pyruvaldehyde has been researched along with Hyperglycemia in 66 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The glucose-derived α-dicarbonyl glyoxal and glycated amino acids arising from a reaction with glyoxal are associated with a poor outcome in ischemic stroke." | 8.31 | Glyoxal in hyperglycaemic ischemic stroke - a cohort study. ( Begemann, K; Fleming, T; Herrmann, O; Inderhees, J; Isa, R; Klika, KD; König, IR; Nawroth, PP; Othman, A; Rhein, S; Royl, G; Schwaninger, M, 2023) |
| " In this study, we investigated the ability of scopoletin (SP) to protect against MG-induced hyperglycemia and insulin resistance." | 7.81 | Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. ( Chang, WC; Cheng, AS; Liao, BC; Wu, JF; Wu, SC; Xu, KD, 2015) |
| "Monascin acts as a novel natural Nrf2 activator with PPARγ-agonist activity were confirmed by Nrf2 and PPARγ reporter assays in Hep G2 cells." | 5.39 | A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. ( Chang, YY; Hsu, WH; Hsu, YW; Lee, BH; Pan, TM, 2013) |
| "The glucose-derived α-dicarbonyl glyoxal and glycated amino acids arising from a reaction with glyoxal are associated with a poor outcome in ischemic stroke." | 4.31 | Glyoxal in hyperglycaemic ischemic stroke - a cohort study. ( Begemann, K; Fleming, T; Herrmann, O; Inderhees, J; Isa, R; Klika, KD; König, IR; Nawroth, PP; Othman, A; Rhein, S; Royl, G; Schwaninger, M, 2023) |
| "In a diabetic pregnancy, an altered maternal metabolism led to increased formation of reactive α-dicarbonyls such as glyoxal (GO) and methylglyoxal (MGO) in the reproductive organs and embryos." | 3.91 | Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits. ( Grybel, KJ; Gürke, J; Haucke, E; Navarrete Santos, A; Pendzialek, SM; Schindler, M; Seeling, T; Simm, A, 2019) |
| "Body weight gain, fat deposits, dyslipidemia, hyperglycemia, and fatty liver were ameliorated by dietary genistein in both studies." | 3.91 | Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet. ( Sang, S; Wang, P; Zhao, Y, 2019) |
| " In this study, we investigated the ability of scopoletin (SP) to protect against MG-induced hyperglycemia and insulin resistance." | 3.81 | Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. ( Chang, WC; Cheng, AS; Liao, BC; Wu, JF; Wu, SC; Xu, KD, 2015) |
| "Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisation of blood glucose concentration, the event risk is amplified-an effect called "glycolytic memory"." | 2.82 | Dicarbonyl Stress in Diabetic Vascular Disease. ( Stratmann, B, 2022) |
| "Chronic hyperglycemia is known to increase tissue glycation and diabetic complications, but controversy exists regarding the independent role of increased postprandial glucose excursions." | 2.70 | alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. ( Beisswenger, PJ; Howell, SK; O'Dell, RM; Szwergold, BS; Touchette, AD; Wood, ME, 2001) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "Long-term hyperglycemia is a typical symptom of diabetes mellitus (DM) which can cause a high level of protein glycation and lead to the formation of advanced glycation end products (AGEs)." | 1.42 | Inhibitory effect of leonurine on the formation of advanced glycation end products. ( Huang, K; Huang, L; Lei, X; Peng, A; Wang, H; Yang, X; Zheng, L, 2015) |
