pyruvic acid has been researched along with Brain Ischemia in 90 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "The effects of treatment with indole-pyruvic acid, an endogenous metabolite of tryptophan converted into kynurenic acid in the brain, were studied in rats after transient forebrain ischemia induced by the 4-vessel occlusion procedure." | 7.68 | Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat. ( Agnati, LF; Biagini, G; Ferraguti, F; Fuxe, K; Merlo Pich, E; Zoli, M, 1993) |
| "The effects of antiedematous agent with intravenous 10% glycerol on cerebral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR)." | 7.67 | Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats. ( Fujishima, M; Ibayashi, S; Ishitsuka, T; Sadoshima, S; Shiokawa, O; Yoshida, F, 1986) |
| "The experimental study presented was undertaken to evaluate the role of thromboxane A2 contributing to aggravating cerebral ischemia, and to examine the effect of a thromboxane A2 synthetase inhibitor, trapidil on cerebral ischemia." | 7.67 | [Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia]. ( Katayama, Y; Memezawa, H; Minamisawa, H; Shimizu, J; Sugimoto, S; Suzuki, S; Terashi, A, 1986) |
| "Treatment with buflomedil attenuated ischemia-induced histological loss and damage of CA1 pyramidal cells." | 5.33 | Protective effect of buflomedil in a rat model of moderate cerebral ischemia. ( Briguglio, FS; De Pasquale, A; Galluzzo, M; Mondello, MR; Raneri, E; Saija, A; Trombetta, D, 2005) |
| "To validate this assay, a focal cerebral ischemia was produced by occlusion of one common carotid artery for 60 min and then reperfusion for additional 3 h in awake gerbils." | 5.31 | Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. ( Chen, SH; Cheng, FC; Lee, CW; Tsai, TH; Yan, DY; Yang, LL, 2000) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 5.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| " The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected." | 5.09 | Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000) |
| "Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population." | 4.12 | Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "Bedside intracerebral microdialysis monitoring of patients with subarachnoid hemorrhage and signs of delayed ischemia revealed dramatic changes in extracellular concentrations of glucose, lactate, and glycerol that could be directly correlated to the clinical status of the patients." | 3.70 | Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration. ( Brandt, L; Nilsson, OG; Säveland, H; Ungerstedt, U, 1999) |
| "The effects of treatment with indole-pyruvic acid, an endogenous metabolite of tryptophan converted into kynurenic acid in the brain, were studied in rats after transient forebrain ischemia induced by the 4-vessel occlusion procedure." | 3.68 | Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat. ( Agnati, LF; Biagini, G; Ferraguti, F; Fuxe, K; Merlo Pich, E; Zoli, M, 1993) |
| "The experimental study presented was undertaken to evaluate the role of thromboxane A2 contributing to aggravating cerebral ischemia, and to examine the effect of a thromboxane A2 synthetase inhibitor, trapidil on cerebral ischemia." | 3.67 | [Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia]. ( Katayama, Y; Memezawa, H; Minamisawa, H; Shimizu, J; Sugimoto, S; Suzuki, S; Terashi, A, 1986) |
