pyruvic acid has been researched along with Asystole in 16 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral metabolic alterations during cardiac arrest, cardiopulmonary resuscitation (CPR) and extracorporeal cardiopulmonary life support (ECLS) are poorly explored." | 1.43 | Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial. ( Ettl, F; Herkner, H; Högler, S; Hosmann, A; Janata, A; Laggner, AN; Magnet, IA; Scherer, T; Schober, A; Sterz, F; Testori, C; Warenits, AM; Weihs, W; Zeitlinger, M, 2016) |
| " Pyruvate treatment also lowered the dosage of vasoconstrictor phenylephrine required to maintain systemic arterial pressure at 15-60 min recovery, hastened clearance of excess glucose, elevated arterial bicarbonate, and raised arterial pH; these statistically significant effects persisted up to 3 h after sodium pyruvate infusion, while infusion-induced hypernatremia subsided." | 1.42 | Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest. ( Cherry, BH; Hollrah, RA; Hoxha, B; Mallet, RT; Nguyen, AQ; Olivencia-Yurvati, AH; Williams, AG, 2015) |
| "Histological features of ischaemia and reperfusion injury were assessed." | 1.40 | Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion. ( Ahmed, N; Mirza, DF; Murphy, N; Neil, DA; Perera, MT; Richards, DA; Silva, MA, 2014) |
| "Neonatal pigs with asphyxia-induced cardiac arrest did not respond to a compression:ventilation ratio of 9:3 better than to 3:1." | 1.36 | Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. ( Dannevig, I; Nakstad, B; Saugstad, OD; Solevåg, AL; Wyckoff, M, 2010) |
| "After induction (t0) of cardiac arrest of 4 min, cardiopulmonary resuscitation was performed for 1 min, and the induced ventricular fibrillation was terminated by electrical defibrillation." | 1.33 | Xenon attenuates cerebral damage after ischemia in pigs. ( Glöggl, E; Marx, T; Reinelt, H; Schirmer, U; Schmidt, M, 2005) |
| "Beagles were subjected to 5 min cardiac arrest and 5 min open-chest cardiac compression (OCCC: 80 compressions min(-1); aortic pressure 60-70 mmHg), then epicardial dc countershocks (5-10 J) were applied to restore sinus rhythm." | 1.33 | Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation. ( Bi, J; Knott, EM; Mallet, RT; Martinez, RR; Sharma, AB; Sun, J, 2005) |
| "After cardiac resuscitation, hypoxic encephalopathy often is the limiting factor regarding outcome due to the oxygen sensitivity of the brain." | 1.32 | Neurochemical monitoring using intracerebral microdialysis during cardiac resuscitation. ( Barbach, J; Bauer, R; Gabl, M; Galiano, K; Mohsenipour, I; Obwegeser, A, 2004) |
| "Ventricular fibrillation has been studied in the isolated rabbit heart to determine the effect of factors modifying the metabolism." | 1.24 | Metabolic factors and ventricular fibrillation. ( GOODFORD, PJ, 1958) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, VHS | 1 |
| Gugino, S | 1 |
| Nielsen, L | 1 |
| Chandrasekharan, P | 1 |
| Koenigsknecht, C | 1 |
| Helman, J | 1 |
| Lakshminrusimha, S | 1 |
| Scott, GF | 1 |
| Nguyen, AQ | 2 |
| Cherry, BH | 2 |
| Hollrah, RA | 2 |
| Salinas, I | 1 |
| Williams, AG | 2 |
| Ryou, MG | 1 |
| Mallet, RT | 4 |
| Perera, MT | 1 |
| Richards, DA | 1 |
| Silva, MA | 1 |
| Ahmed, N | 1 |
| Neil, DA | 1 |
| Murphy, N | 1 |
| Mirza, DF | 1 |
| Hoxha, B | 1 |
| Olivencia-Yurvati, AH | 1 |
| Schober, A | 1 |
| Warenits, AM | 1 |
| Testori, C | 1 |
| Weihs, W | 1 |
| Hosmann, A | 1 |
| Högler, S | 1 |
| Sterz, F | 1 |
| Janata, A | 1 |
| Scherer, T | 1 |
| Magnet, IA | 1 |
| Ettl, F | 1 |
| Laggner, AN | 1 |
| Herkner, H | 1 |
| Zeitlinger, M | 1 |
| Nordmark, J | 1 |
| Enblad, P | 1 |
| Rubertsson, S | 1 |
| Solevåg, AL | 2 |
| Dannevig, I | 2 |
| Nakstad, B | 2 |
| Saugstad, OD | 2 |
| Amer-Wåhlin, I | 1 |
| Nord, A | 1 |
