pyruvaldehyde has been researched along with Neuroblastoma in 18 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to investigate the inhibitory abilities of phenolic acids (chlorogenic acid, syringic acid and vanillic acid) on methylglyoxal-induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis in the progression of diabetic neuropathy." | 3.74 | Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. ( Chuang, HC; Huang, SM; Wu, CH; Yen, GC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Brasil, FB | 1 |
| de Almeida, FJS | 1 |
| Luckachaki, MD | 1 |
| Dall'Oglio, EL | 1 |
| de Oliveira, MR | 5 |
| Qi, L | 1 |
| Gao, R | 1 |
| Chen, Z | 1 |
| Lin, D | 1 |
| Liu, Z | 1 |
| Wang, L | 1 |
| Lin, L | 1 |
| Liu, X | 2 |
| Liu, L | 1 |
| Zhang, D | 3 |
| Li, X | 3 |
| He, X | 3 |
| Xing, Y | 3 |
| Jiang, B | 3 |
| Xiu, Z | 3 |
| Bao, Y | 3 |
| Dong, Y | 3 |
| Barinova, KV | 2 |
| Serebryakova, MV | 2 |
| Melnikova, AK | 2 |
| Medvedeva, MV | 2 |
| Muronetz, VI | 2 |
| Schmalhausen, EV | 2 |
| Coccini, T | 1 |
| Schicchi, A | 1 |
| Locatelli, CA | 1 |
| Caloni, F | 1 |
| Negri, S | 1 |
| Grignani, E | 1 |
| De Simone, U | 1 |
| Custódio de Souza, IC | 1 |
| Fürstenau, CR | 2 |
| de Souza, ICC | 1 |
| Ferreira, GC | 2 |
| Schuck, PF | 1 |
| Dal Bosco, SM | 1 |
| Falone, S | 1 |
| Santini, S | 1 |
| di Loreto, S | 1 |
| Cordone, V | 1 |
| Grannonico, M | 1 |
| Cesare, P | 1 |
| Cacchio, M | 1 |
| Amicarelli, F | 2 |
| Koike, S | 2 |
| Kayama, T | 1 |
| Yamamoto, S | 1 |
| Komine, D | 1 |
| Tanaka, R | 1 |
| Nishimoto, S | 2 |
| Suzuki, T | 2 |
| Kishida, A | 1 |
| Ogasawara, Y | 2 |
| Peres, A | 1 |
| Inoue, N | 1 |
| Huang, SM | 2 |
| Hsu, CL | 1 |
| Chuang, HC | 2 |
| Shih, PH | 1 |
| Wu, CH | 2 |
| Yen, GC | 2 |
| Li, XH | 1 |
| Xie, JZ | 1 |
| Jiang, X | 1 |
| Lv, BL | 1 |
| Cheng, XS | 1 |
| Du, LL | 1 |
| Zhang, JY | 1 |
| Wang, JZ | 1 |
| Zhou, XW | 1 |
| Colafarina, S | 1 |
| Cattani, F | 1 |
| Cimini, A | 1 |
| Di Ilio, C | 1 |
| Ceru, MP | 1 |
| Miranda, M | 1 |
| Kuhla, B | 1 |
| Lüth, HJ | 1 |
| Haferburg, D | 1 |
| Weick, M | 1 |
| Reichenbach, A | 1 |
| Arendt, T | 1 |
| Münch, G | 2 |
| de Arriba, SG | 1 |
| Stuchbury, G | 1 |
| Yarin, J | 1 |
| Burnell, J | 1 |
| Loske, C | 1 |
18 other studies available for pyruvaldehyde and Neuroblastoma
| Article | Year |
|---|---|
The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Glutamate-Cysteine Ligase; Glutathione; Hu | 2023 |
Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells.
Topics: Energy Metabolism; Glucose; Humans; Hypoglycemic Agents; Liraglutide; Neuroblastoma; Neurodegenerati | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma | 2022 |
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval | 2023 |
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval | 2023 |
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval | 2023 |
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval | 2023 |
Methylglyoxal-induced neurotoxic effects in primary neuronal-like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations.
Topics: Animals; Glycation End Products, Advanced; Humans; Mesenchymal Stem Cells; Neuroblastoma; Neurons; N | 2023 |
Promotion of mitochondrial protection by naringenin in methylglyoxal-treated SH-SY5Y cells: Involvement of the Nrf2/GSH axis.
Topics: Antioxidants; Cell Death; Cell Line, Tumor; Flavanones; Glutathione; Humans; Mitochondria; Neuroblas | 2019 |
Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal.
Topics: Abietanes; Cell Line, Tumor; Glutathione; Humans; Hydrogen Peroxide; Malondialdehyde; Mitochondria; | 2019 |
Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells.
Topics: Abietanes; Antioxidants; Apoptosis; Cell Line, Tumor; Cytoprotection; Humans; Neuroblastoma; Neurons | 2015 |
Improved Mitochondrial and Methylglyoxal-Related Metabolisms Support Hyperproliferation Induced by 50 Hz Magnetic Field in Neuroblastoma Cells.
Topics: Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Homeostasis; Humans; Magnetic Fields; Mitoc | 2016 |
Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain.
Topics: Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; Glutathione; Humans; Neuro | 2016 |
Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway.
Topics: Cell Line, Tumor; Cell Survival; Flavanones; Humans; MAP Kinase Signaling System; Mitochondria; Neur | 2017 |
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism.
Topics: Antioxidants; Cell Line, Tumor; Glutathione; Glycation End Products, Advanced; Humans; Imidazoles; I | 2017 |
Inhibitory effect of vanillic acid on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells.
Topics: Animals; Annexin A5; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interaction | 2008 |
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Enzyme Activation; Glycation End Products, Advanced; G | 2012 |
Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury.
Topics: Apoptosis; Caspases; Catalase; Free Radical Scavengers; Glioblastoma; Glutathione Peroxidase; Glutat | 2003 |
Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.
Topics: Alzheimer Disease; Apoptosis; Brain; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Enzyme | 2006 |
Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells--protection by carbonyl scavengers.
Topics: Adenosine Triphosphate; Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; En | 2007 |
Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Chlorogenic Acid; Cytoprotection; Di | 2008 |