| "The effects of antiedematous agent with intravenous 10% glycerol on cerebral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR)." | 3.67 | Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats. ( Fujishima, M; Ibayashi, S; Ishitsuka, T; Sadoshima, S; Shiokawa, O; Yoshida, F, 1986) |
| "Thirteen subarachnoid hemorrhage patients (age, 48." | 2.71 | Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study. ( Amthauer, H; Haux, D; Küchler, I; Lüdemann, L; Plotkin, M; Sarrafzadeh, AS; Unterberg, AW, 2004) |
| "Glycerol is an integral component of cell membranes." | 2.46 | [Use of intracerebral microdialysis in severe traumatic brain injury]. ( Abe, Y; Kawai, N; Kawakita, K; Kuroda, Y; Tamiya, T; Yano, T, 2010) |
| "Delayed cerebral ischemia (DCI) is a devastating complication of aneurysmal subarachnoid hemorrhage (ASAH) causing brain infarction and disability." | 1.91 | Early brain metabolic disturbances associated with delayed cerebral ischemia in patients with severe subarachnoid hemorrhage. ( Aboudhiaf, S; Balança, B; Barcelos, GK; Carrillon, R; Dailler, F; Grousson, S; Lieutaud, T; Marinesco, S; Perret-Liaudet, A; Tholance, Y, 2023) |
| "OBJECTIVE Delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is one of the major contributors to poor outcome." | 1.48 | Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage. ( Enblad, P; Engquist, H; Hillered, L; Howells, T; Johnson, U; Lewén, A; Nilsson, P; Ronne-Engström, E; Rostami, E, 2018) |
| "In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death." | 1.48 | NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia. ( Baranovicova, E; Cierny, D; Grendar, M; Kalenska, D; Lehotsky, J; Tomascova, A, 2018) |
| "According to previous studies, cerebral ischemia was defined as lactate/pyruvate (LP) ratio > 30 with intracerebral pyruvate level < 70 µmol L(-1)." | 1.42 | Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis. ( Andersen, ÅB; Jacobsen, A; Larsen, L; Nielsen, TH; Nordström, CH; Poulsen, FR; Schalén, W; Schulz, M, 2015) |
| "This biochemical pattern contrasts to cerebral ischemia, which is characterized by a marked decrease in cerebral pyruvate." | 1.40 | Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction. ( Nielsen, TH; Nordström, CH; Reinstrup, P; Schalén, W; Ståhl, N; Toft, P, 2014) |
| "Aneurysmal subarachnoid hemorrhage (SAH) is frequently associated with delayed neurological deterioration (DND)." | 1.40 | Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage. ( Jacobsen, A; Nielsen, TH; Nilsson, O; Nordström, CH; Schalén, W, 2014) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome." | 1.33 | Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system. ( Bullock, RM; Choi, S; Gilman, C; Kunene, NK; Mazzeo, AT, 2006) |
| "Treatment with buflomedil attenuated ischemia-induced histological loss and damage of CA1 pyramidal cells." | 1.33 | Protective effect of buflomedil in a rat model of moderate cerebral ischemia. ( Briguglio, FS; De Pasquale, A; Galluzzo, M; Mondello, MR; Raneri, E; Saija, A; Trombetta, D, 2005) |
| "Heatstroke was induced by exposing the anesthetized rats to a high ambient temperature (Ta = 43 degrees C) until the moment at which MAP decreased from its peak level." | 1.33 | Heat shock pretreatment may protect against heatstroke-induced circulatory shock and cerebral ischemia by reducing oxidative stress and energy depletion. ( Ke, DS; Lin, MT; Wang, JL, 2005) |
| "In idiopathic adult hydrocephalus syndrome (IAHS), a pathophysiological model of "chronic ischaemia" caused by an arteriosclerotic process in association with a CSF hydrodynamic disturbance has been proposed." | 1.32 | Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome. ( Agren-Wilsson, A; Bergenheim, AT; Eklund, A; Koskinen, LO; Malm, J; Roslin, M, 2003) |
