Page last updated: 2024-10-19

pyruvaldehyde and Neuroblastoma

pyruvaldehyde has been researched along with Neuroblastoma in 18 studies

Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" The objective of this study was to investigate the inhibitory abilities of phenolic acids (chlorogenic acid, syringic acid and vanillic acid) on methylglyoxal-induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis in the progression of diabetic neuropathy."3.74Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. ( Chuang, HC; Huang, SM; Wu, CH; Yen, GC, 2008)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (27.78)29.6817
2010's8 (44.44)24.3611
2020's5 (27.78)2.80

Authors

AuthorsStudies
Brasil, FB1
de Almeida, FJS1
Luckachaki, MD1
Dall'Oglio, EL1
de Oliveira, MR5
Qi, L1
Gao, R1
Chen, Z1
Lin, D1
Liu, Z1
Wang, L1
Lin, L1
Liu, X2
Liu, L1
Zhang, D3
Li, X3
He, X3
Xing, Y3
Jiang, B3
Xiu, Z3
Bao, Y3
Dong, Y3
Barinova, KV2
Serebryakova, MV2
Melnikova, AK2
Medvedeva, MV2
Muronetz, VI2
Schmalhausen, EV2
Coccini, T1
Schicchi, A1
Locatelli, CA1
Caloni, F1
Negri, S1
Grignani, E1
De Simone, U1
Custódio de Souza, IC1
Fürstenau, CR2
de Souza, ICC1
Ferreira, GC2
Schuck, PF1
Dal Bosco, SM1
Falone, S1
Santini, S1
di Loreto, S1
Cordone, V1
Grannonico, M1
Cesare, P1
Cacchio, M1
Amicarelli, F2
Koike, S2
Kayama, T1
Yamamoto, S1
Komine, D1
Tanaka, R1
Nishimoto, S2
Suzuki, T2
Kishida, A1
Ogasawara, Y2
Peres, A1
Inoue, N1
Huang, SM2
Hsu, CL1
Chuang, HC2
Shih, PH1
Wu, CH2
Yen, GC2
Li, XH1
Xie, JZ1
Jiang, X1
Lv, BL1
Cheng, XS1
Du, LL1
Zhang, JY1
Wang, JZ1
Zhou, XW1
Colafarina, S1
Cattani, F1
Cimini, A1
Di Ilio, C1
Ceru, MP1
Miranda, M1
Kuhla, B1
Lüth, HJ1
Haferburg, D1
Weick, M1
Reichenbach, A1
Arendt, T1
Münch, G2
de Arriba, SG1
Stuchbury, G1
Yarin, J1
Burnell, J1
Loske, C1

Other Studies

18 other studies available for pyruvaldehyde and Neuroblastoma

ArticleYear
The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Glutamate-Cysteine Ligase; Glutathione; Hu

2023
Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells.
    Neurotoxicology, 2022, Volume: 92

    Topics: Energy Metabolism; Glucose; Humans; Hypoglycemic Agents; Liraglutide; Neuroblastoma; Neurodegenerati

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
    Molecules (Basel, Switzerland), 2022, Nov-12, Volume: 27, Issue:22

    Topics: Flavonoids; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Neuroblastoma

2022
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
    Archives of biochemistry and biophysics, 2023, 01-01, Volume: 733

    Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval

2023
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
    Archives of biochemistry and biophysics, 2023, 01-01, Volume: 733

    Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval

2023
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
    Archives of biochemistry and biophysics, 2023, 01-01, Volume: 733

    Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval

2023
Mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in the presence of methylglyoxal.
    Archives of biochemistry and biophysics, 2023, 01-01, Volume: 733

    Topics: Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Magnesium Oxide; Neuroblastoma; Pyruval

2023
Methylglyoxal-induced neurotoxic effects in primary neuronal-like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:12

    Topics: Animals; Glycation End Products, Advanced; Humans; Mesenchymal Stem Cells; Neuroblastoma; Neurons; N

2023
Promotion of mitochondrial protection by naringenin in methylglyoxal-treated SH-SY5Y cells: Involvement of the Nrf2/GSH axis.
    Chemico-biological interactions, 2019, Sep-01, Volume: 310

    Topics: Antioxidants; Cell Death; Cell Line, Tumor; Flavanones; Glutathione; Humans; Mitochondria; Neuroblas

2019
Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal.
    Neurotoxicity research, 2019, Volume: 36, Issue:3

    Topics: Abietanes; Cell Line, Tumor; Glutathione; Humans; Hydrogen Peroxide; Malondialdehyde; Mitochondria;

2019
Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells.
    Chemico-biological interactions, 2015, Dec-05, Volume: 242

    Topics: Abietanes; Antioxidants; Apoptosis; Cell Line, Tumor; Cytoprotection; Humans; Neuroblastoma; Neurons

2015
Improved Mitochondrial and Methylglyoxal-Related Metabolisms Support Hyperproliferation Induced by 50 Hz Magnetic Field in Neuroblastoma Cells.
    Journal of cellular physiology, 2016, Volume: 231, Issue:9

    Topics: Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Homeostasis; Humans; Magnetic Fields; Mitoc

2016
Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain.
    Neurotoxicology, 2016, Volume: 55

    Topics: Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; Glutathione; Humans; Neuro

2016
Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway.
    Neurochemical research, 2017, Volume: 42, Issue:4

    Topics: Cell Line, Tumor; Cell Survival; Flavanones; Humans; MAP Kinase Signaling System; Mitochondria; Neur

2017
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism.
    Biochemical and biophysical research communications, 2017, 02-05, Volume: 483, Issue:2

    Topics: Antioxidants; Cell Line, Tumor; Glutathione; Glycation End Products, Advanced; Humans; Imidazoles; I

2017
Inhibitory effect of vanillic acid on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells.
    Neurotoxicology, 2008, Volume: 29, Issue:6

    Topics: Animals; Annexin A5; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interaction

2008
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
    Neuromolecular medicine, 2012, Volume: 14, Issue:4

    Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Enzyme Activation; Glycation End Products, Advanced; G

2012
Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury.
    Free radical biology & medicine, 2003, Oct-15, Volume: 35, Issue:8

    Topics: Apoptosis; Caspases; Catalase; Free Radical Scavengers; Glioblastoma; Glutathione Peroxidase; Glutat

2003
Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.
    Journal of neuroscience research, 2006, Volume: 83, Issue:8

    Topics: Alzheimer Disease; Apoptosis; Brain; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Enzyme

2006
Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells--protection by carbonyl scavengers.
    Neurobiology of aging, 2007, Volume: 28, Issue:7

    Topics: Adenosine Triphosphate; Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; En

2007
Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:8

    Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Chlorogenic Acid; Cytoprotection; Di

2008