pyruvic acid has been researched along with Aging in 69 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Accordingly, recent studies on cancer and diabetes have identified protein-protein interactions, post-translational processes, and transcriptional factors that modulate MPC function." | 2.66 | Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan. ( Buchanan, JL; Taylor, EB, 2020) |
| "Cataract is one of the major causes of blindness throughout the world." | 2.43 | [Risk factors in cataract]. ( Popescu, L; Vîrgolici, B, 2006) |
| " In this study, we evaluated protective effects of long-term administration of pyruvate in 3xTg-AD mice, a preclinical AD model that develops amyloid-β- and tau-dependent pathology." | 1.42 | Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology. ( Bomba, M; Canzoniero, LM; Ciavardelli, D; Corona, C; Curcio, M; Granzotto, A; Isopi, E; Lattanzio, R; Navarra, R; Piantelli, M; Sensi, SL, 2015) |
| "The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD)." | 1.33 | Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia. ( Andrade, C; Carrasco, JL; Mahy, N; Mas, E; Mascort, J; Pugliese, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (27.54) | 18.7374 |
| 1990's | 11 (15.94) | 18.2507 |
| 2000's | 19 (27.54) | 29.6817 |
| 2010's | 18 (26.09) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Igelmann, S | 1 |
| Lessard, F | 1 |
| Uchenunu, O | 1 |
| Bouchard, J | 1 |
| Fernandez-Ruiz, A | 1 |
| Rowell, MC | 1 |
| Lopes-Paciencia, S | 1 |
| Papadopoli, D | 1 |
| Fouillen, A | 1 |
| Ponce, KJ | 1 |
| Huot, G | 1 |
| Mignacca, L | 1 |
| Benfdil, M | 1 |
| Kalegari, P | 1 |
| Wahba, HM | 1 |
| Pencik, J | 1 |
| Vuong, N | 1 |
| Quenneville, J | 1 |
| Guillon, J | 1 |
| Bourdeau, V | 1 |
| Hulea, L | 1 |
| Gagnon, E | 1 |
| Kenner, L | 1 |
| Moriggl, R | 1 |
| Nanci, A | 1 |
| Pollak, MN | 1 |
| Omichinski, JG | 1 |
| Topisirovic, I | 1 |
| Ferbeyre, G | 1 |
| Buchanan, JL | 1 |
| Taylor, EB | 1 |
| Singh, K | 1 |
| Krug, L | 1 |
| Basu, A | 1 |
| Meyer, P | 1 |
| Treiber, N | 1 |
| Vander Beken, S | 1 |
| Wlaschek, M | 1 |
| Kochanek, S | 1 |
| Bloch, W | 1 |
| Geiger, H | 1 |
| Maity, P | 1 |
| Scharffetter-Kochanek, K | 1 |
| Zhao, MM | 1 |
| Gong, DQ | 1 |
| Gao, T | 1 |
| Zhang, L | 1 |
| Li, JL | 1 |
| Lv, PA | 1 |
| Yu, LL | 1 |
| Gao, F | 1 |
| Zhou, GH | 1 |
| Chang, SC | 1 |
| Lee, I | 1 |
| Ting, H | 1 |
| Chang, YJ | 1 |
| Yang, NC | 1 |
| McMurphy, T | 1 |
| Huang, W | 1 |
| Queen, NJ | 1 |
| Ali, S | 1 |
| Widstrom, KJ | 1 |
| Liu, X | 1 |
| Xiao, R | 1 |
| Siu, JJ | 1 |
| Cao, L | 1 |
| Yanase, S | 1 |
| Ishii, T | 1 |
| Yasuda, K | 1 |
| Ishii, N | 1 |
| Zhao, SJ | 1 |
| Tian, JS | 1 |
| Tai, G | 1 |
| Gao, XX | 1 |
| Liu, HL | 1 |
| Du, GH | 1 |
| Liu, XJ | 1 |
| Qin, XM | 1 |
| Isopi, E | 1 |
| Granzotto, A | 1 |
| Corona, C | 1 |
| Bomba, M | 1 |