| "In the treatment of patients with aneurysmal subarachnoid hemorrhage (SAH), early occlusion of the aneurysm is necessary as well as monitoring and treatment of complications following the primary bleeding episode." | 1.32 | Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Kristensen, SR; Schulz, M; Skjøth-Rasmussen, J, 2004) |
| " In other set of experiments, pyruvate was given either before, immediately after ischemia or in a long-term administration paradigm." | 1.32 | Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. ( Candelario-Jalil, E; García-Cabrera, M; González-Falcón, A; León, OS, 2003) |
| "To validate this assay, a focal cerebral ischemia was produced by occlusion of one common carotid artery for 60 min and then reperfusion for additional 3 h in awake gerbils." | 1.31 | Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. ( Chen, SH; Cheng, FC; Lee, CW; Tsai, TH; Yan, DY; Yang, LL, 2000) |
| "Thirty minutes after the onset of hemorrhagic shock, sodium PYR (n = 8) was infused (0." | 1.31 | Pyruvate improves cerebral metabolism during hemorrhagic shock. ( Bünger, R; Capacchione, J; Fontana, JL; Mongan, PD; West, S, 2001) |
| "Forty patients (35 after subarachnoid hemorrhage and 5 after complex aneurysm surgery) were monitored for a total of 174 days (mean, 4 d; range, 1-12 d)." | 1.31 | Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes. ( Al-Rawi, PG; Gupta, AK; Hutchinson, PJ; Kett-White, R; Kirkpatrick, PJ; Pickard, JD, 2002) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 1.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| "After the cerebral ischemia, the ventriculosubarachnoid space was perfused with an oxygenated fluorocarbon nutrient solution (OFNS) or modified Elliott's B solution (ES) (control perfusion)." | 1.27 | Severe cerebral ischemia treatment by ventriculosubarachnoid perfusion with an oxygenated fluorocarbon emulsion. ( Alderman, JB; D'Amore, BR; Frazer, G; Osterholm, JL; Triolo, AJ; Williams, HD, 1983) |
| "Pulmonary changes in acute cerebral ischemia were studied in anesthetized Mongolian gerbils, in which both carotid arteries were occluded simultaneously." | 1.27 | Pulmonary hemorrhage in experimental cerebral ischemia in mongolian gerbils. Brain metabolism and lung pathology. ( Fujishima, M; Ishitsuka, T; Nakatomi, Y; Ogata, J; Omae, T; Sadoshima, S; Tamaki, K, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (10.00) | 18.7374 |
| 1990's | 13 (14.44) | 18.2507 |
| 2000's | 42 (46.67) | 29.6817 |
| 2010's | 17 (18.89) | 24.3611 |
| 2020's | 9 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C | 1 |
| Qiao, X | 1 |
| Guo, J | 1 |
| Yang, T | 1 |
| Wang, M | 1 |
| Ma, Y | 1 |
| Zhao, S | 1 |
| Ding, L | 1 |
| Liu, H | 1 |
| Wang, J | 1 |
| Svedung Wettervik, T | 1 |
| Howells, T | 3 |
| Hånell, A | 1 |
| Ronne-Engström, E | 4 |
| Lewén, A | 3 |
| Enblad, P | 7 |
| Ho, WM | 1 |
| Schmidt, FA | 1 |
| Thomé, C | 2 |
| Petr, O | 1 |
| Tholance, Y | 1 |
| Aboudhiaf, S | 1 |
| Balança, B | 1 |
| Barcelos, GK | 1 |
| Grousson, S | 1 |
| Carrillon, R | 1 |
| Lieutaud, T | 1 |
| Perret-Liaudet, A | 1 |
| Dailler, F | 1 |
| Marinesco, S | 1 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Hosmann, A | 1 |
| Milivojev, N | 1 |
| Dumitrescu, S | 1 |
| Reinprecht, A | 1 |
| Weidinger, A | 1 |
| Kozlov, AV | 1 |
| Gul, Z | 1 |
| Buyukuysal, RL | 1 |
| Mölström, S | 1 |
| Nielsen, TH | 5 |
