Page last updated: 2024-10-20

pyruvic acid and Aging

pyruvic acid has been researched along with Aging in 69 studies

Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Accordingly, recent studies on cancer and diabetes have identified protein-protein interactions, post-translational processes, and transcriptional factors that modulate MPC function."2.66Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan. ( Buchanan, JL; Taylor, EB, 2020)
"Cataract is one of the major causes of blindness throughout the world."2.43[Risk factors in cataract]. ( Popescu, L; Vîrgolici, B, 2006)
" In this study, we evaluated protective effects of long-term administration of pyruvate in 3xTg-AD mice, a preclinical AD model that develops amyloid-β- and tau-dependent pathology."1.42Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology. ( Bomba, M; Canzoniero, LM; Ciavardelli, D; Corona, C; Curcio, M; Granzotto, A; Isopi, E; Lattanzio, R; Navarra, R; Piantelli, M; Sensi, SL, 2015)
"The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD)."1.33Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia. ( Andrade, C; Carrasco, JL; Mahy, N; Mas, E; Mascort, J; Pugliese, M, 2005)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199019 (27.54)18.7374
1990's11 (15.94)18.2507
2000's19 (27.54)29.6817
2010's18 (26.09)24.3611
2020's2 (2.90)2.80

Authors

AuthorsStudies
Igelmann, S1
Lessard, F1
Uchenunu, O1
Bouchard, J1
Fernandez-Ruiz, A1
Rowell, MC1
Lopes-Paciencia, S1
Papadopoli, D1
Fouillen, A1
Ponce, KJ1
Huot, G1
Mignacca, L1
Benfdil, M1
Kalegari, P1
Wahba, HM1
Pencik, J1
Vuong, N1
Quenneville, J1
Guillon, J1
Bourdeau, V1
Hulea, L1
Gagnon, E1
Kenner, L1
Moriggl, R1
Nanci, A1
Pollak, MN1
Omichinski, JG1
Topisirovic, I1
Ferbeyre, G1
Buchanan, JL1
Taylor, EB1
Singh, K1
Krug, L1
Basu, A1
Meyer, P1
Treiber, N1
Vander Beken, S1
Wlaschek, M1
Kochanek, S1
Bloch, W1
Geiger, H1
Maity, P1
Scharffetter-Kochanek, K1
Zhao, MM1
Gong, DQ1
Gao, T1
Zhang, L1
Li, JL1
Lv, PA1
Yu, LL1
Gao, F1
Zhou, GH1
Chang, SC1
Lee, I1
Ting, H1
Chang, YJ1
Yang, NC1
McMurphy, T1
Huang, W1
Queen, NJ1
Ali, S1
Widstrom, KJ1
Liu, X1
Xiao, R1
Siu, JJ1
Cao, L1
Yanase, S1
Ishii, T1
Yasuda, K1
Ishii, N1
Zhao, SJ1
Tian, JS1
Tai, G1
Gao, XX1
Liu, HL1
Du, GH1
Liu, XJ1
Qin, XM1
Isopi, E1
Granzotto, A1
Corona, C1
Bomba, M1
Ciavardelli, D1
Curcio, M1
Canzoniero, LM1
Navarra, R1
Lattanzio, R1
Piantelli, M1
Sensi, SL1
Chen, CN1
Lin, SY1
Liao, YH1
Li, ZJ1
Wong, AM1
Chen, Y1
Kim, H1
Bok, R1
Sukumar, S1
Mu, X1
Sheldon, RA1
Barkovich, AJ1
Ferriero, DM1
Xu, D1
Scheer, M1
Bischoff, AM1
Kruzliak, P1
Opatrilova, R1
Bovell, D1
Büsselberg, D1
Vives-Bauza, C1
Anand, M1
Shiraz, AK1
Shirazi, AK1
Magrane, J1
Gao, J1
Vollmer-Snarr, HR1
Manfredi, G1
Finnemann, SC1
Hagopian, K2
Ramsey, JJ2
Weindruch, R2
Hyder, A1
Laue, C1
Schrezenmeir, J1
Izumi, Y1
Zorumski, CF1
Wu, IC1
Ohsawa, I1
Fuku, N1
Tanaka, M1
Quistorff, B1
Grunnet, N1
Hong, S1
Quintero-Monzon, O1
Ostaszewski, BL1
Podlisny, DR1
Cavanaugh, WT1
Yang, T1
Holtzman, DM1
Cirrito, JR1
Selkoe, DJ1
Owen, L1
