pyruvic acid has been researched along with Brain Edema in 28 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 7.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 3.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Global cerebral edema is common among patients with poor-grade subarachnoid hemorrhage and is associated with poor outcome." | 1.37 | Global cerebral edema and brain metabolism after subarachnoid hemorrhage. ( Badjatia, N; Choi, HA; Claassen, J; Connolly, ES; Fernandez, L; Helbok, R; Ko, SB; Kurtz, P; Lee, K; Mayer, SA; Schmidt, JM, 2011) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Rats that were exposed to permanent middle cerebral artery occlusion (MCAO) and treated with intravenous 250 mg/kg pyruvate had a smaller volume of infarction and reduced brain edema, resulting in an improved neurological outcome and reduced mortality compared to control rats treated with saline." | 1.37 | Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke. ( Boyko, M; Gruenbaum, BF; Gruenbaum, SE; Kuts, R; Melamed, I; Ohayon, S; Regev, A; Shapira, Y; Teichberg, VI; Zlotnik, A, 2011) |
| "Patients with global cerebral edema have higher interstitial levels of lactate and pyruvate." | 1.36 | Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema. ( Enblad, P; Hallberg, L; Hillered, L; Karlsson, T; Ronne Engström, E; Zetterling, M, 2010) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| " Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "However, the efficacy of CsA to protect cytotoxic brain edema in ALF is problematic because it poorly crosses the blood-brain barrier, which is relatively intact in ALF." | 1.35 | Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes. ( Norenberg, MD; Rama Rao, KV; Reddy, PV, 2009) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 12 (42.86) | 29.6817 |
| 2010's | 12 (42.86) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Kofler, M | 1 |
| Gaasch, M | 1 |
| Rass, V | 1 |
| Schiefecker, AJ | 1 |
| Ianosi, B | 1 |
| Lindner, A | 1 |
| Beer, R | 1 |
| Stover, JF | 1 |
| Rhomberg, P | 1 |
| Pfausler, B | 1 |
| Thomé, C | 1 |
| Schmutzhard, E | 1 |
| Helbok, R | 2 |
| Prazak, J | 1 |
| Laszikova, E | 1 |
| Pantoflicek, T | 1 |
| Ryska, O | 1 |
| Koblihova, E | 1 |
| Ryska, M | 1 |
| Pattarini, JM | 1 |
| Blue, RS | 1 |
| Aikins, LT | 1 |
| Law, J | 1 |
| Walshe, AD | 1 |
| Garbino, A | 1 |
| Turney, MW | 1 |
| Clark, JB | 1 |
| Zhu, HT | 1 |
| Bian, C | 1 |
| Yuan, JC | 1 |
| Liao, XJ | 1 |
| Liu, W | 1 |
| Zhu, G | 1 |
| Feng, H | 1 |
| Lin, JK | 1 |
| Reddy, PV | 1 |
| Rama Rao, KV | 1 |
| Norenberg, MD | 1 |
| Wang, E | 1 |
| Ho, CL | 1 |
| Lee, KK | 1 |
| Ng, I | 1 |
| Ang, BT | 1 |
| Keularts, IM | 1 |
| Leroy, PL | 1 |
| Rubio-Gozalbo, EM | 1 |
| Spaapen, LJ | 1 |
| Weber, B | 1 |
| Dorland, B | 1 |
| de Koning, TJ | 1 |
| Verhoeven-Duif, NM | 1 |
| Zetterling, M | 1 |
| Hallberg, L | 1 |
| Hillered, L | 1 |
| Karlsson, T | 1 |
| Enblad, P | 2 |
| Ronne Engström, E | 1 |
| Bjerring, PN | 2 |
| Hauerberg, J | 2 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 2 |
| Tofteng, F | 2 |
| Hansen, BA | 2 |
| Larsen, FS | 3 |
| Salci, K | 1 |
| Goiny, M | 1 |
| Contant, CF | 1 |
| Piper, I | 1 |
| Nilsson, P | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 1 |
| Ko, SB | 1 |
| Schmidt, JM | 1 |
| Kurtz, P | 1 |
| Fernandez, L | 1 |
| Choi, HA | 1 |
| Connolly, ES | 1 |
| Lee, K | 1 |
| Badjatia, N | 1 |
| Mayer, SA | 1 |
| Claassen, J | 1 |
| Zweckberger, K | 1 |
| Simunovic, F | 1 |
| Kiening, KL | 2 |
| Unterberg, AW | 1 |
| Sakowitz, OW | 2 |
| Boyko, M | 1 |
| Zlotnik, A | 1 |
| Gruenbaum, BF | 1 |
| Gruenbaum, SE | 1 |
| Ohayon, S | 1 |
| Kuts, R | 1 |
| Melamed, I | 1 |
| Regev, A | 1 |
| Shapira, Y | 1 |
