pyruvic acid has been researched along with Alloxan Diabetes in 87 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 7.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state." | 3.77 | Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011) |
| "Studies show that the pyruvate treatment decreased the extent of several biochemical changes known to be associated with cataract formation, such as the elevation in the levels of glycated proteins, sorbitol, lipid peroxidation (MDA) and inhibition of the cation pump." | 3.70 | Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. ( Ali, AH; Devamanoharan, PS; Henein, M; Varma, SD; Zhao, W, 2000) |
| "Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes." | 3.64 | PYRUVATE METABOLISM AND CONTROL: FACTORS AFFECTING PYRUVIC CARBOXYLASE ACTIVITY. ( FREEDMAN, AD; KOHN, L, 1964) |
| "However, earlier animal models of type 1 diabetes are severely catabolic with very low endogenous leptin levels, unlike most patients with diabetes." | 1.56 | UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia. ( Andersen, B; Bokhari, MH; Busby, O; Cannon, B; Conde-Frieboes, KW; Fels, JJ; Nedergaard, J; Paulsson, JF; Rakipovski, G; Raun, K; Zouhar, P, 2020) |
| " Chronic administration of NaSH in particular at high doses impaired carbohydrate metabolism in type 2 diabetic rats." | 1.51 | Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats. ( Ghasemi, A; Gheibi, S; Jeddi, S; Kashfi, K, 2019) |
| "Moderate hypoglycemia is not life-threatening, but if experienced recurrently it may present several clinical complications." | 1.39 | Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. ( Choi, BY; Kim, HJ; Kim, JH; Sohn, M; Song, HK; Suh, SW; Won, SJ; Yoo, JH, 2013) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| " In conclusion, this study suggests that short-term administration of LA at high dosage to normal and diabetic rats causes an inhibition of gluconeogenesis secondary to an interference with hepatic fatty acid oxidation." | 1.30 | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. ( Bashan, N; Gutman, A; Khamaisi, M; Potashnik, R; Rudich, A; Tritschler, HJ, 1999) |
| " Insulin dose-response curves revealed similar sensitivities and responsiveness." | 1.28 | Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM. ( Gavin, JR; Karl, IE; Levy, J, 1990) |
| "Induction of streptozotocin diabetes resulted in loss of pyruvate inhibition of the kinase in heart mitochondria at 48 h but not at 24 h whereas a significant increase of kinase activity was seen at 24 h." | 1.27 | Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable. ( Coore, HG; Lyn, D, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (32.18) | 18.7374 |
| 1990's | 28 (32.18) | 18.2507 |
| 2000's | 15 (17.24) | 29.6817 |
| 2010's | 13 (14.94) | 24.3611 |
| 2020's | 3 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Schoenmann, N | 1 |
| Tannenbaum, N | 1 |
| Hodgeman, RM | 1 |