Sunram-Lea, SI1
von Pföstl, V1
Li, J1
Zaldivar, D1
Goense, J1
Zhang, X1
Serr, N1
Logothetis, NK1
Rauch, A1
Li, B1
Hertz, L1
Peng, L1
St-Pierre, J1
Buckingham, JA1
Roebuck, SJ1
Brand, MD1
Sieck, GC1
Prakash, YS1
Han, YS1
Fang, YH1
Geiger, PC1
Zhan, WZ1
Sakurai, T1
Yang, B1
Yokono, K1
BERSELLI, L1
DE PALMA, C1
KRULIK, R1
ROUX, JF1
DINNERSTEIN, A1
ROMNEY, SL1
Opalka, JR1
Wicke, M1
Gellerich, FN1
Schmidt, R1
Rosner, F1
Zierz, S1
von Lengerken, G1
Gerin, I1
Dolinsky, VW1
Shackman, JG1
Kennedy, RT1
Chiang, SH1
Burant, CF1
Steffensen, KR1
Gustafsson, JA1
MacDougald, OA1
Pugliese, M1
Carrasco, JL1
Andrade, C1
Mas, E1
Mascort, J1
Mahy, N1
Sethumadhavan, S1
Chinnakannu, P1
Vîrgolici, B1
Popescu, L1
Rouleau, C1
Rakotoarivelo, C1
Petite, D1
Lambert, K1
Fabre, C1
Bonardet, A1
Mercier, J1
Baldet, P1
Privat, A1
Langley, K1
Mersel, M1
Zhao, G1
Jeoung, NH1
Burgess, SC1
Rosaaen-Stowe, KA1
Inagaki, T1
Latif, S1
Shelton, JM1
McAnally, J1
Bassel-Duby, R1
Harris, RA2
Richardson, JA1
Kliewer, SA1
Huggins, CE1
Domenighetti, AA1
Ritchie, ME1
Khalil, N1
Favaloro, JM1
Proietto, J1
Smyth, GK1
Pepe, S1
Delbridge, LM1
Puppi, A1
Dely, M1
Deshmukh, DR1
Patel, MS1
Benzi, G1
Arrigoni, E1
Agnoli, A1
Raimondo, S1
Fulle, D1
Pastoris, O1
Curti, D1
Villa, RF1
Aruldhas, MM1
Valivullah, HM1
Govindarajulu, P1
Luboshitzky, R1
Bernardis, LL1
Goldman, JK1
Kodis, M1
Scotini, E1
Caparrotta, L1
Tessari, F1
Fassina, G1
Vámosi, B1
Diószeghy, P1
Molnár, L1
Gibson, G1
Barclay, L1
Blass, J1
Gibson, GE2
Peterson, C2
Booth, RF1
Clark, JB1
Berthon, P1
Freyssenet, D1
Chatard, JC1
Castells, J1
Mujika, I1
Geyssant, A1
Guezennec, CY1
Denis, C1
Eisinger, J1
Plantamura, A1
Ayavou, T1
Boffoli, D1
Scacco, SC1
Vergari, R1
Solarino, G1
Santacroce, G1
Papa, S1
Bhagavathi, R1
Devi, SA1
Anitha, V1
Asha Devi, S1
O'Brien, JK1
Dwarte, D1
Ryan, JP1
Maxwell, WM1
Evans, G1
Pianosi, P1
Seargeant, L1
Haworth, JC1
He, Z1
Ibayashi, S1
Sugimori, H1
Fujii, K1
Sadoshima, S1
Fujishima, M1
Gow, PJ1
Treepongkaruna, S1
Ching, MS1
Ghabrial, H1
Shulkes, A1
Smallwood, RA1
Jin, CJ1
Morgan, DJ1
Paradies, G1
Petrosillo, G1
Gadaleta, MN1
Ruggiero, FM1
Nishikawa, T1
Takahashi, JA1
Matsushita, T1
Ohnishi, K1
Higuchi, K1
Hashimoto, N1
Hosokawa, M1
Cechowska-Pasko, M1
Pałka, J1
Sugden, MC1
Langdown, ML1
Holness, MJ1
López-Torres, M1
Gredilla, R1
Sanz, A1
Barja, G1
Sumida, KD1
Crandall, SC1
Chadha, PL1
Qureshi, T1
Sperl, W1
Sengers, RC1
Trijbels, JM1
Ruitenbeek, W1
De Graaf, R1
Ter Laak, H1
Van Lith, T1
Kerkhoff, C1
Janssen, A1
Trounce, I1
Byrne, E1
Marzuki, S1
Zuurveld, JG1
Wirtz, P1
Loermans, HM1
Veerkamp, JH1
Mohan, PK1
Satyanarayana, N1
Rajendra, W1
Indira, K1
Hoyer, S1
Kmieć, Z1
Myśliwski, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589]35 participants (Actual)Interventional2021-10-06Completed
Effects of Citrulline Supplementation Combined With Exercise on Muscle Function and Functional Capacity in Older Obese Men and Women[NCT02417428]104 participants (Actual)Interventional2015-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for pyruvic acid and Aging

