pyruvaldehyde has been researched along with Innate Inflammatory Response in 59 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the activity of apigenin (API), a natural flavone in scavenging RCS and the molecular mechanism involved in its protective effect against AGEs-induced oxidative stress and inflammation were examined in vitro." | 7.91 | Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells. ( Cheng, KW; Gong, J; Li, ETS; Wang, M; Zhou, Q, 2019) |
| " In the present study, we found that consumption of MG significantly deteriorated azoxymethane (AOM)-induced colonic preneoplastic lesions in ICR mice, in which biomarkers of oxidative stress and inflammation within the body and feces induced by MG-fueled carbonyl stress may have played important roles." | 7.88 | Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts. ( Lin, JA; Wu, CH; Yen, GC, 2018) |
| "To test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse." | 7.88 | Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. ( Dhananjayan, K; Gunawardena, D; Gyengesi, E; Liang, H; Millington, C; Münch, G; Niedermayer, G; Sirijovski, D; Sonego, S; Venigalla, M, 2018) |
| "The pathogenesis of coronavirus disease 2019 (COVID-19) is associated with a hyperinflammatory response." | 5.91 | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells. ( Antognelli, C; Bozza, S; Costantini, C; Graziani, A; Manfredelli, D; Pariano, M; Puccetti, P; Romani, L; Talesa, VN, 2023) |
| "Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score." | 5.72 | Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study. ( Berendschot, TTJM; Dagnelie, PC; Eussen, SJPM; Houben, AJHM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Schram, MT; Stehouwer, CDA; van Greevenbroek, MMJ; Webers, CAB, 2022) |
| "The phloretin-MGO adducts were analyzed in PBS and HUVECs." | 5.51 | Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells. ( Gong, J; Wang, M; Zhou, Q, 2019) |
| "Vescalagin (VES) is an ellagitannin that alleviates insulin resistance in cell study." | 5.39 | Protective effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats. ( Chang, WC; Shen, SC; Wu, JS, 2013) |
| " In this study, the activity of apigenin (API), a natural flavone in scavenging RCS and the molecular mechanism involved in its protective effect against AGEs-induced oxidative stress and inflammation were examined in vitro." | 3.91 | Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells. ( Cheng, KW; Gong, J; Li, ETS; Wang, M; Zhou, Q, 2019) |
| " In the present study, we found that consumption of MG significantly deteriorated azoxymethane (AOM)-induced colonic preneoplastic lesions in ICR mice, in which biomarkers of oxidative stress and inflammation within the body and feces induced by MG-fueled carbonyl stress may have played important roles." | 3.88 | Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts. ( Lin, JA; Wu, CH; Yen, GC, 2018) |
| "To test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse." | 3.88 | Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. ( Dhananjayan, K; Gunawardena, D; Gyengesi, E; Liang, H; Millington, C; Münch, G; Niedermayer, G; Sirijovski, D; Sonego, S; Venigalla, M, 2018) |