| Raju, RP | 1 |
| Choi, YS | 1 |
| Song, JE | 1 |
| Kim, E | 1 |
| Kim, CH | 1 |
| Lee, JE | 1 |
| Song, HT | 1 |
| Zouhar, P | 1 |
| Rakipovski, G | 1 |
| Bokhari, MH | 1 |
| Busby, O | 1 |
| Paulsson, JF | 1 |
| Conde-Frieboes, KW | 1 |
| Fels, JJ | 1 |
| Raun, K | 1 |
| Andersen, B | 1 |
| Cannon, B | 1 |
| Nedergaard, J | 1 |
| Gheibi, S | 1 |
| Jeddi, S | 1 |
| Kashfi, K | 1 |
| Ghasemi, A | 1 |
| Choi, BY | 1 |
| Kim, JH | 1 |
| Kim, HJ | 1 |
| Yoo, JH | 1 |
| Song, HK | 1 |
| Sohn, M | 1 |
| Won, SJ | 1 |
| Suh, SW | 1 |
| Santos, RX | 1 |
| Correia, SC | 1 |
| Alves, MG | 1 |
| Oliveira, PF | 1 |
| Cardoso, S | 1 |
| Carvalho, C | 1 |
| Duarte, AI | 1 |
| Santos, MS | 1 |
| Moreira, PI | 1 |
| McCommis, KS | 1 |
| Chen, Z | 1 |
| Fu, X | 1 |
| McDonald, WG | 1 |
| Colca, JR | 1 |
| Kletzien, RF | 1 |
| Burgess, SC | 1 |
| Finck, BN | 1 |
| Zhou, J | 1 |
| Xu, G | 1 |
| Bai, Z | 1 |
| Li, K | 1 |
| Yan, J | 1 |
| Li, F | 1 |
| Ma, S | 1 |
| Xu, H | 1 |
| Huang, K | 1 |
| Gowda, K | 1 |
| Zinnanti, WJ | 1 |
| LaNoue, KF | 1 |
| Rendon, DA | 1 |
| Alvarez-Bustamante, JA | 1 |
| Rosca, MG | 1 |
| Vazquez, EJ | 1 |
| Chen, Q | 1 |
| Kerner, J | 1 |
| Kern, TS | 1 |
| Hoppel, CL | 1 |
| Konstantopoulos, N | 1 |
| Molero, JC | 1 |
| McGee, SL | 1 |
| Spolding, B | 1 |
| Connor, T | 1 |
| de Vries, M | 1 |
| Wanyonyi, S | 1 |
| Fahey, R | 1 |
| Morrison, S | 1 |
| Swinton, C | 1 |
| Jones, S | 1 |
| Cooper, A | 1 |
| Garcia-Guerra, L | 1 |
| Foletta, VC | 1 |
| Krippner, G | 1 |
| Andrikopoulos, S | 1 |
| Walder, KR | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 2 |
| Sheline, CT | 1 |
| Shi, C | 1 |
| Takata, T | 1 |
| Zhu, J | 1 |
| Zhang, W | 1 |
| Sheline, PJ | 1 |
| Cai, AL | 1 |
| Li, L | 1 |
| Laustsen, C | 1 |
| Østergaard, JA | 1 |
| Lauritzen, MH | 1 |
| Nørregaard, R | 1 |
| Bowen, S | 1 |
| Søgaard, LV | 1 |
| Flyvbjerg, A | 1 |
| Pedersen, M | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Torres-Jacome, J | 1 |
| Gallego, M | 1 |
| Rodríguez-Robledo, JM | 1 |
| Sanchez-Chapula, JA | 1 |
| Casis, O | 1 |
| Pósa, I | 1 |
| Kocsis, E | 1 |
| Nieszner, E | 1 |
| Pogátsa, G | 1 |
| Koltai, MZ | 1 |
| Festuccia, WT | 1 |
| Kawashita, NH | 1 |
| Garofalo, MA | 2 |
| Moura, MA | 1 |
| Brito, SR | 1 |
| Kettelhut, IC | 1 |
| Migliorini, RH | 2 |
| Chang, I | 1 |
| Cho, N | 1 |
| Koh, JY | 1 |
| Lee, MS | 1 |
| MEYER, F | 1 |
| MANDEL, P | 2 |
| SCHMITT, ML | 2 |
| QUARANTA, CA | 2 |
| NAVAZIO, F | 1 |
| SILIPRANDI, N | 1 |
| THIELMANN, K | 1 |
| FRUNDER, H | 1 |
| RICHTER, G | 1 |
| BOERNIG, H | 1 |
| GARLAND, PB | 1 |
| NEWSHOLME, EA | 1 |
| RANDLE, PJ | 2 |
| DOMJAN, G | 1 |
| FAZEKAS, A | 1 |
| JAKI, A | 1 |
| FREEDMAN, AD | 1 |
| KOHN, L | 1 |
| HAFT, DE | 1 |
| LANDAU, BR | 2 |
| HASTINGS, AB | 1 |
| NESBETT, FB | 1 |
| SAVAGE, N | 1 |
| GILLMAN, J | 1 |
| GILBERT, C | 1 |
| Winiarska, K | 1 |
| Drozak, J | 1 |
| Wegrzynowicz, M | 1 |
| Fraczyk, T | 1 |
| Bryla, J | 1 |