ArticleYear
Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan.
    Biomolecules, 2020, 08-08, Volume: 10, Issue:8

    Topics: Aging; Animals; Diabetes Mellitus; Humans; Mitochondrial Membrane Transport Proteins; Monocarboxylic

2020
Metabolic Biomarkers in Nematode C. elegans During Aging.
    Advances in experimental medicine and biology, 2019, Volume: 1134

    Topics: Aging; Animals; Caenorhabditis elegans; Energy Metabolism; Lactic Acid; Mitochondria; Oxidative Phos

2019
Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function.
    Annals of the New York Academy of Sciences, 2010, Volume: 1201

    Topics: Acetates; Aging; Breath Tests; Carbon Isotopes; Citric Acid Cycle; Electron Transport; Humans; Mitoc

2010
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
    Nutrients, 2011, Volume: 3, Issue:8

    Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me

2011
[Risk factors in cataract].
    Oftalmologia (Bucharest, Romania : 1990), 2006, Volume: 50, Issue:2

    Topics: Adrenal Cortex Hormones; Aging; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Cataract;

2006
Tissue redox-state potential (E'0)--as regulator of physiological processes.
    Acta biologica Hungarica, 1983, Volume: 34, Issue:4

    Topics: Aging; Animals; Biological Transport, Active; Blood Physiological Phenomena; Cell Membrane; Cell Phy

1983
The role of the cholinergic system in thiamin deficiency.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Animals; Arecoline; Atropine; Behavior, Animal; Brain; Diet

1982

Other Studies

62 other studies available for pyruvic acid and Aging

ArticleYear
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
    Molecular cell, 2021, 09-16, Volume: 81, Issue:18

    Topics: Aging; Animals; Cell Line, Tumor; Cellular Senescence; Cytosol; Glucose; Humans; Hydrogen; Malate De

2021
Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction.
    Stem cells (Dayton, Ohio), 2017, Volume: 35, Issue:7

    Topics: Adipocytes; Aging; Animals; Animals, Newborn; Cell Death; Cell Differentiation; Chondrocytes; Chroma

2017
In ovo feeding of creatine pyruvate modulates growth performance, energy reserves and mRNA expression levels of gluconeogenesis and glycogenesis enzymes in liver of embryos and neonatal broilers.
    Journal of animal physiology and animal nutrition, 2018, Volume: 102, Issue:2

    Topics: Aging; Animals; Chick Embryo; Chickens; Creatine; Gene Expression Regulation, Developmental; Gene Ex

2018
Parapyruvate, an Impurity in Pyruvate Supplements, Induces Senescence in Human Fibroblastic Hs68 Cells via Inhibition of the α-Ketoglutarate Dehydrogenase Complex.
    Journal of agricultural and food chemistry, 2018, Jul-18, Volume: 66, Issue:28

    Topics: Aging; Cell Line; Dietary Supplements; Drug Contamination; Fibroblasts; Humans; Ketoglutarate Dehydr

2018
Implementation of environmental enrichment after middle age promotes healthy aging.
    Aging, 2018, Jul-20, Volume: 10, Issue:7

    Topics: Adipose Tissue; Aging; Animals; Behavior, Animal; Body Temperature; DNA, Mitochondrial; Female; Gluc

2018
    Journal of ethnopharmacology, 2019, Jun-28, Volume: 238

    Topics: Aging; Amino Acids; Animals; Drugs, Chinese Herbal; Male; Metabolomics; Protective Agents; Proton Ma