| "This study demonstrates that mangiferin can markedly ameliorate diabetes-associated cognitive decline in rats, which is done likely through suppressing methylglyoxal hyperactivity (promoting protein glycation, oxidative stress, and inflammation) mediated noxious effects." | 3.79 | Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. ( Li, HP; Liu, YW; Lu, Q; Wang, JY; Wei, YQ; Yang, QQ; Yin, JL; Yin, XX; Zhu, X, 2013) |
| "We examined 172 young (<45 years old) and older (>60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N(epsilon)-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation." | 3.74 | Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. ( Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H, 2007) |
| "Hypoxia and inflammation have been shown to drive the rapid intracellular accumulation of reactive dicarbonyls, i." | 2.55 | Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness. ( Bergmans, DC; Schalkwijk, CG; van Bussel, BC; van de Poll, MC, 2017) |
| "A role for inflammation is thought to be integral to the pathology." | 2.50 | Possible role of methylglyoxal and glyoxalase in arthritis. ( Ahmed, U; Rabbani, N; Thornalley, PJ, 2014) |
| "Atherosclerosis is a major global cause of morbidity and mortality, and diabetes patients are at increased risk of coronary heart disease development." | 2.44 | Advanced glycation: a novel outlook on atherosclerosis. ( Knight, SC; Price, CL, 2007) |
| "The pathogenesis of coronavirus disease 2019 (COVID-19) is associated with a hyperinflammatory response." | 1.91 | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells. ( Antognelli, C; Bozza, S; Costantini, C; Graziani, A; Manfredelli, D; Pariano, M; Puccetti, P; Romani, L; Talesa, VN, 2023) |
| "Uremic sarcopenia is a serious clinical problem associated with physical disability and increased morbidity and mortality." | 1.72 | Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells. ( Hosoda, Y; Miyazaki, M; Mori, T; Sato, E; Sato, H; Sekimoto, A; Takahashi, N; Todoriki, S; Watanabe, M; Yamamoto, T, 2022) |
| "Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score." | 1.72 | Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study. ( Berendschot, TTJM; Dagnelie, PC; Eussen, SJPM; Houben, AJHM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Schram, MT; Stehouwer, CDA; van Greevenbroek, MMJ; Webers, CAB, 2022) |
| "Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure." | 1.62 | Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021) |
| "Morin is a common plant-produced flavonoid polyphenol that exhibits the ability to enhance the GP-mediated detoxification of MG." | 1.56 | Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. ( Choi, SR; Frandsen, J; Narayanasamy, P, 2020) |
| "The phloretin-MGO adducts were analyzed in PBS and HUVECs." | 1.51 | Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells. ( Gong, J; Wang, M; Zhou, Q, 2019) |
| " As assessed by the ratio of L-arginine/asymmetric dimethylarginine, the bioavailability of nitric oxide was shown to be reduced in hepatic IRI, especially in those patients suffering from perfusion disorders following liver transplantation." | 1.39 | Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation. ( Brenner, T; Bruckner, T; Fleming, TH; Hofer, S; Martin, EO; Schemmer, P; Spranz, D; Uhle, F; Weigand, MA, 2013) |
