pyruvaldehyde has been researched along with Diabetic Retinopathy in 18 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured concentrations of the glycoxidation product Nepsilon-(carboxymethyl)lysine and two non-oxidation-dependent advanced glycation end-products (methylglyoxal-derived and 3-deoxyglucosone-derived) in CD45RA+ T-cells from 21 Type I (insulin-dependent) diabetic patients with and without diabetic retinopathy and from age-matched nondiabetic control subjects." | 7.70 | Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations. ( Bretzel, RG; Brownlee, M; Hammes, HP; Lin, J; Schleicher, E, 1999) |
| "We measured concentrations of the glycoxidation product Nepsilon-(carboxymethyl)lysine and two non-oxidation-dependent advanced glycation end-products (methylglyoxal-derived and 3-deoxyglucosone-derived) in CD45RA+ T-cells from 21 Type I (insulin-dependent) diabetic patients with and without diabetic retinopathy and from age-matched nondiabetic control subjects." | 3.70 | Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations. ( Bretzel, RG; Brownlee, M; Hammes, HP; Lin, J; Schleicher, E, 1999) |
| "Early diabetic retinopathy is characterized by a loss of pericytes from retinal capillaries, the appearance of acellular capillaries and microaneurysms, and a breakdown of the blood-retinal barrier." | 2.49 | Advanced glycation end products and diabetic retinopathy. ( Brownstein, S; Milne, R, 2013) |
| "Coronary atherosclerosis was assessed by computed tomography coronary angiography or intravascular ultrasound." | 1.62 | Autoantibodies Against Methylglyoxal-Modified Apolipoprotein B100 and ApoB100 Peptide Are Associated With Less Coronary Artery Atherosclerosis and Retinopathy in Long-Term Type 1 Diabetes. ( Bech Holte, K; Bengtsson, E; Hanssen, KF; Julsrud Berg, T; Nilsson, J; Svanteson, M; Sveen, KA, 2021) |
| "In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy." | 1.35 | Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone. ( Agardh, CD; Agardh, E; Berg, JP; Fosmark, DS; Hanssen, KF; Jensen, AB; Sandvik, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kamiya, E | 3 |
| Morita, A | 3 |
| Mori, A | 3 |
| Sakamoto, K | 3 |
| Nakahara, T | 3 |
| Alouffi, S | 1 |
| Khan, MWA | 1 |
| Sveen, KA | 1 |
| Bech Holte, K | 1 |
| Svanteson, M | 1 |
| Hanssen, KF | 2 |
| Nilsson, J | 1 |
| Bengtsson, E | 1 |
| Julsrud Berg, T | 1 |
| Schlotterer, A | 4 |
| Kolibabka, M | 3 |
| Lin, J | 4 |
| Acunman, K | 1 |
| Dietrich, N | 3 |
| Sticht, C | 1 |
| Fleming, T | 4 |
| Nawroth, P | 1 |
| Hammes, HP | 5 |
| Wang, J | 1 |
| Wu, L | 1 |
| Busch, S | 2 |
| Genuth, S | 1 |
| Sun, W | 1 |
| Cleary, P | 1 |
| Gao, X | 1 |
| Sell, DR | 1 |
| Lachin, J | 1 |
| Monnier, VM | 1 |
| McVicar, CM | 1 |
| Ward, M | 1 |
| Colhoun, LM | 1 |
| Guduric-Fuchs, J | 1 |
| Bierhaus, A | 1 |
| Chen, M | 1 |
| Stitt, AW | 3 |
| Bugert, P | 1 |
| Kaiser, U | 1 |
| Morcos, M | 1 |
| Klein, T | 1 |
| Fosmark, DS | 1 |
| Berg, JP | 1 |
| Jensen, AB | 1 |
| Sandvik, L | 1 |
| Agardh, E | 1 |
| Agardh, CD | 1 |
| Kim, OS | 1 |
| Kim, J | 2 |
| Kim, CS | 2 |
| Kim, NH | 1 |
| Kim, JS | 2 |
| Bento, CF | 1 |
| Fernandes, R | 1 |
| Matafome, P | 1 |
| Sena, C | 1 |
| Seiça, R | 1 |
| Pereira, P | 1 |
| Milne, R | 1 |
| Brownstein, S | 1 |
| Berner, AK | 1 |
| Brouwers, O | 1 |
| Pringle, R | 1 |
| Klaassen, I | 1 |
| Colhoun, L | 1 |
| McVicar, C | 1 |
| Brockbank, S | 1 |
| Curry, JW | 1 |
| Miyata, T | 1 |
| Brownlee, M | 2 |
| Schlingemann, RO | 1 |
| Schalkwijk, C | 1 |
| Lee, YM | 1 |
| Jo, K | 1 |
| Shin, SD | 1 |
| Swamy-Mruthinti, S | 1 |