| Teichberg, VI | 1 |
| Zhang, J | 1 |
| Deng, Z | 1 |
| Liao, J | 1 |
| Song, C | 1 |
| Liang, C | 1 |
| Xue, H | 1 |
| Wang, L | 1 |
| Zhang, K | 1 |
| Yan, G | 1 |
| Gliemroth, J | 1 |
| Bahlmann, L | 1 |
| Klaus, S | 1 |
| Klöhn, A | 1 |
| Arnold, H | 1 |
| Alessandri, B | 1 |
| Heimann, A | 1 |
| Filippi, R | 1 |
| Kopacz, L | 1 |
| Kempski, O | 1 |
| Berger, C | 3 |
| Dohmen, C | 3 |
| Maurer, MH | 1 |
| Graf, R | 3 |
| Schwab, S | 3 |
| Bosche, B | 1 |
| Reithmeier, T | 1 |
| Ernestus, RI | 1 |
| Brinker, G | 2 |
| Sobesky, J | 1 |
| Heiss, WD | 2 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Geeraerts, T | 1 |
| Friggeri, A | 1 |
| Mazoit, JX | 1 |
| Benhamou, D | 1 |
| Duranteau, J | 1 |
| Vigué, B | 1 |
| Jorgensen, L | 1 |
| Annecke, A | 1 |
| Aschoff, A | 1 |
| Spranger, M | 1 |
| Yamamura, H | 1 |
| Hiraide, A | 1 |
| Matsuoka, T | 1 |
| Takaoka, M | 1 |
| Shimazu, T | 1 |
| Sugimoto, H | 1 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Staub, F | 1 |
| Neveling, M | 1 |
| Bakay, RA | 1 |
| Sweeney, KM | 1 |
| Wood, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvic acid and Brain Edema
| Article | Year |
|---|---|
Flat spin and negative Gz in high-altitude free fall: pathophysiology, prevention, and treatment.
Topics: Altitude; Arrhythmias, Cardiac; Blood Glucose; Brain Edema; Cerebrovascular Circulation; Confusion; | 2013 |
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A | 1986 |
2 trials available for pyruvic acid and Brain Edema
| Article | Year |
|---|---|
Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
Topics: Adult; Aged; Analysis of Variance; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Female; Glutam | 2008 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
24 other studies available for pyruvic acid and Brain Edema
| Article | Year |
|---|---|
The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients.
Topics: Aged; Aneurysm, Ruptured; Brain; Brain Edema; Brain Ischemia; Cohort Studies; Female; Glucose; Gluta | 2020 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.
Topics: Altitude; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Glutamic Acid; Hyperbaric Oxygenation; L | 2015 |
Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Size; Cells, Cultured; C | 2009 |
Fatal cerebral edema associated with serine deficiency in CSF.
Topics: Biomarkers; Blood Glucose; Brain; Brain Edema; Child; Child, Preschool; Energy Metabolism; Fatal Out | 2010 |
Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema.
Topics: Biomarkers; Brain; Brain Chemistry; Brain Edema; Energy Metabolism; Extracellular Fluid; Glucose; Hu | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Global cerebral edema and brain metabolism after subarachnoid hemorrhage.
Topics: Brain; Brain Edema; Female; Glucose; Humans; Lactic Acid; Middle Aged; Oxygen; Prospective Studies; | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke.
Topics: Animals; Aspartate Aminotransferases; Brain Edema; Brain Infarction; Disease Models, Animal; Dose-Re | 2011 |
Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway.
Topics: Animals; Brain Edema; Brain Infarction; Chromones; Energy Metabolism; Enzyme Inhibitors; L-Lactate D | 2013 |
Long-time microdialysis in a patient with meningoencephalitis.
Topics: Adult; Brain Edema; Combined Modality Therapy; Diuretics, Osmotic; Glucose; Glutamic Acid; Glycerol; | 2002 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In | 2005 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Neurochemical monitoring of fatal middle cerebral artery infarction.
Topics: Adult; Biomarkers; Brain Edema; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Fatal Outco | 1999 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |