pyruvic acid has been researched along with Brain Injuries in 89 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9." | 3.74 | Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008) |
| "The effects of coma treatment on the results were also studied." | 2.72 | Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury. ( Contant, CF; Enblad, P; Howells, T; Nilsson, P; Piper, I; Ronne-Engström, E; Salci, K, 2006) |
| "Glycerol is an integral component of cell membranes." | 2.46 | [Use of intracerebral microdialysis in severe traumatic brain injury]. ( Abe, Y; Kawai, N; Kawakita, K; Kuroda, Y; Tamiya, T; Yano, T, 2010) |
| "Early post-traumatic seizures are one potential mechanism for metabolic crisis and hence could be a therapeutic target." | 1.43 | Metabolic crisis occurs with seizures and periodic discharges after brain trauma. ( Buitrago-Blanco, M; Claassen, J; McArthur, D; Nuwer, M; Prins, M; Tu, B; Tubi, M; Velazquez, AG; Vespa, P, 2016) |
| " The effect of LLL was further bolstered by combination with metabolic substrates such as pyruvate or lactate both in vivo and in vitro." | 1.42 | Low-level light in combination with metabolic modulators for effective therapy of injured brain. ( Dong, T; Hamblin, MR; Wu, MX; Zhang, Q, 2015) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| " Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome." | 1.33 | Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system. ( Bullock, RM; Choi, S; Gilman, C; Kunene, NK; Mazzeo, AT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.49) | 18.7374 |
| 1990's | 4 (4.49) | 18.2507 |
| 2000's | 40 (44.94) | 29.6817 |
| 2010's | 38 (42.70) | 24.3611 |
| 2020's | 3 (3.37) | 2.80 |
| Authors | Studies |
|---|---|
| Giannì, G | 1 |
| Minini, A | 1 |
| Fratino, S | 1 |
| Peluso, L | 1 |
| Annoni, F | 1 |
| Oddo, M | 2 |
| Schuind, S | 1 |
| Creteur, J | 1 |
| Taccone, FS | 1 |
| Bogossian, EG | 1 |
| Li, F | 3 |
| Geng, X | 3 |
| Ilagan, R | 3 |
| Bai, S | 3 |
| Chen, Y | 3 |
| Ding, Y | 3 |
| Mölström, S | 1 |
| Nielsen, TH | 1 |
| Nordström, CH | 7 |
| Forsse, A | 1 |
| Möller, S | 1 |
| Venö, S | 1 |
| Mamaev, D | 1 |
| Tencer, T | 1 |
| Schmidt, H | 1 |
| Toft, P | 1 |
| Andelius, TCK | 1 |
| Pedersen, MV | 1 |
| Bøgh, N | 1 |
| Omann, C | 1 |
| Hjortdal, VE | 1 |
| Pedersen, M | 1 |
| Kyng, KJ | 1 |
| Henriksen, TB | 1 |
| Asgari, S | 1 |
| Vespa, P | 3 |
| Hu, X | 1 |
| de Lima Oliveira, M | 2 |
| Paiva, W | 1 |
| Teixeira, MJ | 2 |
| Bor-Seng-Shu, E | 2 |
| Lazaridis, C | 1 |
| Andrews, CM | 1 |
| Sahuquillo, J | 2 |
| Merino, MA | 2 |
| Sánchez-Guerrero, A | 1 |
| Arikan, F | 1 |
| Vidal-Jorge, M | 1 |
| Martínez-Valverde, T | 1 |
| Rey, A | 1 |
| Riveiro, M | 2 |
| Poca, MA | 2 |
| Dienel, GA | 1 |
| Dong, T | 1 |
| Zhang, Q | 1 |
| Hamblin, MR | 1 |
| Wu, MX | 1 |
| Tubi, M | 1 |
| Claassen, J | 2 |
