pyruvic acid has been researched along with Autoimmune Diabetes in 25 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to assess glucose, lactate, glycerol, and pyruvate concentrations in the interstitial fluid of the adipose tissue as well as the glucose relative recovery coefficient in reference to capillary blood (RC) during the first two days of the standard treatment of diabetic ketoacidosis (DKA) in patients with type 1 and type 2 diabetes." | 7.79 | Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. ( Ciechanowska, A; Foltynski, P; Karnafel, W; Kawiak, J; Krzymien, J; Ladyzynski, P; Pulawska, E; Sabalinska, S; Wojcicki, JM, 2013) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 7.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "The objective was to assess glucose, lactate, glycerol, and pyruvate concentrations in the interstitial fluid of the adipose tissue as well as the glucose relative recovery coefficient in reference to capillary blood (RC) during the first two days of the standard treatment of diabetic ketoacidosis (DKA) in patients with type 1 and type 2 diabetes." | 3.79 | Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. ( Ciechanowska, A; Foltynski, P; Karnafel, W; Kawiak, J; Krzymien, J; Ladyzynski, P; Pulawska, E; Sabalinska, S; Wojcicki, JM, 2013) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 3.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Measurements were made of lactate, pyruvate and 2,3-diphosphoglycerate in 69 children admitted to the hospital in a state of diabetic ketoacidosis of different intensity." | 3.68 | [Diagnostic value of detection of blood levels of lactate, pyruvate and 2,3-diphosphoglycerate in children with diabetes mellitus]. ( Baturin, AA; Marchenko, LF; Terent'eva, EA, 1991) |
| "Type 1 and type 2 diabetes are both diseases of insulin insufficiency, although they develop by distinct pathways." | 2.42 | Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. ( Burgess, S; Chen, G; Hohmeier, HE; Jensen, MV; Lu, D; Newgard, CB; Sherry, AD; Tran, VV, 2004) |
| "However, earlier animal models of type 1 diabetes are severely catabolic with very low endogenous leptin levels, unlike most patients with diabetes." | 1.56 | UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia. ( Andersen, B; Bokhari, MH; Busby, O; Cannon, B; Conde-Frieboes, KW; Fels, JJ; Nedergaard, J; Paulsson, JF; Rakipovski, G; Raun, K; Zouhar, P, 2020) |
| "Moderate hypoglycemia is not life-threatening, but if experienced recurrently it may present several clinical complications." | 1.39 | Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. ( Choi, BY; Kim, HJ; Kim, JH; Sohn, M; Song, HK; Suh, SW; Won, SJ; Yoo, JH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (44.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zouhar, P | 1 |
| Rakipovski, G | 1 |
| Bokhari, MH | 1 |
| Busby, O | 1 |
| Paulsson, JF | 1 |
| Conde-Frieboes, KW | 1 |
| Fels, JJ | 1 |
| Raun, K | 1 |
| Andersen, B | 1 |
| Cannon, B | 1 |
| Nedergaard, J | 1 |
| Choi, BY | 1 |
| Kim, JH | 1 |
| Kim, HJ | 1 |
| Yoo, JH | 1 |
| Song, HK | 1 |
| Sohn, M | 1 |
| Won, SJ | 1 |
| Suh, SW | 1 |
| Ciechanowska, A | 1 |
| Ladyzynski, P | 1 |
| Wojcicki, JM | 1 |
| Sabalinska, S | 1 |
| Krzymien, J | 1 |
| Pulawska, E | 1 |
| Karnafel, W | 1 |
| Foltynski, P | 1 |
| Kawiak, J | 1 |
| Santos, RX | 1 |
| Correia, SC | 1 |
| Alves, MG | 1 |
| Oliveira, PF | 1 |
| Cardoso, S | 1 |
| Carvalho, C | 1 |
| Duarte, AI | 1 |
| Santos, MS | 1 |
| Moreira, PI | 1 |
| Vadvalkar, SS | 1 |
| Matsuzaki, S | 1 |
| Eyster, CA | 1 |
| Giorgione, JR | 1 |
| Bockus, LB | 1 |
| Kinter, CS | 1 |
| Kinter, M | 1 |
| Humphries, KM | 1 |
| Rendon, DA | 1 |
| Alvarez-Bustamante, JA | 1 |
| Newgard, CB | 1 |
| Hohmeier, HE | 1 |
| Lu, D | 1 |
| Jensen, MV | 1 |
| Tran, VV | 1 |
| Chen, G | 1 |
| Burgess, S | 1 |
| Sherry, AD | 1 |
| de Cavanagh, EM | 1 |
| Ferder, L | 1 |
| Toblli, JE | 1 |
| Piotrkowski, B | 1 |
| Stella, I | 1 |
| Fraga, CG | 1 |
| Inserra, F | 1 |
| Husband, DJ | 1 |
| Marshall, SM | 1 |
| Walford, S | 1 |
| Hanning, I | 1 |
| Wright, PD | 1 |
| Alberti, KG | 2 |
| Brunetti, P | 1 |
| Bueti, A | 1 |
| Antonella, MA | 1 |
| Calabrese, G | 1 |
| Fabietti, PG | 1 |
| Santeusanio, F | 1 |
| Massi Benedetti, M | 1 |
| Capaldo, B | 1 |
| Home, PD | 1 |
| Massi-Benedetti, M | 1 |
| Worth, R | 1 |
| Cook, DB | 1 |
| Heaton, A | 1 |
| Sigal, RJ | 1 |
| Fisher, SJ | 2 |
| Halter, JB | 1 |
| Vranic, M | 2 |
| Marliss, EB | 1 |
| Shi, ZQ | 1 |
| Lickley, HL | 1 |
| Efendic, S | 1 |
| Giacca, A | 1 |
| Terekhina, NA | 1 |
| Nenasheva, OIu | 1 |
| Akimov, PA | 1 |
| Kalhan, SC | 1 |
| Parimi, P | 1 |
| Van Beek, R | 1 |
| Gilfillan, C | 1 |
| Saker, F | 1 |
| Gruca, L | 1 |
| Sauer, PJ | 1 |
| Marchenko, LF | 1 |
| Baturin, AA | 1 |
| Terent'eva, EA | 1 |
| Hale, PJ | 2 |
| Nattrass, M | 4 |
| Akanji, AO | 1 |
| Humphreys, S | 1 |
| Thursfield, V | 1 |
| Hockaday, TD | 1 |