2019
Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.
    Neurobiology of disease, 2015, Volume: 81

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Cerebral Cortex;

2015
Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism.
    American journal of physiology. Endocrinology and metabolism, 2015, Jun-01, Volume: 308, Issue:11

    Topics: Age Factors; Aging; Animals; Caloric Restriction; Energy Metabolism; Isoenzymes; L-Lactate Dehydroge

2015
Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain.
    Developmental neuroscience, 2016, Volume: 38, Issue:1

    Topics: Adolescent; Aging; Animals; Brain; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonan

2016
Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system.
    Experimental and molecular pathology, 2016, Volume: 101, Issue:1

    Topics: Aging; Animals; Creatine; Hypoxia; Mice; Motor Activity; Phrenic Nerve; Pyruvic Acid; Respiratory Sy

2016
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.
    The Journal of biological chemistry, 2008, Sep-05, Volume: 283, Issue:36

    Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Cell Death; Cell Line; DNA, Mitochondrial; Epi

2008
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2-

2009
Metabolic aspects of neonatal rat islet hypoxia tolerance.
    Transplant international : official journal of the European Society for Organ Transplantation, 2010, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cyclic AMP; Gluc

2010
Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices.
    Neuroscience letters, 2010, Jul-12, Volume: 478, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Brain Injuries; CA1 Region, Hippocampal; Enzyme Inhibitors;

2010
High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Feb-15, Volume: 108, Issue:7

    Topics: Aging; Animals; Biomarkers; Brain; Cytosol; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactic Ac

2011
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-02, Volume: 31, Issue:44

    Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analys

2011
Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis.
    NeuroImage, 2012, May-15, Volume: 61, Issue:1

    Topics: Aging; Animals; Brain Chemistry; Cerebrovascular Circulation; Data Interpretation, Statistical; Elec

2012
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
    Neurochemistry international, 2012, Volume: 61, Issue:8

    Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senesce

2012
Topology of superoxide production from different sites in the mitochondrial electron transport chain.
    The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47

    Topics: Aging; Animals; Antimycin A; Columbidae; Electron Transport; Enzyme Inhibitors; Female; Hydrogen Per

2002
Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 94, Issue:5

    Topics: Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Algorithms; Animals; Body Weig

2003
Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice.
    Experimental gerontology, 2003, Volume: 38, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Caloric Restriction; Fructosediphosphates; Glu

2003
[Synaptic utilization of lactate/pyruvate and neural function in the aging].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2003, Volume: 40, Issue:4

    Topics: Aging; Animals; Brain; Glucose; Guinea Pigs; Hippocampus; Lactic Acid; Neurons; Pyruvic Acid; Synaps

2003
[Blood pyruvate curve after oral glucose loading in senile diabetes].
    Giornale di gerontologia, 1959, Volume: 7

    Topics: Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Pyruvates; Pyruv

1959
[The effect of isoniazid on glucide metabolism. III. The relation between the pyruvic acid and alpha-ketoglutaric acid concentrations in the rat liver and the level of isoniazid administration. The influence of the age of the experimental animal on the is
    Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung, 1962, Volume: 125

    Topics: Aging; Animals; Isoniazid; Keto Acids; Ketoglutaric Acids; Liver; Pyruvates; Pyruvic Acid; Rats

1962
Ageing and environmental manifestations in pyruvate metabolism of rabbit foetal and neonatal liver.
    Nature, 1962, Jun-02, Volume: 194

    Topics: Aging; Animals; Environment; Fetus; Liver; Metabolism; Pyruvates; Pyruvic Acid; Rabbits

1962
Mitochondrial function in turkey skeletal muscle--impact on meat quality.
    British poultry science, 2004, Volume: 45, Issue:3

    Topics: Acidosis; Aging; Animals; Body Composition; Glycolysis; Histocytochemistry; Hydrogen-Ion Concentrati

2004
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
    The Journal of biological chemistry, 2005, Jun-17, Volume: 280, Issue:24

    Topics: Adipocytes; Adipose Tissue; Aging; Animals; Body Composition; Carbohydrate Metabolism; Cholesterol;

2005
Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Biomarkers; Brain Chemistry; Cerebrospinal Flui

2005
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:7

    Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates;

2006
Pyruvate modifies glycolytic and oxidative metabolism of rat embryonic spinal cord astrocyte cell lines and prevents their spontaneous transformation.
    Journal of neurochemistry, 2007, Volume: 100, Issue:6