| Buitrago-Blanco, M | 1 |
| McArthur, D | 2 |
| Velazquez, AG | 1 |
| Tu, B | 1 |
| Prins, M | 1 |
| Nuwer, M | 1 |
| Ghosh, A | 3 |
| Highton, D | 2 |
| Kolyva, C | 2 |
| Tachtsidis, I | 4 |
| Elwell, CE | 3 |
| Smith, M | 6 |
| Brody, DL | 1 |
| Magnoni, S | 1 |
| Schwetye, KE | 1 |
| Spinner, ML | 1 |
| Esparza, TJ | 1 |
| Stocchetti, N | 2 |
| Zipfel, GJ | 1 |
| Holtzman, DM | 1 |
| Tisdall, MM | 2 |
| Leung, TS | 2 |
| Marcoux, J | 1 |
| McArthur, DA | 1 |
| Miller, C | 2 |
| Glenn, TC | 2 |
| Villablanca, P | 1 |
| Martin, NA | 2 |
| Hovda, DA | 5 |
| Alger, JR | 1 |
| Vespa, PM | 4 |
| Mazzeo, AT | 2 |
| Alves, OL | 1 |
| Gilman, CB | 1 |
| Hayes, RL | 1 |
| Tolias, C | 1 |
| Niki Kunene, K | 1 |
| Ross Bullock, M | 1 |
| Hillered, L | 2 |
| Enblad, P | 4 |
| Hartley, CE | 1 |
| Varma, M | 1 |
| Fischer, JP | 1 |
| Riccardi, R | 1 |
| Strauss, JA | 1 |
| Shah, S | 1 |
| Zhang, S | 1 |
| Yang, ZJ | 1 |
| Schmidt, JM | 1 |
| Carrera, E | 1 |
| Badjatia, N | 2 |
| Connolly, ES | 1 |
| Presciutti, M | 1 |
| Ostapkovich, ND | 1 |
| Levine, JM | 1 |
| Le Roux, P | 2 |
| Mayer, SA | 2 |
| Hutchinson, PJ | 8 |
| O'Connell, MT | 5 |
| Seal, A | 1 |
| Nortje, J | 5 |
| Timofeev, I | 5 |
| Al-Rawi, PG | 7 |
| Coles, JP | 3 |
| Fryer, TD | 2 |
| Menon, DK | 5 |
| Pickard, JD | 6 |
| Carpenter, KL | 2 |
| Dahyot-Fizelier, C | 1 |
| Keong, N | 1 |
| Czosnyka, M | 3 |
| Kirkpatrick, PJ | 5 |
| Gupta, AK | 7 |
| Afinowi, R | 1 |
| Tisdall, M | 1 |
| Keir, G | 1 |
| Kitchen, N | 2 |
| Petzold, A | 2 |
| Fukushima, M | 1 |
| Lee, SM | 1 |
| Moro, N | 2 |
| Sutton, RL | 2 |
| Meierhans, R | 1 |
| Béchir, M | 1 |
| Ludwig, S | 1 |
| Sommerfeld, J | 1 |
| Brandi, G | 1 |
| Haberthür, C | 1 |
| Stocker, R | 1 |
| Stover, JF | 1 |
| Lakshmanan, R | 1 |
| Loo, JA | 1 |
| Drake, T | 1 |
| Leblanc, J | 1 |
| Ytterberg, AJ | 1 |
| McArthur, DL | 3 |
| Etchepare, M | 2 |
| Izumi, Y | 1 |
| Zorumski, CF | 1 |
| Borrull, A | 1 |
| Expósito, L | 1 |
| Kawai, N | 1 |
| Kawakita, K | 1 |
| Yano, T | 1 |
| Abe, Y | 1 |
| Kuroda, Y | 1 |
| Tamiya, T | 1 |
| Salci, K | 2 |
| Goiny, M | 1 |
| Contant, CF | 3 |
| Piper, I | 2 |
| Nilsson, P | 2 |
| Clausen, F | 1 |
| Gustafsson, J | 1 |
| De Fazio, M | 1 |
| Rammo, R | 1 |
| O'Phelan, K | 2 |
| Bullock, MR | 2 |
| Ghavim, SS | 1 |
| Smielewski, P | 2 |
| Larach, DB | 1 |
| Kofke, WA | 1 |
| Pritchard, C | 1 |
| Yokobori, S | 2 |
| Watanabe, A | 2 |
| Matsumoto, G | 2 |
| Onda, H | 2 |
| Masuno, T | 2 |
| Fuse, A | 2 |
| Kushimoto, S | 2 |
| Yokota, H | 2 |
| Zweckberger, K | 2 |
| Simunovic, F | 1 |
| Kiening, KL | 2 |
| Unterberg, AW | 3 |
| Sakowitz, OW | 3 |
| Karathanou, A | 1 |
| Paterakis, K | 1 |
| Pakopoulou, M | 1 |
| Tasiou, A | 1 |
| Hadjigeorgiou, G | 1 |
| Chovas, A | 1 |
| Paraforos, G | 1 |
| Fountas, K | 1 |
| Komnos, A | 1 |
| Hackenberg, K | 1 |
