pyruvaldehyde has been researched along with Disease Models, Animal in 69 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we found that consumption of MG significantly deteriorated azoxymethane (AOM)-induced colonic preneoplastic lesions in ICR mice, in which biomarkers of oxidative stress and inflammation within the body and feces induced by MG-fueled carbonyl stress may have played important roles." | 7.88 | Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts. ( Lin, JA; Wu, CH; Yen, GC, 2018) |
| "Taurine treatment normalized the expression levels of γ-glutamyl ligase C/M, GS, OPLAH, and glyoxalase-1, and reversed HCU-induced deficits in protein glutathionylation by acting to double GSH levels relative to controls." | 5.48 | Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. ( Aivazidis, S; Allen, RH; Harris, PS; Jiang, H; Kim, E; Maclean, KN; Petersen, DR; Roede, JR; Shearn, CT; Stabler, SP, 2018) |
| "Bortezomib is a first-line chemotherapeutic drug widely used for multiple myeloma and other nonsolid malignancies." | 5.46 | Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib. ( Ding, HH; Lei, WL; Liu, CC; Liu, M; Ma, C; Ouyang, HD; Wei, JY; Wu, SL; Xie, MX; Xin, WJ, 2017) |
| " In the present study, we found that consumption of MG significantly deteriorated azoxymethane (AOM)-induced colonic preneoplastic lesions in ICR mice, in which biomarkers of oxidative stress and inflammation within the body and feces induced by MG-fueled carbonyl stress may have played important roles." | 3.88 | Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts. ( Lin, JA; Wu, CH; Yen, GC, 2018) |
| "We prepared peritoneal fibrosis rats by intraperitoneal administration of PD fluids containing MGO for 21 days." | 1.56 | Hypermetabolism of glutathione, glutamate and ornithine via redox imbalance in methylglyoxal-induced peritoneal injury rats. ( Hirahara, I; Jin, D; Kusano, E; Takai, S, 2020) |
| "MGO induced parietal and visceral peritoneal fibrosis in wild-type mice, which was significantly reduced in mice deficient in NLRP3, ASC, and interleukin-1β (IL-1β)." | 1.51 | Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis. ( Aizawa, E; Akimoto, T; Hishida, E; Ito, H; Kamata, R; Karasawa, T; Kasahara, T; Kimura, H; Komada, T; Morishita, Y; Nagata, D; Takahashi, M; Watanabe, S, 2019) |
| "Taurine treatment normalized the expression levels of γ-glutamyl ligase C/M, GS, OPLAH, and glyoxalase-1, and reversed HCU-induced deficits in protein glutathionylation by acting to double GSH levels relative to controls." | 1.48 | Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. ( Aivazidis, S; Allen, RH; Harris, PS; Jiang, H; Kim, E; Maclean, KN; Petersen, DR; Roede, JR; Shearn, CT; Stabler, SP, 2018) |