| Bottalico, B | 1 |
| Hansson, SR | 1 |
| Ley, D | 1 |
| Marsál, K | 1 |
| Ungerstedt, U | 1 |
| Nordström, CH | 1 |
| Wyckoff, M | 1 |
| Hua, R | 1 |
| Li, C | 1 |
| Gong, P | 1 |
| Tang, Z | 1 |
| Mei, X | 1 |
| Zhao, H | 1 |
| GOODFORD, PJ | 1 |
| Bauer, R | 1 |
| Gabl, M | 1 |
| Obwegeser, A | 1 |
| Galiano, K | 1 |
| Barbach, J | 1 |
| Mohsenipour, I | 1 |
| Schmidt, M | 1 |
| Marx, T | 1 |
| Glöggl, E | 1 |
| Reinelt, H | 1 |
| Schirmer, U | 1 |
| Sharma, AB | 2 |
| Knott, EM | 1 |
| Bi, J | 1 |
| Martinez, RR | 1 |
| Sun, J | 1 |
| Barlow, MA | 1 |
| Yang, SH | 1 |
| Simpkins, JW | 1 |
| Peuhkurinen, KJ | 1 |
| Nuutinen, EM | 1 |
| Pietiläinen, EP | 1 |
| Hiltunen, JK | 1 |
| Hassinen, IE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SURV1VE-Trial - Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns: A Randomized Controlled Trial[NCT02858583] | 25 participants (Actual) | Interventional | 2017-10-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for pyruvic acid and Asystole
| Article | Year |
|---|---|
Protection from systemic pyruvate at resuscitation in newborn lambs with asphyxial cardiac arrest.
Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Disease Models, Animal; Heart Arrest; Hypoxia-I | 2020 |
Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Glutathione Reductase; Glyceraldehyde-3-Pho | 2017 |
Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion.
Topics: Adult; Aged; Brain Death; Cryopreservation; Energy Metabolism; Glycerol; Graft Survival; Heart Arres | 2014 |
Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest.
Topics: Animals; Antioxidants; Blood Pressure; Cardiopulmonary Resuscitation; Electrocardiography; Female; H | 2015 |
Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial.
Topics: Animals; Biomarkers; Blood Pressure; CA1 Region, Hippocampal; Cardiopulmonary Resuscitation; Cerebra | 2016 |
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase.
Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease | 2009 |
Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21% or 100% oxygen.
Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cardiopulmonary Resuscitation; | 2010 |
Fetal cerebral energy metabolism and electrocardiogram during experimental umbilical cord occlusion and resuscitation.
Topics: Animals; Brain; Brain Chemistry; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardi | 2010 |
Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Asphyxia; Bronchoalveolar Lavage Fluid; Disease Mod | 2010 |
Cerebrospinal fluid biochemistry reflects effects of therapeutic hypothermia after cardiac arrest in a porcine model.
Topics: Animals; Body Temperature; Disease Models, Animal; Glucose; Glutamic Acid; Glycerol; Heart Arrest; H | 2012 |
Metabolic factors and ventricular fibrillation.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Glucose; Heart; Heart Arr | 1958 |
Neurochemical monitoring using intracerebral microdialysis during cardiac resuscitation.
Topics: Adult; Biomarkers; Brain Chemistry; Cause of Death; Cerebral Infarction; Energy Metabolism; Fatal Ou | 2004 |
Xenon attenuates cerebral damage after ischemia in pigs.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Body Temperature; Bra | 2005 |
Pyruvate improves cardiac electromechanical and metabolic recovery from cardiopulmonary arrest and resuscitation.
Topics: Analysis of Variance; Animals; Antioxidants; Cardiopulmonary Resuscitation; Dogs; Energy Metabolism; | 2005 |
Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Cardiopulmonary Resuscitation; Caspase 3; Cerebr | 2008 |
Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of tricarboxylic acid-cycle intermediates in the myocardium.
Topics: Alanine; Animals; Aspartic Acid; Bicarbonates; Citrates; Citric Acid; Citric Acid Cycle; Female; Glu | 1982 |