| Jung, CS | 1 |
| Hertle, DN | 1 |
| Omerhodzić, I | 1 |
| Dizdarević, K | 1 |
| Rotim, K | 1 |
| Hajdarpasić, E | 1 |
| Niksić, M | 1 |
| Bejtić-Custović, E | 1 |
| Selimović, E | 1 |
| Custović, M | 1 |
| Zlotnik, A | 1 |
| Sinelnikov, I | 1 |
| Gruenbaum, BF | 1 |
| Gruenbaum, SE | 1 |
| Dubilet, M | 1 |
| Dubilet, E | 1 |
| Leibowitz, A | 1 |
| Ohayon, S | 1 |
| Regev, A | 1 |
| Boyko, M | 1 |
| Shapira, Y | 1 |
| Teichberg, VI | 1 |
| Tanguy, M | 1 |
| Seguin, P | 1 |
| Laviolle, B | 1 |
| Bleichner, JP | 1 |
| Morandi, X | 1 |
| Malledant, Y | 1 |
| Purins, K | 1 |
| Wiklund, L | 1 |
| Lewén, A | 1 |
| Stein, NR | 1 |
| Sánchez-Porras, R | 1 |
| Santos, E | 1 |
| Zheng, Z | 1 |
| Blanié, A | 1 |
| Vigué, B | 2 |
| Benhamou, D | 2 |
| Duranteau, J | 2 |
| Geeraerts, T | 2 |
| Elwell, C | 1 |
| Helbok, R | 1 |
| Kurtz, P | 1 |
| Schmidt, MJ | 1 |
| Stuart, MR | 1 |
| Fernandez, L | 1 |
| Connolly, SE | 1 |
| Lee, K | 1 |
| Schmutzhard, E | 1 |
| James, ML | 1 |
| Olson, DM | 1 |
| Graffagnino, C | 1 |
| Peerdeman, SM | 1 |
| Girbes, AR | 1 |
| Vandertop, WP | 1 |
| Marion, DW | 3 |
| Puccio, A | 1 |
| Wisniewski, SR | 1 |
| Kochanek, P | 1 |
| Dixon, CE | 1 |
| Bullian, L | 1 |
| Carlier, P | 1 |
| Diaz-Parejo, P | 1 |
| Ståhl, N | 3 |
| Xu, W | 2 |
| Reinstrup, P | 3 |
| Ungerstedt, U | 6 |
| Gärdenfors, A | 1 |
| Alessandri, B | 1 |
| Heimann, A | 1 |
| Filippi, R | 1 |
| Kopacz, L | 1 |
| Kempski, O | 1 |
| Hlatky, R | 1 |
| Valadka, AB | 1 |
| Goodman, JC | 1 |
| Robertson, CS | 1 |
| Tolias, CM | 1 |
| Reinert, M | 1 |
| Seiler, R | 1 |
| Gilman, C | 3 |
| Scharf, A | 1 |
| Wagner, AK | 1 |
| Fabio, A | 1 |
| Puccio, AM | 2 |
| Hirschberg, R | 1 |
| Li, W | 1 |
| Zafonte, RD | 1 |
| Bergsneider, M | 1 |
| Hattori, N | 1 |
| Wu, HM | 1 |
| Huang, SC | 1 |
| Engström, M | 1 |
| Polito, A | 1 |
| Romner, B | 1 |
| Ryding, E | 1 |
| Howells, T | 1 |
| Ronne-Engström, E | 1 |
| Kunene, NK | 1 |
| Choi, S | 1 |
| Bullock, RM | 1 |
| Phillips, DJ | 1 |
| Nguyen, P | 1 |
| Adamides, AA | 1 |
| Bye, N | 1 |
| Rosenfeld, JV | 1 |
| Kossmann, T | 1 |
| Vallance, S | 1 |
| Murray, L | 1 |
| Morganti-Kossmann, MC | 1 |
| Eliseo, M | 1 |
| Hirt, D | 1 |
| Glenn, T | 1 |
| Samuelson, R | 1 |
| Mazzeo, A | 1 |
| Kunene, N | 1 |
| Bullock, R | 2 |
| Young, HF | 1 |
| Friggeri, A | 1 |
| Mazoit, JX | 1 |
| Aigbirhio, FI | 2 |
| Outtrim, JG | 1 |
| Chatfield, DA | 2 |
| Belli, A | 1 |
| Sen, J | 1 |
| Russo, S | 1 |
| Brandt, L | 1 |
| Filos, K | 1 |
| Link, J | 1 |
| Yuan, XQ | 1 |
| Wade, CE | 1 |
| Yamamura, H | 1 |
| Hiraide, A | 1 |
| Matsuoka, T | 1 |
| Takaoka, M | 1 |
| Shimazu, T | 1 |
| Sugimoto, H | 1 |
| Letarte, PB | 1 |
| Brown, SD | 1 |
| Shiogai, T | 1 |
| Nara, I | 1 |
| Saruta, K | 1 |
| Hara, M | 1 |
| Saito, I | 1 |
| Aquilani, R | 1 |
| Viglio, S | 1 |