| Miriam, KC | 1 |
| Kumar, SK | 1 |
| Biswas, J | 1 |
| Ramakrishnan, S | 1 |
| Nagaraj, RH | 1 |
| Sulochana, KN | 1 |
| Bhatwadekar, AD | 1 |
| Glenn, JV | 1 |
| Li, G | 1 |
| Curtis, TM | 1 |
| Gardiner, TA | 1 |
| McLellan, AC | 1 |
| Thornalley, PJ | 1 |
| Benn, J | 1 |
| Sonksen, PH | 1 |
| Schleicher, E | 1 |
| Bretzel, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relationship of Advanced Glycation Endproducts in the Anterior Lens Capsule to Glycemic Status and Diabetic Retinopathy: A Cross Sectional Study of Patients With and Without Type 2 Diabetes Mellitus Undergoing Cataract Surgery[NCT02662010] | 157 participants (Actual) | Observational | 2016-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvaldehyde and Diabetic Retinopathy
| Article | Year |
|---|---|
Dicarbonyls Generation, Toxicities, Detoxifications and Potential Roles in Diabetes Complications.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Ret | 2020 |
Advanced glycation end products and diabetic retinopathy.
Topics: Animals; Blood-Retinal Barrier; Diabetic Retinopathy; Glycation End Products, Advanced; Molecular Ta | 2013 |
16 other studies available for pyruvaldehyde and Diabetic Retinopathy
| Article | Year |
|---|---|
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats.
Topics: Animals; Diabetic Retinopathy; Endothelial Cells; Pericytes; Pyruvaldehyde; Rats; Retina; Retinal Ve | 2023 |
Autoantibodies Against Methylglyoxal-Modified Apolipoprotein B100 and ApoB100 Peptide Are Associated With Less Coronary Artery Atherosclerosis and Retinopathy in Long-Term Type 1 Diabetes.
Topics: Apolipoprotein B-100; Atherosclerosis; Autoantibodies; Coronary Artery Disease; Diabetes Mellitus, T | 2021 |
Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; | 2019 |
CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; CD11 Antigens; Diabetic Retinopathy; Female; Gluco | 2014 |
Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopath | 2015 |
Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Lactoylglutathione Ly | 2015 |
The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy.
Topics: Animals; Blood Glucose; Caenorhabditis elegans; Diabetic Retinopathy; Dipeptidyl Peptidase 4; Dipept | 2016 |
Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetic Retinopathy; F | 2009 |
KIOM-79 prevents methyglyoxal-induced retinal pericyte apoptosis in vitro and in vivo.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Cells, Cultured; Diabetic Retinopathy; Fluorescent | 2010 |
Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.
Topics: Amino Acid Sequence; Angiopoietin-2; Animals; Apoptosis; Cell Line; Cell Proliferation; Culture Medi | 2010 |
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.
Topics: Animals; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Hyperglycemia; Immunohistoc | 2012 |
Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.
Topics: Animals; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Chromatogr | 2012 |
Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.
Topics: Adolescent; Adult; Blood Glucose; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Epiretina | 2002 |
Advanced glycation of fibronectin impairs vascular repair by endothelial progenitor cells: implications for vasodegeneration in diabetic retinopathy.
Topics: Animals; Cattle; Cell Adhesion; Cell Movement; Chemokine CXCL12; Chemotaxis; Diabetic Retinopathy; E | 2008 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations.
Topics: Adult; Deoxyglucose; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Glycated Hemoglobin; G | 1999 |