| "Bortezomib is a first-line chemotherapeutic drug widely used for multiple myeloma and other nonsolid malignancies." | 1.46 | Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib. ( Ding, HH; Lei, WL; Liu, CC; Liu, M; Ma, C; Ouyang, HD; Wei, JY; Wu, SL; Xie, MX; Xin, WJ, 2017) |
| "For a long time cancer cells are known for increased uptake of glucose and its metabolization through glycolysis." | 1.43 | Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. ( Bag, AK; Chakrabarti, S; Das, MR; Das, P; Dey, SK; Ghosh, A; Jana, SS; Mandal, C; Ray, M; Ray, S; Saha, S, 2016) |
| "We investigated its role in human colon cancer and the underlying mechanism using human colon cancer cells and animal model." | 1.43 | Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. ( Chen, X; Chen, Y; He, T; Li, C; Lyu, J; Mao, J; Meng, QH; Zhou, H, 2016) |
| "Hyperexcitability in diabetic polyneuropathy may, at least in part, be caused by dysfunctional axonal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels." | 1.42 | Upregulation of axonal HCN current by methylglyoxal: Potential association with diabetic polyneuropathy. ( Banzrai, C; Endo, S; Kaji, R; Nodera, H; Osaki, Y; Shibuta, Y; Shimatani, Y; Takayasu, K, 2015) |
| "At worst, peritoneal injury leads to encapsulating peritoneal sclerosis (EPS), which is a serious complication of PD." | 1.42 | Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. ( Hirahara, I; Imai, T; Kusano, E; Morishita, Y; Muto, S; Nagata, D; Onishi, A; Sato, H, 2015) |
| "8 mg/mL is both safe to mucosa and efficacious against S." | 1.40 | Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model. ( Drilling, AJ; Jardeleza, C; Jervis-Bardy, J; Paramasivan, S; Vreugde, S; Wormald, PJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (11.59) | 29.6817 |
| 2010's | 45 (65.22) | 24.3611 |
| 2020's | 16 (23.19) | 2.80 |
| Authors | Studies |
|---|---|
| Oliveira, AL | 2 |
| de Oliveira, MG | 2 |
| Medeiros, ML | 3 |
| Mónica, FZ | 2 |
| Antunes, E | 3 |
| Santos, DFS | 1 |
| Donahue, RR | 1 |
| Laird, DE | 1 |
| Oliveira, MCG | 1 |
| Taylor, BK | 1 |
| Moreira, AP | 1 |
| Vizuete, AFK | 1 |
| Zin, LEF | 1 |
| de Marques, CO | 1 |
| Pacheco, RF | 1 |
| Leal, MB | 1 |
| Gonçalves, CA | 3 |
| Wei, CC | 1 |
| Li, SW | 1 |
| Wu, CT | 1 |
| How, CM | 1 |
| Pan, MH | 1 |
| Mello, GC | 2 |
| Hirahara, I | 4 |
| Kusano, E | 3 |
| Jin, D | 1 |
| Takai, S | 1 |
| Tate, M | 1 |
| Higgins, GC | 1 |
| De Blasio, MJ | 1 |
| Lindblom, R | 1 |
| Prakoso, D | 1 |
| Deo, M | 1 |
| Kiriazis, H | 1 |
| Park, M | 1 |
| Baeza-Garza, CD | 2 |
| Caldwell, ST | 2 |
| Hartley, RC | 3 |
| Krieg, T | 3 |
| Murphy, MP | 3 |
| Coughlan, MT | 2 |
| Ritchie, RH | 1 |
| Ahmed, OAA | 1 |
| El-Bassossy, HM | 1 |
| Azhar, AS | 1 |
| Tarkhan, MM | 1 |
| El-Mas, MM | 1 |
| Emidio, GD | 1 |
| Placidi, M | 1 |
| Rea, F | 1 |
| Rossi, G | 1 |
| Falone, S | 1 |
| Cristiano, L | 1 |