| Iadarola, P | 1 |
| Guarnaschelli, C | 1 |
| Arrigoni, N | 1 |
| Fugazza, G | 1 |
| Catapano, M | 1 |
| Boschi, F | 1 |
| Dossena, M | 1 |
| Pastoris, O | 1 |
| Bentzer, P | 1 |
| Davidsson, H | 1 |
| Grände, PO | 2 |
| Maskell, LB | 2 |
| Kett-White, R | 2 |
| Richards, HK | 1 |
| Hutchinson, DB | 2 |
| Möller, AD | 1 |
| Clausen, T | 1 |
| Zauner, A | 1 |
| Levasseur, JE | 1 |
| Rice, AC | 1 |
| Mellergård, P | 1 |
| Hallström, A | 1 |
| Meixensberger, J | 1 |
| Kunze, E | 1 |
| Barcsay, E | 1 |
| Vaeth, A | 1 |
| Roosen, K | 1 |
| Fryer, TF | 1 |
| Minhas, PS | 1 |
| Clark, JC | 1 |
| Bakay, RA | 1 |
| Sweeney, KM | 1 |
| Wood, JH | 1 |
| Odinak, MM | 1 |
| Zaporoshchenko, IA | 1 |
| Frewen, TC | 1 |
| Sumabat, WO | 1 |
| Han, VK | 1 |
| Campbell, K | 1 |
| Tiffin, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Uncovering the 'ORIGINS' of Diabetes[NCT02226640] | 80 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM): a Knowledge Translation Study.[NCT03907904] | 40 participants (Anticipated) | Observational | 2019-07-01 | Recruiting | |||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2019-12-04 | Recruiting | ||
| Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in the Emergency Department With Severe Traumatic Brain Injury (INACHOS): a Pilot Randomized Controlled Trial[NCT05464277] | 50 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | |||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pyruvic acid and Brain Injuries
| Article | Year |
|---|---|
The Impact of Short-Term Hyperoxia on Cerebral Metabolism: A Systematic Review and Meta-Analysis.
Topics: Brain Injuries; Glucose; Humans; Hyperoxia; Lactic Acid; Microdialysis; Observational Studies as Top | 2022 |
Brain tissue oxygenation, lactate-pyruvate ratio, and cerebrovascular pressure reactivity monitoring in severe traumatic brain injury: systematic review and viewpoint.
Topics: Arterial Pressure; Brain Injuries; Cerebrovascular Circulation; Humans; Lactic Acid; Monitoring, Phy | 2014 |
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Lactic Acid; Mitochondria; Oxidation | 2014 |
[Use of intracerebral microdialysis in severe traumatic brain injury].
Topics: Adult; Aged; Animals; Brain Chemistry; Brain Injuries; Brain Ischemia; Glucose; Glutamic Acid; Glyce | 2010 |
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A | 1986 |
15 trials available for pyruvic acid and Brain Injuries
| Article | Year |
|---|---|
Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.
Topics: Adult; Aged; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Veins; Energy Metabolism; F | 2021 |
Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury.
Topics: Adult; Brain Injuries; Female; Humans; Hyperoxia; Lactic Acid; Male; Microdialysis; Middle Aged; Oxi | 2008 |
Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study.