| "The presence of both IGM and type 2 diabetes was significantly associated with higher α-dicarbonyl incremental areas under the curve (iAUCs), as calculated from the OGTT (for IGM, MGO β = 0." | 1.42 | Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. ( Hanssen, NM; Maessen, DE; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM, 2015) |
| "Monascin acts as a novel natural Nrf2 activator with PPARγ-agonist activity were confirmed by Nrf2 and PPARγ reporter assays in Hep G2 cells." | 1.39 | A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. ( Chang, YY; Hsu, WH; Hsu, YW; Lee, BH; Pan, TM, 2013) |
| "Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alterations of their function." | 1.36 | Hyperglycemia impairs proteasome function by methylglyoxal. ( Brownlee, M; Geisler, S; Hammes, HP; Lochnit, G; Preissner, KT; Queisser, MA; Schleicher, ED; Yao, D, 2010) |
| "Hyperglycemia is the most important factor for the onset and progress of diabetic complications." | 1.35 | Methylglyoxal: its presence and potential scavengers. ( Ho, CT; Lo, CY; Tan, D; Wang, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.03) | 18.7374 |
| 1990's | 3 (4.55) | 18.2507 |
| 2000's | 13 (19.70) | 29.6817 |
| 2010's | 40 (60.61) | 24.3611 |
| 2020's | 8 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Pignalosa, FC | 1 |
| Desiderio, A | 1 |
| Mirra, P | 1 |
| Nigro, C | 1 |
| Perruolo, G | 1 |
| Ulianich, L | 1 |
| Formisano, P | 1 |
| Beguinot, F | 1 |
| Miele, C | 1 |
| Napoli, R | 1 |
| Fiory, F | 1 |
| Cortizo, FG | 1 |
| Pfaff, D | 2 |
| Wirth, A | 1 |
| Schlotterer, A | 2 |
| Medert, R | 1 |
| Morgenstern, J | 2 |
| Weber, T | 1 |
| Hammes, HP | 3 |
| Fleming, T | 4 |
| Nawroth, PP | 3 |
| Freichel, M | 1 |
| Teleman, AA | 2 |
| Rabbani, N | 2 |
| Stratmann, B | 2 |
| Alomar, FA | 3 |
| Rhein, S | 1 |
| Inderhees, J | 1 |
| Herrmann, O | 1 |
| Othman, A | 1 |
| Begemann, K | 1 |
| Klika, KD | 1 |
| Isa, R | 1 |
| König, IR | 1 |
| Royl, G | 1 |
| Schwaninger, M | 1 |
| Seeling, T | 1 |
| Haucke, E | 1 |
| Navarrete Santos, A | 2 |
| Grybel, KJ | 1 |
| Gürke, J | 1 |
| Pendzialek, SM | 1 |
| Schindler, M | 1 |
| Simm, A | 2 |
| Anandan, S | 1 |
| Mahadevamurthy, M | 1 |
| Ansari, MA | 1 |
| Alzohairy, MA | 1 |
| Alomary, MN | 1 |
| Farha Siraj, S | 1 |
| Halugudde Nagaraja, S | 1 |
| Chikkamadaiah, M | 1 |
| Thimappa Ramachandrappa, L | 1 |
| Naguvanahalli Krishnappa, HK | 1 |
| Ledesma, AE | 1 |
| Nagaraj, AK | 1 |
| Urooj, A | 1 |
| Rehman, S | 1 |
| Alouffi, S | 1 |
| Faisal, M | 1 |
| Qahtan, AA | 1 |
| Alatar, AA | 1 |
| Ahmad, S | 1 |
| Nguyen, H | 1 |
| Koh, JY | 1 |