| Nottola, S | 1 |
| D'Alessandro, AM | 1 |
| Amicarelli, F | 1 |
| Palmerini, MG | 1 |
| Tatone, C | 1 |
| Chen, SM | 3 |
| Lin, CE | 2 |
| Chen, HH | 1 |
| Cheng, YF | 1 |
| Cheng, HW | 1 |
| Imai, K | 1 |
| Tavares, EG | 1 |
| Anhê, GF | 1 |
| Al-Hazmi, A | 1 |
| Lin, PY | 1 |
| Yang, WC | 1 |
| Huang, YS | 1 |
| Lin, TY | 1 |
| Chen, CM | 1 |
| Chen, HS | 1 |
| Lee, JA | 2 |
| Yoshimine, H | 1 |
| Tanoue, S | 1 |
| Ibi, Y | 1 |
| Minami, M | 1 |
| Nakahara, M | 1 |
| Tokunaga, K | 1 |
| Kanmura, S | 1 |
| Ido, A | 1 |
| Tan, SM | 1 |
| Lindblom, RSJ | 1 |
| Ziemann, M | 1 |
| Laskowski, A | 1 |
| Granata, C | 1 |
| Snelson, M | 1 |
| Thallas-Bonke, V | 1 |
| El-Osta, A | 1 |
| Cooper, ME | 1 |
| Ahmad, S | 1 |
| Khan, MS | 1 |
| Alouffi, S | 1 |
| Khan, S | 1 |
| Khan, M | 1 |
| Akashah, R | 1 |
| Faisal, M | 1 |
| Shahab, U | 1 |
| Abharzanjani, F | 1 |
| Hemmati, M | 1 |
| Scott, GF | 1 |
| Nguyen, AQ | 1 |
| Cherry, BH | 1 |
| Hollrah, RA | 1 |
| Salinas, I | 1 |
| Williams, AG | 1 |
| Ryou, MG | 1 |
| Mallet, RT | 1 |
| Vicente Miranda, H | 1 |
| Szego, ÉM | 1 |
| Oliveira, LMA | 1 |
| Breda, C | 1 |
| Darendelioglu, E | 1 |
| de Oliveira, RM | 1 |
| Ferreira, DG | 1 |
| Gomes, MA | 1 |
| Rott, R | 1 |
| Oliveira, M | 1 |
| Munari, F | 1 |
| Enguita, FJ | 1 |
| Simões, T | 1 |
| Rodrigues, EF | 1 |
| Heinrich, M | 1 |
| Martins, IC | 1 |
| Zamolo, I | 1 |
| Riess, O | 1 |
| Cordeiro, C | 1 |
| Ponces-Freire, A | 1 |
| Lashuel, HA | 1 |
| Santos, NC | 1 |
| Lopes, LV | 1 |
| Xiang, W | 1 |
| Jovin, TM | 1 |
| Penque, D | 1 |
| Engelender, S | 1 |
| Zweckstetter, M | 1 |
| Klucken, J | 1 |
| Giorgini, F | 1 |
| Quintas, A | 1 |
| Outeiro, TF | 1 |
| Aikawa, T | 1 |
| Matsubara, H | 1 |
| Ugaji, S | 1 |
| Shirakawa, J | 1 |
| Nagai, R | 2 |
| Munesue, S | 1 |
| Harashima, A | 1 |
| Yamamoto, Y | 1 |
| Tsuchiya, H | 1 |
| Wei, JY | 1 |
| Liu, CC | 1 |
| Ouyang, HD | 1 |
| Ma, C | 1 |
| Xie, MX | 1 |
| Liu, M | 1 |
| Lei, WL | 1 |
| Ding, HH | 1 |
| Wu, SL | 1 |
| Xin, WJ | 1 |
| Blackburn, NJR | 1 |
| Vulesevic, B | 1 |
| McNeill, B | 1 |
| Cimenci, CE | 1 |
| Ahmadi, A | 1 |
| Gonzalez-Gomez, M | 1 |
| Ostojic, A | 1 |
| Zhong, Z | 1 |
| Brownlee, M | 4 |
| Beisswenger, PJ | 1 |
| Milne, RW | 1 |
| Suuronen, EJ | 1 |
| Maclean, KN | 1 |
| Jiang, H | 1 |
| Aivazidis, S | 1 |
| Kim, E | 1 |
| Shearn, CT | 1 |
| Harris, PS | 1 |
| Petersen, DR | 1 |
| Allen, RH | 1 |
| Stabler, SP | 1 |
| Roede, JR | 1 |
| Lin, JA | 1 |
| Wu, CH | 1 |
| Yen, GC | 1 |
| Domingo-Espín, J | 1 |
| Nilsson, O | 1 |
| Bernfur, K | 1 |
| Del Giudice, R | 1 |
| Lagerstedt, JO | 1 |
| Zanotto, C | 1 |
| Hansen, F | 2 |
| Galland, F | 2 |
| Batassini, C | 2 |
| Federhen, BC | 1 |
| da Silva, VF | 1 |
| Leite, MC | 2 |
| Nardin, P | 1 |
| Barragán-Iglesias, P | 1 |
| Kuhn, J | 1 |
| Vidal-Cantú, GC | 1 |
| Salinas-Abarca, AB | 1 |
| Granados-Soto, V | 1 |
| Dussor, GO | 1 |
| Campbell, ZT | 1 |
| Price, TJ | 1 |
| Iguchi, D | 1 |
| Mizuno, M | 1 |
| Suzuki, Y | 1 |
| Sakata, F | 1 |
| Maruyama, S | 1 |
| Okada, A | 1 |
| Okada, H | 1 |
| Ito, Y | 1 |
| Papadaki, M | 1 |
| Holewinski, RJ | 1 |
| Previs, SB | 1 |
| Martin, TG | 1 |
| Stachowski, MJ | 1 |
| Li, A | 1 |
| Blair, CA | 1 |
| Moravec, CS | 1 |
| Van Eyk, JE | 1 |
| Campbell, KS | 1 |
| Warshaw, DM | 1 |
| Kirk, JA | 1 |
| Schlotterer, A | 1 |
| Kolibabka, M | 1 |
| Lin, J | 1 |
| Acunman, K | 1 |
| Dietrich, N | 1 |
| Sticht, C | 1 |
| Fleming, T | 2 |
| Nawroth, P | 1 |
| Hammes, HP | 1 |
| Li, H | 1 |
| O'Meara, M | 1 |
| Zhang, X | 1 |
| Zhang, K | 1 |
| Seyoum, B | 1 |
| Yi, Z | 1 |
| Kaufman, RJ | 1 |
| Monks, TJ | 1 |
| Wang, JM | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Morgenstern, J | 1 |
| Fleming, TH | 1 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Nawroth, PP | 2 |
| Kroll, J | 1 |
| Cheng, RX | 1 |
| Feng, Y | 1 |
| Liu, D | 1 |
| Wang, ZH | 1 |
| Zhang, JT | 1 |
| Chen, LH | 1 |
| Su, CJ | 1 |
| Wang, B | 1 |
| Huang, Y | 1 |
| Ji, RR | 1 |
| Hu, J | 1 |
| Liu, T | 1 |
| Hishida, E | 1 |
| Ito, H | 1 |
| Komada, T | 1 |
| Karasawa, T | 1 |
| Kimura, H | 1 |
| Watanabe, S | 1 |
| Kamata, R | 1 |
| Aizawa, E | 1 |
| Kasahara, T | 1 |
| Morishita, Y | 3 |
| Akimoto, T | 3 |
| Nagata, D | 4 |
| Takahashi, M | 1 |
| More, SS | 1 |
| Vartak, AP | 1 |
| Vince, R | 1 |
| Pun, PB | 1 |
| Logan, A | 1 |
| Darley-Usmar, V | 1 |
| Chacko, B | 1 |
| Johnson, MS | 1 |
| Huang, GW | 1 |
| Rogatti, S | 1 |
| Prime, TA | 1 |
| Methner, C | 1 |
| Fearnley, IM | 1 |
| Larsen, L | 1 |
| Larsen, DS | 1 |
| Menger, KE | 1 |
| Collins, Y | 1 |
| James, AM | 1 |
| Kumar, GD | 1 |
| Smith, RA | 1 |
| Paramasivan, S | 1 |
| Drilling, AJ | 1 |
| Jardeleza, C | 1 |
| Jervis-Bardy, J | 1 |
| Vreugde, S | 1 |
| Wormald, PJ | 1 |
| Dhar, I | 1 |
| Dhar, A | 1 |
| Wu, L | 2 |
| Desai, KM | 1 |
| Hirata, H | 1 |
| Miyamoto, H | 1 |
| Shimokawa, K | 1 |
| Nakashima, M | 1 |
| Nakayama, M | 1 |
| Fumoto, S | 1 |
| Nishida, K | 1 |
| Szwergold, BS | 1 |
| Miller, CB | 1 |
| Shimatani, Y | 1 |
| Nodera, H | 1 |
| Osaki, Y | 1 |
| Banzrai, C | 1 |
| Takayasu, K | 1 |
| Endo, S | 1 |
| Shibuta, Y | 1 |
| Kaji, R | 1 |
| Cheng, AS | 1 |
| Cheng, YH | 1 |
| Lee, CY | 1 |
| Chung, CY | 1 |
| Chang, WC | 1 |
| Sato, H | 1 |
| Imai, T | 2 |
| Onishi, A | 2 |
| Muto, S | 3 |
| Karumanchi, DK | 1 |
| Karunaratne, N | 1 |
| Lurio, L | 1 |
| Dillon, JP | 1 |
| Gaillard, ER | 1 |
| Dornadula, S | 1 |
| Elango, B | 1 |
| Balashanmugam, P | 1 |
| Palanisamy, R | 1 |
| Kunka Mohanram, R | 1 |
| Urabe, M | 1 |
| Ozawa, K | 1 |
| Zhang, MM | 1 |
| Ong, CL | 1 |
| Walker, MJ | 1 |
| McEwan, AG | 1 |