| Ciavardelli, D | 1 |
| Curcio, M | 1 |
| Canzoniero, LM | 1 |
| Navarra, R | 1 |
| Lattanzio, R | 1 |
| Piantelli, M | 1 |
| Sensi, SL | 1 |
| Chen, CN | 1 |
| Lin, SY | 1 |
| Liao, YH | 1 |
| Li, ZJ | 1 |
| Wong, AM | 1 |
| Chen, Y | 1 |
| Kim, H | 1 |
| Bok, R | 1 |
| Sukumar, S | 1 |
| Mu, X | 1 |
| Sheldon, RA | 1 |
| Barkovich, AJ | 1 |
| Ferriero, DM | 1 |
| Xu, D | 1 |
| Scheer, M | 1 |
| Bischoff, AM | 1 |
| Kruzliak, P | 1 |
| Opatrilova, R | 1 |
| Bovell, D | 1 |
| Büsselberg, D | 1 |
| Vives-Bauza, C | 1 |
| Anand, M | 1 |
| Shiraz, AK | 1 |
| Shirazi, AK | 1 |
| Magrane, J | 1 |
| Gao, J | 1 |
| Vollmer-Snarr, HR | 1 |
| Manfredi, G | 1 |
| Finnemann, SC | 1 |
| Hagopian, K | 2 |
| Ramsey, JJ | 2 |
| Weindruch, R | 2 |
| Hyder, A | 1 |
| Laue, C | 1 |
| Schrezenmeir, J | 1 |
| Izumi, Y | 1 |
| Zorumski, CF | 1 |
| Wu, IC | 1 |
| Ohsawa, I | 1 |
| Fuku, N | 1 |
| Tanaka, M | 1 |
| Quistorff, B | 1 |
| Grunnet, N | 1 |
| Hong, S | 1 |
| Quintero-Monzon, O | 1 |
| Ostaszewski, BL | 1 |
| Podlisny, DR | 1 |
| Cavanaugh, WT | 1 |
| Yang, T | 1 |
| Holtzman, DM | 1 |
| Cirrito, JR | 1 |
| Selkoe, DJ | 1 |
| Owen, L | 1 |
| Sunram-Lea, SI | 1 |
| von Pföstl, V | 1 |
| Li, J | 1 |
| Zaldivar, D | 1 |
| Goense, J | 1 |
| Zhang, X | 1 |
| Serr, N | 1 |
| Logothetis, NK | 1 |
| Rauch, A | 1 |
| Li, B | 1 |
| Hertz, L | 1 |
| Peng, L | 1 |
| St-Pierre, J | 1 |
| Buckingham, JA | 1 |
| Roebuck, SJ | 1 |
| Brand, MD | 1 |
| Sieck, GC | 1 |
| Prakash, YS | 1 |
| Han, YS | 1 |
| Fang, YH | 1 |
| Geiger, PC | 1 |
| Zhan, WZ | 1 |
| Sakurai, T | 1 |
| Yang, B | 1 |
| Yokono, K | 1 |
| BERSELLI, L | 1 |
| DE PALMA, C | 1 |
| KRULIK, R | 1 |
| ROUX, JF | 1 |
| DINNERSTEIN, A | 1 |
| ROMNEY, SL | 1 |
| Opalka, JR | 1 |
| Wicke, M | 1 |
| Gellerich, FN | 1 |
| Schmidt, R | 1 |
| Rosner, F | 1 |
| Zierz, S | 1 |
| von Lengerken, G | 1 |
| Gerin, I | 1 |
| Dolinsky, VW | 1 |
| Shackman, JG | 1 |
| Kennedy, RT | 1 |
| Chiang, SH | 1 |
| Burant, CF | 1 |
| Steffensen, KR | 1 |
| Gustafsson, JA | 1 |
| MacDougald, OA | 1 |
| Pugliese, M | 1 |
| Carrasco, JL | 1 |
| Andrade, C | 1 |
| Mas, E | 1 |
| Mascort, J | 1 |
| Mahy, N | 1 |
| Sethumadhavan, S | 1 |
| Chinnakannu, P | 1 |
| Vîrgolici, B | 1 |
| Popescu, L | 1 |
| Rouleau, C | 1 |
| Rakotoarivelo, C | 1 |
| Petite, D | 1 |
| Lambert, K | 1 |
| Fabre, C | 1 |
| Bonardet, A | 1 |
| Mercier, J | 1 |
| Baldet, P | 1 |
| Privat, A | 1 |
| Langley, K | 1 |
| Mersel, M | 1 |
| Zhao, G | 1 |
| Jeoung, NH | 1 |
| Burgess, SC | 1 |
| Rosaaen-Stowe, KA | 1 |
| Inagaki, T | 1 |
| Latif, S | 1 |
| Shelton, JM | 1 |
| McAnally, J | 1 |
| Bassel-Duby, R | 1 |
| Harris, RA | 2 |
| Richardson, JA | 1 |
| Kliewer, SA | 1 |
| Huggins, CE | 1 |
| Domenighetti, AA | 1 |
| Ritchie, ME | 1 |
| Khalil, N | 1 |
| Favaloro, JM | 1 |
| Proietto, J | 1 |
| Smyth, GK | 1 |
| Pepe, S | 1 |
| Delbridge, LM | 1 |