| Nordström, CH | 7 |
| Forsse, A | 1 |
| Möller, S | 1 |
| Venö, S | 1 |
| Mamaev, D | 1 |
| Tencer, T | 1 |
| Schmidt, H | 1 |
| Toft, P | 2 |
| Rostami, E | 1 |
| Engquist, H | 1 |
| Johnson, U | 1 |
| Nilsson, P | 1 |
| Hillered, L | 6 |
| Khalilov, RA | 1 |
| Dzhafarova, AM | 1 |
| Khizrieva, SI | 1 |
| Baranovicova, E | 1 |
| Grendar, M | 1 |
| Kalenska, D | 1 |
| Tomascova, A | 1 |
| Cierny, D | 1 |
| Lehotsky, J | 1 |
| Kofler, M | 1 |
| Gaasch, M | 1 |
| Rass, V | 1 |
| Schiefecker, AJ | 1 |
| Ianosi, B | 1 |
| Lindner, A | 1 |
| Beer, R | 1 |
| Stover, JF | 1 |
| Rhomberg, P | 1 |
| Pfausler, B | 1 |
| Schmutzhard, E | 1 |
| Helbok, R | 1 |
| Asgari, S | 1 |
| Vespa, P | 2 |
| Hu, X | 1 |
| Schalén, W | 4 |
| Ståhl, N | 2 |
| Reinstrup, P | 3 |
| Jacobsen, A | 2 |
| Nilsson, O | 1 |
| Poulsen, FR | 1 |
| Schulz, M | 2 |
| Andersen, ÅB | 1 |
| Larsen, L | 1 |
| Dienel, GA | 1 |
| Ungerstedt, U | 5 |
| Patet, C | 1 |
| Quintard, H | 1 |
| Zerlauth, JB | 1 |
| Maibach, T | 1 |
| Carteron, L | 1 |
| Suys, T | 1 |
| Bouzat, P | 1 |
| Bervini, D | 1 |
| Levivier, M | 1 |
| Daniel, RT | 1 |
| Eckert, P | 1 |
| Meuli, R | 1 |
| Oddo, M | 1 |
| Nordmark, J | 1 |
| Rubertsson, S | 1 |
| Macdonald, RL | 1 |
| Zetterling, M | 1 |
| Samuelsson, C | 2 |
| Karlsson, T | 1 |
| Kumlien, E | 1 |
| Lakshmanan, R | 1 |
| Loo, JA | 1 |
| Drake, T | 1 |
| Leblanc, J | 1 |
| Ytterberg, AJ | 1 |
| McArthur, DL | 2 |
| Etchepare, M | 1 |
| Vespa, PM | 1 |
| Tovedal, T | 1 |
| Jonsson, O | 1 |
| Zemgulis, V | 1 |
| Myrdal, G | 1 |
| Thelin, S | 1 |
| Lennmyr, F | 1 |
| Sarrafzadeh, A | 1 |
| Schlenk, F | 1 |
| Gericke, C | 1 |
| Vajkoczy, P | 1 |
| Kawai, N | 1 |
| Kawakita, K | 1 |
| Yano, T | 1 |
| Abe, Y | 1 |
| Kuroda, Y | 1 |
| Tamiya, T | 1 |
| Purins, K | 1 |
| Wiklund, L | 1 |
| Tu, J | 1 |
| A, J | 1 |
| Wang, G | 1 |
| Wen, H | 1 |
| Wang, A | 1 |
| Di, L | 1 |
| Cao, B | 1 |
| Liu, L | 1 |
| Schurr, A | 1 |
| Kett-White, R | 2 |
| Hutchinson, PJ | 2 |
| al-Rawi, PG | 2 |
| Gupta, AK | 2 |
| O'Connell, MT | 1 |
| Pickard, JD | 2 |
| Kirkpatrick, PJ | 2 |
| Marion, DW | 1 |
| Puccio, A | 1 |
| Wisniewski, SR | 1 |
| Kochanek, P | 1 |
| Dixon, CE | 1 |
| Bullian, L | 1 |
| Carlier, P | 1 |
| Agren-Wilsson, A | 1 |
| Roslin, M | 1 |
| Eklund, A | 1 |
| Koskinen, LO | 1 |
| Bergenheim, AT | 1 |
| Malm, J | 1 |
| Romsi, P | 2 |
| Kaakinen, T | 2 |
| Kiviluoma, K | 2 |
| Vainionpää, V | 1 |
| Hirvonen, J | 1 |
| Pokela, M | 1 |
| Ohtonen, P | 1 |
| Biancari, F | 2 |
| Nuutinen, M | 2 |
| Juvonen, T | 2 |
| Chou, YT | 1 |
| Lai, ST | 1 |
| Lee, CC | 1 |
| Lin, MT | 4 |
| González-Falcón, A | 1 |
| Candelario-Jalil, E | 1 |
| García-Cabrera, M | 1 |
| León, OS | 1 |
| Chang, CK | 1 |
| Chiu, WT | 1 |
| Chang, CP | 2 |
| Skjøth-Rasmussen, J | 1 |
| Kristensen, SR | 1 |
| Bjerre, P | 2 |
| Sarrafzadeh, AS | 1 |
| Haux, D | 1 |
| Lüdemann, L | 1 |
| Amthauer, H | 1 |
| Plotkin, M | 1 |
| Küchler, I | 1 |
| Unterberg, AW | 1 |
| Scheufler, KM | 1 |
| Lehnert, A | 1 |
| Rohrborn, HJ | 1 |
| Nadstawek, J | 1 |
| Thees, C | 1 |
| Hlatky, R | 1 |
| Valadka, AB | 1 |
| Goodman, JC | 1 |
| Contant, CF | 1 |
| Robertson, CS | 1 |
| Wang, JL | 1 |
| Ke, DS | 1 |
| Bergsneider, M | 1 |
| Hattori, N | 1 |
| Wu, HM | 1 |
| Huang, SC | 1 |
| Martin, NA | 1 |
| Glenn, TC | 1 |
| Hovda, DA | 1 |
| Frenzel, J | 1 |
| Richter, J | 1 |
| Eschrich, K | 1 |
| Briguglio, FS | 1 |
| Mondello, MR | 1 |
| Galluzzo, M | 1 |
| Raneri, E | 1 |
| De Pasquale, A | 1 |
| Saija, A | 1 |
| Trombetta, D | 1 |