| McMurray, KM | 1 |
| Du, X | 1 |
| Palmer, AA | 1 |
| Fan, YP | 1 |
| Hsia, CC | 1 |
| Tseng, KW | 1 |
| Liao, CK | 1 |
| Fu, TW | 1 |
| Ko, TL | 1 |
| Chiu, MM | 1 |
| Shih, YH | 1 |
| Huang, PY | 1 |
| Chiang, YC | 1 |
| Yang, CC | 1 |
| Fu, YS | 1 |
| Wortmann, M | 1 |
| Hakimi, M | 1 |
| Peters, AS | 1 |
| Sijmonsma, TP | 1 |
| Herzig, S | 1 |
| Böckler, D | 1 |
| Dihlmann, S | 1 |
| Das, MR | 1 |
| Bag, AK | 1 |
| Saha, S | 1 |
| Ghosh, A | 1 |
| Dey, SK | 1 |
| Das, P | 1 |
| Mandal, C | 1 |
| Ray, S | 1 |
| Chakrabarti, S | 1 |
| Ray, M | 1 |
| Jana, SS | 1 |
| Pandolfo, P | 1 |
| Torres, FV | 1 |
| Dutra, MF | 1 |
| Guerra, MC | 1 |
| He, T | 1 |
| Zhou, H | 1 |
| Li, C | 2 |
| Chen, Y | 1 |
| Chen, X | 1 |
| Mao, J | 1 |
| Lyu, J | 1 |
| Meng, QH | 1 |
| Igarashi, Y | 1 |
| Yoshizawa, H | 1 |
| Imai, R | 1 |
| Ookawara, S | 1 |
| Ishibashi, K | 1 |
| Kumagai, T | 1 |
| Nangaku, M | 1 |
| Kojima, I | 1 |
| Ingelfinger, JR | 1 |
| Miyata, T | 2 |
| Fujita, T | 1 |
| Inagi, R | 1 |
| Thangarajah, H | 1 |
| Yao, D | 1 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Galvez, MG | 1 |
| Januszyk, M | 1 |
| Gurtner, GC | 1 |
| Nobécourt, E | 1 |
| Tabet, F | 1 |
| Lambert, G | 1 |
| Puranik, R | 1 |
| Bao, S | 1 |
| Yan, L | 1 |
| Davies, MJ | 1 |
| Brown, BE | 1 |
| Jenkins, AJ | 1 |
| Dusting, GJ | 1 |
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| Barter, PJ | 1 |
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| Matafome, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Action of Glycation and Inflammation in Operative Ischemic Heart Disease[NCT05112731] | 60 participants (Anticipated) | Observational | 2022-02-01 | Recruiting | |||
| Serum Levels of Advanced Glycation End-products After Dietary Intervention in Hypertensive Patients: Study Protocol of a Randomized Clinical Trial.[NCT02848677] | Phase 2 | 120 participants (Anticipated) | Interventional | 2015-11-30 | Recruiting | ||
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Pathophysiological insights of methylglyoxal induced type-2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Pyruvaldehyde | 2015 |
1 trial available for pyruvaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
The association between soluble intercellular adhesion molecule-1 levels in drained dialysate and peritoneal injury in peritoneal dialysis.
Topics: Adult; Aged; Animals; Biomarkers; Dialysis Solutions; Disease Models, Animal; Female; Humans; Interc | 2017 |
67 other studies available for pyruvaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Metformin abrogates the voiding dysfunction induced by prolonged methylglyoxal intake.
Topics: Administration, Oral; Animals; Disease Models, Animal; Glycation End Products, Advanced; Humans; Mal | 2021 |
The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy.