| Puppi, A | 1 |
| Dely, M | 1 |
| Deshmukh, DR | 1 |
| Patel, MS | 1 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Agnoli, A | 1 |
| Raimondo, S | 1 |
| Fulle, D | 1 |
| Pastoris, O | 1 |
| Curti, D | 1 |
| Villa, RF | 1 |
| Aruldhas, MM | 1 |
| Valivullah, HM | 1 |
| Govindarajulu, P | 1 |
| Luboshitzky, R | 1 |
| Bernardis, LL | 1 |
| Goldman, JK | 1 |
| Kodis, M | 1 |
| Scotini, E | 1 |
| Caparrotta, L | 1 |
| Tessari, F | 1 |
| Fassina, G | 1 |
| Vámosi, B | 1 |
| Diószeghy, P | 1 |
| Molnár, L | 1 |
| Gibson, G | 1 |
| Barclay, L | 1 |
| Blass, J | 1 |
| Gibson, GE | 2 |
| Peterson, C | 2 |
| Booth, RF | 1 |
| Clark, JB | 1 |
| Berthon, P | 1 |
| Freyssenet, D | 1 |
| Chatard, JC | 1 |
| Castells, J | 1 |
| Mujika, I | 1 |
| Geyssant, A | 1 |
| Guezennec, CY | 1 |
| Denis, C | 1 |
| Eisinger, J | 1 |
| Plantamura, A | 1 |
| Ayavou, T | 1 |
| Boffoli, D | 1 |
| Scacco, SC | 1 |
| Vergari, R | 1 |
| Solarino, G | 1 |
| Santacroce, G | 1 |
| Papa, S | 1 |
| Bhagavathi, R | 1 |
| Devi, SA | 1 |
| Anitha, V | 1 |
| Asha Devi, S | 1 |
| O'Brien, JK | 1 |
| Dwarte, D | 1 |
| Ryan, JP | 1 |
| Maxwell, WM | 1 |
| Evans, G | 1 |
| Pianosi, P | 1 |
| Seargeant, L | 1 |
| Haworth, JC | 1 |
| He, Z | 1 |
| Ibayashi, S | 1 |
| Sugimori, H | 1 |
| Fujii, K | 1 |
| Sadoshima, S | 1 |
| Fujishima, M | 1 |
| Gow, PJ | 1 |
| Treepongkaruna, S | 1 |
| Ching, MS | 1 |
| Ghabrial, H | 1 |
| Shulkes, A | 1 |
| Smallwood, RA | 1 |
| Jin, CJ | 1 |
| Morgan, DJ | 1 |
| Paradies, G | 1 |
| Petrosillo, G | 1 |
| Gadaleta, MN | 1 |
| Ruggiero, FM | 1 |
| Nishikawa, T | 1 |
| Takahashi, JA | 1 |
| Matsushita, T | 1 |
| Ohnishi, K | 1 |
| Higuchi, K | 1 |
| Hashimoto, N | 1 |
| Hosokawa, M | 1 |
| Cechowska-Pasko, M | 1 |
| Pałka, J | 1 |
| Sugden, MC | 1 |
| Langdown, ML | 1 |
| Holness, MJ | 1 |
| López-Torres, M | 1 |
| Gredilla, R | 1 |
| Sanz, A | 1 |
| Barja, G | 1 |
| Sumida, KD | 1 |
| Crandall, SC | 1 |
| Chadha, PL | 1 |
| Qureshi, T | 1 |
| Sperl, W | 1 |
| Sengers, RC | 1 |
| Trijbels, JM | 1 |
| Ruitenbeek, W | 1 |
| De Graaf, R | 1 |
| Ter Laak, H | 1 |
| Van Lith, T | 1 |
| Kerkhoff, C | 1 |
| Janssen, A | 1 |
| Trounce, I | 1 |
| Byrne, E | 1 |
| Marzuki, S | 1 |
| Zuurveld, JG | 1 |
| Wirtz, P | 1 |
| Loermans, HM | 1 |
| Veerkamp, JH | 1 |
| Mohan, PK | 1 |
| Satyanarayana, N | 1 |
| Rajendra, W | 1 |
| Indira, K | 1 |
| Hoyer, S | 1 |
| Kmieć, Z | 1 |
| Myśliwski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589] | 35 participants (Actual) | Interventional | 2021-10-06 | Completed | |||
| Effects of Citrulline Supplementation Combined With Exercise on Muscle Function and Functional Capacity in Older Obese Men and Women[NCT02417428] | 104 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for pyruvic acid and Aging
| Article | Year |
|---|---|
Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan.