| "Vescalagin (VES) is an ellagitannin that alleviates insulin resistance in cell study." | 1.39 | Protective effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats. ( Chang, WC; Shen, SC; Wu, JS, 2013) |
| "Candesartan treatment for 4 weeks significantly reduced these parameters." | 1.39 | Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. ( Chen, X; Endo, S; Guo, Q; Hu, C; Ito, S; Jiang, Y; Miyata, T; Mori, T; Nakayama, K; Nakayama, M; Ogawa, S; Ohsaki, Y; Yoneki, Y; Zhu, W, 2013) |
| " NO bioavailability was significantly attenuated and accompanied by an increase in superoxide anion immunofluorescence." | 1.38 | Methylglyoxal promotes oxidative stress and endothelial dysfunction. ( Crisóstomo, J; Fernandes, R; Matafome, P; Pereira, P; Rodrigues, L; Seiça, RM; Sena, CM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (6.78) | 29.6817 |
| 2010's | 33 (55.93) | 24.3611 |
| 2020's | 22 (37.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pucci, M | 1 |
| Aria, F | 1 |
| Premoli, M | 1 |
| Maccarinelli, G | 1 |
| Mastinu, A | 1 |
| Bonini, S | 1 |
| Memo, M | 1 |
| Uberti, D | 1 |
| Abate, G | 1 |
| Wang, G | 1 |
| Wang, Y | 1 |
| Yang, Q | 1 |
| Xu, C | 1 |
| Zheng, Y | 1 |
| Wang, L | 1 |
| Wu, J | 1 |
| Zeng, M | 1 |
| Luo, M | 1 |
| Francisco, FA | 1 |
| Saavedra, LPJ | 1 |
| Ferreira-Junior, MD | 1 |
| Cavalcante, KVN | 1 |
| Moreira, VM | 1 |
| Prates, KV | 1 |
| Borges, SC | 1 |
| Buttow, NC | 1 |
| Ribeiro, TA | 1 |
| Pedrino, GR | 1 |
| Xavier, CH | 1 |
| Matafome, P | 3 |
| de Freitas Mathias, PC | 1 |
| Gomes, RM | 1 |
| Todoriki, S | 1 |
| Hosoda, Y | 1 |
| Yamamoto, T | 1 |
| Watanabe, M | 1 |
| Sekimoto, A | 1 |
| Sato, H | 1 |
| Mori, T | 2 |
| Miyazaki, M | 1 |
| Takahashi, N | 1 |
| Sato, E | 1 |
| Maasen, K | 1 |
| Eussen, SJPM | 1 |
| Dagnelie, PC | 1 |
| Houben, AJHM | 1 |
| Webers, CAB | 1 |
| Schram, MT | 1 |
| Berendschot, TTJM | 1 |
| Stehouwer, CDA | 4 |
| Opperhuizen, A | 1 |
| van Greevenbroek, MMJ | 1 |
| Schalkwijk, CG | 7 |
| Lim, JM | 1 |
| Yoo, HJ | 1 |
| Lee, KW | 1 |
| Di Martino, D | 1 |
| Cappelletti, M | 1 |
| Tondo, M | 1 |
| Basello, K | 1 |
| Garbin, C | 1 |
| Speciani, A | 1 |
| Ferrazzi, E | 1 |
| Piazza, M | 3 |
| Hanssen, NMJ | 3 |
| Scheijen, JLJM | 5 |
| Vd Waarenburg, M | 3 |
| Caroccia, B | 3 |
| Seccia, TM | 3 |
| Rossi, GP | 3 |
| de Graaf, MCG | 1 |
| Spooren, CEGM | 1 |
| Mujagic, Z | 1 |
| Pierik, MJ | 1 |
| Feskens, EJM | 1 |
| Keszthelyi, D | 1 |
| Jonkers, DMAE | 1 |
| Medeiros, ML | 1 |
| Oliveira, AL | 1 |
| Mello, GC | 1 |
| Antunes, E | 1 |
| Manfredelli, D | 1 |
| Pariano, M | 1 |
| Costantini, C | 1 |
| Graziani, A | 1 |
| Bozza, S | 1 |
| Romani, L | 1 |
| Puccetti, P | 1 |
| Talesa, VN | 1 |
| Antognelli, C | 1 |
| Frandsen, J | 1 |
| Choi, SR | 1 |
| Narayanasamy, P | 1 |
| Chen, SM | 1 |
| Lin, CE | 1 |
| Chen, HH | 1 |
| Cheng, YF | 1 |
| Cheng, HW | 1 |
| Imai, K | 1 |
| Becker, AK | 1 |
| Auditore, A | 1 |
| Pischetsrieder, M | 1 |
| Messlinger, K | 1 |
| Fleming, T | 1 |
| Reeh, PW | 1 |
| Sauer, SK | 1 |
| Nomiyama, T | 1 |
| Prantner, D | 1 |
| Nallar, S | 1 |
| Richard, K | 1 |
| Spiegel, D | 1 |
| Collins, KD | 1 |
| Vogel, SN | 1 |
| Fujita, Y | 1 |
| Murakami, T | 1 |
| Nakamura, A | 1 |
| Kim, D | 1 |
| Cheon, J | 1 |
| Yoon, H | 1 |
| Jun, HS | 1 |
| Lee, HW | 1 |
| Gu, MJ | 1 |
| Lee, JY | 1 |
| Lee, S | 1 |
| Kim, Y | 1 |
| Ha, SK | 1 |
| Parwani, K | 1 |
| Patel, F | 1 |
| Patel, D | 1 |
| Mandal, P | 1 |
| Driessen, RGH | 1 |
| Kiers, D | 1 |
| Gerretsen, J | 1 |
| Pickkers, P | 1 |
| van de Poll, MCG | 1 |
| van der Horst, ICC | 1 |
| Bergmans, DCJJ | 1 |
| Kox, M | 1 |
| van Bussel, BCT | 1 |
| Rabbani, N | 3 |
| Xue, M | 1 |
| Weickert, MO | 1 |
| Thornalley, PJ | 3 |
| Dafre, AL | 1 |
| Schmitz, AE | 1 |
| Maher, P | 1 |
| Ishibashi, Y | 1 |
| Matsui, T | 3 |
| Nakamura, N | 1 |
| Sotokawauchi, A | 1 |
| Higashimoto, Y | 1 |
| Yamagishi, SI | 2 |
| Lin, JA | 1 |
| Wu, CH | 1 |
| Yen, GC | 1 |
| Gyengesi, E | 1 |
| Liang, H | 1 |
| Millington, C | 1 |
| Sonego, S | 1 |
| Sirijovski, D | 1 |
| Gunawardena, D | 1 |
| Dhananjayan, K | 1 |
| Venigalla, M | 1 |
| Niedermayer, G | 1 |
| Münch, G | 1 |
| Settem, RP | 1 |
| Honma, K | 1 |
| Shankar, M | 1 |
| Li, M | 1 |
| LaMonte, M | 1 |
| Xu, D | 1 |
| Genco, RJ | 1 |
| Browne, RW | 1 |
| Sharma, A | 1 |
| Tahara, N | 1 |
| Kojima, R | 1 |
| Yoshida, R | 1 |
| Bekki, M | 1 |
| Sugiyama, Y | 1 |
| Tahara, A | 1 |
| Maeda, S | 1 |
| Honda, A | 1 |
| Igata, S | 1 |
| Nakamura, T | 1 |
| Sun, J | 1 |
| Fukumoto, Y | 1 |
| Zhou, Q | 2 |
| Gong, J | 2 |
| Wang, M | 3 |
| Cheng, KW | 1 |
| Li, ETS | 1 |
| Hajizadeh-Sharafabad, F | 1 |
| Sahebkar, A | 1 |
| Zabetian-Targhi, F | 1 |
| Maleki, V | 1 |
| Bezold, V | 1 |
| Rosenstock, P | 1 |
| Scheffler, J | 1 |
| Geyer, H | 1 |
| Horstkorte, R | 1 |
| Bork, K | 1 |
| Lee, BH | 1 |
| Hsu, WH | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Liu, YW | 1 |
| Zhu, X | 1 |
| Yang, QQ | 1 |
| Lu, Q | 1 |
| Wang, JY | 1 |
| Li, HP | 1 |
| Wei, YQ | 1 |
| Yin, JL | 1 |
| Yin, XX | 1 |
| Brenner, T | 1 |
| Fleming, TH | 1 |
| Spranz, D | 1 |
| Schemmer, P | 1 |
| Bruckner, T | 1 |
| Uhle, F | 1 |
| Martin, EO | 1 |
| Weigand, MA | 1 |
| Hofer, S | 1 |
| Chang, WC | 2 |
| Shen, SC | 1 |
| Wu, JS | 1 |
| Ahmed, U | 1 |
| Cheng, AS | 1 |
| Cheng, YH | 1 |
| Lee, CY | 1 |
| Chung, CY | 1 |
| Sun, YP | 1 |
| Gu, JF | 1 |
| Tan, XB | 1 |
| Wang, CF | 1 |
| Jia, XB | 1 |
| Feng, L | 1 |
| Liu, JP | 1 |
| Chu, JM | 1 |
| Lee, DK | 1 |
| Wong, DP | 1 |
| Wong, GT | 1 |
| Yue, KK | 1 |
| Alomar, F | 1 |
| Singh, J | 1 |
| Jang, HS | 1 |
| Rozanzki, GJ | 1 |
| Shao, CH | 1 |
| Padanilam, BJ | 1 |
| Mayhan, WG | 1 |
| Bidasee, KR | 1 |
| van Bussel, BC | 1 |
| van de Poll, MC | 1 |
| Bergmans, DC | 1 |
| Hollenbach, M | 1 |
| Thonig, A | 1 |
| Pohl, S | 1 |
| Ripoll, C | 1 |
| Michel, M | 1 |
| Zipprich, A | 1 |
| Yamawaki, H | 1 |
| Saito, K | 1 |
| Okada, M | 1 |
| Hara, Y | 1 |
| Kuntz, S | 1 |
| Rudloff, S | 1 |
| Ehl, J | 1 |
| Bretzel, RG | 1 |
| Kunz, C | 1 |
| Nobécourt, E | 1 |
| Tabet, F | 1 |
| Lambert, G | 1 |
| Puranik, R | 1 |
| Bao, S | 1 |
| Yan, L | 1 |
| Davies, MJ | 1 |
| Brown, BE | 1 |
| Jenkins, AJ | 1 |
| Dusting, GJ | 1 |
| Bonnet, DJ | 1 |
| Curtiss, LK | 1 |
| Barter, PJ | 1 |
| Rye, KA | 1 |
| Lu, J | 1 |
| Randell, E | 1 |
| Han, Y | 1 |
| Adeli, K | 1 |
| Krahn, J | 1 |
| Meng, QH | 1 |
| Kuhla, A | 1 |
| Trieglaff, C | 1 |
| Vollmar, B | 1 |
| Zhao, Y | 1 |
| Banerjee, S | 1 |
| LeJeune, WS | 1 |
| Choudhary, S | 1 |
| Tilton, RG | 1 |
| Kitamura, M | 1 |
| Nishino, T | 1 |
| Obata, Y | 1 |
| Furusu, A | 1 |
| Hishikawa, Y | 1 |
| Koji, T | 1 |
| Kohno, S | 1 |
| Santos-Silva, D | 1 |
| Crisóstomo, J | 2 |
| Rodrigues, T | 1 |
| Rodrigues, L | 2 |
| Sena, CM | 2 |
| Pereira, P | 2 |
| Seiça, R | 1 |
| Fernandes, R | 1 |
| Seiça, RM | 1 |
| Dmitriev, VA | 2 |
| Oshchepkova, EV | 1 |
| Titov, VN | 2 |
| Balakhonova, TV | 2 |
| Tripoten', MI | 2 |
| Rogoza, AN | 1 |
| Shiriaeva, IuK | 2 |
| Oshchepkov, EV | 1 |
| Chen, NK | 1 |
| Chong, TW | 1 |
| Loh, HL | 1 |
| Lim, KH | 1 |
| Gan, VH | 1 |
| Kon, OL | 1 |
| Chen, X | 1 |
| Guo, Q | 1 |
| Hu, C | 1 |
| Ohsaki, Y | 1 |
| Yoneki, Y | 1 |
| Zhu, W | 1 |
| Jiang, Y | 1 |
| Endo, S | 1 |
| Nakayama, K | 1 |
| Ogawa, S | 1 |
| Nakayama, M | 1 |
| Miyata, T | 1 |
| Ito, S | 1 |
| Uribarri, J | 1 |
| Cai, W | 1 |
| Peppa, M | 1 |
| Goodman, S | 1 |
| Ferrucci, L | 1 |
| Striker, G | 1 |
| Vlassara, H | 1 |
| Price, CL | 1 |
| Knight, SC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy[NCT00967629] | Phase 1 | 20 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | m/s (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 7.9 | 8.0 |
| Placebo | 8.3 | 8.5 |
A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | mM h (Mean) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 10.8 | 9.9 |
| Placebo | 11.0 | 10.6 |
After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | number of capillaries per mm2 (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 115 | 125 |
| Placebo | 119 | 128 |
Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | percentage of baseline value (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 0.17 | 0.12 |
| Placebo | 0.18 | 0.26 |
6 reviews available for pyruvaldehyde and Innate Inflammatory Response
| Article | Year |
|---|---|
Recent Advances in Biomarkers and Regenerative Medicine for Diabetic Neuropathy.
Topics: Animals; Biomarkers; Cytokines; Diabetic Neuropathies; Exosomes; Glyoxal; Humans; Inflammation; Lact | 2021 |
The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review.
Topics: Animals; Antigens, Neoplasm; Antioxidants; Atherosclerosis; Diabetes Mellitus, Experimental; Gene Ex | 2019 |
Possible role of methylglyoxal and glyoxalase in arthritis.
Topics: Animals; Arthritis, Rheumatoid; Humans; Inflammation; Lactoylglutathione Lyase; Osteoarthritis; Pyru | 2014 |
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
Topics: Aging; Aldehydes; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Glyoxal; Humans; Inflamm | 2015 |
Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness.
Topics: Biomarkers; Comorbidity; Critical Care; Critical Illness; Deoxyglucose; Glyoxal; Humans; Hypoxia; In | 2017 |
Advanced glycation: a novel outlook on atherosclerosis.
Topics: Animals; Atherosclerosis; Bacterial Infections; Cysteine Endopeptidases; Dendritic Cells; Diabetes C | 2007 |
2 trials available for pyruvaldehyde and Innate Inflammatory Response
| Article | Year |
|---|---|
Reversal of Insulin Resistance in Overweight and Obese Subjects by
Topics: Adult; Blood Pressure; Body Mass Index; Carrier Proteins; Correlation of Data; Cross-Over Studies; D | 2021 |
Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine.
Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Gly | 2019 |
51 other studies available for pyruvaldehyde and Innate Inflammatory Response
| Article | Year |
|---|---|
Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Catalase; Cognition; Cytokines; Diet; Female; Glycation En | 2021 |
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Topics: Animals; Apoptosis; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; | 2022 |
Early postnatal exposure of rat pups to methylglyoxal induces oxidative stress, inflammation and dysmetabolism at adulthood.
Topics: Animals; Female; Fibrosis; Inflammation; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Wistar | 2022 |
Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells.
Topics: Adenosine Triphosphate; Animals; Female; Humans; Indican; Inflammation; Male; Mice; Muscular Atrophy | 2022 |
Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Female; Glycation End Pr | 2022 |
High Molecular Weight Fucoidan Restores Intestinal Integrity by Regulating Inflammation and Tight Junction Loss Induced by Methylglyoxal-Derived Hydroimidazolone-1.
Topics: Animals; Caco-2 Cells; Claudin-1; Fluoresceins; Humans; Imidazoles; Inflammation; Intestinal Mucosa; | 2022 |
Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes.
Topics: COVID-19; Female; Glucose; Glycosylation; Humans; Infant, Newborn; Inflammation; Obesity; Overweight | 2022 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.
Topics: Adenoma; Aldosterone; Angiotensin II; Autoantibodies; Chromatography, Liquid; Glycation End Products | 2023 |
The Intake of Dicarbonyls and Advanced Glycation Endproducts as Part of the Habitual Diet Is Not Associated with Intestinal Inflammation in Inflammatory Bowel Disease and Irritable Bowel Syndrome Patients.
Topics: Diet; Glycation End Products, Advanced; Humans; Inflammation; Inflammatory Bowel Diseases; Irritable | 2022 |
Metformin Counteracts the Deleterious Effects of Methylglyoxal on Ovalbumin-Induced Airway Eosinophilic Inflammation and Remodeling.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Lung | 2023 |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells.
Topics: Angiotensin-Converting Enzyme 2; COVID-19; Glycation End Products, Advanced; Humans; Inflammation; P | 2023 |
Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model.
Topics: Alzheimer Disease; Animals; Antioxidants; Flavonoids; Inflammation; Lactoylglutathione Lyase; Mice, | 2020 |
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Topics: Animals; Aristolochic Acids; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; F | 2020 |
Reactive dicarbonyl compounds cause Calcitonin Gene-Related Peptide release and synergize with inflammatory conditions in mouse skin and peritoneum.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Deoxyglucose; Drug Interactions; Inflammation; | 2020 |
Can SGLT2 Inhibitor be Used for Diabetes Mellitus or Vascular Diseases?
Topics: Animals; Atherosclerosis; Blood Glucose; Canagliflozin; Clinical Trials as Topic; Diabetes Mellitus; | 2020 |
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response.
Topics: Aerobiosis; Animals; Cell Death; Cell Polarity; Cells, Cultured; Female; Glycolysis; Guanidines; Inf | 2021 |
Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells.
Topics: Cell Line; Humans; Inflammation; Kidney; Kidney Tubules, Proximal; Moraceae; NADPH Oxidase 4; Oxidat | 2021 |
Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells.
Topics: Animals; Cell Line; Glycation End Products, Advanced; Inflammation; Lysine; Mesangial Cells; Mice; M | 2021 |
Protective Effects of Swertiamarin against Methylglyoxal-Induced Epithelial-Mesenchymal Transition by Improving Oxidative Stress in Rat Kidney Epithelial (NRK-52E) Cells.
Topics: Animals; Cattle; Cell Shape; Cell Survival; Chromatography, High Pressure Liquid; Endoplasmic Reticu | 2021 |
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Topics: Adolescent; Adult; Biomarkers; Down-Regulation; Endotoxemia; Healthy Volunteers; Humans; Hypoxia; In | 2021 |
Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells.
Topics: Acetyl-CoA Carboxylase; Alzheimer Disease; AMP-Activated Protein Kinase Kinases; Animals; Autophagy; | 2017 |
Methylglyoxal-derived hydroimidazolone-1 evokes inflammatory reactions in endothelial cells via an interaction with receptor for advanced glycation end products.
Topics: Cell Adhesion; Cell Line; Glycation End Products, Advanced; Human Umbilical Vein Endothelial Cells; | 2017 |
Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Line; Cholesterol, LDL; Colorectal Neoplasm | 2018 |
Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cerebellum; Chronic | 2018 |
Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes.
Topics: Cytokines; Glycation End Products, Advanced; Humans; Inflammation; Monocytes; Periodontitis; Pyruval | 2018 |
Phloretin and its methylglyoxal adduct: Implications against advanced glycation end products-induced inflammation in endothelial cells.
Topics: Cell-Free System; Endothelium, Vascular; Glycation End Products, Advanced; Human Umbilical Vein Endo | 2019 |
Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells.
Topics: Animals; Apigenin; Cell Survival; Dose-Response Relationship, Drug; Glycation End Products, Advanced | 2019 |
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency.
Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glycosylation; Humans | 2019 |
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus; Diketopiperazines; Glucose; Glycation End Products, Advanc | 2013 |
Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats.
Topics: Animals; Behavior, Animal; Cognition Disorders; Diabetes Mellitus, Experimental; Dose-Response Relat | 2013 |
Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation.
Topics: Antioxidants; Arginine; Female; Glycation End Products, Advanced; Humans; Inflammation; Liver Transp | 2013 |
Protective effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats.
Topics: Animals; C-Peptide; Carbohydrate Metabolism; Cholesterol; Fruit; Glucose Tolerance Test; Hydrolyzabl | 2013 |
Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hy | 2015 |
Curcumin inhibits advanced glycation end product-induced oxidative stress and inflammatory responses in endothelial cell damage via trapping methylglyoxal.
Topics: Cell Death; Cell Survival; Chromatography, High Pressure Liquid; Curcumin; Glycation End Products, A | 2016 |
Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals.
Topics: Animals; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Gliosis; Hippocampus; Inflam | 2016 |
Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.
Topics: Animals; Arterioles; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2016 |
Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Topics: Animals; Cells, Cultured; Cytokines; Glutathione; Inflammation; Lactoylglutathione Lyase; Liver; Liv | 2017 |
Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells.
Topics: Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Fluorescent A | 2008 |
Food derived carbonyl compounds affect basal and stimulated secretion of interleukin-6 and -8 in Caco-2 cells.
Topics: Caco-2 Cells; Dose-Response Relationship, Immunologic; Glyoxal; Humans; Inflammation; Inflammation M | 2009 |
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apolipoprotein A-I; Carotid Arter | 2010 |
Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.
Topics: Albumins; Biomarkers; Blood Glucose; Case-Control Studies; Cell Adhesion Molecules; Creatinine; Diab | 2011 |
Role of age and uncoupling protein-2 in oxidative stress, RAGE/AGE interaction and inflammatory liver injury.
Topics: Animals; Cellular Senescence; Glutathione; Glutathione Disulfide; Glycation End Products, Advanced; | 2011 |
NF-κB-inducing kinase increases renal tubule epithelial inflammation associated with diabetes.
Topics: Animals; Cells, Cultured; Diabetic Nephropathies; Gene Expression Regulation; Humans; Inflammation; | 2011 |
Epigallocatechin gallate suppresses peritoneal fibrosis in mice.
Topics: Animals; Catechin; Chemokine CCL2; Dialysis Solutions; Inflammation; Male; Mice; Mice, Inbred C57BL; | 2012 |
Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity.
Topics: Adipokines; Adipose Tissue; Animals; Apoptosis; Biomarkers; Cell Hypoxia; Fibrosis; Hyperglycemia; I | 2012 |
Methylglyoxal promotes oxidative stress and endothelial dysfunction.
Topics: Animals; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glycation End Pr | 2012 |
[Nonspecific inflammation and structural changes in the arteries of hypertensive males at high and moderate risk for cardiovascular events].
Topics: Adult; Aged; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Elas | 2012 |
[The biological reaction of inflammation, methylglyoxal of blood plasma, functional and structural alterations in elastic type arteries at the early stage of hypertension disease].
Topics: Adult; Arteries; Biomarkers; Blood Pressure; Humans; Hypertension; Inflammation; Male; Middle Aged; | 2012 |
Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus.
Topics: Antioxidants; Cytokines; Diabetes Mellitus, Type 2; Epithelial Cells; Female; Gene Expression Regula | 2013 |
Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; B | 2013 |
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; G | 2007 |