pyruvaldehyde has been researched along with Diabetic Neuropathies in 19 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to investigate the inhibitory abilities of phenolic acids (chlorogenic acid, syringic acid and vanillic acid) on methylglyoxal-induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis in the progression of diabetic neuropathy." | 3.74 | Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. ( Chuang, HC; Huang, SM; Wu, CH; Yen, GC, 2008) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "Although diabetic polyneuropathy (DPN) is a frequent diabetic complication, no effective therapeutic approach has been established." | 1.62 | Glucagon Prevents Cytotoxicity Induced by Methylglyoxal in a Rat Neuronal Cell Line Model. ( Himeno, T; Kamiya, H; Kato, Y; Kondo, M; Mohiuddin, MS; Morishita, Y; Nakamura, J; Tsunekawa, S; Yamada, Y, 2021) |
| "Hyperexcitability in diabetic polyneuropathy may, at least in part, be caused by dysfunctional axonal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels." | 1.42 | Upregulation of axonal HCN current by methylglyoxal: Potential association with diabetic polyneuropathy. ( Banzrai, C; Endo, S; Kaji, R; Nodera, H; Osaki, Y; Shibuta, Y; Shimatani, Y; Takayasu, K, 2015) |
| "This hyperalgesia is reflected by increased blood flow in brain regions that are involved in pain processing." | 1.38 | Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. ( Babes, A; Bierhaus, A; Brownlee, M; Cooper, ME; Dehmer, T; Eberhardt, M; Edelstein, D; Elvert, R; Fleming, T; Forbes, J; Haberkorn, U; Humpert, PM; Kichko, TI; Konrade, I; Lasischka, F; Lasitschka, F; Leffler, A; Lukic, IK; Mier, W; Morcos, M; Nau, C; Nawroth, PP; Neacsu, C; Neuhuber, WL; Pirags, V; Rabbani, N; Reeh, PW; Sauer, SK; Schnölzer, M; Schwaninger, M; Stern, DM; Stoyanov, S; Thornalley, PJ; Ziegler, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Santos, DFS | 1 |
| Donahue, RR | 2 |
| Laird, DE | 2 |
| Oliveira, MCG | 1 |
| Taylor, BK | 2 |
| Alouffi, S | 1 |
| Khan, MWA | 1 |
| Strom, A | 1 |
| Strassburger, K | 1 |
| Schmuck, M | 1 |
| Shevalye, H | 2 |
| Davidson, E | 1 |
| Zivehe, F | 1 |
| Bönhof, G | 1 |
| Reimer, R | 1 |
| Belgardt, BF | 1 |
| Fleming, T | 6 |
| Biermann, B | 1 |
| Burkart, V | 1 |
| Müssig, K | 1 |
| Szendroedi, J | 1 |
| Yorek, MA | 2 |
| Fritsche, E | 1 |
| Nawroth, PP | 4 |
| Roden, M | 1 |
| Ziegler, D | 2 |
| Fujita, Y | 1 |
| Murakami, T | 1 |
| Nakamura, A | 1 |
| Mohiuddin, MS | 1 |
| Himeno, T | 1 |
| Yamada, Y | 1 |
| Morishita, Y | 1 |
| Kondo, M | 1 |
| Tsunekawa, S | 1 |
| Kato, Y | 1 |
| Nakamura, J | 1 |
| Kamiya, H | 1 |
| Griggs, RB | 1 |
| Santos, DF | 1 |
| Doolen, S | 1 |
| Wessel, CR | 1 |
| Fu, W | 1 |
| Sinha, GP | 1 |
| Wang, P | 1 |
| Zhou, J | 1 |
| Brings, S | 1 |
| Susuki, K | 1 |
| Cheng, RX | 1 |
| Feng, Y | 1 |
| Liu, D | 1 |
| Wang, ZH | 1 |
| Zhang, JT | 1 |
| Chen, LH | 1 |
| Su, CJ | 1 |
| Wang, B | 1 |
| Huang, Y | 1 |
| Ji, RR | 1 |
| Hu, J | 1 |
| Liu, T | 1 |
| Lupachyk, S | 1 |
| Watcho, P | 1 |
| Vareniuk, I | 1 |
| Obrosov, A | 1 |
| Obrosova, IG | 1 |
| Andersson, DA | 1 |
| Gentry, C | 1 |
| Light, E | 1 |
| Vastani, N | 1 |
| Vallortigara, J | 1 |
| Bierhaus, A | 2 |
| Bevan, S | 1 |
| Hansen, CS | 1 |
| Jensen, TM | 1 |
| Jensen, JS | 1 |
| Nawroth, P | 1 |
| Witte, DR | 1 |
| Lauritzen, T | 1 |
| Sandbaek, A | 1 |
| Charles, M | 1 |
| Fleischer, J | 1 |
| Vistisen, D | 1 |
| Jørgensen, ME | 1 |
| Shimatani, Y | 1 |
| Nodera, H | 1 |
| Osaki, Y | 1 |
| Banzrai, C | 1 |
| Takayasu, K | 1 |
| Endo, S | 1 |
| Shibuta, Y | 1 |
| Kaji, R | 1 |
| Vucic, S | 1 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| Huang, Q | 1 |
| Chen, Y | 1 |
| Gong, N | 1 |
| Wang, YX | 1 |
| Stoyanov, S | 1 |
| Leffler, A | 1 |
| Babes, A | 1 |
| Neacsu, C | 1 |
| Sauer, SK | 1 |
| Eberhardt, M | 1 |
| Schnölzer, M | 1 |