| Hegde, KR | 2 |
| Varma, SD | 4 |
| Coffe, V | 2 |
| Carbajal, RC | 1 |
| Salceda, R | 2 |
| Diederen, RM | 1 |
| Starnes, CA | 1 |
| Berkowitz, BA | 1 |
| Winkler, BS | 1 |
| Qi, Y | 1 |
| Zhang, J | 1 |
| Martins-Santos, ME | 1 |
| Chaves, VE | 1 |
| Frasson, D | 1 |
| Boschini, RP | 1 |
| Kettelhut, Ido C | 1 |
| de Cavanagh, EM | 1 |
| Ferder, L | 1 |
| Toblli, JE | 1 |
| Piotrkowski, B | 1 |
| Stella, I | 1 |
| Fraga, CG | 1 |
| Inserra, F | 1 |
| Qi, YX | 1 |
| Yu, HL | 1 |
| Meng, DX | 1 |
| Zhang, D | 1 |
| Zhang, JS | 1 |
| Fuller, SJ | 1 |
| Kilberg, MS | 1 |
| Gwynn, MB | 1 |
| Kakemi, M | 1 |
| Sasaki, H | 2 |
| Saeki, K | 1 |
| Endoh, M | 1 |
| Katayama, K | 1 |
| Koizumi, T | 1 |
| Dahlkvist, HH | 1 |
| Arnqvist, HJ | 1 |
| Norrby, K | 1 |
| McCormack, JG | 2 |
| Edgell, NJ | 1 |
| Denton, RM | 1 |
| Kielducka, A | 1 |
| Paradies, G | 1 |
| Papa, S | 1 |
| Szutowicz, A | 1 |
| Tomaszewicz, M | 1 |
| Jankowska, A | 1 |
| Kisielevski, Y | 1 |
| Abdel-aleem, S | 2 |
| Sharwi, S | 1 |
| Badr, M | 1 |
| Sayed-Ahmed, M | 1 |
| Anstadt, MP | 1 |
| Lowe, JE | 2 |
| Yamatani, K | 1 |
| Marubashi, S | 1 |
| Wakasugi, K | 1 |
| Saito, K | 1 |
| Sato, N | 1 |
| Takahashi, K | 1 |
| Moir, AM | 1 |
| Zammit, VA | 1 |
| Tilton, RG | 1 |
| Chang, K | 1 |
| Nyengaard, JR | 1 |
| Van den Enden, M | 1 |
| Ido, Y | 1 |
| Williamson, JR | 1 |
| Longhurst, PA | 1 |
| Briscoe, JA | 1 |
| Leggett, RE | 1 |
| Samadzadeh, S | 1 |
| Levin, RM | 1 |
| Hotta, N | 1 |
| Komori, T | 1 |
| Kobayashi, M | 1 |
| Sakakibara, F | 1 |
| Koh, N | 1 |
| Sakamoto, N | 1 |
| Rastellini, C | 1 |
| Cicalese, L | 1 |
| Zeevi, A | 1 |
| Mattes, C | 1 |
| Stanko, RT | 1 |
| Starzl, TE | 1 |
| Rao, AS | 1 |
| Tormo, MA | 1 |
| Gómez-Zubeldia, MA | 1 |
| Ropero, F | 1 |
| Muñoz-Casillas, M | 1 |
| Moreno, JC | 1 |
| Campillo, JE | 1 |
| Kalapos, MP | 1 |
| Riba, P | 1 |
| Garzo, T | 1 |
| Mandl, J | 1 |
| Reddy, TN | 1 |
| Padmaja, C | 1 |
| Rao, JV | 1 |
| Reddy, PU | 1 |
| Strödter, D | 1 |
| Overbeck, A | 1 |
| Syed Ali, S | 1 |
| Seitz, S | 1 |
| Bretzel, RG | 1 |
| Federlin, K | 1 |
| Hall, JL | 1 |
| Stanley, WC | 1 |
| Lopaschuk, GD | 1 |
| Wisneski, JA | 1 |
| Pizzurro, RD | 1 |
| Hamilton, CD | 1 |
| Fischer, Y | 1 |
| Böttcher, U | 1 |
| Eblenkamp, M | 1 |
| Thomas, J | 1 |
| Jüngling, E | 1 |
| Rösen, P | 1 |
| Kammermeier, H | 1 |
| Ferraz, M | 1 |
| Brunaldi, K | 1 |
| Oliveira, CE | 1 |
| Bazotte, RB | 2 |
| Devamanoharan, PS | 2 |
| Ali, AH | 2 |
| Beyer-Mears, A | 1 |
| Diecke, FP | 1 |
| Mistry, K | 1 |
| Ellison, C | 1 |
| Cruz, E | 1 |
| Karim, AM | 1 |
| Zarouk, WA | 1 |
| Taylor, DA | 1 |
| el-Awady, MK | 1 |
| Vilchis, C | 1 |
| Hernández-Muñoz, R | 1 |
| Khamaisi, M | 1 |
| Rudich, A | 1 |
| Potashnik, R | 1 |
| Tritschler, HJ | 1 |
| Gutman, A | 1 |
| Bashan, N | 1 |
| Large, V | 1 |
| Beylot, M | 1 |
| Mellors, LJ | 1 |
| Kotsanas, G | 1 |
| Wendt, IR | 1 |
| Zhao, W | 1 |
| Henein, M | 1 |
