pyruvaldehyde has been researched along with Hypertension in 17 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension is a life-threatening disease that is associated with increased cardiovascular risks." | 2.43 | Is methylglyoxal a causative factor for hypertension development? ( Wu, L, 2006) |
| "Candesartan treatment for 4 weeks significantly reduced these parameters." | 1.39 | Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. ( Chen, X; Endo, S; Guo, Q; Hu, C; Ito, S; Jiang, Y; Miyata, T; Mori, T; Nakayama, K; Nakayama, M; Ogawa, S; Ohsaki, Y; Yoneki, Y; Zhu, W, 2013) |
| "After 4-week treatment insulin resistance was evaluated by an euglycemic hyperinsulinemic glucose clamp technique." | 1.35 | Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats. ( Guo, Q; Hosoya, T; Hu, C; Ito, S; Jiang, Y; Kawamata, A; Miyata, T; Mori, T; Nakayama, M; Ogawa, S; Osaki, Y; Sun, Y; Yoneki, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhar, I | 1 |
| Dhar, A | 1 |
| Wu, L | 9 |
| Desai, KM | 1 |
| Cao, W | 1 |
| Chang, T | 5 |
| Li, XQ | 1 |
| Wang, R | 2 |
| Guo, Q | 2 |
| Mori, T | 3 |
| Jiang, Y | 2 |
| Hu, C | 2 |
| Osaki, Y | 1 |
| Yoneki, Y | 2 |
| Sun, Y | 1 |
| Hosoya, T | 1 |
| Kawamata, A | 1 |
| Ogawa, S | 3 |
| Nakayama, M | 3 |
| Miyata, T | 3 |
| Ito, S | 3 |
| Nakayama, K | 2 |
| Matsushima, M | 1 |
| Okamura, M | 1 |
| Senda, M | 1 |
| Nako, K | 1 |
| Liu, J | 1 |
| Desai, K | 4 |
| Mukohda, M | 1 |
| Okada, M | 1 |
| Hara, Y | 1 |
| Yamawaki, H | 1 |
| Dmitriev, VA | 2 |
| Oshchepkova, EV | 1 |
| Titov, VN | 2 |
| Balakhonova, TV | 2 |
| Tripoten', MI | 2 |
| Rogoza, AN | 1 |
| Shiriaeva, IuK | 2 |
| Oshchepkov, EV | 1 |
| Chen, X | 1 |
| Ohsaki, Y | 1 |
| Zhu, W | 1 |
| Endo, S | 1 |
| Uribarri, J | 1 |
| Peppa, M | 1 |
| Cai, W | 1 |
| Goldberg, T | 1 |
| Lu, M | 1 |
| Baliga, S | 1 |
| Vassalotti, JA | 1 |
| Vlassara, H | 1 |
| Wang, X | 3 |
| Jiang, B | 1 |
| Jia, X | 1 |
| Vasdev, S | 1 |
| Ford, CA | 1 |
| Longerich, L | 1 |
| Parai, S | 1 |
| Gadag, V | 1 |
| Wadhawan, S | 1 |
| Juurlink, BH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Serum Levels of Advanced Glycation End-products After Dietary Intervention in Hypertensive Patients: Study Protocol of a Randomized Clinical Trial.[NCT02848677] | Phase 2 | 120 participants (Anticipated) | Interventional | 2015-11-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvaldehyde and Hypertension
| Article | Year |
|---|---|
Is methylglyoxal a causative factor for hypertension development?
Topics: Animals; Glucose; Humans; Hypertension; Hypertrophy; Mitogen-Activated Protein Kinases; Muscle, Smoo | 2006 |
Methylglyoxal, oxidative stress, and hypertension.
Topics: Animals; Glycation End Products, Advanced; Glycosylation; Humans; Hypertension; Oxidative Stress; Py | 2006 |
15 other studies available for pyruvaldehyde and Hypertension
| Article | Year |
|---|---|
Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats.
Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Catecholami | 2014 |
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Topics: Adult; Aged; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Proliferatio | 2017 |
Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.
Topics: Animals; Blood Pressure; Body Composition; Glycation End Products, Advanced; Hypertension; Immunohis | 2009 |
Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.
Topics: Biomarkers; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; H | 2010 |
Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Topics: Aldehyde Reductase; Amine Oxidase (Copper-Containing); Animals; Aorta; Cells, Cultured; Cytochrome P | 2011 |
Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats.
Topics: Acetylcholine; Angiotensin II; Animals; Endothelium, Vascular; Glycation End Products, Advanced; Gua | 2012 |
[Nonspecific inflammation and structural changes in the arteries of hypertensive males at high and moderate risk for cardiovascular events].
Topics: Adult; Aged; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Elas | 2012 |
[The biological reaction of inflammation, methylglyoxal of blood plasma, functional and structural alterations in elastic type arteries at the early stage of hypertension disease].
Topics: Adult; Arteries; Biomarkers; Blood Pressure; Humans; Hypertension; Inflammation; Male; Middle Aged; | 2012 |
Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; B | 2013 |
Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.
Topics: Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Diet; Diet Records; Food Analysi | 2003 |
Vascular methylglyoxal metabolism and the development of hypertension.
Topics: Age Factors; Animals; Aorta; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glycation E | 2005 |
Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal.
Topics: Animals; Aorta; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Free Radicals; Glutathione | 2007 |
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.
Topics: Animals; Aorta; Dietary Carbohydrates; Fructose; Glutathione; Glycation End Products, Advanced; Hydr | 2008 |
Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine.
Topics: Acetylcysteine; Aldehydes; Animals; Arterioles; Blood Platelets; Blood Pressure; Body Weight; Calciu | 1998 |
Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Fluoresceins; Glutathione; Glutathione Peroxidase; Glutathione Reductase; | 2002 |