| Chen, SH | 3 |
| Haugen, O | 1 |
| Farstad, M | 1 |
| Lise Kvalheim, V | 1 |
| Rynning, SE | 1 |
| Hammersborg, S | 1 |
| Mongstad, A | 1 |
| Husby, P | 1 |
| Mazzeo, AT | 1 |
| Kunene, NK | 1 |
| Choi, S | 1 |
| Gilman, C | 1 |
| Bullock, RM | 1 |
| Heikkinen, J | 1 |
| Dahlbacka, S | 1 |
| Alaoja, H | 1 |
| Laurila, P | 1 |
| Salomäki, T | 1 |
| Tuominen, H | 1 |
| Lepola, P | 1 |
| Yi, JS | 1 |
| Kim, TY | 1 |
| Kyu Kim, D | 1 |
| Koh, JY | 1 |
| Eide, PK | 1 |
| Bentsen, G | 1 |
| Stanisic, M | 1 |
| Stubhaug, A | 1 |
| Zoremba, N | 1 |
| Schnoor, J | 1 |
| Berens, M | 1 |
| Kuhlen, R | 1 |
| Rossaint, R | 1 |
| Pan, XD | 1 |
| Sun, LZ | 1 |
| Ma, WG | 1 |
| Tian, LX | 1 |
| Liu, NN | 1 |
| Li, M | 1 |
| Feng, ZY | 1 |
| Long, C | 1 |
| Zheng, J | 1 |
| Fatar, M | 1 |
| Stroick, M | 1 |
| Griebe, M | 1 |
| Alonso, A | 1 |
| Kreisel, S | 1 |
| Kern, R | 1 |
| Hennerici, M | 1 |
| Meairs, S | 1 |
| Siesjö, BK | 1 |
| Osterholm, JL | 1 |
| Alderman, JB | 1 |
| Triolo, AJ | 1 |
| D'Amore, BR | 1 |
| Williams, HD | 1 |
| Frazer, G | 1 |
| Ishitsuka, T | 3 |
| Fujishima, M | 5 |
| Sadoshima, S | 5 |
| Nakatomi, Y | 3 |
| Tamaki, K | 1 |
| Ogata, J | 1 |
| Omae, T | 1 |
| Matsumoto, K | 1 |
| Yamada, K | 1 |
| Kohmura, E | 1 |
| Kinoshita, A | 1 |
| Hayakawa, T | 1 |
| Kunievsky, B | 1 |
| Pretsky, J | 1 |
| Yavin, E | 1 |
| Ueki, A | 1 |
| Rosén, L | 1 |
| Andbjer, B | 1 |
| Agnati, LF | 2 |
| Hallström, A | 2 |
| Goiny, M | 1 |
| Tanganelli, S | 1 |
| Fuxe, K | 2 |
| Zoli, M | 1 |
| Merlo Pich, E | 1 |
| Ferraguti, F | 1 |
| Biagini, G | 1 |
| He, Z | 1 |
| Ibayashi, S | 3 |
| Sugimori, H | 1 |
| Fujii, K | 2 |
| Valtysson, J | 2 |
| Persson, L | 2 |
| Cheng, FC | 3 |
| Yang, DY | 1 |
| Wu, TF | 1 |
| Nilsson, OG | 1 |
| Brandt, L | 1 |
| Säveland, H | 1 |
| Shiogai, T | 1 |
| Nara, I | 1 |
| Saruta, K | 1 |
| Hara, M | 1 |
| Saito, I | 1 |
| Yang, LL | 1 |
| Yan, DY | 1 |
| Tsai, TH | 1 |
| Lee, CW | 1 |
| Schulz, MK | 1 |
| Wang, LP | 1 |
| Tange, M | 1 |
| Yamane, K | 1 |
| Yokono, K | 1 |
| Okada, Y | 2 |
| Phillis, JW | 1 |
| Ren, J | 1 |
| O'Regan, MH | 1 |
| Frykholm, P | 1 |
| Silander, HC | 1 |
| Andersson, J | 1 |
| Fasth, KJ | 1 |
| Watanabe, Y | 1 |
| Långström, B | 1 |
| Mongan, PD | 1 |
| Capacchione, J | 1 |
| Fontana, JL | 1 |
| West, S | 1 |
| Bünger, R | 1 |
| Sanni, LA | 1 |
| Rae, C | 1 |
| Maitland, A | 1 |
| Stocker, R | 1 |
| Hunt, NH | 1 |
| Mellergård, P | 1 |
| Badr, AE | 1 |
| Yin, W | 1 |
| Mychaskiw, G | 1 |
| Zhang, JH | 1 |
| Massieu, L | 1 |
| Del Río, P | 1 |
| Montiel, T | 1 |
| Schäbitz, WR | 1 |
| Berger, C | 1 |
| Schellinger, PD | 1 |
| Aschoff, A | 1 |
| Steiner, T | 1 |
| Schwab, S | 1 |
| Lin, JY | 1 |
| Chung, SY | 1 |
| Lin, MC | 1 |
| Matsuoka, M | 1 |
| Igisu, H | 1 |
| Nakane, H | 1 |
| Kotwica, Z | 1 |
| Nishizawa, K | 1 |
| Tanaka, K | 1 |
| Shimada, M | 1 |
| Ooboshi, H | 1 |
| Hara, T | 1 |
| Yokoi, F | 1 |
| Iio, M | 1 |
| Vannucci, RC | 1 |
| Vasta, F | 1 |
| Vannucci, SJ | 1 |
| Katayama, Y | 1 |
| Shimizu, J | 1 |
| Memezawa, H | 1 |
| Minamisawa, H | 1 |
| Suzuki, S | 1 |
| Sugimoto, S | 1 |
| Terashi, A | 1 |
| Yoshida, F | 1 |
| Shiokawa, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage[NCT03987139] | 45 participants (Anticipated) | Interventional | 2019-06-15 | Active, not recruiting | |||
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pyruvic acid and Brain Ischemia
| Article | Year |
|---|---|
CSF metabolomics alterations after aneurysmal subarachnoid hemorrhage: what do we know?
