pyruvic acid has been researched along with Amino Acid Metabolism Disorders, Inborn in 6 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Accumulation of 2-methylcitric acid (2MCA) is observed in methylmalonic and propionic acidemias, which are clinically characterized by severe neurological symptoms." | 3.83 | 2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. ( Amaral, AU; Castilho, RF; Cecatto, C; Wajner, M, 2016) |
| "It has been suggested that the hyperphenylalaninaemia in patients with PKU reduces complex I (NADH:ubiquinone reductase) activity of the mitochondrial respiratory chain (MRC) and/or biosynthesis of coenzyme Q(10) (CoQ(10)), which acts as an electron carrier in the MRC, leading to impaired energy metabolism in the brain of patients with PKU and hence the neurological pathology." | 1.35 | Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia. ( Hargreaves, I; Kyprianou, N; Lee, P; Murphy, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amaral, AU | 1 |
| Cecatto, C | 1 |
| Castilho, RF | 1 |
| Wajner, M | 1 |
| Kyprianou, N | 1 |
| Murphy, E | 1 |
| Lee, P | 1 |
| Hargreaves, I | 1 |
| Andrade, VS | 1 |
| Rojas, DB | 1 |
| Oliveira, L | 1 |
| Nunes, ML | 1 |
| de Castro, FL | 1 |
| Garcia, C | 1 |
| Gemelli, T | 1 |
| de Andrade, RB | 1 |
| Wannmacher, CM | 1 |
| Kodama, H | 1 |
| Nose, O | 1 |
| Okada, S | 1 |
| Yabuuchi, H | 1 |
| Wijburg, FA | 1 |
| Feller, N | 1 |
| Ruitenbeek, W | 1 |
| Trijbels, JM | 1 |
| Sengers, RC | 1 |
| Scholte, HR | 1 |
| Przyrembel, H | 1 |
| Wanders, RJ | 1 |
| Kolodny, EH | 1 |
| Yatziv, S | 1 |
6 other studies available for pyruvic acid and Amino Acid Metabolism Disorders, Inborn
| Article | Year |
|---|---|
2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Metabolism, Inborn Errors; Animals; Brain; | 2016 |
Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cell Line, Tumor; Cells, Cultured; Culture Media; Elect | 2009 |
Creatine and pyruvate prevent behavioral and oxidative stress alterations caused by hypertryptophanemia in rats.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Behavior, Animal; Creatine; Male; Oxidative Stress; P | 2012 |
The study of organic acids metabolism in a patient with ornithine transcarbamylase (OTC) deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Child; Citrates; Citric Acid; Female; Humans; Ketoglu | 1982 |
Detection of respiratory chain dysfunction by measuring lactate and pyruvate production in cultured fibroblasts.
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Child, Preschool; Cytochrome-c Oxidase Defici | 1990 |
Laboratory approaches for inherited neurometabolic diseases.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Galactosemias; Homocystinuria; Humans; Lactates; Lact | 1985 |