pyruvic acid has been researched along with BH4 Deficiency in 7 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenylketonuria is characterized by a variable degree of mental retardation and other neurological features whose mechanisms are not fully understood." | 1.38 | Pyruvate and creatine prevent oxidative stress and behavioral alterations caused by phenylalanine administration into hippocampus of rats. ( Berti, SL; Castro, FL; Dutra-Filho, CS; Garcia, C; Moraes, TB; Nasi, GM; Nunes, ML; Rojas, DB; Wannmacher, CM, 2012) |
| "It has been suggested that the hyperphenylalaninaemia in patients with PKU reduces complex I (NADH:ubiquinone reductase) activity of the mitochondrial respiratory chain (MRC) and/or biosynthesis of coenzyme Q(10) (CoQ(10)), which acts as an electron carrier in the MRC, leading to impaired energy metabolism in the brain of patients with PKU and hence the neurological pathology." | 1.35 | Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia. ( Hargreaves, I; Kyprianou, N; Lee, P; Murphy, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bortoluzzi, VT | 1 |
| Brust, L | 1 |
| Preissler, T | 1 |
| de Franceschi, ID | 1 |
| Wannmacher, CMD | 1 |
| Dos Reis, EA | 1 |
| Rieger, E | 1 |
| de Souza, SS | 1 |
| Rasia-Filho, AA | 1 |
| Wannmacher, CM | 2 |
| Kyprianou, N | 1 |
| Murphy, E | 1 |
| Lee, P | 1 |
| Hargreaves, I | 1 |
| Berti, SL | 1 |
| Nasi, GM | 1 |
| Garcia, C | 1 |
| Castro, FL | 1 |
| Nunes, ML | 1 |
| Rojas, DB | 1 |
| Moraes, TB | 1 |
| Dutra-Filho, CS | 1 |
| JONXIS, JH | 1 |
| COWIE, V | 1 |
| Kolodny, EH | 1 |
| Yatziv, S | 1 |
7 other studies available for pyruvic acid and BH4 Deficiency
| Article | Year |
|---|---|
Creatine plus pyruvate supplementation prevents oxidative stress and phosphotransfer network disturbances in the brain of rats subjected to chemically-induced phenylketonuria.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Creatine; Disease Models, Animal; Energy Metaboli | 2019 |
Effects of a co-treatment with pyruvate and creatine on dendritic spines in rat hippocampus and posterodorsal medial amygdala in a phenylketonuria animal model.
Topics: Amygdala; Animals; CA1 Region, Hippocampal; Cell Count; Coloring Agents; Creatine; Dendritic Spines; | 2013 |
Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cell Line, Tumor; Cells, Cultured; Culture Media; Elect | 2009 |
Pyruvate and creatine prevent oxidative stress and behavioral alterations caused by phenylalanine administration into hippocampus of rats.
Topics: Animals; Antioxidants; Creatine; Energy Metabolism; Exploratory Behavior; Habituation, Psychophysiol | 2012 |
Excretion of phenylalanine; report of two cases of phenyl pyruvic acid oligophrenia.
Topics: Biological Transport; Humans; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Pyruvic Acid | 1957 |
Phenylpyruvic oligophrenia.
Topics: Body Fluids; Humans; Intellectual Disability; Phenylketonurias; Pyruvic Acid; Urine | 1951 |
Laboratory approaches for inherited neurometabolic diseases.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Galactosemias; Homocystinuria; Humans; Lactates; Lact | 1985 |