Topics: Biomarkers; Brain Ischemia; Humans; Lactic Acid; Pyruvic Acid; Subarachnoid Hemorrhage | 2023 |
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Lactic Acid; Mitochondria; Oxidation | 2014 |
[Use of intracerebral microdialysis in severe traumatic brain injury].
Topics: Adult; Aged; Animals; Brain Chemistry; Brain Injuries; Brain Ischemia; Glucose; Glutamic Acid; Glyce | 2010 |
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance.
Topics: Acidosis; Animals; Blood Glucose; Brain; Brain Ischemia; Carbon Dioxide; Glucose; Hypoxia, Brain; In | 1982 |
5 trials available for pyruvic acid and Brain Ischemia
| Article | Year |
|---|---|
Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.
Topics: Adult; Aged; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Veins; Energy Metabolism; F | 2021 |
Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury.
Topics: Adult; Brain; Brain Injuries; Brain Ischemia; Female; Glutamic Acid; Humans; Hyperventilation; Lacti | 2002 |
Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study.
Topics: Adult; Aged; Biomarkers; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Ex | 2004 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose; | 2000 |
80 other studies available for pyruvic acid and Brain Ischemia
| Article | Year |
|---|---|
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I | 2022 |
Intracranial Pressure Variability: A New Potential Metric of Cerebral Ischemia and Energy Metabolic Dysfunction in Aneurysmal Subarachnoid Hemorrhage?
Topics: Brain Ischemia; Humans; Intracranial Pressure; Pyruvic Acid; Retrospective Studies; Subarachnoid Hem | 2023 |
Early brain metabolic disturbances associated with delayed cerebral ischemia in patients with severe subarachnoid hemorrhage.
Topics: Brain; Brain Ischemia; Cerebral Infarction; Glucose; Glutamic Acid; Humans; Lactic Acid; Pyruvic Aci | 2023 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach.
Topics: Animals; Brain Ischemia; Cerebrum; Energy Metabolism; Female; Glutamic Acid; Humans; Lactic Acid; Ma | 2021 |
Glutamate-induced modulation in energy metabolism contributes to protection of rat cortical slices against ischemia-induced damage.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Chromatography, High Pressure Liquid; Energy Metabolism; G | 2021 |
Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Cerebr | 2018 |
Effect of Hypothermia on Kinetic Characteristics of Lactate Dehydrogenase in Rat Brain under Conditions of Global Ischemia and Reperfusion.
Topics: Animals; Animals, Outbred Strains; Biocatalysis; Blood Flow Velocity; Brain; Brain Chemistry; Brain | 2017 |
NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.
Topics: Acetic Acid; Animals; Biomarkers; Blood Glucose; Brain Ischemia; Cerebrovascular Disorders; Creatine | 2018 |
The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients.
Topics: Aged; Aneurysm, Ruptured; Brain; Brain Edema; Brain Ischemia; Cohort Studies; Female; Glucose; Gluta | 2020 |
Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase?
Topics: Adult; Aged; Algorithms; Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Female; | 2013 |
Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Cerebrum; Decompressive Craniectomy; Female; Humans; Infarc | 2014 |
Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage.
Topics: Aged; Biomarkers; Brain Ischemia; Energy Metabolism; Female; Glucose; Glutamic Acid; Glycerol; Human | 2014 |
Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Child; Child, Preschool; Disease Transmission, Infectious; | 2015 |
Biochemical indications of cerebral ischaemia and mitochondrial dysfunction in severe brain trauma analysed with regard to type of lesion.
Topics: Adult; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Infarction; Energy Metabolism; Female; Gl | 2016 |
Bedside cerebral microdialysis monitoring of delayed cerebral hypoperfusion in comatose patients with poor grade aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Blood Glucose; Brain; Brain Ischemia; Cohort Studies; Coma; Critica | 2017 |
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase.
Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease | 2009 |
Subarachnoid hemorrhage and microdialysis.
Topics: Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Databases, Factual; Energy Metabolism; | 2009 |
Temporal patterns of interstitial pyruvate and amino acids after subarachnoid haemorrhage are related to the level of consciousness--a clinical microdialysis study.
Topics: Aged; Amino Acids; Biomarkers; Brain; Brain Chemistry; Brain Ischemia; Consciousness Disorders; Down | 2009 |
Response.
Topics: Blood Pressure; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gly | 2009 |
Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.
Topics: Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Cerebral Hemorrhage, Traumatic; Energy Metabol | 2010 |
Venous obstruction and cerebral perfusion during experimental cardiopulmonary bypass.
Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Cardiopulmonary Bypass; Cent | 2010 |
Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage.
Topics: Biomarkers; Brain Ischemia; C-Reactive Protein; Critical Care; Encephalitis; Extracellular Fluid; Fe | 2010 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Fructose; Glyceric Acids; Hydroxyproline; Lactic Aci | 2012 |
Extracellular lactate/pyruvate and glutamate changes in patients during per-operative episodes of cerebral ischaemia.
Topics: Adult; Aged; Biomarkers; Brain; Brain Ischemia; Carotid Artery, Internal; Craniotomy; Glutamic Acid; | 2002 |
Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome.
Topics: Aged; Blood Glucose; Brain; Brain Ischemia; Cerebrospinal Fluid; Cerebrospinal Fluid Shunts; Female; | 2003 |
Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs.
Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium; Creatine Kinase; Creatine Kinase, MB Form; Diseas | 2003 |
Hypothermia attenuates circulatory shock and cerebral ischemia in experimental heatstroke.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Ischemia; Cerebrovascular Circulation; Corpus | 2003 |
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Chronic Disease; Infarction, Middle Cerebral Arter | 2003 |
Effect of hypervolaemic haemodilution on cerebral glutamate, glycerol, lactate and free radicals in heatstroke rats.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Free Radicals; Glutamic Acid; Glycerol; | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Individual value of brain tissue oxygen pressure, microvascular oxygen saturation, cytochrome redox level, and energy metabolites in detecting critically reduced cerebral energy state during acute changes in global cerebral perfusion.
Topics: Algorithms; Animals; Brain Chemistry; Brain Ischemia; Brain Stem; Capillaries; Cerebrovascular Circu | 2004 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Heat shock pretreatment may protect against heatstroke-induced circulatory shock and cerebral ischemia by reducing oxidative stress and energy depletion.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Catechols; Cerebrovascular Circulation; Glut | 2005 |
Pyruvate protects glucose-deprived Müller cells from nitric oxide-induced oxidative stress by radical scavenging.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain Ischemia; Cells, Cultured; Energ | 2005 |
Protective effect of buflomedil in a rat model of moderate cerebral ischemia.
Topics: Animals; Blood Glucose; Brain Ischemia; Cell Death; Cerebrovascular Circulation; Hippocampus; Lactic | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Mean arterial pressure about 40 mmHg during CPB is associated with cerebral ischemia in piglets.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; | 2006 |
Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system.
Topics: Adult; Age Factors; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Fluid; Female; Gl | 2006 |
Fructose-1,6-bisphosphate supports cerebral energy metabolism in pigs after ischemic brain injury caused by experimental particle embolization.
Topics: Animals; Brain; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal | 2006 |
Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Cell Death; Cerebral Infarction; Dose-Response Rela | 2007 |
Association between intracranial pulse pressure levels and brain energy metabolism in a patient with an aneurysmal subarachnoid haemorrhage.
Topics: Aged; Brain; Brain Ischemia; Female; Glutamic Acid; Glycerol; Humans; Intracranial Aneurysm; Intracr | 2007 |
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid | 2007 |
Neuroprotective effect of deep hypothermic circulatory arrest with low priming volume: study in a rabbit model.
Topics: Animals; Blood Volume; Brain Ischemia; Chromatography, High Pressure Liquid; Circulatory Arrest, Dee | 2008 |
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; La | 2008 |
Severe cerebral ischemia treatment by ventriculosubarachnoid perfusion with an oxygenated fluorocarbon emulsion.