| Obrosova, IG | 1 |
| Stevens, MJ | 1 |
| Lang, HJ | 1 |
| Akimoto, LS | 1 |
| Pedrinho, SR | 1 |
| Lopes, G | 1 |
| Kondoh, Y | 1 |
| Kawase, M | 1 |
| Kawakami, Y | 1 |
| Ohmori, S | 1 |
| Grill, V | 1 |
| Sako, Y | 1 |
| Ostenson, CG | 1 |
| Jalkanen, P | 1 |
| Wu, GY | 2 |
| Field, CJ | 2 |
| Marliss, EB | 2 |
| Burns, AH | 1 |
| Burns, LA | 1 |
| Jurenka, LU | 1 |
| Summer, WR | 1 |
| Karl, IE | 1 |
| Gavin, JR | 1 |
| Levy, J | 1 |
| Challiss, RA | 1 |
| Vranic, M | 1 |
| Palaiologos, G | 1 |
| Philippidis, H | 1 |
| Chomatas, H | 1 |
| Iakovou, D | 1 |
| Linardou, A | 1 |
| Kosugi, K | 1 |
| Scofield, RF | 1 |
| Chandramouli, V | 1 |
| Kumaran, K | 1 |
| Schumann, WC | 1 |
| Johnston, DG | 1 |
| Johnson, GA | 1 |
| Alberti, KG | 1 |
| Millward-Sadler, GH | 1 |
| Mitchell, J | 1 |
| Wright, R | 1 |
| Albisser, AM | 1 |
| Nomura, M | 1 |
| McPhedran, NT | 1 |
| Lyn, D | 1 |
| Coore, HG | 1 |
| Boquist, L | 1 |
| Ericsson, I | 1 |
| Lorentzon, R | 1 |
| Nelson, L | 1 |
| Cuezva, JM | 1 |
| Patel, MS | 1 |
| Cirkel, U | 1 |
| Burkart, W | 1 |
| Stähler, E | 1 |
| Buchholz, R | 1 |
| Kuo, TH | 1 |
| Giacomelli, F | 1 |
| Wiener, J | 1 |
| Aftring, RP | 1 |
| Manos, PN | 1 |
| Buse, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger.
Topics: Animals; Diabetes Mellitus, Experimental; Oxidoreductases; Pyruvate Dehydrogenase Acetyl-Transferrin | 2023 |
86 other studies available for pyruvic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Hyperpolarized [1-
Topics: Agmatine; Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lactic Acid; M | 2023 |
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Corticosterone; Diabetes Melli | 2020 |
Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Di | 2019 |
Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats.
Topics: Animals; Cell Death; Cerebral Cortex; Dendrites; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2013 |
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
Topics: Animals; Autophagy; Caspase 3; Caspase 9; Cerebral Cortex; Diabetes Mellitus, Experimental; Diabetes | 2014 |
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
Topics: Alanine; Animals; Blood Glucose; Cell Line; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluc | 2015 |
Selenite exacerbates hepatic insulin resistance in mouse model of type 2 diabetes through oxidative stress-mediated JNK pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fasting; Gene E | 2015 |
The influence of diabetes on glutamate metabolism in retinas.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Disease Models, Animal; Glutamic Acid; In | 2011 |
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes?
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease | 2011 |
Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes.
Topics: Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Fatty Acids; Kidney Tubu | 2012 |
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.