| Li, H | 1 |
| Islas-Robles, A | 1 |
| Meda Venkata, SP | 1 |
| Wang, JM | 1 |
| Monks, TJ | 1 |
| Ramalho, AR | 1 |
| Toscano, A | 1 |
| Pereira, P | 2 |
| Girão, H | 1 |
| Gonçalves, L | 1 |
| Marques, C | 1 |
| Abdullah, KM | 1 |
| Qais, FA | 1 |
| Ahmad, I | 1 |
| Naseem, I | 1 |
| Moraru, A | 1 |
| Wiederstein, J | 1 |
| Miller, AK | 1 |
| Nawroth, P | 2 |
| Dorenkamp, M | 1 |
| Müller, JP | 1 |
| Shanmuganathan, KS | 1 |
| Schulten, H | 1 |
| Müller, N | 1 |
| Löffler, I | 1 |
| Müller, UA | 1 |
| Wolf, G | 1 |
| Böhmer, FD | 1 |
| Godfrey, R | 1 |
| Waltenberger, J | 1 |
| Kolibabka, M | 1 |
| Lin, J | 1 |
| Acunman, K | 1 |
| Dietrich, N | 1 |
| Sticht, C | 1 |
| Bellier, J | 1 |
| Nokin, MJ | 1 |
| Lardé, E | 1 |
| Karoyan, P | 1 |
| Peulen, O | 1 |
| Castronovo, V | 1 |
| Bellahcène, A | 1 |
| Zhao, Y | 1 |
| Wang, P | 1 |
| Sang, S | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Fleming, TH | 1 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Kroll, J | 1 |
| Hsu, WH | 1 |
| Lee, BH | 1 |
| Chang, YY | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Xiao, H | 1 |
| Gu, Z | 1 |
| Wang, G | 1 |
| Zhao, T | 1 |
| Pun, PB | 1 |
| Logan, A | 1 |
| Darley-Usmar, V | 1 |
| Chacko, B | 1 |
| Johnson, MS | 1 |
| Huang, GW | 1 |
| Rogatti, S | 1 |
| Prime, TA | 1 |
| Methner, C | 1 |
| Krieg, T | 1 |
| Fearnley, IM | 1 |
| Larsen, L | 1 |
| Larsen, DS | 1 |
| Menger, KE | 1 |
| Collins, Y | 1 |
| James, AM | 1 |
| Kumar, GD | 1 |
| Hartley, RC | 1 |
| Smith, RA | 1 |
| Murphy, MP | 1 |
| Tikellis, C | 1 |
| Pickering, RJ | 1 |
| Tsorotes, D | 1 |
| Huet, O | 1 |
| Cooper, ME | 1 |
| Jandeleit-Dahm, K | 1 |
| Thomas, MC | 1 |
| Jacobson, R | 1 |
| Mignemi, N | 1 |
| Rose, K | 1 |
| O'Rear, L | 1 |
| Sarilla, S | 1 |
| Hamm, HE | 1 |
| Barnett, JV | 1 |
| Verhamme, IM | 1 |
| Schoenecker, J | 1 |
| Huang, L | 1 |
| Yang, X | 1 |
| Peng, A | 1 |
| Wang, H | 1 |
| Lei, X | 1 |
| Zheng, L | 1 |
| Huang, K | 1 |
| Chang, WC | 2 |
| Wu, SC | 1 |
| Xu, KD | 1 |
| Liao, BC | 1 |
| Wu, JF | 1 |
| Cheng, AS | 3 |
| Maessen, DE | 1 |
| Hanssen, NM | 1 |
| Scheijen, JL | 1 |
| van der Kallen, CJ | 1 |
| van Greevenbroek, MM | 1 |
| Stehouwer, CD | 3 |
| Schalkwijk, CG | 3 |
| Xie, B | 1 |
| Lin, F | 1 |
| Ullah, K | 1 |
| Peng, L | 1 |
| Ding, W | 1 |
| Dai, R | 1 |
| Qing, H | 1 |
| Deng, Y | 1 |
| Cheng, YH | 2 |
| Lee, CY | 1 |
| Chung, CY | 1 |
| Wang, L | 1 |
| Zhang, X | 1 |
| Pang, N | 1 |
| Xiao, L | 1 |
| Li, Y | 1 |
| Chen, N | 1 |
| Ren, M | 1 |
| Deng, X | 1 |
| Wu, J | 1 |
| Hansen, F | 1 |
| Battú, CE | 1 |
| Dutra, MF | 1 |
| Galland, F | 1 |
| Lirio, F | 1 |
| Broetto, N | 1 |
| Nardin, P | 1 |
| Gonçalves, CA | 2 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| Engelbrecht, B | 1 |
| Espelage, BC | 1 |
| Klusmeier, N | 1 |
| Tiemann, J | 1 |
| Gawlowski, T | 1 |
| Mattern, Y | 1 |
| Eisenacher, M | 1 |
| Meyer, HE | 1 |
| Thornalley, PJ | 5 |
| Tschoepe, D | 1 |
| Poschmann, G | 1 |