Topics: Animals; Brain Ischemia; Carbon Dioxide; Cats; Cerebral Cortex; Cerebral Ventricles; Electroencephal | 1983 |
Pulmonary hemorrhage in experimental cerebral ischemia in mongolian gerbils. Brain metabolism and lung pathology.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain; Brain Ischemia; Female; Gerbillinae; Hemorrh | 1984 |
[Effect of recirculation on experimental cerebral ischemia. 3. Therapy].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulatio | 1982 |
Role of pyruvate in ischaemia-like conditions on cultured neurons.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Do | 1994 |
Transient rise of glucose uptake in the fetal rat brain after brief episodes of intrauterine ischemia.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Deoxyglucose; Energy Metabo | 1994 |
Evidence for a preventive action of the vigilance-promoting drug modafinil against striatal ischemic injury induced by endothelin-1 in the rat.
Topics: Amphetamine; Animals; Arousal; Benzhydryl Compounds; Blood Pressure; Brain Ischemia; Cerebrovascular | 1993 |
Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat.
Topics: Animals; Atrophy; Brain Ischemia; Cell Survival; Corpus Striatum; Dopamine and cAMP-Regulated Phosph | 1993 |
Age-related ischemia in the brain following bilateral carotid artery occlusion--collateral blood flow and brain metabolism.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Suckling; Arterial Occlusive Diseases; Brain; Brain | 1997 |
Extracellular ischaemia markers in repeated global ischaemia and secondary hypoxaemia monitored by microdialysis in rat brain.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroencephalography; Energy Metabolism; Extracellular S | 1998 |
Rapid on-line microdialysis hyphenated technique for the dynamic monitoring of extracellular pyruvate, lactic acid and ascorbic acid during cerebral ischemia.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Extracellular Space; Gerbillinae; Lactic Acid; Microdialysis | 1999 |
Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Brain Ischemia; Cerebral Cortex; Female; Glutamic Acid; Glyc | 1999 |
Continuous monitoring of cerebrospinal fluid acid-base balance and oxygen metabolism in patients with severe head injury: pathophysiology and treatments for cerebral acidosis and ischemia.
Topics: Acidosis; Adolescent; Adult; Brain Injuries; Brain Ischemia; Carbon Dioxide; Fever; Glasgow Coma Sca | 1999 |
Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Gerbillinae; Lactic Acid; Microdialysis; Pyruvic Acid | 2000 |
Anaerobic glycolysis is crucial for the maintenance of neural activity in guinea pig hippocampal slices.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Brain Ischemia; Energy Metabolism; Fructose; Glu | 2000 |
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease | 2001 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction | 2001 |
Pyruvate improves cerebral metabolism during hemorrhagic shock.
Topics: Animals; Brain; Brain Ischemia; Energy Metabolism; Oxidation-Reduction; Pyruvic Acid; Shock, Hemorrh | 2001 |
Is ischemia involved in the pathogenesis of murine cerebral malaria?
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Animals; Brain; Brain Ischemia; Chromatography, High P | 2001 |
Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions.
Topics: Adult; Aged; Brain; Brain Injuries; Brain Ischemia; Energy Metabolism; Female; Glucose; Glycerol; Hu | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic | 2001 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; I | 2001 |
Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes.
Topics: Brain; Brain Ischemia; Carbon Dioxide; Cerebral Angiography; Cerebral Infarction; Disabled Persons; | 2002 |
Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Energy Metabolism; Gerbillinae; Gluco | 2002 |
Brain energy metabolites in mice intoxicated with acrylamide: effects of ischemia.
Topics: Acrylamide; Acrylamides; Adenosine Triphosphate; Animals; Body Weight; Brain; Brain Ischemia; Energy | 1992 |
A new ergopeptide, CBM 36-733, improves ischaemic cerebral metabolism in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Ergolines; Female; Hemodynamics; Lactates; L | 1991 |
Interstitial and cerebrospinal fluid levels of energy-related metabolites after middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Arteries; Energy Metabolism; Extracel | 1991 |
[Experimental study on pathogenesis of neonatal hypoxic-ischemic encephalopathy. II. Energy metabolism in the brain].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cer | 1990 |
Effect of recirculation on the recovery of cerebral metabolism after experimental cerebral ischemia in male and female spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cerebrov | 1988 |
Brain ischemia and infarction positively visualized by pyruvate-1-11C using positron-emission tomography.
Topics: Adult; Aged; Brain Ischemia; Carbon Radioisotopes; Cerebral Infarction; Female; Humans; Male; Middle | 1986 |
Cerebral metabolic responses of hyperglycemic immature rats to hypoxia-ischemia.
Topics: Adenine Nucleotides; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Ischemia; Glucose; Hyper | 1987 |
[Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebral Arteries; Lactates; Lactic Acid; Ma | 1986 |
Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; | 1986 |