Topics: Aging; Animals; Diabetes Mellitus; Humans; Mitochondrial Membrane Transport Proteins; Monocarboxylic | 2020 |
Metabolic Biomarkers in Nematode C. elegans During Aging.
Topics: Aging; Animals; Caenorhabditis elegans; Energy Metabolism; Lactic Acid; Mitochondria; Oxidative Phos | 2019 |
Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function.
Topics: Acetates; Aging; Breath Tests; Carbon Isotopes; Citric Acid Cycle; Electron Transport; Humans; Mitoc | 2010 |
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me | 2011 |
[Risk factors in cataract].
Topics: Adrenal Cortex Hormones; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Cataract; | 2006 |
Tissue redox-state potential (E'0)--as regulator of physiological processes.
Topics: Aging; Animals; Biological Transport, Active; Blood Physiological Phenomena; Cell Membrane; Cell Phy | 1983 |
The role of the cholinergic system in thiamin deficiency.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Animals; Arecoline; Atropine; Behavior, Animal; Brain; Diet | 1982 |
62 other studies available for pyruvic acid and Aging
| Article | Year |
|---|---|
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Topics: Aging; Animals; Cell Line, Tumor; Cellular Senescence; Cytosol; Glucose; Humans; Hydrogen; Malate De | 2021 |
Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction.
Topics: Adipocytes; Aging; Animals; Animals, Newborn; Cell Death; Cell Differentiation; Chondrocytes; Chroma | 2017 |
In ovo feeding of creatine pyruvate modulates growth performance, energy reserves and mRNA expression levels of gluconeogenesis and glycogenesis enzymes in liver of embryos and neonatal broilers.
Topics: Aging; Animals; Chick Embryo; Chickens; Creatine; Gene Expression Regulation, Developmental; Gene Ex | 2018 |
Parapyruvate, an Impurity in Pyruvate Supplements, Induces Senescence in Human Fibroblastic Hs68 Cells via Inhibition of the α-Ketoglutarate Dehydrogenase Complex.
Topics: Aging; Cell Line; Dietary Supplements; Drug Contamination; Fibroblasts; Humans; Ketoglutarate Dehydr | 2018 |
Implementation of environmental enrichment after middle age promotes healthy aging.
Topics: Adipose Tissue; Aging; Animals; Behavior, Animal; Body Temperature; DNA, Mitochondrial; Female; Gluc | 2018 |
Topics: Aging; Amino Acids; Animals; Drugs, Chinese Herbal; Male; Metabolomics; Protective Agents; Proton Ma | 2019 |
Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Cerebral Cortex; | 2015 |
Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism.
Topics: Age Factors; Aging; Animals; Caloric Restriction; Energy Metabolism; Isoenzymes; L-Lactate Dehydroge | 2015 |
Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain.
Topics: Adolescent; Aging; Animals; Brain; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonan | 2016 |
Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system.
Topics: Aging; Animals; Creatine; Hypoxia; Mice; Motor Activity; Phrenic Nerve; Pyruvic Acid; Respiratory Sy | 2016 |
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.
Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Cell Death; Cell Line; DNA, Mitochondrial; Epi | 2008 |
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2- | 2009 |
Metabolic aspects of neonatal rat islet hypoxia tolerance.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Gluc | 2010 |
Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Injuries; CA1 Region, Hippocampal; Enzyme Inhibitors; | 2010 |
High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.
Topics: Aging; Animals; Biomarkers; Brain; Cytosol; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactic Ac | 2011 |
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analys | 2011 |
Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis.