Topics: Animals; Blood Glucose; Carbonic Anhydrase Inhibitors; Diabetes Mellitus, Experimental; Glucose Clam | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates β-cell death in nonobese diabetic mice, islets, and insulinoma cells.
Topics: Animals; Benzamides; Calcium Channel Blockers; Carrier Proteins; Cell Line, Tumor; Diabetes Mellitus | 2012 |
Assessment of early diabetic renal changes with hyperpolarized [1-(13) C]pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Diabetes Mellitus, Experimental; Female; Kidney; L-Lactate D | 2013 |
Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes.
Topics: Action Potentials; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experim | 2013 |
Haemodynamic and metabolic effects of low daily dose sulphonylureas in diabetic dog hearts.
Topics: Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Diabetes Mellitus, Experimental; Dogs; | 2002 |
Control of glyceroneogenic activity in rat brown adipose tissue.
Topics: Adipose Tissue, Brown; Animal Feed; Animals; Carbon Radioisotopes; Denervation; Diabetes Mellitus, E | 2003 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell | 2003 |
[Disorder of utilization of pyruvic acid and alloxan diabetes].
Topics: Alloxan; Animals; Biochemical Phenomena; Diabetes Mellitus, Experimental; Pyruvates; Pyruvic Acid | 1953 |
[Increase of adenosinetriphosphatase activity and pyruvic acid consumption in the crystalline lens in experimental diabetes and its significance].
Topics: Adenosine Triphosphatases; Animals; Diabetes Mellitus, Experimental; Hydrolysis; Lens, Crystalline; | 1956 |
The action of cocarboxylase on pyruvate utilisation and citrate formation in the liver of normal and diabetic rats.
Topics: Animals; Citrates; Citric Acid; Diabetes Mellitus, Experimental; Liver; Pyruvates; Pyruvic Acid; Rat | 1955 |
[Pyruvic acid consumption in the crystalline lens in experimental diabetes].
Topics: Animals; Diabetes Mellitus, Experimental; Lens, Crystalline; Physiological Phenomena; Pyruvates; Pyr | 1956 |
[On the metabolism of injured tissues. 11. Pyridine nucleotide content, lactic acid content, and pyruvic acid content of the liver of normal and alloxan-diabetic mice after glucose and fructose loading].
Topics: Alloxan; Animals; Coenzymes; Diabetes Mellitus, Experimental; Fructose; Glucose; Lactates; Lactic Ac | 1960 |
Effect of fatty acids, ketone bodies, diabetes and starvation on pyruvate metabolism in rat heart and diaphragm muscle.
Topics: Animals; Diabetes Mellitus, Experimental; Diaphragm; Fatty Acids; Ketone Bodies; Myocardium; Pyruvat | 1962 |
[CHANGES IN THE GLUTAMIC-PYRUVIC ACID TRANSAMINASE AND GLUTAMIC ACID DEHYDRASE ACTIVITY OF THE RAT LIVER IN ALLOXAN DIABETES].
Topics: Alanine Transaminase; Animals; D-Alanine Transaminase; Diabetes Mellitus, Experimental; Glutamic Aci | 1963 |
PYRUVATE METABOLISM AND CONTROL: FACTORS AFFECTING PYRUVIC CARBOXYLASE ACTIVITY.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Diabetes Mellitus, Experimental; Electronic Da | 1964 |
EVIDENCE FOR INHIBITION OF ACETYL-COENZYME A FORMATION FROM PYRUVATE IN DIABETIC RAT LIVER.
Topics: Acetates; Animals; Carbon Dioxide; Carbon Isotopes; Cholesterol; Coenzyme A; Diabetes Mellitus, Expe | 1964 |
Origin of glucose and glycogen carbons formed from C14-labeled pyruvate by livers of normal and diabetic rats.
Topics: Animals; Carbohydrate Metabolism; Carbon; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucos | 1955 |
Influence of insulin on the incorporation of 2-14C-sodium pyruvate into glyceride glycerol in diabetic and normal baboons.
Topics: Animals; Diabetes Mellitus, Experimental; Fats; Glycerides; Glycerol; Insulin; Lipid Metabolism; Pap | 1960 |
Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules.
