pyruvic acid has been researched along with Brain Injuries, Traumatic in 12 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arterial hyperglycemia is associated with poor outcome in traumatic brain injury (TBI), but the pathophysiology is not completely understood." | 1.51 | High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury. ( Enblad, P; Hillered, L; Howells, T; Lewén, A; Ronne-Engström, E; Rostami, E; Svedung Wettervik, T, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guilfoyle, MR | 2 |
| Helmy, A | 2 |
| Donnelly, J | 1 |
| Stovell, MG | 1 |
| Timofeev, I | 2 |
| Pickard, JD | 1 |
| Czosnyka, M | 1 |
| Smielewski, P | 1 |
| Menon, DK | 1 |
| Carpenter, KLH | 2 |
| Hutchinson, PJ | 2 |
| Venturini, S | 1 |
| Bhatti, F | 1 |
| Lekomtseva, Y | 1 |
| DeVience, SJ | 1 |
| Lu, X | 1 |
| Proctor, J | 1 |
| Rangghran, P | 1 |
| Melhem, ER | 1 |
| Gullapalli, R | 1 |
| Fiskum, GM | 1 |
| Mayer, D | 1 |
| Gupta, D | 1 |
| Singla, R | 1 |
| Mazzeo, AT | 1 |
| Schnieder, EB | 1 |
| Tandon, V | 1 |
| Kale, SS | 1 |
| Mahapatra, AK | 1 |
| Svedung Wettervik, T | 1 |
| Howells, T | 1 |
| Ronne-Engström, E | 1 |
| Hillered, L | 1 |
| Lewén, A | 1 |
| Enblad, P | 1 |
| Rostami, E | 1 |
| Bouzat, P | 2 |
| Sala, N | 1 |
| Suys, T | 2 |
| Zerlauth, JB | 2 |
| Marques-Vidal, P | 1 |
| Feihl, F | 1 |
| Bloch, J | 1 |
| Messerer, M | 1 |
| Levivier, M | 1 |
| Meuli, R | 2 |
| Magistretti, PJ | 2 |
| Oddo, M | 2 |
| Quintard, H | 1 |
| Patet, C | 1 |
| Pellerin, L | 1 |
| Moro, N | 1 |
| Ghavim, SS | 2 |
| Harris, NG | 2 |
| Hovda, DA | 1 |
| Sutton, RL | 2 |
| Nordström, CH | 2 |
| Nielsen, TH | 1 |
| Schalén, W | 1 |
| Reinstrup, P | 1 |
| Ungerstedt, U | 1 |
| Dienel, GA | 1 |
| Rothman, DL | 1 |
| Shijo, K | 1 |
| Bartnik-Olson, BL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury[NCT01573507] | 42 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Microdialysis-Based Classifications of Abnormal Metabolic States after Traumatic Brain Injury: A Systematic Review of the Literature.
Topics: Brain; Brain Injuries, Traumatic; Energy Metabolism; Glucose; Humans; Microdialysis; Pyruvic Acid | 2023 |
2 trials available for pyruvic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio.
Topics: Adult; Blood Glucose; Brain Injuries, Traumatic; Energy Metabolism; Female; Humans; Imaging, Three-D | 2016 |
9 other studies available for pyruvic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients.
Topics: Adult; Arterial Pressure; Brain; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Glucose; Hum | 2021 |
Targeting higher levels of lactate in the post-injury period following traumatic brain injury.
Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Female; Humans; Lactic Acid; Male; Middle Aged; Pyruvi | 2020 |
Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-
Topics: Animals; Brain Injuries, Traumatic; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Imag | 2017 |
Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: A microdialysis study.
Topics: Brain Injuries, Traumatic; Cerebrovascular Circulation; Decompressive Craniectomy; Female; Glasgow O | 2017 |
High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury.
Topics: Adult; Arterial Pressure; Blood Glucose; Blood Pressure; Brain; Brain Injuries, Traumatic; Cerebrova | 2019 |
Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Cell Survival; Cerebral Cortex; Disease Models, Animal; Glucose; | 2016 |
Biochemical indications of cerebral ischaemia and mitochondrial dysfunction in severe brain trauma analysed with regard to type of lesion.
Topics: Adult; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Infarction; Energy Metabolism; Female; Gl | 2016 |
Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients.
Topics: Brain; Brain Injuries, Traumatic; Critical Care; Energy Metabolism; Glucose; Humans; Lactic Acid; Mi | 2016 |
Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Glucose; Glutamic Acid; Glutamine | 2017 |