Topics: Aging; Animals; Brain Chemistry; Cerebrovascular Circulation; Data Interpretation, Statistical; Elec | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senesce | 2012 |
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
Topics: Aging; Animals; Antimycin A; Columbidae; Electron Transport; Enzyme Inhibitors; Female; Hydrogen Per | 2002 |
Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development.
Topics: Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Algorithms; Animals; Body Weig | 2003 |
Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Caloric Restriction; Fructosediphosphates; Glu | 2003 |
[Synaptic utilization of lactate/pyruvate and neural function in the aging].
Topics: Aging; Animals; Brain; Glucose; Guinea Pigs; Hippocampus; Lactic Acid; Neurons; Pyruvic Acid; Synaps | 2003 |
[Blood pyruvate curve after oral glucose loading in senile diabetes].
Topics: Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Pyruvates; Pyruv | 1959 |
[The effect of isoniazid on glucide metabolism. III. The relation between the pyruvic acid and alpha-ketoglutaric acid concentrations in the rat liver and the level of isoniazid administration. The influence of the age of the experimental animal on the is
Topics: Aging; Animals; Isoniazid; Keto Acids; Ketoglutaric Acids; Liver; Pyruvates; Pyruvic Acid; Rats | 1962 |
Ageing and environmental manifestations in pyruvate metabolism of rabbit foetal and neonatal liver.
Topics: Aging; Animals; Environment; Fetus; Liver; Metabolism; Pyruvates; Pyruvic Acid; Rabbits | 1962 |
Mitochondrial function in turkey skeletal muscle--impact on meat quality.
Topics: Acidosis; Aging; Animals; Body Composition; Glycolysis; Histocytochemistry; Hydrogen-Ion Concentrati | 2004 |
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
Topics: Adipocytes; Adipose Tissue; Aging; Animals; Body Composition; Carbohydrate Metabolism; Cholesterol; | 2005 |
Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Biomarkers; Brain Chemistry; Cerebrospinal Flui | 2005 |
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates; | 2006 |
Pyruvate modifies glycolytic and oxidative metabolism of rat embryonic spinal cord astrocyte cell lines and prevents their spontaneous transformation.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Electron Transport Chain Complex Proteins; Embryo, Mamm | 2007 |
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
Topics: Aging; Animals; Blotting, Western; Calcineurin; Cardiomyopathies; Humans; Lactic Acid; Mice; Mice, T | 2008 |
Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention.
Topics: Aging; Animals; Blood Pressure; Body Weight; Down-Regulation; Energy Metabolism; Glucose; Glucose Tr | 2008 |
Age-dependent changes in pyruvate uptake by nonsynaptic and synaptic mitochondria from rat brain.
Topics: Aging; Animals; Brain; Cytochrome c Group; In Vitro Techniques; Malates; Male; Mitochondria; Oxygen | 1982 |
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid | 1982 |
Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
Topics: Aging; Animals; ATP Citrate (pro-S)-Lyase; Isocitrate Dehydrogenase; Lipids; Malate Dehydrogenase; M | 1983 |
Brown adipose tissue metabolism in hypothalamic-obese rats.
Topics: Adipose Tissue, Brown; Aging; Animals; Diet; Fatty Acids; Glucose; Hypothalamus; Lactates; Lactic Ac | 1983 |
Age-related changes in rat adipose tissue in response to fasting: protein, lactate and pyruvate levels.
Topics: Adipose Tissue; Aging; Animals; Fasting; Lactates; Lactic Acid; Male; NAD; Proteins; Pyruvates; Pyru | 1983 |
Lactate and pyruvate content of the human cisternal cerebrospinal fluid. Normal values, age and sex dependency, correlations with glucose concentrations.
Topics: Adolescent; Adult; Aged; Aging; Blood Glucose; Cisterna Magna; Female; Humans; Lactates; Lactic Acid | 1983 |
Neurotransmitter and carbohydrate metabolism during senescence.
Topics: Acetylcholine; Aging; Animals; Brain; Calcium; Glucose; In Vitro Techniques; Mice; Mice, Inbred BALB | 1982 |
Energy metabolism in rat brain: inhibition of pyruvate decarboxylation by 3-hydroxybutyrate in neonatal mitochondria.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Brain; Female; Hydroxybutyrates; Male; Mito | 1981 |
Aging decreases oxidative metabolism and the release and synthesis of acetylcholine.