Topics: Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Cyclosporine; Double-Blind Method; Energy | 2008 |
Ventriculostomy for control of raised ICP in acute traumatic brain injury.
Topics: Adult; Blood Pressure; Brain Injuries; Cerebrospinal Fluid; Female; Glasgow Coma Scale; Humans; Intr | 2008 |
Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes.
Topics: Adult; Biomarkers; Brain Injuries; Critical Care; Female; Follow-Up Studies; Humans; Lactic Acid; Ma | 2011 |
Cerebral microdialysis: perioperative monitoring and treatment of severe neurosurgical patient.
Topics: Brain Injuries; Glucose; Glycerol; Humans; Intracranial Hemorrhage, Traumatic; Lactic Acid; Microdia | 2011 |
Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury.
Topics: Adult; Biomarkers; Brain Chemistry; Brain Injuries; Cerebral Cortex; Female; Glucose; Glutamic Acid; | 2012 |
A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
Topics: Body Temperature; Brain Injuries; Consciousness Monitors; Cross-Over Studies; Dexmedetomidine; Glasg | 2012 |
Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury.
Topics: Adult; Biomarkers; Brain; Brain Injuries; Disease-Free Survival; Female; Glucose; Humans; Hydrogen-I | 2013 |
Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury.
Topics: Adult; Brain; Brain Injuries; Brain Ischemia; Female; Glutamic Acid; Humans; Hyperventilation; Lacti | 2002 |
Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism.
Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Brain Chemistry; Brain Injuries; Cerebrovascular Circul | 2003 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury.
Topics: Adult; Brain Injuries; Coma; Compliance; Female; Fever; Glasgow Coma Scale; Humans; Lactic Acid; Mal | 2006 |
Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements.
Topics: Adult; Aged; Biomarkers; Brain Injuries; Energy Metabolism; Epoprostenol; Female; Humans; Hypoxia; J | 2000 |
Clinical cerebral microdialysis: brain metabolism and brain tissue oxygenation after acute brain injury.
Topics: Adolescent; Adult; Brain; Brain Injuries; Critical Care; Female; Glucose; Glutamic Acid; Humans; Int | 2001 |
69 other studies available for pyruvic acid and Brain Injuries
| Article | Year |
|---|---|
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Consequence of insertion trauma - effect on early measurements when using intracerebral devices.
Topics: Animals; Brain; Brain Injuries; Glucose; Glycerol; Lactic Acid; Microdialysis; Prostheses and Implan | 2019 |
Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase?
Topics: Adult; Aged; Algorithms; Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Female; | 2013 |
Brain metabolic crisis in traumatic brain injury: what does it mean?
Topics: Brain; Brain Chemistry; Brain Injuries; Humans; Lactic Acid; Microdialysis; Pyruvic Acid | 2014 |
Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries.
Topics: Adult; Biomarkers; Brain Injuries; Energy Metabolism; Female; Glucose; Humans; Lactic Acid; Male; Mi | 2014 |
Low-level light in combination with metabolic modulators for effective therapy of injured brain.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Line, Tumor; Hippocampus; Humans; Lactic Acid; Light; Me | 2015 |
Metabolic crisis occurs with seizures and periodic discharges after brain trauma.
Topics: Adult; Aged; Aged, 80 and over; Brain Injuries; Electroencephalography; Female; Humans; Lactic Acid; | 2016 |
Hyperoxia results in increased aerobic metabolism following acute brain injury.
Topics: Blood Flow Velocity; Brain; Brain Injuries; Cerebrovascular Circulation; Cytochromes c; Energy Metab | 2017 |
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Topics: Amyloid beta-Peptides; Brain; Brain Injuries; Extracellular Fluid; Glasgow Coma Scale; Glucose; Huma | 2008 |
Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury.
Topics: Adolescent; Adult; Atrophy; Biomarkers; Brain Diseases; Brain Injuries; Chronic Disease; Cohort Stud | 2008 |
Nonischemic energy metabolic crisis in acute brain injury.
Topics: Biomarkers; Brain Injuries; Critical Care; Critical Illness; Energy Metabolism; Female; Glasgow Coma | 2008 |
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.
Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Energy Metabolism; Erythropoietin; G | 2008 |
Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study.
Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries; Female; Glucose; Hospitals, University; Humans; H | 2008 |
A combined microdialysis and FDG-PET study of glucose metabolism in head injury.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Energy Metabolism; Extracellular Fluid; | 2009 |
Improving the recovery of S100B protein in cerebral microdialysis: implications for multimodal monitoring in neurocritical care.
