pyruvaldehyde has been researched along with Obesity in 26 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study has found that dietary genistein could ameliorate high-fat diet (HFD)-induced obesity and especially lower methylglyoxal (MGO) and advanced glycation end product (AGE) accumulation in healthy mice exposed to genistein and HFD." | 3.96 | Dietary Genistein Reduces Methylglyoxal and Advanced Glycation End Product Accumulation in Obese Mice Treated with High-Fat Diet. ( Sang, S; Wang, P; Zhao, Y; Zhu, Y, 2020) |
| "Body weight gain, fat deposits, dyslipidemia, hyperglycemia, and fatty liver were ameliorated by dietary genistein in both studies." | 3.91 | Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet. ( Sang, S; Wang, P; Zhao, Y, 2019) |
| "Pink urine syndrome (PUS) is attributed to the precipitation of uric acid caused by low urinary pH (U-pH)." | 3.81 | Elucidation of the etiology and characteristics of pink urine in young healthy subjects. ( Ito, S; Kabayama, S; Kinouchi, Y; Mori, T; Nako, K; Ogawa, S; Okamura, M; Sakamoto, T; Takiguchi, J, 2015) |
| "Obesity is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age, and diet." | 2.72 | Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease. ( Hernandez-Castillo, C; Shuck, SC, 2021) |
| "Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate." | 1.48 | Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents. ( Bains, Y; Caccavello, R; Garay-Sevilla, ME; Gugliucci, A; Luevano-Contreras, C; Rodríguez-Mortera, R; Solorio-Meza, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 16 (61.54) | 24.3611 |
| 2020's | 8 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Cortizo, FG | 1 |
| Pfaff, D | 2 |
| Wirth, A | 1 |
| Schlotterer, A | 1 |
| Medert, R | 1 |
| Morgenstern, J | 2 |
| Weber, T | 1 |
| Hammes, HP | 1 |
| Fleming, T | 2 |
| Nawroth, PP | 2 |
| Freichel, M | 1 |
| Teleman, AA | 2 |
| Hernandez-Castillo, C | 1 |
| Shuck, SC | 1 |
| Rabbani, N | 4 |
| Thornalley, PJ | 4 |
| Di Martino, D | 1 |
| Cappelletti, M | 1 |
| Tondo, M | 1 |
| Basello, K | 1 |
| Garbin, C | 1 |
| Speciani, A | 1 |
| Ferrazzi, E | 1 |
| Van den Eynde, MDG | 1 |
| Houben, AJHM | 1 |
| Scheijen, JLJM | 1 |
| Linkens, AMA | 1 |
| Niessen, PM | 1 |
| Simons, N | 1 |
| Hanssen, NMJ | 1 |
| Kusters, YHAM | 1 |
| Eussen, SJMP | 1 |
| Miyata, T | 1 |
| Stehouwer, CDA | 1 |
| Schalkwijk, CG | 2 |
| Medeiros, ML | 1 |
| de Oliveira, MG | 1 |
| Tavares, EG | 1 |
| Mello, GC | 1 |
| Anhê, GF | 1 |
| Mónica, FZ | 1 |
| Antunes, E | 1 |
| Zhao, Y | 2 |
| Zhu, Y | 1 |
| Wang, P | 2 |
| Sang, S | 2 |
| Xue, M | 2 |
| Weickert, MO | 2 |
| Rodrigues, T | 2 |
| Matafome, P | 3 |
| Sereno, J | 1 |
| Almeida, J | 1 |
| Castelhano, J | 1 |
| Gamas, L | 1 |
| Neves, C | 1 |
| Gonçalves, S | 1 |
| Carvalho, C | 1 |
| Arslanagic, A | 1 |
| Wilcken, E | 1 |
| Fonseca, R | 1 |
| Simões, I | 1 |
| Conde, SV | 1 |
| Castelo-Branco, M | 1 |
| Seiça, R | 3 |
| Rodríguez-Mortera, R | 1 |
| Luevano-Contreras, C | 1 |
| Solorio-Meza, S | 1 |
| Caccavello, R | 1 |
| Bains, Y | 1 |
| Garay-Sevilla, ME | 2 |
| Gugliucci, A | 1 |
| Moraru, A | 1 |
| Wiederstein, J | 1 |
| Miller, AK | 1 |
| Nawroth, P | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Fleming, TH | 1 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Kroll, J | 1 |
| Paneni, F | 1 |
| Costantino, S | 1 |
| Cosentino, F | 1 |
| Ogawa, S | 1 |
| Takiguchi, J | 1 |
| Nako, K | 1 |
| Okamura, M | 1 |
| Sakamoto, T | 1 |
| Kabayama, S | 1 |
| Mori, T | 1 |
| Kinouchi, Y | 1 |
| Ito, S | 1 |
| Macías-Cervantes, MH | 1 |
| Rodríguez-Soto, JM | 1 |
| Uribarri, J | 1 |
| Díaz-Cisneros, FJ | 1 |
| Cai, W | 1 |
| Qureshi, S | 1 |
| Kandala, NB | 1 |
| Anwar, A | 1 |
| Waldron, M | 1 |
| Shafie, A | 1 |
| Messenger, D | 1 |
| Fowler, M | 1 |
| Jenkins, G | 1 |
| Masania, J | 1 |
| Malczewska-Malec, M | 1 |
| Razny, U | 1 |
| Goralska, J | 1 |
| Zdzienicka, A | 1 |
| Kiec-Wilk, B | 1 |
| Gruca, A | 1 |
| Stancel-Mozwillo, J | 1 |
| Dembinska-Kiec, A | 1 |
| Francisco, FA | 1 |
| Barella, LF | 1 |
| Silveira, SDS | 1 |
| Saavedra, LPJ | 1 |
| Prates, KV | 1 |
| Alves, VS | 1 |
| Franco, CCDS | 1 |
| Miranda, RA | 1 |
| Ribeiro, TA | 1 |
| Tófolo, LP | 1 |
| Malta, A | 1 |
| Vieira, E | 1 |
| Palma-Rigo, K | 1 |
| Pavanello, A | 1 |
| Martins, IP | 1 |
| Moreira, VM | 1 |
| de Oliveira, JC | 1 |
| Mathias, PCF | 1 |
| Gomes, RM | 1 |
| Liu, J | 1 |
| Wang, R | 1 |
| Desai, K | 2 |
| Wu, L | 3 |
| Santos-Silva, D | 1 |
| Crisóstomo, J | 1 |
| Rodrigues, L | 1 |
| Sena, CM | 1 |
| Pereira, P | 1 |
| Jia, X | 1 |
| Chang, T | 1 |
| Wilson, TW | 1 |
| Sena, C | 1 |
| Gaens, KH | 1 |
| Stehouwer, CD | 1 |
| Atkins, TW | 1 |
| Thornally, PJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | m/s (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 7.9 | 8.0 |
| Placebo | 8.3 | 8.5 |
A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | mM h (Mean) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 10.8 | 9.9 |
| Placebo | 11.0 | 10.6 |
After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | number of capillaries per mm2 (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 115 | 125 |
| Placebo | 119 | 128 |
Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | percentage of baseline value (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 0.17 | 0.12 |
| Placebo | 0.18 | 0.26 |
6 reviews available for pyruvaldehyde and Obesity
| Article | Year |
|---|---|
Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease.
