pyruvaldehyde has been researched along with Neoplasms in 48 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression." | 2.61 | Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging. ( Armeni, T; Atlante, A; de Bari, L; Kalapos, MP, 2019) |
| "Glo-1 has a dual role in cancer as a tumour suppressor protein prior to tumour development and mediator of multi-drug resistance in cancer treatment, implicating dicarbonyl glycation of DNA in carcinogenesis and dicarbonyl-driven cytotoxicity in mechanism of action of anticancer drugs." | 2.53 | Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics. ( Rabbani, N; Thornalley, PJ; Xue, M, 2016) |
| "Moreover, a new hypothesis on cancer has been proposed, suggesting that excessive ATP formation in cells may lead to malignancy." | 2.44 | A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients. ( Das, S; Ray, M; Ray, S; Talukdar, D, 2008) |
| "In glycolytic cancer cells cultured in high glucose, we observed a significant increase of the conversion of MG to D-lactate through the glyoxalase system." | 1.46 | Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death. ( Bellahcène, A; Bellier, J; Castronovo, V; Cochrane, JR; Durieux, F; Hutton, CA; Nokin, MJ; Peulen, O; Spiegel, DA; Uchida, K, 2017) |
| "The association of glyoxidation with cancer has also been reported." | 1.43 | Circulating autoantibodies in cancer patients have high specificity for glycoxidation modified histone H2A. ( Islam, S; Mir, AR, 2016) |
| "For a long time cancer cells are known for increased uptake of glucose and its metabolization through glycolysis." | 1.43 | Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. ( Bag, AK; Chakrabarti, S; Das, MR; Das, P; Dey, SK; Ghosh, A; Jana, SS; Mandal, C; Ray, M; Ray, S; Saha, S, 2016) |
| "GLO1 is known to be overexpressed in cancer cells and causes resistance to anticancer agents." | 1.38 | Targeting the glyoxalase pathway enhances TRAIL efficacy in cancer cells by downregulating the expression of antiapoptotic molecules. ( Goda, AE; Horinaka, M; Sakai, T; Taniguchi, H; Wakada, M; Yano, K; Yasuda, S; Yoshida, T, 2012) |
| "Tumors are generally characterized by an increased glucose uptake and a high rate of glycolysis." | 1.33 | Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine. ( Hoekman, K; Niessen, HW; Schalkwijk, CG; van Heijst, JW, 2005) |
| "Cancer or neoplasia occurs, according A." | 1.29 | Force, development, and neoplasia: development from another perspective as illustrated through a study of in vitro plant development from neoplasm. ( Lieber, MM, 1996) |
| "Cancer is unable to go into the radical state." | 1.26 | The living state and cancer. ( Szent-Györgyi, A, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (22.92) | 18.7374 |
| 1990's | 11 (22.92) | 18.2507 |
| 2000's | 5 (10.42) | 29.6817 |
| 2010's | 16 (33.33) | 24.3611 |
| 2020's | 5 (10.42) | 2.80 |
| Authors | Studies |
|---|---|
| Sruthi, CR | 1 |
| Raghu, KG | 1 |
| Liu, J | 1 |
| Li, M | 1 |
| Dang, Y | 1 |
| Lou, H | 1 |
| Xu, Z | 1 |
| Zhang, W | 1 |
| Schalkwijk, CG | 3 |
| Stehouwer, CDA | 1 |
| Khanam, A | 1 |