| Stühler, K | 1 |
| Thangarajah, H | 1 |
| Yao, D | 3 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Galvez, MG | 1 |
| Januszyk, M | 1 |
| Brownlee, M | 7 |
| Gurtner, GC | 2 |
| Price, CL | 1 |
| Knight, SC | 1 |
| Queisser, MA | 1 |
| Geisler, S | 1 |
| Lochnit, G | 1 |
| Schleicher, ED | 1 |
| Preissner, KT | 1 |
| Nass, N | 1 |
| Vogel, K | 1 |
| Hofmann, B | 1 |
| Presek, P | 1 |
| Silber, RE | 1 |
| Brouwers, O | 3 |
| Niessen, PM | 2 |
| Haenen, G | 1 |
| Miyata, T | 3 |
| De Mey, JG | 1 |
| Kim, J | 1 |
| Sohn, E | 1 |
| Kim, CS | 1 |
| Kim, JS | 2 |
| Ferreira, I | 1 |
| Scheffer, PG | 1 |
| Teerlink, T | 1 |
| Schrauwen, P | 1 |
| Masterjohn, C | 1 |
| Mah, E | 1 |
| Guo, Y | 1 |
| Koo, SI | 1 |
| Bruno, RS | 1 |
| Chetyrkin, S | 1 |
| Mathis, M | 1 |
| Pedchenko, V | 1 |
| Sanchez, OA | 1 |
| McDonald, WH | 1 |
| Hachey, DL | 1 |
| Madu, H | 1 |
| Stec, D | 1 |
| Hudson, B | 1 |
| Voziyan, P | 1 |
| Remor, AP | 1 |
| de Matos, FJ | 1 |
| Ghisoni, K | 1 |
| da Silva, TL | 1 |
| Eidt, G | 1 |
| Búrigo, M | 1 |
| de Bem, AF | 1 |
| Silveira, PC | 1 |
| de León, A | 1 |
| Sanchez, MC | 1 |
| Hohl, A | 1 |
| Glaser, V | 1 |
| Quincozes-Santos, A | 1 |
| Borba Rosa, R | 1 |
| Latini, A | 1 |
| Kim, KM | 1 |
| Kim, YS | 1 |
| Jung, DH | 1 |
| Lee, J | 1 |
| Berner, AK | 1 |
| Pringle, R | 1 |
| Klaassen, I | 1 |
| Colhoun, L | 1 |
| McVicar, C | 1 |
| Brockbank, S | 1 |
| Curry, JW | 1 |
| Schlingemann, RO | 1 |
| Schalkwijk, C | 1 |
| Stitt, AW | 1 |
| Matafome, P | 1 |
| Santos-Silva, D | 1 |
| Crisóstomo, J | 1 |
| Rodrigues, T | 1 |
| Rodrigues, L | 1 |
| Sena, CM | 1 |
| Seiça, R | 1 |
| Kender, Z | 1 |
| Torzsa, P | 1 |
| Grolmusz K, V | 1 |
| Patócs, A | 1 |
| Lichthammer, A | 1 |
| Veresné Bálint, M | 1 |
| Rácz, K | 1 |
| Reismann, P | 1 |
| Adolphe, JL | 1 |
| Drew, MD | 1 |
| Huang, Q | 1 |
| Silver, TI | 1 |
| Weber, LP | 1 |
| Kumskova, EM | 1 |
| Aksenov, DV | 1 |
| Konovalova, GG | 1 |
| Tikhaze, AK | 1 |
| Lankin, VZ | 1 |
| Chiou, CH | 1 |
| Chang, TL | 1 |
| Williams, MA | 1 |
| Enquobahrie, DA | 1 |
| Zimmer, J | 1 |
| Qiu, CF | 1 |
| Hevner, K | 1 |
| Abetew, D | 1 |
| Christianson, C | 1 |
| Sheaff, C | 1 |
| Wu, L | 1 |
| Davies, GF | 1 |
| Roesler, WJ | 1 |
| Juurlink, BH | 1 |
| Aleksandrovski, YA | 1 |
| BLOCK, J | 1 |
| OPPELT, WW | 1 |
| KIRKHAM, WR | 1 |
| RALL, DP | 1 |
| Dmitriev, LF | 1 |
| Dugin, SF | 1 |
| Miller, AG | 1 |
| Smith, DG | 1 |
| Bhat, M | 1 |
| Nagaraj, RH | 1 |
| Nobecourt, E | 1 |
| Davies, MJ | 1 |
| Brown, BE | 1 |
| Curtiss, LK | 1 |
| Bonnet, DJ | 1 |
| Charlton, F | 1 |
| Januszewski, AS | 1 |
| Jenkins, AJ | 1 |
| Barter, PJ | 1 |
| Rye, KA | 1 |
| Ahmad, MS | 1 |
| Pischetsrieder, M | 1 |
| Ahmed, N | 1 |
| Ceradini, DJ | 1 |
| Grogan, RH | 1 |
| Callaghan, MJ | 1 |
| Edelstein, D | 1 |
| Tan, D | 1 |
| Wang, Y | 1 |
| Lo, CY | 1 |
| Ho, CT | 1 |
| Shinohara, M | 1 |
| Giardino, I | 1 |
| Beisswenger, P | 1 |
| Thorpe, SR | 1 |
| Onorato, J | 1 |
| Piskorska, D | 1 |
| Kopieczna-Grzebieniak, E | 1 |
| Eriksson, UJ | 1 |
| Wentzel, P | 1 |
| Minhas, HS | 1 |
| Jahan, I | 1 |
| Ng, R | 1 |
| Beisswenger, PJ | 1 |
| Howell, SK | 1 |
| O'Dell, RM | 1 |
| Wood, ME | 1 |
| Touchette, AD | 1 |
| Szwergold, BS | 1 |
| Portero-Otín, M | 1 |
| Pamplona, R | 1 |
| Bellmunt, MJ | 1 |
| Ruiz, MC | 1 |
| Prat, J | 1 |
| Salvayre, R | 1 |
| Nègre-Salvayre, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| A Double-blind, Randomized, Placebo-controlled, Parallel Design Study to Evaluate the Effects of the Cardio Formulation on Oxidized LDL in Individuals Who Are Overweight to Mildly Obese and Otherwise Healthy[NCT04317287] | 9 participants (Actual) | Interventional | 2019-12-10 | Terminated (stopped due to COVID-19 Pandemic) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
10 reviews available for pyruvaldehyde and Hyperglycemia
| Article | Year |
|---|---|
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction.
Topics: Animals; Cognition; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus; Diabetes Melli | 2021 |
Dicarbonyl Stress in Diabetic Vascular Disease.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced; | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.
Topics: Animals; Diabetes Complications; Glycation End Products, Advanced; Humans; Hyperglycemia; Meta-Analy | 2019 |
The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies.
Topics: Animals; Humans; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Prolyl Hydroxylases; Pyru | 2013 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
[The role of methylglyoxal metabolism in type-2 diabetes and its complications].
Topics: Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glycation End Products, Advanced; | 2012 |
Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects.
Topics: Animals; Cell Division; Diabetes Mellitus; Humans; Hyperglycemia; Neoplasms; Neutrophils; Protein Ki | 2002 |
[Mechanisms of hyperglycemia development and possible methods of carbohydrate metabolism normalization (review)].
Topics: Animals; Carbohydrate Metabolism; Humans; Hyperglycemia; Insulin; Insulin Resistance; Models, Biolog | 2005 |
[Participation of glyoxalases and methylglyoxal in diabetic complication development].
Topics: Diabetes Mellitus, Type 1; Humans; Hyperglycemia; Lactoylglutathione Lyase; Pyruvaldehyde | 1998 |
1 trial available for pyruvaldehyde and Hyperglycemia
| Article | Year |
|---|---|
alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Cross-Over Studies; Deoxyglucose; Diabetes Melli | 2001 |
55 other studies available for pyruvaldehyde and Hyperglycemia
| Article | Year |
|---|---|
The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Glucose; Glycation End Products, Advanced; HEK29 | 2022 |
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Humans; Hyperglycemia; Insulin R | 2022 |
Glyoxal in hyperglycaemic ischemic stroke - a cohort study.
Topics: Amino Acids; Antifibrinolytic Agents; Chromatography, Liquid; Cohort Studies; Glucose; Glycopyrrolat | 2023 |
Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits.
Topics: Animals; Blastocyst; Cell Line; Diabetes Mellitus, Experimental; Female; Glyoxal; Humans; Hyperglyce | 2019 |
Biosynthesized ZnO-NPs from
Topics: Animals; Cattle; Diabetes Mellitus, Experimental; Erythrocytes; Glycation End Products, Advanced; Hy | 2019 |
Methylglyoxal mediated glycation leads to neo-epitopes generation in fibrinogen: Role in the induction of adaptive immune response.
Topics: Adaptive Immunity; Animals; Autoantibodies; Cross Reactions; Diabetes Mellitus, Type 2; Enzyme-Linke | 2021 |
A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.
Topics: Animals; Hindlimb; Hyperglycemia; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Im | 2021 |
Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Mi | 2017 |
Inhibitory effect of vitamin B
Topics: Glucose; Glycation End Products, Advanced; Glycosylation; Humans; Hyperglycemia; Molecular Docking S | 2017 |
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Drosophila melanogaster; Hyperglycemia; Insulin | 2018 |
Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis.
Topics: Animals; Chemotaxis; Humans; Hyperglycemia; Mice; Monocytes; Protein Tyrosine Phosphatase, Non-Recep | 2018 |
Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; | 2019 |
Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue; Aldehyde Reductase; Animals; Diabetes Mellitus; Diet, High-Fat; Dietary Fats; Dyslip | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.
Topics: Animals; Dose-Response Relationship, Drug; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Hyp | 2013 |
A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.
Topics: Animals; Cattle; Cell Line; Chromatography, Liquid; Diabetes Mellitus, Type 1; Disease Models, Anima | 2014 |
Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes.
Topics: Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Diabetes Mellitus, Experimental; Glycatio | 2014 |
The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.
Topics: Anticoagulants; Antithrombin III; Blood Coagulation; Dose-Response Relationship, Drug; Heparin; Huma | 2014 |
Inhibitory effect of leonurine on the formation of advanced glycation end products.
Topics: Animals; Blood Glucose; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Gallic Acid; Gl | 2015 |
Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation.
Topics: Animals; Glycation End Products, Advanced; Hyperglycemia; Insulin Resistance; Male; Pyruvaldehyde; R | 2015 |
Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study.
Topics: Atherosclerosis; Blood Glucose; Chromatography, Liquid; Cross-Sectional Studies; Deoxyglucose; Diabe | 2015 |
A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease.
Topics: alpha-Synuclein; Animals; Brain; Cell Death; Cell Line; Diabetes Mellitus, Experimental; Dopaminergi | 2015 |
Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hy | 2015 |
Glycation of vitronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2-αvβ3 integrin cross-talk.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Diabetes Complications; Diabetes Mellitus, Ex | 2015 |
Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation.
Topics: Animals; Astrocytes; Biological Transport; Diabetes Mellitus; Energy Metabolism; Glucose; Glutamate- | 2016 |
Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates.
Topics: Aorta; Apoptosis; Cells, Cultured; Chemokine CCL2; Collagen; Diabetes Complications; Endothelin-1; E | 2016 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
Methylglyoxal: possible link between hyperglycaemia and immune suppression?
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Immunologic Fac | 2009 |
Hyperglycemia impairs proteasome function by methylglyoxal.
Topics: Albumins; Animals; Cattle; Cell Line; Chymotrypsin; Diabetes Mellitus, Experimental; Endothelial Cel | 2010 |
Glycation of PDGF results in decreased biological activity.
Topics: Animals; Becaplermin; Blood Platelets; Cell Line; Cell Proliferation; Diabetes Mellitus; Extracellul | 2010 |
Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.
Topics: Analysis of Variance; Animals; Cell Count; Cell Line; Cells, Cultured; Endothelium, Vascular; Humans | 2010 |
Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Diabetes Mellitus, Experimental; Di | 2011 |
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Gene Expressio | 2011 |
γ-Tocopherol abolishes postprandial increases in plasma methylglyoxal following an oral dose of glucose in healthy, college-aged men.
Topics: Administration, Oral; Antioxidants; Chromans; Dietary Supplements; gamma-Tocopherol; Glucose; Humans | 2012 |
Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.
Topics: Amino Acid Motifs; Animals; Arginine; Collagen Type IV; Diabetes Mellitus, Experimental; Glucose; Gl | 2011 |
Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: involvement of advanced glycosylated end products.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Blood Glucose; Case-Control St | 2011 |
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Apoptosis; Caspase 3; Cell Line; Cells, Cultured; D | 2012 |
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.
Topics: Animals; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Hyperglycemia; Immunohistoc | 2012 |
Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity.
Topics: Adipokines; Adipose Tissue; Animals; Apoptosis; Biomarkers; Cell Hypoxia; Fibrosis; Hyperglycemia; I | 2012 |
Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs.
Topics: Animals; Blood Glucose; Cross-Over Studies; Dietary Carbohydrates; Dogs; Female; Glycemic Index; Hem | 2012 |
[The role of oxidative processes in augmentation of atherogenity of low density lipoprotein particles].
Topics: Apolipoprotein B-100; Atherosclerosis; Blood Protein Electrophoresis; Free Radicals; Humans; Hypergl | 2012 |
Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells.
Topics: Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heme Oxygenase-1; Hep G2 Cel | 2012 |
Maternal plasma advanced glycation end products concentrations in response to oral 50-gram glucose load in mid-pregnancy: a pilot study.
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Female; Glucose; Glucose Tolerance Test; Glyc | 2012 |
Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide.
Topics: Animals; Brain; Cells, Cultured; Cerebrovascular Circulation; Chromans; Dose-Response Relationship, | 2002 |
BLOOD SUGAR CHANGES INDUCED BY METHYLGLYOXAL BIS(GUANYLHYDRAZONE) IN OPSANUS TAU.
Topics: Animals; Batrachoidiformes; Blood Glucose; Carbohydrate Metabolism; Fishes; Glucose; Glycosuria; Gua | 1964 |
Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions.
Topics: Adult; Aged; Apoptosis; Capillaries; Cells, Cultured; Glucose; Humans; Hyperglycemia; Lactoylglutath | 2006 |
The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase.
Topics: Apolipoprotein A-I; Enzyme Activation; Glycosylation; Humans; Hyperglycemia; Lipoproteins, HDL; Phos | 2007 |
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.
Topics: Aging; Antioxidants; Cysteine; Diabetes Complications; Electrophoresis, Polyacrylamide Gel; Free Rad | 2007 |
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.
Topics: Animals; Bone Marrow Transplantation; Diabetes Mellitus, Experimental; Glucose; Hyperglycemia; Hypox | 2008 |
Methylglyoxal: its presence and potential scavengers.
Topics: Biflavonoids; Catechin; Chromatography, High Pressure Liquid; Gallic Acid; Glycation End Products, A | 2008 |
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
Topics: Acetone; Aldehydes; Animals; Cattle; Endocytosis; Endothelium, Vascular; Gene Expression Regulation, | 1998 |
Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.
Topics: Animals; Deoxyglucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Embryo, Ma | 1998 |
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans; | 2001 |
Advanced glycation end product precursors impair epidermal growth factor receptor signaling.
Topics: Cell Line, Transformed; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Glycation End Products, Adva | 2002 |
Modification of the glyoxalase system in human red blood cells by glucose in vitro.
Topics: Erythrocytes; Glucose; Glutathione; Humans; Hyperglycemia; In Vitro Techniques; Lactates; Lactic Aci | 1988 |