Topics: Diet; Humans; Metabolic Diseases; Molecular Structure; Obesity; Pyruvaldehyde | 2021 |
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Induction; Glutathione; Glycos | 2022 |
Dicarbonyl stress in clinical obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Lactic Acid; Lactoylglutathione Lyase; Mice; Non-alcohol | 2016 |
Methylglyoxal, obesity, and diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Ob | 2013 |
Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity.
Topics: Adipocytes; Adipose Tissue; Glycation End Products, Advanced; Humans; Hyperlipidemias; Lactoylglutat | 2013 |
Methylglyoxal and advanced glycation endproducts: new therapeutic horizons?
Topics: Glycation End Products, Advanced; Models, Biological; Molecular Structure; Obesity; Oxygen; Pyruvald | 2007 |
4 trials available for pyruvaldehyde and Obesity
| Article | Year |
|---|---|
Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.
Topics: Female; Glycation End Products, Advanced; Humans; Insulin Resistance; Magnesium Oxide; Maillard Reac | 2023 |
Reversal of Insulin Resistance in Overweight and Obese Subjects by
Topics: Adult; Blood Pressure; Body Mass Index; Carrier Proteins; Correlation of Data; Cross-Over Studies; D | 2021 |
Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Mass Index; Diet; Diet, Reducing; Energy Intake; Exercise | 2015 |
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Cell Line; Cross-Over Studies; Female; Gl | 2016 |
16 other studies available for pyruvaldehyde and Obesity
| Article | Year |
|---|---|
The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Glucose; Glycation End Products, Advanced; HEK29 | 2022 |
Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes.
Topics: COVID-19; Female; Glucose; Glycosylation; Humans; Infant, Newborn; Inflammation; Obesity; Overweight | 2022 |
Long-term methylglyoxal intake aggravates murine Th2-mediated airway eosinophil infiltration.
Topics: Allergens; Animals; Asthma; Cell Movement; Disease Models, Animal; Eosinophils; Humans; Interleukin- | 2020 |
Dietary Genistein Reduces Methylglyoxal and Advanced Glycation End Product Accumulation in Obese Mice Treated with High-Fat Diet.
Topics: Aldehyde Reductase; Animals; Diet, High-Fat; Genistein; Glycation End Products, Advanced; Humans; La | 2020 |
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Fasting; Fibrosis; Glycated Hemoglobin; Glycoconjugates; Gl | 2017 |
Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents.
Topics: Adolescent; Biomarkers; Body Mass Index; Carotid Intima-Media Thickness; Cross-Sectional Studies; Dy | 2018 |
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Drosophila melanogaster; Hyperglycemia; Insulin | 2018 |
Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue; Aldehyde Reductase; Animals; Diabetes Mellitus; Diet, High-Fat; Dietary Fats; Dyslip | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
p66(Shc)-induced redox changes drive endothelial insulin resistance.
Topics: Animals; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fatty Acids, Nonesterified; Insulin; | 2014 |
Elucidation of the etiology and characteristics of pink urine in young healthy subjects.
Topics: Adolescent; Angiotensinogen; Asian People; Blood Pressure; Body Mass Index; Color; Female; Humans; H | 2015 |
Methylglyoxal treatment in lactating mothers leads to type 2 diabetes phenotype in male rat offspring at adulthood.
Topics: Adiposity; Administration, Oral; Animals; Diabetes Mellitus, Type 2; Dyslipidemias; Environmental Po | 2018 |
Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Topics: Aldehyde Reductase; Amine Oxidase (Copper-Containing); Animals; Aorta; Cells, Cultured; Cytochrome P | 2011 |
Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity.
Topics: Adipokines; Adipose Tissue; Animals; Apoptosis; Biomarkers; Cell Hypoxia; Fibrosis; Hyperglycemia; I | 2012 |
Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Cycle Proteins; Cell Proliferation; Glutathione; Lactoylglut | 2012 |
Erythrocyte glyoxalase activity in genetically obese (ob/ob) and streptozotocin diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glutathione; Mice; Mice, Obes | 1989 |