| Ahmad, S | 2 |
| Husain, A | 1 |
| Rehman, S | 1 |
| Farooqui, A | 1 |
| Yusuf, MA | 1 |
| He, Y | 1 |
| Zhou, C | 1 |
| Huang, M | 1 |
| Tang, C | 1 |
| Liu, X | 1 |
| Yue, Y | 1 |
| Diao, Q | 1 |
| Zheng, Z | 1 |
| Liu, D | 1 |
| Rabbani, N | 2 |
| Xue, M | 2 |
| Weickert, MO | 1 |
| Thornalley, PJ | 6 |
| Nokin, MJ | 2 |
| Durieux, F | 1 |
| Bellier, J | 2 |
| Peulen, O | 2 |
| Uchida, K | 1 |
| Spiegel, DA | 1 |
| Cochrane, JR | 1 |
| Hutton, CA | 1 |
| Castronovo, V | 2 |
| Bellahcène, A | 2 |
| Lardé, E | 1 |
| Karoyan, P | 1 |
| de Bari, L | 1 |
| Atlante, A | 1 |
| Armeni, T | 1 |
| Kalapos, MP | 3 |
| Garrido, D | 1 |
| Rubin, T | 1 |
| Poidevin, M | 1 |
| Maroni, B | 1 |
| Le Rouzic, A | 1 |
| Parvy, JP | 1 |
| Montagne, J | 1 |
| Maessen, DE | 1 |
| Stehouwer, CD | 1 |
| Mir, AR | 3 |
| Uddin, M | 1 |
| Khan, F | 1 |
| Alam, K | 1 |
| Ali, A | 1 |
| Islam, S | 1 |
| Lin, JA | 1 |
| Wu, CH | 1 |
| Lu, CC | 1 |
| Hsia, SM | 1 |
| Yen, GC | 1 |
| Das, MR | 1 |
| Bag, AK | 1 |
| Saha, S | 1 |
| Ghosh, A | 2 |
| Dey, SK | 1 |
| Das, P | 1 |
| Mandal, C | 1 |
| Ray, S | 6 |
| Chakrabarti, S | 1 |
| Ray, M | 6 |
| Jana, SS | 1 |
| Habib, S | 1 |
| Reztsova, VV | 1 |
| Kovalenko, IG | 1 |
| Bershteĭn, LM | 1 |
| Talukdar, D | 1 |
| Das, S | 1 |
| Titov, VN | 1 |
| Dmitriev, LF | 1 |
| Krylin, VA | 1 |
| Dmitriev, VA | 1 |
| Ahmad, MI | 1 |
| Bera, S | 1 |
| Ghosal, S | 1 |
| Basu, A | 1 |
| Taniguchi, H | 1 |
| Horinaka, M | 1 |
| Yoshida, T | 1 |
| Yano, K | 1 |
| Goda, AE | 1 |
| Yasuda, S | 1 |
| Wakada, M | 1 |
| Sakai, T | 1 |
| Aleksandrovski, YA | 1 |
| LEWIS, KF | 1 |
| MAJANE, EH | 1 |
| WEINHOUSE, S | 1 |
| MIHICH, E | 1 |
| BAIOCCHI, F | 1 |
| CHENG, CC | 2 |
| HAGGERTY, WJ | 1 |
| LEWIS, LR | 1 |
| LIAO, TK | 1 |
| NYBERG, WH | 2 |
| O'BRIEN, DE | 1 |
| PODREBARAC, EG | 2 |
| FRENCH, FA | 1 |
| van Heijst, JW | 1 |
| Niessen, HW | 1 |
| Hoekman, K | 1 |
| Szent-Györgyi, A | 3 |
| Winter, R | 1 |
| Piskorska, D | 1 |
| Ranganathan, S | 1 |
| Walsh, ES | 1 |
| Tew, KD | 1 |
| Lieber, MM | 1 |
| Basu, N | 1 |
| Thomson, C | 1 |
| Ball, JR | 1 |
| Holden, C | 1 |
| Egyud, LG | 1 |
| Lipinski, B | 1 |
| Halder, J | 1 |
| Dutta, SK | 1 |
| Furihata, C | 1 |
| Matsushima, T | 1 |
21 reviews available for pyruvaldehyde and Neoplasms
| Article | Year |
|---|---|
Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Lactoylglutathione Lyase; Neopl | 2020 |
Glycation and Antioxidants: Hand in the Glove of Antiglycation and Natural Antioxidants.
Topics: Antigens, Neoplasm; Antioxidants; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus, Type 2; | 2020 |
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators.
Topics: Animals; Biological Products; Cardiovascular Diseases; Drug Evaluation, Preclinical; Enzyme Inhibito | 2020 |
Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Death; Drug Resistance, Neoplasm; Glycosylat | 2018 |
Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.
Topics: Animals; Diabetes Complications; Glycation End Products, Advanced; Humans; Hyperglycemia; Meta-Analy | 2019 |
Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging.
Topics: Aging, Premature; Alzheimer Disease; Animals; Energy Metabolism; Glutathione; Glycolysis; Humans; La | 2019 |
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Angiopathies; D | 2015 |
Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression.
Topics: Biological Factors; Glycation End Products, Advanced; Glycosylation; Neoplasms; Oxidation-Reduction; | 2016 |
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.
Topics: Aging; Animals; Dyslipidemias; Glycation End Products, Advanced; Humans; Lactoylglutathione Lyase; N | 2016 |
[Role of methyl glyoxal and glyoxalase in diabetes and tumor growth].
Topics: Adenylate Kinase; Diabetes Mellitus; Humans; Lactoylglutathione Lyase; Neoplasms; Nitric Oxide Synth | 2008 |
Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research.
Topics: Animals; Antineoplastic Agents; Biochemistry; Evolution, Molecular; Glycolysis; History, 19th Centur | 2008 |
A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Clinical Trials as Topic; Diabetes Complica | 2008 |
Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects.
Topics: Animals; Cell Division; Diabetes Mellitus; Humans; Hyperglycemia; Neoplasms; Neutrophils; Protein Ki | 2002 |
CURRENT STUDIES WITH METHYLGLYOXAL-BIS(GUANYLHYDRAZONE).
Topics: Antineoplastic Agents; Hypoglycemia; Leukemia; Liver Glycogen; Neoplasms; Pharmacology; Pyruvaldehyd | 1963 |
[Glyoxalases in normal and neoplastic tissues (author's transl)].
Topics: Cell Division; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Humans; Lactoylglutat | 1980 |
Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced glyca
Topics: Animals; Antineoplastic Agents; Endocytosis; Esters; Glutathione; Glycation End Products, Advanced; | 1995 |
[Submolecular theory of cancer. In memoriam Albert Szent-Györgyi].
Topics: Animals; Antineoplastic Agents; Cell Division; Electron Spin Resonance Spectroscopy; History, 20th C | 1993 |
The glyoxalase system in health and disease.
Topics: Amino Acid Sequence; Antineoplastic Agents; Bacterial Infections; Catalysis; Diabetes Mellitus; Glut | 1993 |
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.
Topics: Animals; Antineoplastic Agents; Biotransformation; Humans; Neoplasms; Nucleic Acids; Proteins; Pyruv | 1996 |
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
Topics: Animals; Cell Division; Diabetes Mellitus; Glutathione; Humans; Lactoylglutathione Lyase; Lyases; Ne | 1990 |
Mutagens and carcinogens in foods.
Topics: Amines; Amino Acids; Animals; Carbohydrate Metabolism; Carcinogens; Chemical Phenomena; Chemistry; C | 1986 |
27 other studies available for pyruvaldehyde and Neoplasms
| Article | Year |
|---|---|
Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation.
Topics: Glucose; Glycation End Products, Advanced; Hep G2 Cells; Humans; Magnesium Oxide; Neoplasms; Pyruval | 2022 |
NIR-I fluorescence imaging tumorous methylglyoxal by an activatable nanoprobe based on peptide nanotubes by FRET process.
Topics: Biosensing Techniques; Fluorescence Resonance Energy Transfer; Humans; Nanotubes, Peptide; Neoplasms | 2022 |
Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death.
Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Glycation End Products, Advanced; Glycolysis; Horm | 2017 |
Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.
Topics: Animals; Diabetes Mellitus, Type 2; Dietary Sucrose; Drosophila; Fatty Acid Synthase, Type I; Glycat | 2015 |
Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer.
Topics: Animals; Autoimmunity; Cattle; Histones; Humans; Neoplasms; Protein Conformation; Pyruvaldehyde; Rab | 2015 |
Circulating autoantibodies in cancer patients have high specificity for glycoxidation modified histone H2A.
Topics: Adult; Animals; Antibody Specificity; Autoantibodies; Cattle; Female; Glycation End Products, Advanc | 2016 |
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Disease Models, Animal; Enzyme Activation; Gene Expression; Gluco | 2016 |
Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of oesophagus, stomach, gall bladder and ovary.
Topics: Adult; Animals; Cross Reactions; Epitopes; Esophageal Neoplasms; Female; Gallbladder Neoplasms; Hist | 2017 |
[Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)].
Topics: Animals; Cytosol; Diabetes Mellitus; Diabetic Ketoacidosis; Energy Metabolism; Fatty Acids; Gluconeo | 2010 |
Preferential recognition of methylglyoxal-modified calf thymus DNA by circulating antibodies in cancer patients.
Topics: Animals; Autoantibodies; Cattle; DNA; Electrophoresis, Agar Gel; Enzyme-Linked Immunosorbent Assay; | 2011 |
Differential inhibition/inactivation of mitochondrial complex I implicates its alteration in malignant cells.
Topics: Adult; Aged; Aldehydes; Animals; Down-Regulation; Electron Transport Complex I; Female; Humans; Male | 2011 |
Targeting the glyoxalase pathway enhances TRAIL efficacy in cancer cells by downregulating the expression of antiapoptotic molecules.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Down-Regulation; Drug Screenin | 2012 |
Metabolism of neoplastic tissue. XIV. Methylglyoxal formation during glucose catabolism in tumors.
Topics: Aldehydes; Encephalomyelitis; Glucose; Neoplasms; Pyruvaldehyde | 1959 |
STUDIES ON METHYLGLYOXAL BIS(GUANYLHYDRAZONE) ANALOGS. II. STRUCTURAL VARIATIONS ON METHYLGLYOXAL BIS(GUANYLHYDRAZONE).
Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Guanidine; Guanidines; Mitoguazone; Neoplasms; Neo | 1963 |
STUDIES ON METHYLGLYOXAL BIS(GUANYLHYDRAZONE) ANALOGS. I. HOMOLOGS OF METHYLGLYOXAL BIS(GUANYLHYDRAZONE).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Guanidines; Hydrazines; L | 1963 |
Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine.
Topics: Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycolysis; Humans; Lysine; Neo | 2005 |
The living state and cancer.
Topics: Aldehydes; Ascorbic Acid; Biological Evolution; Chemical Phenomena; Chemistry; Electric Conductivity | 1980 |
Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; DNA, Complementary; Humans; Inactivation, Metabolic; Lact | 1995 |
Force, development, and neoplasia: development from another perspective as illustrated through a study of in vitro plant development from neoplasm.
Topics: Adaptation, Physiological; Animals; Ascorbic Acid; Biological Evolution; Culture Media; Culture Tech | 1996 |
Does excessive adenosine 5'-triphosphate formation in cells lead to malignancy? A hypothesis on cancer.
Topics: Adenosine Triphosphate; Animals; Cell Respiration; Cell Transformation, Neoplastic; Energy Metabolis | 1997 |
Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal.
Topics: Carcinoma, Squamous Cell; Enzyme Activation; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Huma | 1997 |
Quantum chemical investigations of charge-transfer interactions in relation to the electronic theory of cancer.
Topics: Animals; Ascorbic Acid; Diacetyl; Electron Transport; Energy Transfer; Formamides; Humans; Molecular | 1978 |
The living state and cancer.
Topics: Animals; Ascorbic Acid; Biological Evolution; Electrons; Free Radicals; Humans; Molecular Biology; N | 1978 |
The living state and cancer.
Topics: Aldehydes; Caseins; Cell Division; Chemical Phenomena; Chemistry; Chemistry, Physical; Free Radicals | 1977 |
Albert-Szent-Györgyi, electrons, and cancer.
Topics: Animals; Cell Division; Electrons; Electrophysiology; Free Radicals; History, 20th Century; Humans; | 1979 |
Significance of fibrin formation and dissolution in the pathogenesis and treatment of cancer.
Topics: Arginine; Fibrin; Fibrinolysis; Humans; Models, Biological; Neoplasms; Pyruvaldehyde; Sulfhydryl Com | 1991 |
Inhibition of respiration of tumor cells by methylglyoxal and protection of inhibition by lactaldehyde.
Topics: Aldehydes; Animals; Ascorbic Acid; Carcinoma, Ehrlich Tumor; Cell Survival; Female; Humans; In Vitro | 1991 |