    Topics: Aging; Animals; Astrocytes; Cells, Cultured; Electron Transport Chain Complex Proteins; Embryo, Mamm

2007
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:2

    Topics: Aging; Animals; Blotting, Western; Calcineurin; Cardiomyopathies; Humans; Lactic Acid; Mice; Mice, T

2008
Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention.
    Journal of molecular and cellular cardiology, 2008, Volume: 44, Issue:2

    Topics: Aging; Animals; Blood Pressure; Body Weight; Down-Regulation; Energy Metabolism; Glucose; Glucose Tr

2008
Age-dependent changes in pyruvate uptake by nonsynaptic and synaptic mitochondria from rat brain.
    Mechanisms of ageing and development, 1982, Volume: 20, Issue:4

    Topics: Aging; Animals; Brain; Cytochrome c Group; In Vitro Techniques; Malates; Male; Mitochondria; Oxygen

1982
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
    Experimental gerontology, 1982, Volume: 17, Issue:1

    Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid

1982
Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
    Biochimica et biophysica acta, 1983, Jan-04, Volume: 755, Issue:1

    Topics: Aging; Animals; ATP Citrate (pro-S)-Lyase; Isocitrate Dehydrogenase; Lipids; Malate Dehydrogenase; M

1983
Brown adipose tissue metabolism in hypothalamic-obese rats.
    Metabolism: clinical and experimental, 1983, Volume: 32, Issue:2

    Topics: Adipose Tissue, Brown; Aging; Animals; Diet; Fatty Acids; Glucose; Hypothalamus; Lactates; Lactic Ac

1983
Age-related changes in rat adipose tissue in response to fasting: protein, lactate and pyruvate levels.
    Life sciences, 1983, Jun-06, Volume: 32, Issue:23

    Topics: Adipose Tissue; Aging; Animals; Fasting; Lactates; Lactic Acid; Male; NAD; Proteins; Pyruvates; Pyru

1983
Lactate and pyruvate content of the human cisternal cerebrospinal fluid. Normal values, age and sex dependency, correlations with glucose concentrations.
    Archiv fur Psychiatrie und Nervenkrankheiten, 1983, Volume: 232, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Blood Glucose; Cisterna Magna; Female; Humans; Lactates; Lactic Acid

1983
Neurotransmitter and carbohydrate metabolism during senescence.
    Experimental brain research, 1982, Volume: Suppl 5

    Topics: Acetylcholine; Aging; Animals; Brain; Calcium; Glucose; In Vitro Techniques; Mice; Mice, Inbred BALB

1982
Energy metabolism in rat brain: inhibition of pyruvate decarboxylation by 3-hydroxybutyrate in neonatal mitochondria.
    Journal of neurochemistry, 1981, Volume: 37, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Newborn; Brain; Female; Hydroxybutyrates; Male; Mito

1981
Aging decreases oxidative metabolism and the release and synthesis of acetylcholine.
    Journal of neurochemistry, 1981, Volume: 37, Issue:4

    Topics: Acetylcholine; Aging; Anaerobiosis; Animals; Brain; Glucose; In Vitro Techniques; Male; Mice; Mice,

1981
Mitochondrial ATP production rate in 55 to 73-year-old men: effect of endurance training.
    Acta physiologica Scandinavica, 1995, Volume: 154, Issue:2

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adenosine Triphosphate; Aged; Aging; Carnitine O-Palmitoyltransfer

1995
Glycolysis abnormalities in fibromyalgia.
    Journal of the American College of Nutrition, 1994, Volume: 13, Issue:2

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Aging; Diphosphoglyc

1994
Decline with age of the respiratory chain activity in human skeletal muscle.
    Biochimica et biophysica acta, 1994, Apr-12, Volume: 1226, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ascorbic Acid; Cytochromes; Electron Transport Co

1994
Interaction of exercise and age on substrates of carbohydrate metabolism.
    Indian journal of experimental biology, 1993, Volume: 31, Issue:1

    Topics: Aging; Animals; Blood Glucose; Carbohydrate Metabolism; Glycogen; Lactates; Lactic Acid; Male; Physi

1993
Age-related responses of right ventricle in swim-trained rats: changes in lactate and pyruvate contents and lactate dehydrogenase activity.
    Mechanisms of ageing and development, 1996, Sep-18, Volume: 90, Issue:2