Topics: Brain Injuries; Catheterization; Enzyme-Linked Immunosorbent Assay; Extracellular Fluid; Glucose; Hu | 2009 |
Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Cell Count; Glucose; Lactic Acid; Male; Microd | 2009 |
Brain metabolism is significantly impaired at blood glucose below 6 mM and brain glucose below 1 mM in patients with severe traumatic brain injury.
Topics: Adolescent; Adult; Blood Glucose; Brain; Brain Injuries; Female; Glutamic Acid; Humans; Insulin; Int | 2010 |
Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.
Topics: Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Cerebral Hemorrhage, Traumatic; Energy Metabol | 2010 |
Traumatic brain injury and metabolism.
Topics: Blood Flow Velocity; Blood Glucose; Brain; Brain Injuries; Craniotomy; Decompression, Surgical; Ener | 2010 |
Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Injuries; CA1 Region, Hippocampal; Enzyme Inhibitors; | 2010 |
[Is lactate a good indicator of brain tissue hypoxia in the acute phase of traumatic brain injury? Results of a pilot study in 21 patients].
Topics: Adult; Biomarkers; Brain Injuries; Diagnosis, Differential; Energy Metabolism; Glucose; Humans; Hypo | 2010 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
Cerebral glucose metabolism after traumatic brain injury in the rat studied by 13C-glucose and microdialysis.
Topics: Anaerobiosis; Animals; Blood Glucose; Brain Damage, Chronic; Brain Injuries; Carbon Radioisotopes; E | 2011 |
Alterations in cerebral oxidative metabolism following traumatic brain injury.
Topics: Brain; Brain Injuries; Female; Humans; Lactic Acid; Microdialysis; Oxygen; Pyruvic Acid; Tomography, | 2011 |
Delayed sodium pyruvate treatment improves working memory following experimental traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Male; Maze Learning; Memory, Short | 2011 |
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.
Topics: Adult; Biomarkers; Brain Injuries; Cerebral Cortex; Extracellular Fluid; Female; Glasgow Coma Scale; | 2011 |
Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature.
Topics: Aerobiosis; Anaerobiosis; Blood Glucose; Brain; Brain Injuries; Critical Care; Energy Metabolism; Ex | 2011 |
Analysis of the changes in the oxidation of brain tissue cytochrome-c-oxidase in traumatic brain injury patients during hypercapnoea: a broadband NIRS study.
Topics: Adult; Brain; Brain Injuries; Electron Transport Complex IV; Female; Humans; Hypercapnia; Lactic Aci | 2011 |
Time course of recovery from cerebral vulnerability after severe traumatic brain injury: a microdialysis study.
Topics: Analysis of Variance; Biomarkers; Body Temperature; Brain Injuries; Extracellular Fluid; Female; Gla | 2011 |
Lower extracellular glucose level prolonged in elderly patients with severe traumatic brain injury: a microdialysis study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Brain; Brain Chemistry; Brain Injuries; | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats.
Topics: Animals; Brain Injuries; Cerebral Cortex; Craniotomy; Decompression, Surgical; Disease Models, Anima | 2011 |
Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats.
Topics: Animals; Behavior, Animal; Blood Gas Analysis; Blood Glucose; Brain; Brain Injuries; Cell Survival; | 2012 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation.
Topics: Adult; Blood Pressure; Brain; Brain Diseases, Metabolic; Brain Injuries; Cardiopulmonary Resuscitati | 2012 |
'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.
Topics: Adult; Algorithms; Arterial Pressure; Blood Glucose; Brain; Brain Injuries; Disability Evaluation; F | 2012 |
The frontal lobe and thalamus have different sensitivities to hypoxia-hypotension after traumatic brain injury: a microdialysis study in rats.
Topics: Animals; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Frontal Lob | 2012 |
Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury.
Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Electron Transport Complex IV; Female; Hem | 2013 |
Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients.
Topics: Adult; Brain; Brain Chemistry; Brain Injuries; Deep Sedation; Female; Glucose; Hemodynamics; Humans; | 2012 |
Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis.
Topics: Adolescent; Aged; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Critical Care; Criti | 2002 |
Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma.