Topics: Analgesics; Animals; Diabetic Neuropathies; Disease Models, Animal; Female; Hyperalgesia; Male; Mice | 2022 |
The Methylglyoxal/RAGE/NOX-2 Pathway is Persistently Activated in the Hippocampus of Rats with STZ-Induced Sporadic Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Humans; Maze Learning; Pyruvaldehyd | 2022 |
Dietary Methylglyoxal Exposure Induces Alzheimer's Disease by Promoting Amyloid β Accumulation and Disrupting Autophagy in
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Autophagy; Caenorh | 2022 |
Metformin Counteracts the Deleterious Effects of Methylglyoxal on Ovalbumin-Induced Airway Eosinophilic Inflammation and Remodeling.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Lung | 2023 |
Hypermetabolism of glutathione, glutamate and ornithine via redox imbalance in methylglyoxal-induced peritoneal injury rats.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Glutathione; Male; Ornithine; Oxidation-Reduction; P | 2020 |
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
Topics: Amides; Animals; Benzamides; Cardiotonic Agents; Diabetic Cardiomyopathies; Diphenylamine; Disease M | 2019 |
Interference with AGEs formation and AGEs-induced vascular injury mediates curcumin vascular protection in metabolic syndrome.
Topics: Animals; Aorta; Curcumin; Disease Models, Animal; Endothelium, Vascular; Free Radical Scavengers; Gl | 2020 |
Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Glycation End Products, Advanced; G | 2020 |
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Topics: Animals; Aristolochic Acids; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; F | 2020 |
Long-term methylglyoxal intake aggravates murine Th2-mediated airway eosinophil infiltration.
Topics: Allergens; Animals; Asthma; Cell Movement; Disease Models, Animal; Eosinophils; Humans; Interleukin- | 2020 |
Antioxidant Activity of Silymarin in Microcystin-LR Cardiac and Pulmonary Induced Injuries on Mice.
Topics: Animals; Antioxidants; Biomarkers; Cardiotoxicity; Disease Models, Animal; Glutathione; Heart Diseas | 2020 |
Evaluation of the nephrotoxicity and safety of low-dose aristolochic acid, extending to the use of Xixin (Asurum), by determination of methylglyoxal and d-lactate.
Topics: Animals; Aristolochic Acids; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fibros | 2021 |
Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model.
Topics: Actins; Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Gene Expression; Hepato | 2021 |
Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide.
Topics: Animals; Benzamides; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal | 2021 |
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Ani | 2021 |
Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: in vivo and in vitro analysis.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Calcium-Binding Proteins; Carboxylic Ester Hydrola | 2021 |
Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Glutathione Reductase; Glyceraldehyde-3-Pho | 2017 |
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Topics: Aging; alpha-Synuclein; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Model | 2017 |
Contribution of methylglyoxal to delayed healing of bone injury in diabetes.
Topics: Animals; Blood Glucose; Bone and Bones; Cell Line; Diabetes Complications; Diabetes Mellitus, Experi | 2017 |
Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib.
Topics: Animals; Antineoplastic Agents; Bortezomib; Central Nervous System Sensitization; Disease Models, An | 2017 |
Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction.
Topics: Animals; Apoptosis; Cells, Cultured; Collagen Type I; Disease Models, Animal; Genetic Predisposition | 2017 |
Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Topics: Amino Acids; Aminobutyrates; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Female; g | 2018 |
Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Line; Cholesterol, LDL; Colorectal Neoplasm | 2018 |
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.
Topics: Acetaldehyde; Animals; Apolipoprotein A-I; Blood Glucose; Cardiovascular Diseases; Cell Line; Choles | 2018 |
Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4.
Topics: Animals; Astrocytes; Diabetes Mellitus, Experimental; Disease Models, Animal; Exenatide; Glutamic Ac | 2019 |
Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain.
Topics: Analgesics, Non-Narcotic; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA-Bind | 2019 |
Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rats pretreated with methylglyoxal.
Topics: Animals; Complement Activation; Complement C5a; Complement Inactivating Agents; Disease Models, Anim | 2018 |
Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function.
Topics: Actins; Adult; Animals; Arginine; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Disease Models | 2018 |
Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; | 2019 |
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
Topics: Animals; Bone Marrow Cells; Cell- and Tissue-Based Therapy; Diabetes Mellitus, Type 2; Disease Model | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
The role of Na
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Disease Models, Animal; Humans; Male; Mic | 2019 |
Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis.
Topics: Animals; CARD Signaling Adaptor Proteins; Disease Models, Animal; Endothelial Cells; Female; Human U | 2019 |
Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Coenzymes; Disease Model | 2013 |
A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.
Topics: Animals; Cattle; Cell Line; Chromatography, Liquid; Diabetes Mellitus, Type 1; Disease Models, Anima | 2014 |
Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model.
Topics: Administration, Topical; Animals; Biofilms; Biomass; Chronic Disease; Cilia; Disease Models, Animal; | 2014 |
Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats.
Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Catecholami | 2014 |
Novel diagnostic method of peritoneal injury using dual macromolecular markers.
Topics: Animals; Ascitic Fluid; Biomarkers; Disease Models, Animal; Male; Molecular Weight; Peritoneal Cavit | 2014 |
Potential of birds to serve as pathology-free models of type 2 diabetes, part 2: do high levels of carbonyl-scavenging amino acids (e.g., taurine) and low concentrations of methylglyoxal limit the production of advanced glycation end-products?
Topics: Albumins; Animals; Arginine; Birds; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructosamine; | 2014 |
Upregulation of axonal HCN current by methylglyoxal: Potential association with diabetic polyneuropathy.
Topics: Aged; Aged, 80 and over; Animals; Axons; Biomarkers; Case-Control Studies; Diabetic Neuropathies; Di | 2015 |
Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hy | 2015 |
Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model.
Topics: Animals; Basophils; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Hum | 2015 |
Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases.
Topics: Aging; alpha-Crystallins; Animals; Apoptosis; Cataract; Cattle; Diabetes Mellitus; Disease Models, A | 2015 |
Attenuation of methylglyoxal-induced peritoneal fibrosis: immunomodulation by interleukin-10.
Topics: Adenoviridae; Animals; Body Weight; Disease Models, Animal; Genetic Therapy; Immunomodulation; Inter | 2015 |
Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?
Topics: Animals; Bacteremia; Computational Biology; Cytotoxicity, Immunologic; Disease Models, Animal; Immun | 2016 |
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Disease Models, Animal | 2016 |
The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis.
Topics: Actins; Animals; Biomarkers; Cell Death; Culture Media; Disease Models, Animal; Epithelial Cells; Fi | 2016 |
A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice.
Topics: Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Calorimetry, Indirect; Diet, High-Fat; | 2016 |
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Disease Models, Animal; Enzyme Activation; Gene Expression; Gluco | 2016 |
Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Cognition Disorders; Disease Models, Animal; Glial Fi | 2016 |
Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Down-Regulation; Glycolysis; H | 2016 |
Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Disease Models, Animal; Glutathione; Humans; Kidney; La | 2009 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apolipoprotein A-I; Carotid Arter | 2010 |
Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.
Topics: Amino Acid Sequence; Angiopoietin-2; Animals; Apoptosis; Cell Line; Cell Proliferation; Culture Medi | 2010 |
Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse.
Topics: Animals; Blood Glucose; Chickens; Diabetic Nephropathies; Disease Models, Animal; Gene Deletion; Glo | 2010 |
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Gene Expressio | 2011 |
Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Topics: Aldehyde Reductase; Amine Oxidase (Copper-Containing); Animals; Aorta; Cells, Cultured; Cytochrome P | 2011 |
Exogenous collagen cross-linking recovers tendon functional integrity in an experimental model of partial tear.
Topics: Animals; Collagen; Cross-Linking Reagents; Disease Models, Animal; Elasticity; Horses; Iridoids; Lac | 2012 |
Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy.
Topics: Animals; Aristolochic Acids; Creatine; Disease Models, Animal; Female; Kidney; Lysine; Mice; Mice, I | 2012 |
Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.
Topics: Animals; Blood Glucose; Cholesterol; Diabetic Angiopathies; Disease Models, Animal; Fructosamine; In | 2005 |
Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.
Topics: alpha-Crystallin B Chain; Animals; Antioxidants; Apoptosis; Capillaries; Cattle; Diabetes Mellitus, | 2005 |
wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death.
Topics: Animals; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Female; Glycation End | 2006 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.
Topics: Animals; Body Weight; Disease Models, Animal; Glycation End Products, Advanced; Glyoxal; Kidney Fail | 2007 |
The anticonvulsant activity of acetone does not depend upon its metabolites.
Topics: Acetone; Animals; Anticonvulsants; Blood-Brain Barrier; Disease Models, Animal; Humans; Injections, | 2008 |