Topics: Animals; Catechols; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glucose-6-Phosphate; | 2004 |
Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate.
Topics: Animals; Apoptosis; Cataract; Cell Differentiation; Cell Movement; Diabetes Complications; Diabetes | 2004 |
Prevention of cataract by pyruvate in experimentally diabetic mice.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Glycosylation; Lens, Crystalline; Mice; Mice, In | 2005 |
Glucose metabolism in rat retinal pigment epithelium.
Topics: Animals; Carbon Dioxide; Diabetes Mellitus, Experimental; Female; Glucose; Glycogen; Lactic Acid; Pi | 2006 |
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp | 2006 |
Effect of pyruvate on polyol pathway and lens epithelial cells apoptosis in diabetic rats.
Topics: Animals; Apoptosis; Caspase 3; Cells, Cultured; Diabetes Mellitus, Experimental; Epithelial Cells; L | 2006 |
Glyceroneogenesis and the supply of glycerol-3-phosphate for glyceride-glycerol synthesis in liver slices of fasted and diabetic rats.
Topics: Adenosine Triphosphate; Animals; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Food Depriva | 2007 |
Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Antioxidants; | 2008 |
[Effect of pyruvate on polyol pathway and lens epithelium apoptosis in diabetic rats].
Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Epithelial Cells; Female; Lens, Crys | 2007 |
Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes.
Topics: Adenosine Triphosphate; Animals; Calcium; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Enzy | 1984 |
Plasma membrane transport of 2-ketoisocaproate by rat hepatocytes in primary culture.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Dexamethasone; Diabetes Mellitus, Exp | 1983 |
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Tes | 1983 |
Influence of diabetes on oxidation of exogenous substrates in rat aorta.
Topics: 3-Hydroxybutyric Acid; Animals; Aorta; Diabetes Mellitus, Experimental; Glucose; Hydroxybutyrates; I | 1981 |
Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes.
Topics: Adenosine Diphosphate; Animals; Calcium; Diabetes Mellitus, Experimental; Epinephrine; Heart; In Vit | 1982 |
A comparative study of the transport of pyruvate in liver mitochondria from normal and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biological Transport; Blood Glucose; Diabetes Mellitu | 1981 |
Acetylcholine synthesis in nerve terminals of diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Diabetes Mellitus, Experime | 1994 |
Reduced induction of carbohydrate utilization by inhibition of fatty acid oxidation in myocytes from diabetic animals.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; | 1995 |
Catecholamine-induced cAMP response in streptozotocin-induced diabetic rat liver.
Topics: Adipose Tissue; Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Emaciation; Epineph | 1994 |
Insulin-independent and extremely rapid switch in the partitioning of hepatic fatty acids from oxidation to esterification in starved-refed diabetic rats. Possible roles for changes in cell pH and volume.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cholesterol Esters; Diabetes Mellitus, Experimental; Este | 1995 |
Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Eye; Fructos | 1995 |
The influence of diabetes mellitus on glucose utilization by the rat urinary bladder.
Topics: Adenosine Triphosphate; Animals; Bethanechol; Bethanechol Compounds; Body Weight; Chromatography, Hi | 1993 |
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Biological Transport, Active; Buformin; Cell | 1993 |
Long-term culture of viable human pancreatic islets in pyruvate-rich medium.
Topics: Animals; Blood Glucose; Cell Separation; Cell Survival; Cells, Cultured; Culture Media; Diabetes Mel | 1995 |
Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glycolysis; In Vitro Tech | 1995 |
Glucose formation from methylglyoxal in hepatocytes from streptozotocin-induced diabetic mice: the effect of insulin.
Topics: Acetone; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; | 1996 |
Modulatory effect of sepia shell extract on activity of glucose-6-phosphatase and alanine amino transferase in diabetic mice.
Topics: Alanine Transaminase; Animals; Diabetes Mellitus, Experimental; Glucose-6-Phosphatase; India; Liver | 1995 |
Improvement of cardiac performance and metabolism in long-term diabetes mellitus after treatment with insulin [see comment].
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Glucose; Heart; In | 1995 |
Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work.
Topics: Acetyl-CoA Carboxylase; Animals; Coenzyme A; Diabetes Mellitus, Experimental; Dobutamine; Esters; Gl | 1996 |
Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes.