| Benn, JJ | 1 |
| Bozzard, SJ | 1 |
| Kelley, D | 1 |
| Mitrakou, A | 1 |
| Aoki, T | 1 |
| Sorensen, J | 1 |
| Gerich, J | 1 |
| Sonksen, PH | 1 |
| Hübinger, A | 1 |
| Ridderskamp, I | 1 |
| Lehmann, E | 1 |
| Gries, FA | 1 |
| Ruddy, TD | 1 |
| Shumak, SL | 1 |
| Liu, PP | 1 |
| Barnie, A | 1 |
| Seawright, SJ | 1 |
| McLaughlin, PR | 1 |
| Zinman, B | 1 |
| Black, E | 1 |
| Hocking, MD | 2 |
| Crase, J | 1 |
| Rayner, PH | 2 |
| Gräfenstein, K | 1 |
| Duchna, W | 1 |
1 review available for pyruvic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.
Topics: Animals; Cell Survival; Cytokines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Hu | 2004 |
2 trials available for pyruvic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Continuous intraperitoneal insulin infusion in the management of severely brittle diabetes--a metabolic and clinical comparison with intravenous infusion.
Topics: Adolescent; Adult; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Female; Human | 1984 |
Metabolic response to different forms of physical exercise in type I diabetics and the duration of the glucose lowering effect.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hormones; Humans; Lactates; Lactic Acid; Ma | 1985 |
22 other studies available for pyruvic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Corticosterone; Diabetes Melli | 2020 |
Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats.
Topics: Animals; Cell Death; Cerebral Cortex; Dendrites; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2013 |
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis.
Topics: Adipose Tissue; Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus | 2013 |
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
Topics: Animals; Autophagy; Caspase 3; Caspase 9; Cerebral Cortex; Diabetes Mellitus, Experimental; Diabetes | 2014 |
Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION.
Topics: Acetylation; Animals; Anion Transport Proteins; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies | 2017 |
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes?
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease | 2011 |
Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxidants; | 2008 |
Metabolic effects of intensified insulin therapy.
Topics: Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Drug Administration Schedule; Fatty Acids, Nonest | 1984 |
The response of blood intermediary metabolite levels to 24 hours treatment with a blood glucose-controlled insulin infusion system in type 1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycerol; H | 1984 |
Glucoregulation during and after intense exercise: effects of beta-adrenergic blockade in subjects with type 1 diabetes mellitus.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrin | 1999 |
Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Typ | 2001 |
[Novel methods in diabetes mellitus diagnosis].
Topics: Cadaver; Coma; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; | 2001 |
Estimation of gluconeogenesis in newborn infants.
Topics: Amino Acids; Blood Glucose; Body Water; Carbon Isotopes; Deuterium; Diabetes Mellitus, Type 1; Femal | 2001 |
[Diagnostic value of detection of blood levels of lactate, pyruvate and 2,3-diphosphoglycerate in children with diabetes mellitus].
Topics: 2,3-Diphosphoglycerate; Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Com | 1991 |
The short-term effect of nicotinic acid on intermediary metabolism in insulin-dependent diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glycerol; Humans; Insul | 1991 |
The relationship of plasma acetate with glucose and other blood intermediary metabolites in non-diabetic and diabetic subjects.
Topics: Acetates; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Fatty | 1989 |
Persistent abnormalities of the metabolism of an oral glucose load in insulin-treated type I diabetics.
Topics: Administration, Oral; Alanine; Blood Glucose; Calorimetry, Indirect; Diabetes Mellitus, Type 1; Fore | 1989 |
The relationship of cardiac diastolic dysfunction to concurrent hormonal and metabolic status in type I diabetes mellitus.
Topics: Adult; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Type 1; Diastole; Epinephrine; Female; Gl | 1988 |
Metabolic effects of low-dose incremental insulin infusion in diabetic man.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glycerol; Huma | 1986 |
Metabolic rhythms in adolescents with diabetes during treatment with porcine or human insulin.
Topics: Adolescent; Animals; Blood Glucose; Child; Diabetes Mellitus, Type 1; Drug Administration Schedule; | 1986 |
Metabolic rhythms in adolescents with diabetes.
Topics: Activity Cycles; Adolescent; Blood Glucose; Child; Circadian Rhythm; Diabetes Mellitus, Type 1; Fema | 1986 |
[Relation between glycohemoglobin, hypoxia parameters and diabetic microangiopathy].
Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Re | 1985 |