    Topics: Aging; Anaerobiosis; Animals; Glycolysis; Hypertrophy, Right Ventricular; Isoenzymes; L-Lactate Dehy

1996
Developmental capacity, energy metabolism and ultrastructure of mature oocytes from prepubertal and adult sheep.
    Reproduction, fertility, and development, 1996, Volume: 8, Issue:7

    Topics: Aging; Animals; Blastocyst; Cytoplasm; Cytoplasmic Granules; Energy Metabolism; Female; Glucose; Glu

1996
Blood lactate and pyruvate concentrations, and their ratio during exercise in healthy children: developmental perspective.
    European journal of applied physiology and occupational physiology, 1995, Volume: 71, Issue:6

    Topics: Adolescent; Aging; Child; Child Development; Female; Humans; Lactic Acid; Male; Osmolar Concentratio

1995
Age-related ischemia in the brain following bilateral carotid artery occlusion--collateral blood flow and brain metabolism.
    Neurochemical research, 1997, Volume: 22, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Animals, Suckling; Arterial Occlusive Diseases; Brain; Brain

1997
Uptake and excretion of sodium taurocholate by the isolated perfused neonatal sheep liver.
    Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:4

    Topics: Aging; Algorithms; Animals; Animals, Newborn; Bile; Blood Pressure; Lactic Acid; Liver; Liver Circul

1999
The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria.
    FEBS letters, 1999, Jul-09, Volume: 454, Issue:3

    Topics: Acetylcarnitine; Aging; Animals; Male; Mitochondria, Heart; Nootropic Agents; Oxidation-Reduction; P

1999
Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM.
    Mechanisms of ageing and development, 2000, Mar-13, Volume: 114, Issue:2

    Topics: Aging; Animals; Female; Lactates; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Pyruvic Acid

2000
Age-dependent changes in glycosaminoglycan content in the skin of fasted rats. A possible mechanism.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:2

    Topics: Aging; Animals; Blood Glucose; Fasting; Glycosaminoglycans; Lactic Acid; Male; NAD; Pyruvic Acid; Ra

2000
Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.
    The Biochemical journal, 2000, Dec-15, Volume: 352 Pt 3

    Topics: Aging; Animals; Blotting, Western; Dietary Fats; Embryonic and Fetal Development; Female; Gene Expre

2000
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.
    Free radical biology & medicine, 2002, May-01, Volume: 32, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Cell Nucleus; Deoxyguanosine; Diet, Reducing; DNA; DNA

2002
Hepatic gluconeogenic capacity from various precursors in young versus old rats.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:7

    Topics: Aging; Alanine; Animals; Body Weight; Cell Separation; Cell Survival; Dihydroxyacetone; Fasting; Fru

2002
Postnatal development of pyruvate oxidation in quadriceps muscle of the rat.
    Biology of the neonate, 1992, Volume: 61, Issue:3

    Topics: Acetyltransferases; Aging; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Citra

1992
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing.
    Lancet (London, England), 1989, Mar-25, Volume: 1, Issue:8639

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; DNA, Mitochondrial; Electron Transport Complex I

1989
Postnatal growth and differentiation in three hindlimb muscles of the rat. Characterization with biochemical and enzyme-histochemical methods.
    Cell and tissue research, 1985, Volume: 241, Issue:1

    Topics: Adenosine Triphosphatases; Aging; Animals; Animals, Newborn; Cell Differentiation; Citrate (si)-Synt

1985
Age related metabolic changes in muscle energy metabolism of exhausted albino rats.
    Indian journal of experimental biology, 1987, Volume: 25, Issue:8

    Topics: Aging; Animals; Energy Metabolism; Glycogen; Male; Muscles; Physical Exertion; Pyruvates; Pyruvic Ac

1987
The effect of age on glucose and energy metabolism in brain cortex of rats.
    Archives of gerontology and geriatrics, 1985, Volume: 4, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Cerebral Cortex; Citrates; Citric Acid; Energy Metabolism; G

1985
Urea synthesis in hepatocytes isolated from young and old rats.
    Experimental gerontology, 1985, Volume: 20, Issue:5

    Topics: Aging; Ammonium Chloride; Animals; Epinephrine; Glucagon; Gluconeogenesis; In Vitro Techniques; Lact

1985