pyruvic acid has been researched along with Acute Hepatic Failure in 15 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "In patients with acute liver failure cerebral microdialysis studies show a linear correlation between the lactate to pyruvate ratio and the glutamine concentration, as well as to some of the adenosine triphosphate degradation products." | 2.49 | Changes in cerebral oxidative metabolism in patients with acute liver failure. ( Bjerring, PN; Larsen, FS, 2013) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "Hepatocyte regeneration in acute hepatic failure is essential for recovery, but requires a large amount of energy." | 1.29 | Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure. ( Maeda, T; Onishi, S; Saibara, T; Yamamoto, Y, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sasaki, K | 1 |
| Sakamoto, S | 1 |
| Uchida, H | 1 |
| Narumoto, S | 1 |
| Shigeta, T | 1 |
| Fukuda, A | 1 |
| Ito, R | 1 |
| Irie, R | 1 |
| Yoshioka, T | 1 |
| Murayama, K | 1 |
| Kasahara, M | 1 |
| Prazak, J | 1 |
| Laszikova, E | 1 |
| Pantoflicek, T | 1 |
| Ryska, O | 1 |
| Koblihova, E | 1 |
| Ryska, M | 1 |
| Amathieu, R | 1 |
| Triba, MN | 1 |
| Nahon, P | 1 |
| Bouchemal, N | 1 |
| Kamoun, W | 1 |
| Haouache, H | 1 |
| Trinchet, JC | 1 |
| Savarin, P | 1 |
| Le Moyec, L | 1 |
| Dhonneur, G | 1 |
| Chavarria, L | 1 |
| Romero-Giménez, J | 1 |
| Monteagudo, E | 1 |
| Lope-Piedrafita, S | 1 |
| Cordoba, J | 1 |
| Hertz, L | 1 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Feldman, AG | 1 |
| Sokol, RJ | 1 |
| Hardison, RM | 1 |
| Alonso, EM | 1 |
| Squires, RH | 1 |
| Narkewicz, MR | 1 |
| Bjerring, PN | 4 |
| Hauerberg, J | 4 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 4 |
| Tofteng, F | 2 |
| Hansen, BA | 3 |
| Larsen, FS | 6 |
| Dabos, KJ | 1 |
| Whalen, HR | 1 |
| Newsome, PN | 1 |
| Parkinson, JA | 1 |
| Henderson, NC | 1 |
| Sadler, IH | 1 |
| Hayes, PC | 1 |
| Plevris, JN | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Eefsen, M | 1 |
| Dethloff, T | 1 |
| Jorgensen, L | 1 |
| Saibara, T | 1 |
| Maeda, T | 1 |
| Onishi, S | 1 |
| Yamamoto, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Changes in cerebral oxidative metabolism in patients with acute liver failure.
Topics: Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Humans; Hyperammonemia; Lactic Acid; Liver Fa | 2013 |
13 other studies available for pyruvic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A Single-Center Experience and Excellent Marker of Differential Diagnosis.
Topics: Adult; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver | 2017 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis.
Topics: Biomarkers; Creatinine; Glutamine; Humans; Intensive Care Units; Ketone Bodies; Lactic Acid; Liver C | 2014 |
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.
Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid | 2015 |
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure.
Topics: Adolescent; Age Factors; Biomarkers; Child; Child, Preschool; Cohort Studies; Female; Humans; Lactic | 2017 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.
Topics: Acetaminophen; Amino Acids; Animals; Biomarkers; Citric Acid Cycle; Disease Models, Animal; Gluconeo | 2011 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Extracellular Fluid; Female; Humans; Intracra | 2007 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Arteries; Child; Citrates; Citric Acid; Female; H | 1994 |