pyruvaldehyde has been researched along with Hypoxia in 8 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypoxia and inflammation have been shown to drive the rapid intracellular accumulation of reactive dicarbonyls, i." | 2.55 | Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness. ( Bergmans, DC; Schalkwijk, CG; van Bussel, BC; van de Poll, MC, 2017) |
| "Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure." | 1.62 | Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terán, G | 1 |
| Li, H | 1 |
| Catrina, SB | 1 |
| Liu, R | 1 |
| Brighenti, S | 1 |
| Zheng, X | 1 |
| Grünler, J | 1 |
| Nylén, S | 1 |
| Carow, B | 1 |
| Rottenberg, ME | 1 |
| Driessen, RGH | 1 |
| Kiers, D | 1 |
| Schalkwijk, CG | 2 |
| Scheijen, JLJM | 1 |
| Gerretsen, J | 1 |
| Pickkers, P | 1 |
| van de Poll, MCG | 1 |
| van der Horst, ICC | 1 |
| Bergmans, DCJJ | 1 |
| Kox, M | 1 |
| van Bussel, BCT | 1 |
| Rodrigues, T | 1 |
| Matafome, P | 1 |
| Sereno, J | 1 |
| Almeida, J | 1 |
| Castelhano, J | 1 |
| Gamas, L | 1 |
| Neves, C | 1 |
| Gonçalves, S | 1 |
| Carvalho, C | 1 |
| Arslanagic, A | 1 |
| Wilcken, E | 1 |
| Fonseca, R | 1 |
| Simões, I | 1 |
| Conde, SV | 1 |
| Castelo-Branco, M | 1 |
| Seiça, R | 1 |
| van Bussel, BC | 1 |
| van de Poll, MC | 1 |
| Bergmans, DC | 1 |
| Thangarajah, H | 1 |
| Yao, D | 2 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Galvez, MG | 1 |
| Januszyk, M | 1 |
| Brownlee, M | 2 |
| Gurtner, GC | 2 |
| Inagi, R | 2 |
| Kumagai, T | 2 |
| Fujita, T | 1 |
| Nangaku, M | 2 |
| Ceradini, DJ | 1 |
| Grogan, RH | 1 |
| Callaghan, MJ | 1 |
| Edelstein, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvaldehyde and Hypoxia
| Article | Year |
|---|---|
Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness.
Topics: Biomarkers; Comorbidity; Critical Care; Critical Illness; Deoxyglucose; Glyoxal; Humans; Hypoxia; In | 2017 |
7 other studies available for pyruvaldehyde and Hypoxia
| Article | Year |
|---|---|
High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages.
Topics: Animals; Deferoxamine; Glucose; Hypoxia; Hypoxia-Inducible Factor 1; Macrophages; Magnesium Oxide; M | 2022 |
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Topics: Adolescent; Adult; Biomarkers; Down-Regulation; Endotoxemia; Healthy Volunteers; Humans; Hypoxia; In | 2021 |
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Fasting; Fibrosis; Glycated Hemoglobin; Glycoconjugates; Gl | 2017 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
The role of glyoxalase system in renal hypoxia.
Topics: Animals; Glycosylation; Humans; Hypoxia; Inactivation, Metabolic; Kidney Diseases; Lactoylglutathion | 2010 |
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.
Topics: Animals; Bone Marrow Transplantation; Diabetes Mellitus, Experimental; Glucose; Hyperglycemia; Hypox | 2008 |
Pathophysiological role of the glyoxalase system in renal hypoxic injury.
Topics: Acute Kidney Injury; Glycation End Products, Advanced; Humans; Hypoxia; Kidney Diseases; Lactoylglut | 2008 |