Topics: Acetylcholine; Aging; Anaerobiosis; Animals; Brain; Glucose; In Vitro Techniques; Male; Mice; Mice, | 1981 |
Mitochondrial ATP production rate in 55 to 73-year-old men: effect of endurance training.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adenosine Triphosphate; Aged; Aging; Carnitine O-Palmitoyltransfer | 1995 |
Glycolysis abnormalities in fibromyalgia.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Aging; Diphosphoglyc | 1994 |
Decline with age of the respiratory chain activity in human skeletal muscle.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ascorbic Acid; Cytochromes; Electron Transport Co | 1994 |
Interaction of exercise and age on substrates of carbohydrate metabolism.
Topics: Aging; Animals; Blood Glucose; Carbohydrate Metabolism; Glycogen; Lactates; Lactic Acid; Male; Physi | 1993 |
Age-related responses of right ventricle in swim-trained rats: changes in lactate and pyruvate contents and lactate dehydrogenase activity.
Topics: Aging; Anaerobiosis; Animals; Glycolysis; Hypertrophy, Right Ventricular; Isoenzymes; L-Lactate Dehy | 1996 |
Developmental capacity, energy metabolism and ultrastructure of mature oocytes from prepubertal and adult sheep.
Topics: Aging; Animals; Blastocyst; Cytoplasm; Cytoplasmic Granules; Energy Metabolism; Female; Glucose; Glu | 1996 |
Blood lactate and pyruvate concentrations, and their ratio during exercise in healthy children: developmental perspective.
Topics: Adolescent; Aging; Child; Child Development; Female; Humans; Lactic Acid; Male; Osmolar Concentratio | 1995 |
Age-related ischemia in the brain following bilateral carotid artery occlusion--collateral blood flow and brain metabolism.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Suckling; Arterial Occlusive Diseases; Brain; Brain | 1997 |
Uptake and excretion of sodium taurocholate by the isolated perfused neonatal sheep liver.
Topics: Aging; Algorithms; Animals; Animals, Newborn; Bile; Blood Pressure; Lactic Acid; Liver; Liver Circul | 1999 |
The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria.
Topics: Acetylcarnitine; Aging; Animals; Male; Mitochondria, Heart; Nootropic Agents; Oxidation-Reduction; P | 1999 |
Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM.
Topics: Aging; Animals; Female; Lactates; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Pyruvic Acid | 2000 |
Age-dependent changes in glycosaminoglycan content in the skin of fasted rats. A possible mechanism.
Topics: Aging; Animals; Blood Glucose; Fasting; Glycosaminoglycans; Lactic Acid; Male; NAD; Pyruvic Acid; Ra | 2000 |
Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.
Topics: Aging; Animals; Blotting, Western; Dietary Fats; Embryonic and Fetal Development; Female; Gene Expre | 2000 |
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Cell Nucleus; Deoxyguanosine; Diet, Reducing; DNA; DNA | 2002 |
Hepatic gluconeogenic capacity from various precursors in young versus old rats.
Topics: Aging; Alanine; Animals; Body Weight; Cell Separation; Cell Survival; Dihydroxyacetone; Fasting; Fru | 2002 |
Postnatal development of pyruvate oxidation in quadriceps muscle of the rat.
Topics: Acetyltransferases; Aging; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Citra | 1992 |
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; DNA, Mitochondrial; Electron Transport Complex I | 1989 |
Postnatal growth and differentiation in three hindlimb muscles of the rat. Characterization with biochemical and enzyme-histochemical methods.
Topics: Adenosine Triphosphatases; Aging; Animals; Animals, Newborn; Cell Differentiation; Citrate (si)-Synt | 1985 |
Age related metabolic changes in muscle energy metabolism of exhausted albino rats.
Topics: Aging; Animals; Energy Metabolism; Glycogen; Male; Muscles; Physical Exertion; Pyruvates; Pyruvic Ac | 1987 |
The effect of age on glucose and energy metabolism in brain cortex of rats.
Topics: Adenosine Triphosphate; Aging; Animals; Cerebral Cortex; Citrates; Citric Acid; Energy Metabolism; G | 1985 |
Urea synthesis in hepatocytes isolated from young and old rats.
Topics: Aging; Ammonium Chloride; Animals; Epinephrine; Glucagon; Gluconeogenesis; In Vitro Techniques; Lact | 1985 |