Topics: Blood Glucose; Brain Injuries; Cerebrovascular Circulation; Energy Metabolism; Female; Glutamic Acid | 2003 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury.
Topics: Adult; Brain Injuries; Female; Glasgow Coma Scale; Glutamic Acid; Humans; Hypothermia, Induced; Lact | 2005 |
Intracerebral microdialysis in severe brain trauma: the importance of catheter location.
Topics: Adult; Aged; Brain Injuries; Catheters, Indwelling; Child; Female; Glucose; Humans; Lactic Acid; Mal | 2005 |
Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system.
Topics: Adult; Age Factors; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Fluid; Female; Gl | 2006 |
Activin a release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury.
Topics: Activins; Adolescent; Adult; Aged; Brain Injuries; Case-Control Studies; Female; Follistatin; Glutam | 2006 |
Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure.
Topics: Adolescent; Adult; Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Female; Glasgow C | 2007 |
Synthes Award For Resident Research On Craniofacial And Brain Injury: effect of cyclosporin A, topiramate, or 100% oxygen as proposed "neuroprotective" therapies on the neurochemical analytes in patients with severe traumatic brain injury.
Topics: Adult; Awards and Prizes; Brain Injuries; Case-Control Studies; Cohort Studies; Cyclosporine; Fructo | 2006 |
Sleeping Beauty: a tale still with an uncertain happy ending after head trauma.
Topics: Biomarkers; Brain; Brain Injuries; Cerebrovascular Circulation; Glasgow Coma Scale; Hospitals, Unive | 2007 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.
Topics: Adolescent; Adult; Brain Injuries; Cerebrum; Female; Humans; Hyperoxia; Intracranial Pressure; Lacti | 2008 |
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti | 2008 |
[Effect of therapeutic hyperventilation on blood lactate concentration].
Topics: Adult; Aged; Brain Injuries; Carbon Dioxide; Child; Child, Preschool; Female; Humans; Lactates; Lact | 1983 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |
Effect of hypocapnea on CBF and extracellular intermediates of secondary brain injury.
Topics: Brain; Brain Injuries; Carbon Dioxide; Chromatography, High Pressure Liquid; Extracellular Space; Gl | 1999 |
Continuous monitoring of cerebrospinal fluid acid-base balance and oxygen metabolism in patients with severe head injury: pathophysiology and treatments for cerebral acidosis and ischemia.
Topics: Acidosis; Adolescent; Adult; Brain Injuries; Brain Ischemia; Carbon Dioxide; Fever; Glasgow Coma Sca | 1999 |
Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury.
Topics: Adolescent; Adult; Aged; Amino Acids; Biomarkers; Brain Injuries; Carnitine; Disability Evaluation; | 2000 |
Microdialysis-based long-term measurements of energy-related metabolites in the rat brain following a fluid percussion trauma.
Topics: Animals; Brain Chemistry; Brain Injuries; Cerebral Cortex; Energy Metabolism; Extracellular Space; G | 2000 |
Clinical cerebral microdialysis: a methodological study.
Topics: Adult; Blood Glucose; Brain Chemistry; Brain Injuries; Catheters, Indwelling; Chromatography, High P | 2000 |
On-line monitoring of substrate delivery and brain metabolism in head injury.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain Injuries; Catheters, Indwelling; Energy Metabolism; Fe | 2000 |
Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events.
Topics: Animals; Brain; Brain Injuries; Carbon Dioxide; Cats; Cerebrovascular Circulation; Energy Metabolism | 2001 |
Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Injuries; Cerebrovascular Circulation; Child; Child, Pres | 2001 |
Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions.
Topics: Adult; Aged; Brain; Brain Injuries; Brain Ischemia; Energy Metabolism; Female; Glucose; Glycerol; Hu | 2001 |
Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.
Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Injuries; Cerebrovascular Circulation; Female; Gluc | 2002 |
[Enzymes and metabolic products in the cerebrospinal fluid in acute craniocerebral trauma].
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Brain Injuries; Cerebrospinal Fluid; Clini | 1989 |
Effects of hyperventilation, hypothermia, and altered blood viscosity on cerebral blood flow, cross-brain oxygen extraction, and cerebral metabolic rate for oxygen in cats.
Topics: Animals; Blood Viscosity; Brain Injuries; Cats; Cerebrovascular Circulation; Hyperventilation; Hypot | 1989 |