| Lasitschka, F | 1 |
| Lasischka, F | 1 |
| Neuhuber, WL | 1 |
| Kichko, TI | 1 |
| Konrade, I | 1 |
| Elvert, R | 1 |
| Mier, W | 1 |
| Pirags, V | 1 |
| Lukic, IK | 1 |
| Morcos, M | 1 |
| Dehmer, T | 1 |
| Rabbani, N | 1 |
| Thornalley, PJ | 2 |
| Edelstein, D | 1 |
| Nau, C | 1 |
| Forbes, J | 1 |
| Humpert, PM | 1 |
| Schwaninger, M | 1 |
| Stern, DM | 1 |
| Cooper, ME | 1 |
| Haberkorn, U | 1 |
| Brownlee, M | 1 |
| Reeh, PW | 1 |
| Ohkawara, S | 1 |
| Tanaka-Kagawa, T | 1 |
| Furukawa, Y | 1 |
| Jinno, H | 1 |
| Huang, SM | 1 |
| Chuang, HC | 1 |
| Wu, CH | 1 |
| Yen, GC | 1 |
| McLellan, AC | 1 |
| Benn, J | 1 |
| Sonksen, PH | 1 |
4 reviews available for pyruvaldehyde and Diabetic Neuropathies
| Article | Year |
|---|---|
Dicarbonyls Generation, Toxicities, Detoxifications and Potential Roles in Diabetes Complications.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Ret | 2020 |
Recent Advances in Biomarkers and Regenerative Medicine for Diabetic Neuropathy.
Topics: Animals; Biomarkers; Cytokines; Diabetic Neuropathies; Exosomes; Glyoxal; Humans; Inflammation; Lact | 2021 |
Reactive metabolites as a cause of late diabetic complications.
Topics: Animals; Diabetes Complications; Diabetic Neuropathies; Glycation End Products, Advanced; Humans; La | 2014 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
1 trial available for pyruvaldehyde and Diabetic Neuropathies
| Article | Year |
|---|---|
The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Denmark; Diabetes Mellitus, Type 2; D | 2015 |
14 other studies available for pyruvaldehyde and Diabetic Neuropathies
| Article | Year |
|---|---|
The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy.
Topics: Analgesics; Animals; Diabetic Neuropathies; Disease Models, Animal; Female; Hyperalgesia; Male; Mice | 2022 |
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Topics: Animals; Cross-Sectional Studies; Diabetes Mellitus; Diabetic Neuropathies; Energy Metabolism; Femal | 2021 |
Glucagon Prevents Cytotoxicity Induced by Methylglyoxal in a Rat Neuronal Cell Line Model.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Diabetic Neuropa | 2021 |
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Topics: Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Cyclic AMP-Dependent Protein Kinas | 2019 |
The role of Na
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Disease Models, Animal; Humans; Male; Mic | 2019 |
Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.
Topics: Aldehydes; Animals; Arterioles; Behavior, Animal; Blood Glucose; Blotting, Western; Body Weight; Dia | 2013 |
Methylglyoxal evokes pain by stimulating TRPA1.
Topics: Acetanilides; Acute Pain; Animals; Calcium Signaling; Diabetic Neuropathies; Dogs; Glucose; Insulin- | 2013 |
Upregulation of axonal HCN current by methylglyoxal: Potential association with diabetic polyneuropathy.
Topics: Aged; Aged, 80 and over; Animals; Axons; Biomarkers; Case-Control Studies; Diabetic Neuropathies; Di | 2015 |
Methylglyoxal modulates axonal excitability in diabetic polyneuropathy: A potential pathophysiological link?
Topics: Animals; Axons; Diabetic Neuropathies; Female; Humans; Hyperpolarization-Activated Cyclic Nucleotide | 2015 |
Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels.
Topics: Analgesics; Aniline Compounds; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neu | 2016 |
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Topics: Animals; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans | 2012 |
Methylglyoxal activates the human transient receptor potential ankyrin 1 channel.
Topics: Acrolein; Calcium; Calcium Channels; Capsaicin; Cloning, Molecular; Diabetic Neuropathies; HEK293 Ce | 2012 |
Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Chlorogenic Acid; Cytoprotection; Di | 2008 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |