pyruvic acid has been researched along with Acidosis, Lactic in 51 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyruvate Ringer's solution efficiently treated hypoxic lactic acidosis and significantly increased the survival rate in rats with lethal hemorrhagic shock." | 7.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 7.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| " We propose low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis as an indication of dysfunction of the tricarboxylic acid cycle." | 7.68 | Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. ( Aupetit, J; Bonnefont, JP; Charpentier, C; Chretien, D; Munnich, A; Rabier, D; Robinson, B; Rustin, P; Saudubray, JM; Vassault, A, 1992) |
| "A mitochondrial defect was investigated in an infant with fatal congenital lactic acidosis (3-14 mM), high lactate-to-pyruvate ratio, hypotonia, and cardiomyopathy." | 7.67 | Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy. ( Dahms, B; Hoppel, CL; Kerr, DS; Roessmann, U, 1987) |
| "Treatment with thiamine and carnitine resulted in a decrease in blood lactate to normal levels and a dramatic clinical improvement." | 5.28 | Neonatal cardiomyopathy and lactic acidosis responsive to thiamine. ( Abeling, NG; Bakker, HD; Lam, J; Luyt-Houwen, IE; Scholte, HR; van Gennip, AH, 1991) |
| " However, the mutual dependence between lactate dehydrogenase (LDH) catalytic action and lactic acidosis is far from being fully understood." | 4.12 | Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme. ( Binda, C; Brigotti, M; Cerini, S; Dal Piaz, F; Di Stefano, G; Hochkoeppler, A; Iacovino, LG; Pasti, AP; Rossi, M; Rossi, V; Tomaselli, F, 2022) |
| " A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0." | 3.91 | Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease. ( Inoue, E; Koga, Y; Nashiki, K; Povalko, N; Tanaka, M, 2019) |
| "Lactic acidosis during metformin intoxication is classically mainly attributed to diminished lactate clearance through liver gluconeogenesis." | 3.83 | Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis. ( Bassani, G; Ferrero, S; Gattinoni, L; Guenzani, S; Langer, T; Magnoni, S; Properzi, P; Protti, A; Santini, A; Stocchetti, N, 2016) |
| "Pyruvate Ringer's solution efficiently treated hypoxic lactic acidosis and significantly increased the survival rate in rats with lethal hemorrhagic shock." | 3.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 3.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| "During constant work-rate exercise above the lactic acidosis threshold, oxygen consumption fails to plateau by 3 minutes, but continues to rise slowly." | 3.72 | Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII. ( Lovell, S; Nicholls, DP; O'Dochartaigh, CS; Ong, HY; Patterson, VH; Riley, MS; Wasserman, K, 2004) |
| "Sixty consecutive adult patients who developed septic shock and lactic acidosis requiring the administration of vasopressors." | 3.70 | Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. ( Bollaert, PE; Gelot, AM; Larcan, A; Levy, B; Nabet, P; Sadoune, LO, 2000) |
| " Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion." | 3.70 | Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000) |
| " Above the anaerobic threshold, accelerated glycolysis increases muscle lactic acidosis." | 3.69 | Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects. ( Casaburi, R; Cooper, CB; Koike, A; Stringer, WW; Wasserman, K, 1994) |
| " The lactic acidosis threshold and VO2 kinetics were examined." | 3.68 | Is the anaerobic threshold truly anaerobic? ( Koike, A; Wasserman, K, 1992) |
| " We propose low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis as an indication of dysfunction of the tricarboxylic acid cycle." | 3.68 | Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. ( Aupetit, J; Bonnefont, JP; Charpentier, C; Chretien, D; Munnich, A; Rabier, D; Robinson, B; Rustin, P; Saudubray, JM; Vassault, A, 1992) |
| "We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual and auditory hallucinations." | 3.68 | Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS. ( Hashimoto, T; Ito, M; Kuroda, Y; Naito, E; Saijo, T; Takeda, E, 1991) |
| " Patients with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes demonstrated only minor changes in redox state and in the behavior of the mitochondrial respiratory chain." | 3.68 | The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia. ( Capaldi, R; Chow, W; Glerum, DM; Lightowlers, R; Petrova-Benedict, R; Robinson, BH, 1990) |
| "A mitochondrial defect was investigated in an infant with fatal congenital lactic acidosis (3-14 mM), high lactate-to-pyruvate ratio, hypotonia, and cardiomyopathy." | 3.67 | Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy. ( Dahms, B; Hoppel, CL; Kerr, DS; Roessmann, U, 1987) |
| "We have investigated the effect of dichloroacetate (DCA) on the urinary excretion of lactate and pyruvate in a patient with congenital lactic acidosis and in healthy human controls." | 3.67 | Renal effects of dichloroacetate in vivo. ( Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S, 1986) |
| "Early-onset hyperlactatemia is that which develops in the operating room or very early following intensive care unit (ICU) admission." | 2.55 | Hyperlactatemia and Cardiac Surgery. ( Minton, J; Sidebotham, DA, 2017) |
| "Hypoxic lactic acidosis was efficiently reversed in group PR, instead of group CR, (pH 7." | 1.48 | Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats. ( Li, ZY; Liu, R; Wang, SM; Yu, W; Zhang, HP; Zhou, FQ, 2018) |
| "Hypoxic lactic acidosis was fully corrected in group PORS in 4 h, whereas it worsened in group BORS, and the 24-h survival rate was twice higher in group PORS than in group BORS (45." | 1.42 | Pyruvate oral rehydration solution improved visceral function and survival in shock rats. ( He, ZJ; Hu, S; Lin, HY; Luo, HM; Sheng, ZY; Xie, ZY; Yu, W; Zhou, FQ, 2015) |
| "Children with MELAS had various clinical manifestations." | 1.39 | [Clinical, pathological and molecular biological characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episode in children]. ( Bao, XH; Chang, XZ; Liu, XL; Ma, YN; Qin, J; Wu, XR, 2013) |
| "Both steroids and hemorrhage may affect the hepatic energy metabolism." | 1.30 | [Effects of steroids on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage]. ( Ikeya, K; Kashimoto, S; Kumazawa, T; Kume, M, 1997) |
| "The majority of patients with PDHC deficiency have abnormalities in the major catalytic and regulatory subunit, E1 alpha, which is encoded on the X chromosome." | 1.29 | Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency. ( Arnold, DL; Brown, GK; Brown, RM; Legris, M; Matthews, PM; Otero, LJ; Scriver, CR; Shevell, MI, 1994) |
| "Treatment with thiamine and carnitine resulted in a decrease in blood lactate to normal levels and a dramatic clinical improvement." | 1.28 | Neonatal cardiomyopathy and lactic acidosis responsive to thiamine. ( Abeling, NG; Bakker, HD; Lam, J; Luyt-Houwen, IE; Scholte, HR; van Gennip, AH, 1991) |
| "Pyruvate dehydrogenase complex deficiency is thought to be a common cause of lactic acidosis." | 1.27 | Fatal lactic acidosis due to deficiency of E1 component of the pyruvate dehydrogenase complex. ( Aynsley-Green, A; Birch-Machin, MA; Gardner-Medwin, D; Lindsay, JG; Shepherd, IM; Sherratt, HS; Solomon, M; Turnbull, DM; Yeaman, SJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (11.76) | 18.7374 |
| 1990's | 14 (27.45) | 18.2507 |
| 2000's | 13 (25.49) | 29.6817 |
| 2010's | 16 (31.37) | 24.3611 |
| 2020's | 2 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Iacovino, LG | 1 |
| Rossi, M | 1 |
| Di Stefano, G | 1 |
| Rossi, V | 1 |
| Binda, C | 1 |
| Brigotti, M | 1 |
| Tomaselli, F | 1 |
| Pasti, AP | 1 |
| Dal Piaz, F | 1 |
| Cerini, S | 1 |
| Hochkoeppler, A | 1 |
| Li, J | 1 |
| Yang, Y | 1 |
| Peng, Z | 1 |
| Yang, J | 2 |
| Li, Y | 1 |
| Liu, R | 1 |
| Wang, SM | 1 |
| Li, ZY | 1 |
| Yu, W | 2 |
| Zhang, HP | 1 |
| Zhou, FQ | 4 |
| Wang, Y | 1 |
| Huang, Y | 1 |
| Zhao, L | 1 |
| Zhou, H | 1 |
| Koga, Y | 1 |
| Povalko, N | 1 |
| Inoue, E | 1 |
| Nashiki, K | 1 |
| Tanaka, M | 1 |
| Katsu-Jiménez, Y | 1 |
| Vázquez-Calvo, C | 1 |
| Maffezzini, C | 1 |
| Halldin, M | 1 |
| Peng, X | 1 |
| Freyer, C | 1 |
| Wredenberg, A | 1 |
| Giménez-Cassina, A | 1 |
| Wedell, A | 1 |
| Arnér, ESJ | 1 |
| Ambrus, A | 1 |
| Liu, XL | 1 |
| Bao, XH | 1 |
| Ma, YN | 1 |
| Chang, XZ | 1 |
| Qin, J | 1 |
| Wu, XR | 1 |
| Ching, CK | 1 |
| Mak, CM | 1 |
| Au, KM | 1 |
| Chan, KY | 1 |
| Yuen, YP | 1 |
| Yau, EK | 1 |
| Ma, LC | 1 |
| Chow, HL | 1 |
| Chan, AY | 1 |
| Hu, S | 2 |
| Bai, XD | 1 |
| Liu, XQ | 1 |
| Wang, HB | 1 |
| Zhong, YX | 1 |
| Fang, T | 1 |
| Moustafa, F | 1 |
| Garrouste, C | 1 |
| Bertrand, PM | 1 |
| Kauffmann, S | 1 |
| Schmidt, J | 1 |
| Xie, ZY | 1 |
| He, ZJ | 1 |
| Luo, HM | 1 |
| Lin, HY | 1 |
| Sheng, ZY | 1 |
| Danhauser, K | 1 |
| Smeitink, JA | 1 |
| Freisinger, P | 2 |
| Sperl, W | 2 |
| Sabir, H | 1 |
| Hadzik, B | 1 |
| Mayatepek, E | 1 |
| Morava, E | 1 |
| Distelmaier, F | 1 |
| Protti, A | 1 |
| Properzi, P | 1 |
| Magnoni, S | 1 |
| Santini, A | 1 |
| Langer, T | 1 |
| Guenzani, S | 1 |
| Ferrero, S | 1 |
| Bassani, G | 1 |
| Stocchetti, N | 1 |
| Gattinoni, L | 1 |
| Minton, J | 1 |
| Sidebotham, DA | 1 |
| Kovacevic, A | 1 |
| Schwahn, B | 1 |
| Schuster, A | 1 |
| Levy, B | 2 |
| Perez, P | 1 |
| Perny, J | 1 |
| Thivilier, C | 1 |
| Gerard, A | 1 |
| Mayr, JA | 1 |
| Schlachter, K | 1 |
| Rolinski, B | 1 |
| Zimmermann, FA | 1 |
| Scheffner, T | 1 |
| Haack, TB | 1 |
| Koch, J | 1 |
| Ahting, U | 1 |
| Prokisch, H | 1 |
| Schurr, A | 1 |
| Totani, M | 1 |
| Ong, HY | 1 |
| O'Dochartaigh, CS | 1 |
| Lovell, S | 1 |
| Patterson, VH | 1 |
| Wasserman, K | 4 |
| Nicholls, DP | 1 |
| Riley, MS | 1 |
| Seino, H | 1 |
| Hiraizumi, M | 1 |
| Dote, T | 1 |
| Kono, K | 1 |
| Usuda, K | 1 |
| Shimizu, H | 1 |
| Tanimoto, Y | 1 |
| Dote, E | 1 |
| Hayashi, S | 1 |
| Gutierrez, G | 1 |
| Wulf, ME | 1 |
| Debray, FG | 1 |
| Mitchell, GA | 1 |
| Allard, P | 1 |
| Robinson, BH | 2 |
| Hanley, JA | 1 |
| Lambert, M | 1 |
| Hosein, RB | 1 |
| Morris, KP | 1 |
| Brawn, WJ | 1 |
| Barron, DJ | 1 |
| Shevell, MI | 1 |
| Matthews, PM | 1 |
| Scriver, CR | 1 |
| Brown, RM | 1 |
| Otero, LJ | 1 |
| Legris, M | 1 |
| Brown, GK | 1 |
| Arnold, DL | 1 |
| Stringer, WW | 1 |
| Casaburi, R | 1 |
| Koike, A | 2 |
| Cooper, CB | 1 |
| Yuan, XQ | 1 |
| Wade, CE | 1 |
| Feriani, M | 1 |
| Ikeya, K | 1 |
| Kashimoto, S | 1 |
| Kume, M | 1 |
| Kumazawa, T | 1 |
| Sadoune, LO | 1 |
| Gelot, AM | 1 |
| Bollaert, PE | 1 |
| Nabet, P | 1 |
| Larcan, A | 1 |
| Suistomaa, M | 1 |
| Ruokonen, E | 1 |
| Kari, A | 1 |
| Takala, J | 1 |
| Arbour, R | 1 |
| Esparis, B | 1 |
| Giordano, G | 1 |
| Corradi, D | 1 |
| D'Adda, T | 1 |
| Melissari, M | 1 |
| Hirai, M | 1 |
| Suzuki, S | 1 |
| Ito, M | 3 |
| Kobashi, H | 3 |
| Naito, E | 5 |
| Saijo, T | 3 |
| Takeda, E | 4 |
| Huq, AH | 1 |
| Kuroda, Y | 5 |
| Merinero, B | 1 |
| Pérez-Cerda, C | 1 |
| Ugarte, M | 1 |
| Bonnefont, JP | 1 |
| Chretien, D | 1 |
| Rustin, P | 1 |
| Robinson, B | 1 |
| Vassault, A | 1 |
| Aupetit, J | 1 |
| Charpentier, C | 1 |
| Rabier, D | 1 |
| Saudubray, JM | 1 |
| Munnich, A | 1 |
| Bakker, HD | 1 |
| Scholte, HR | 1 |
| Luyt-Houwen, IE | 1 |
| van Gennip, AH | 1 |
| Abeling, NG | 1 |
| Lam, J | 1 |
| Abe, K | 1 |
| Fujimura, H | 1 |
| Nishikawa, Y | 1 |
| Yorifuji, S | 1 |
| Mezaki, T | 1 |
| Hirono, N | 1 |
| Nishitani, N | 1 |
| Kameyama, M | 1 |
| Hashimoto, T | 1 |
| Glerum, DM | 1 |
| Chow, W | 1 |
| Petrova-Benedict, R | 1 |
| Lightowlers, R | 1 |
| Capaldi, R | 1 |
| Beaver, WL | 1 |
| Whipp, BJ | 1 |
| Toshima, K | 1 |
| Yokota, I | 2 |
| Miyao, M | 1 |
| Hoppel, CL | 1 |
| Kerr, DS | 1 |
| Dahms, B | 1 |
| Roessmann, U | 1 |
| Birch-Machin, MA | 1 |
| Shepherd, IM | 1 |
| Solomon, M | 1 |
| Yeaman, SJ | 1 |
| Gardner-Medwin, D | 1 |
| Sherratt, HS | 1 |
| Lindsay, JG | 1 |
| Aynsley-Green, A | 1 |
| Turnbull, DM | 1 |
| Kodama, H | 1 |
| Yamaguchi, S | 1 |
| Okabe, I | 1 |
| Kodama, M | 1 |
| Orii, T | 1 |
| Kamoshita, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mean Arterial Pressure (MAP) Trial: Study Protocol for a Multicenter, Randomized, Controlled Trial to Compare Three Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass[NCT05740397] | 900 participants (Anticipated) | Interventional | 2021-05-03 | Recruiting | |||
| "Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861] | 200 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
| Phase 3 Trial of Coenzyme Q10 in Mitochondrial Disease[NCT00432744] | Phase 3 | 24 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The McMaster Gross Motor Function is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. One of the links in this report is to the the GMFM scale and how it is scored. A link to the instrument is included. (NCT00432744)
Timeframe: Taken at 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -0.002 |
| CoenzymeQ10 Frist | -0.12 |
This is a multivariate analysis of the first two outcomes: Period 2 minus Period 1 GMFM88 and Peds Quality of Life, analyzed as follows: First, to be in the analysis, subjects must contribute at least one of these endpoints. Second, if the subject became totally disabled during period 1, the difference was defined as + infinity, (highest possible evidence favoring period 2), and if the subject became totally disabled in period 2, the subject was scored as - infinity (highest possible evidence favoring period 1). Period 2 minus period 1 differences were ranked form low to high with missing values scores at the mid-rank. The Hotelling T-square was computed on these ranks and the P-value was obtained from 100,000 rerandomizations as the fraction of rerandomizations with T-sq at least as large as that observed. (NCT00432744)
Timeframe: end of 12 month minus end of 6 month difference.
| Intervention | participants (Number) |
|---|---|
| Placebo First | 7 |
| CoenzymeQ10 Frist | 8 |
"The Pediatric Quality of Life Scale is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. Goggle pedsQL and Mapi to browse the copyrighted manual. A link to the instrument is included." (NCT00432744)
Timeframe: At 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -1.1 |
| CoenzymeQ10 Frist | -11.9 |
10 reviews available for pyruvic acid and Acidosis, Lactic
| Article | Year |
|---|---|
Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis.
Topics: Acidosis, Lactic; Antacids; Bicarbonates; Erythropoietin; Fluid Therapy; Humans; Hypoxia; Hypoxia-In | 2018 |
An Updated View on the Molecular Pathomechanisms of Human Dihydrolipoamide Dehydrogenase Deficiency in Light of Novel Crystallographic Evidence.
Topics: Acidosis, Lactic; Amino Acid Oxidoreductases; Cytochrome-B(5) Reductase; Dihydrolipoamide Dehydrogen | 2019 |
Treatment options for lactic acidosis and metabolic crisis in children with mitochondrial disease.
Topics: Acidosis, Lactic; Child; Child, Preschool; Disease Management; Humans; Hypothermia; Mitochondrial Di | 2015 |
Hyperlactatemia and Cardiac Surgery.
Topics: Acidosis, Lactic; Biomarkers; Cardiac Surgical Procedures; Humans; Hyperlactatemia; Hypoxia; Lactic | 2017 |
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
[Lactate . pyruvate].
Topics: Acidosis, Lactic; Biomarkers; Diabetes Mellitus; Humans; Lactic Acid; Neoplasms; Pyruvic Acid | 2002 |
[Progress in diagnosis of and therapy for diabetic lactic acidosis].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Blood Gas Analysis; Consciousness Disorders; Diabetes Compl | 2004 |
Buffers: bicarbonate, lactate and pyruvate.
Topics: Acidosis, Lactic; Bicarbonates; Buffers; Dialysis Solutions; Humans; Lactic Acid; Peritoneal Dialysi | 1996 |
[Lactic acidosis].
Topics: Acidosis, Lactic; Diagnosis, Differential; Humans; Mitochondria; Mitochondrial Diseases; Prognosis; | 2002 |
Gas exchange theory and the lactic acidosis (anaerobic) threshold.
Topics: Acidosis, Lactic; Anaerobic Threshold; Heart Failure; Humans; Models, Cardiovascular; Oxygen Consump | 1990 |
1 trial available for pyruvic acid and Acidosis, Lactic
| Article | Year |
|---|---|
Comparison of norepinephrine-dobutamine to epinephrine for hemodynamics, lactate metabolism, and organ function variables in cardiogenic shock. A prospective, randomized pilot study.
Topics: Acidosis, Lactic; Aged; Blood Gas Analysis; Blood Pressure; Cardiac Output; Dobutamine; Epinephrine; | 2011 |
40 other studies available for pyruvic acid and Acidosis, Lactic
| Article | Year |
|---|---|
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Topics: Acidosis, Lactic; Animals; Citrates; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; | 2022 |
A novel photoelectrochemical microfluidic chip for multi-index determination of diabetes and its complications.
Topics: 3-Hydroxybutyric Acid; Acidosis, Lactic; Biomarkers; Biosensing Techniques; Diabetes Mellitus; Diabe | 2022 |
Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats.
Topics: Acidosis, Lactic; Administration, Oral; Animals; Bicarbonates; Burns; Citric Acid; Disease Models, A | 2018 |
Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.
Topics: Acidosis, Lactic; Adolescent; Adult; Biomarkers; Female; Fibroblast Growth Factors; Growth Different | 2019 |
Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate.
Topics: Acidosis, Lactic; Carrier Proteins; Child; Child, Preschool; Female; Fibroblasts; Glycolysis; Humans | 2019 |
[Clinical, pathological and molecular biological characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episode in children].
Topics: Acidosis, Lactic; Adolescent; Brain; Child; Child, Preschool; DNA Mutational Analysis; DNA, Mitochon | 2013 |
A patient with congenital hyperlactataemia and Leigh syndrome: an uncommon mitochondrial variant.
Topics: Acidosis, Lactic; DNA, Mitochondrial; Female; Humans; Infant; Lactic Acid; Leigh Disease; Pyruvic Ac | 2013 |
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models, | 2013 |
[Lactic acidosis after inhaled beta-2 agonists: about 2 cases].
Topics: Acidosis, Lactic; Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Albuterol; Asthma | 2014 |
Pyruvate oral rehydration solution improved visceral function and survival in shock rats.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Disease Models, Animal; Fluid Therapy; Glucose; Lipid Perox | 2015 |
Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.
Topics: Acidosis, Lactic; Animals; Glycolysis; Hypoglycemic Agents; Infusions, Parenteral; Lactic Acid; Metf | 2016 |
Hyperlactic acidosis as metabolic side-effect of albuterol and theophylline in acute severe asthma.
Topics: Acidosis, Lactic; Administration, Inhalation; Adolescent; Albuterol; Anti-Asthmatic Agents; Anti-Inf | 2010 |
Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway.
Topics: Abnormalities, Multiple; Acidosis, Lactic; Adolescent; Amino Acid Sequence; Base Sequence; Brain Dis | 2011 |
Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII.
Topics: Acidosis, Lactic; Adult; Case-Control Studies; Epinephrine; Exercise; Exercise Test; Exercise Tolera | 2004 |
Systemic effects and skin injury after experimental dermal exposure to monochloroacetic acid.
Topics: Accidents, Occupational; Acetates; Acidosis, Lactic; Animals; Blood Chemical Analysis; Burns, Chemic | 2003 |
Lactic acidosis in sepsis: another commentary.
Topics: Acidosis, Lactic; Glucose; Humans; Lactic Acid; Pyruvic Acid; Sepsis | 2005 |
Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis.
Topics: Acidosis, Lactic; Child; Diagnosis, Differential; Female; Hospitals, Pediatric; Humans; Lactic Acid; | 2007 |
Use of tissue microdialysis to investigate hyperlactataemia following paediatric cardiac surgery.
Topics: Abdominal Wall; Acidosis, Lactic; Biomarkers; Child, Preschool; Epinephrine; Feasibility Studies; Fo | 2008 |
Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Agenesis of Corpus Callosum; Brain; Brain Damage, Chronic; Brain Diseases, Metabol | 1994 |
Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anaerobic Threshold; Bicarbonates; Carbon Dioxide; E | 1994 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
[Effects of steroids on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage].
Topics: Acidosis, Lactic; Acute Disease; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Glycogen | 1997 |
Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Case-Control Studies; Catecholamines; Female; Hemo | 2000 |
Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions.
Topics: Acidosis, Lactic; APACHE; Biomarkers; Critical Care; Emergencies; Female; Finland; Glasgow Coma Scal | 2000 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou | 2000 |
[An autopsy case of neonatal lactic acidosis].
Topics: Acidosis, Lactic; Atrophy; Autopsy; Body Fluids; Brain; Cardiomegaly; Epilepsy, Generalized; Fatal O | 2001 |
Decrease of pyruvate dehydrogenase phosphatase activity in patients with congenital lactic acidemia.
Topics: Acidosis, Lactic; Child; Enzyme Activation; Female; Fibroblasts; Humans; Infant; Male; Mitochondria; | 1992 |
Investigation of enzyme defects in children with lactic acidosis.
Topics: Acidosis, Lactic; Body Fluids; Child; Citrate (si)-Synthase; Electron Transport Complex IV; Fibrobla | 1992 |
Is the anaerobic threshold truly anaerobic?
Topics: Acidosis, Lactic; Anaerobic Threshold; Anaerobiosis; Exercise; Exercise Test; Humans; Lactates; Lact | 1992 |
Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis.
Topics: Acidosis, Lactic; Humans; Infant, Newborn; Ketoglutarate Dehydrogenase Complex; Ketone Bodies; Lacta | 1992 |
Neonatal cardiomyopathy and lactic acidosis responsive to thiamine.
Topics: Acidosis, Lactic; Cardiomyopathies; Carnitine; Child; Child, Preschool; Female; Humans; Infant; Keto | 1991 |
Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).
Topics: Acidosis, Lactic; Adult; Agnosia; Cerebrovascular Disorders; Delirium; Dose-Response Relationship, D | 1991 |
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS.
Topics: Acidosis, Lactic; Administration, Oral; Adult; Auditory Perception; Dichloroacetic Acid; Hallucinati | 1991 |
The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia.
Topics: Acidosis, Lactic; Brain Diseases; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Hum | 1990 |
Effect of sodium dichloroacetate on human pyruvate metabolism.
Topics: Acetates; Acidosis, Lactic; Adolescent; Blood Platelets; Dichloroacetic Acid; Humans; Male; Muscular | 1989 |
Detection of pyruvate metabolism disorders by culture of skin fibroblasts with dichloroacetate.
Topics: Acetates; Acidosis, Lactic; Cells, Cultured; Child; Dichloroacetic Acid; Enzyme Activation; Female; | 1988 |
Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy.
Topics: Acidosis, Lactic; Bone and Bones; Brain; Electron Transport; Energy Metabolism; Humans; Infant, Newb | 1987 |
Fatal lactic acidosis due to deficiency of E1 component of the pyruvate dehydrogenase complex.
Topics: Acidosis, Lactic; Humans; Infant; Male; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvat | 1988 |
[Congenital lactic acidemia].
Topics: Acidosis, Lactic; Biological Transport; Energy Metabolism; Humans; Mitochondria; NAD; Pyruvate Dehyd | 1988 |
Renal effects of dichloroacetate in vivo.
Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromat | 1986 |