Topics: 3-Hydroxybutyric Acid; 3-O-Methylglucose; Animals; Biological Transport; Cells, Cultured; Deoxygluco | 1997 |
Hepatic glucose production from L-alanine is absent in perfused liver of diabetic rats.
Topics: Alanine; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gluconeogenesis; | 1997 |
Formation of advanced glycation end (AGE) products in diabetes: prevention by pyruvate and alpha-keto glutarate.
Topics: Animals; Cattle; Crystallins; Diabetes Mellitus, Experimental; Glutarates; Glycation End Products, A | 1997 |
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract.
Topics: Animals; Biological Transport; Carbohydrates; Cataract; Culture Media; Culture Techniques; Diabetes | 1997 |
Reduced effects of L-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Carbon Radioisotopes; Carnitine; Citric Acid Cycle; Dia | 1997 |
Changes in the redox state in the retina and brain during the onset of diabetes in rats.
Topics: Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; L-Lactate Dehydrogenase; Lactic Acid; Len | 1998 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; | 1999 |
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glutamic Acid | 1999 |
Effects of pyruvate on intracellular Ca2+ regulation in cardiac myocytes from normal and diabetic rats.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Electric Stimulation; Fura-2; Glucose; Heart; In | 1999 |
Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cataract; Crystallins; Diabetes Mellitus, Experimental | 2000 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, | 2001 |
Rates of gluconeogenesis in perfused liver of alloxan-diabetic fed rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Fructose; Gluconeogenesis; Glucose; Glutamine; In | 2000 |
Concentrations of D-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats.
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus, Experimental; Enzymes; Food Depr | 1992 |
Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Caprylates; Diabetes Mellitus, Experimental; | 1991 |
Glucose and glutamine metabolism in rat macrophages: enhanced glycolysis and unaltered glutaminolysis in spontaneously diabetic BB rats.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Female; Gl | 1991 |
Glutamine and glucose metabolism in thymocytes from normal and spontaneously diabetic BB rats.
Topics: Adenosine Triphosphate; Animals; Cell Count; Diabetes Mellitus, Experimental; Female; Glucose; Gluta | 1991 |
Myocardial metabolic effects of in vivo hydralazine treatment of streptozotocin-diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Female; Glucose; Heart; | 1991 |
Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 1990 |
Bioenergetic changes during contraction and recovery in diabetic rat skeletal muscle.
Topics: Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Energy Metabolism; Glycogen; Hydroge | 1989 |
Effects of branched chain amino acids, pyruvate, or ketone bodies on the free amino acid pool and release from brain cortex slices of normal and streptozotocin-diabetic rats.
Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; | 1987 |
Pathways of acetone's metabolism in the rat.
Topics: Acetone; Acetyl Coenzyme A; Animals; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Female; | 1986 |
Hepatic regeneration and metabolism after partial hepatectomy in diabetic rats: effects of insulin therapy.
Topics: Adenine Nucleotides; Animals; Diabetes Mellitus, Experimental; DNA; Glucose; Hepatectomy; Insulin; L | 1986 |
Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Noneste | 1986 |
Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable.
Topics: Adipose Tissue; Animals; Brain; Diabetes Mellitus, Experimental; Insulin; Kidney; Male; Mitochondria | 1985 |
Alterations in mitochondrial aconitase activity and respiration, and in concentration of citrate in some organs of mice with experimental or genetic diabetes.
Topics: Aconitate Hydratase; Animals; Citrates; Citric Acid; Diabetes Mellitus, Experimental; Female; Islets | 1985 |
Effect of glucose and insulin administration on hepatic adenylate energy charge and the cytosolic redox state in the neonates of normal and insulin-treated diabetic rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Animals, Newborn; Cytosol; Diabetes Mellitus, | 1985 |
Effects of alloxan-induced diabetes mellitus on the metabolism of the rat placenta.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransfe | 1986 |
Oxidative metabolism of Polytron versus Nagarse mitochondria in hearts of genetically diabetic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Animals; Cell Fractionation; Diabete | 1985 |
Catabolism of branched-chain amino acids by diaphragm muscles of fasted and diabetic rats.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amination; Amino Acids, Branched-Chain; Animals; | 1985 |