pyruvic acid has been researched along with Amyotrophic Lateral Sclerosis in 8 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the toxic effects of excess extracellular copper on motor neuronal cells expressing human mutant SOD1 (G93A), and evaluated the neuroprotective effects of energy metabolism intermediates or cofactors." | 1.33 | Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity. ( Kim, HJ; Kim, JM; Kim, M; Lee, KW; Park, JH; Sung, JJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bøgh, N | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Tankisi, H | 1 |
| Bertelsen, LB | 1 |
| Blicher, JU | 1 |
| Manzo, E | 1 |
| Lorenzini, I | 1 |
| Barrameda, D | 1 |
| O'Conner, AG | 1 |
| Barrows, JM | 1 |
| Starr, A | 1 |
| Kovalik, T | 1 |
| Rabichow, BE | 1 |
| Lehmkuhl, EM | 1 |
| Shreiner, DD | 1 |
| Joardar, A | 1 |
| Liévens, JC | 1 |
| Bowser, R | 1 |
| Sattler, R | 1 |
| Zarnescu, DC | 1 |
| Valbuena, GN | 1 |
| Rizzardini, M | 1 |
| Cimini, S | 1 |
| Siskos, AP | 1 |
| Bendotti, C | 1 |
| Cantoni, L | 1 |
| Keun, HC | 1 |
| Pradat, PF | 1 |
| Bruneteau, G | 1 |
| Gordon, PH | 1 |
| Dupuis, L | 1 |
| Bonnefont-Rousselot, D | 1 |
| Simon, D | 1 |
| Salachas, F | 1 |
| Corcia, P | 1 |
| Frochot, V | 1 |
| Lacorte, JM | 1 |
| Jardel, C | 1 |
| Coussieu, C | 1 |
| Le Forestier, N | 1 |
| Lacomblez, L | 1 |
| Loeffler, JP | 1 |
| Meininger, V | 1 |
| Kim, HJ | 2 |
| Kim, JM | 1 |
| Park, JH | 2 |
| Sung, JJ | 2 |
| Kim, M | 1 |
| Lee, KW | 2 |
| Hong, YH | 1 |
| Kim, SM | 1 |
| Kim, MJ | 1 |
| Park, KS | 1 |
| Esposito, E | 1 |
| Capasso, M | 1 |
| di Tomasso, N | 1 |
| Corona, C | 1 |
| Pellegrini, F | 1 |
| Uncini, A | 1 |
| Vitaglione, P | 1 |
| Fogliano, V | 1 |
| Piantelli, M | 1 |
| Sensi, SL | 1 |
| Xu, GP | 1 |
| Dave, KR | 1 |
| Moraes, CT | 1 |
| Busto, R | 1 |
| Sick, TJ | 1 |
| Bradley, WG | 1 |
| Pérez-Pinzón, MA | 1 |
8 other studies available for pyruvic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Humans; Lactic Acid; Magnetic Resonance Imaging; Neurod | 2022 |
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; DNA-Binding Proteins; Drosophila mel | 2019 |
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.
Topics: Aerobiosis; Alanine; Amino Acids; Amyotrophic Lateral Sclerosis; Animals; Caspase 3; Caspase 7; Cell | 2016 |
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.
Topics: Adiponectin; Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Blood Glucose; Fatty Acids, Non | 2010 |
Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.
Topics: Amyotrophic Lateral Sclerosis; Cell Death; Cell Line, Tumor; Copper; Energy Metabolism; Free Radical | 2005 |
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progre | 2007 |
Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Carotenoids; Disease Models, Ani | 2007 |
Dysfunctional mitochondrial respiration in the wobbler mouse brain.
Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Brain; Cell Respiration; Disease Models, Anim | 2001 |