (13) C-enriched compounds.
Topics: Animals; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Equipment Design; Glioma; Magne | 2014 |
Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Glioma; Image Processing, Computer-Assisted; Magne | 2016 |
Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.
Topics: Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Glioma; Humans; Isoci | 2016 |
An indirect method for in vivo T
Topics: Algorithms; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; | 2017 |
Cerebral metabolism during air transport of patients after surgery for malignant glioma.
Topics: Air Ambulances; Brain; Brain Neoplasms; Glioma; Glucose; Glutamic Acid; Glycerol; Humans; Lactic Aci | 2008 |
Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas.
Topics: Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cerebral C | 2009 |
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Glioma; Lactic Acid; Ma | 2011 |
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Daca | 2011 |
Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Female; Glioma; Kinetics; Magnetic Reso | 2012 |
Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells.
Topics: Animals; Antioxidants; Brain Neoplasms; Cell Survival; Glycolysis; Hydrogen Peroxide; Kinetics; Mice | 2003 |
Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC.
Topics: Antioxidants; Apoptosis; Blotting, Western; Brain Neoplasms; Caspase 3; Caspases; Cell Line, Tumor; | 2003 |
In vivo study of tumor metabolism: an application of new multi-probe microdialysis system in the striatum of freely moving rats grafted with C6 cells.
Topics: Animals; Brain Neoplasms; Corpus Striatum; Glioma; Glucose; Lactic Acid; Male; Microdialysis; Pyruvi | 2000 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mito | 1985 |
Synthesis of pyruvate-1-11C as a radiopharmaceutical for tumor imaging.
Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Female; Humans; Isotope Labeling; Male; Middle Aged; | 1985 |