pyruvaldehyde has been researched along with Diabetic Glomerulosclerosis in 41 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Secondary goals examined albuminuria, age, race, sex, and metformin prescription." | 5.20 | Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease. ( Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM, 2015) |
| "The importance of the dicarbonyls in diabetic kidney disease is clearly demonstrated by the reno-protective benefits of structurally-disparate dicarbonyl scavengers in experimental studies." | 2.66 | Dicarbonyl-mediated AGEing and diabetic kidney disease. ( Dimitropoulos, A; Rosado, CJ; Thomas, MC, 2020) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "Cell treatment by aldosterone+glycated albumin increased intracellular MGO, MR and RAGE expression; hampered antioxidant, detoxification enzyme activities and reduced NRF-2, Keap-1 expression." | 1.72 | Mineralocorticoid interaction with glycated albumin downregulates NRF - 2 signaling pathway in renal cells: Insights into diabetic nephropathy. ( Apte, MM; Bangar, NS; Gaikwad, DD; Gvalani, A; Tupe, RS, 2022) |
| "In conclusion, progression of diabetic nephropathy is significantly related to elevated dicarbonyl stress and possibly related to oxidative stress in three separate populations, suggesting that these factors play a role in determining individual susceptibility." | 1.33 | Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. ( Beisswenger, PJ; Drummond, KS; Howell, SK; Mauer, M; Nelson, RG; Szwergold, BS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 23 (56.10) | 24.3611 |
| 2020's | 8 (19.51) | 2.80 |
| Authors | Studies |
|---|---|
| Koivisto, A | 1 |
| Hukkanen, M | 1 |
| Saarnilehto, M | 1 |
| Chapman, H | 1 |
| Kuokkanen, K | 1 |
| Wei, H | 1 |
| Viisanen, H | 1 |
| Akerman, KE | 1 |
| Lindstedt, K | 1 |
| Pertovaara, A | 1 |
| Darenskaya, MA | 1 |
| Chugunova, EV | 1 |
| Kolesnikov, SI | 1 |
| Grebenkina, LA | 1 |
| Semenova, NV | 1 |
| Nikitina, OA | 1 |
| Kolesnikova, LI | 1 |
| Cho, CH | 1 |
| Lee, CJ | 1 |
| Kim, MG | 1 |
| Ryu, B | 1 |
| Je, JG | 1 |
| Kim, Y | 2 |
| Lee, SH | 1 |
| Gaikwad, DD | 1 |
| Bangar, NS | 1 |
| Apte, MM | 1 |
| Gvalani, A | 1 |
| Tupe, RS | 1 |
| Rabbani, N | 1 |
| Adaikalakoteswari, A | 1 |
| Larkin, JR | 1 |
| Panagiotopoulos, S | 1 |
| MacIsaac, RJ | 1 |
| Yue, DK | 1 |
| Fulcher, GR | 1 |
| Roberts, MA | 1 |
| Thomas, M | 1 |
| Ekinci, E | 1 |
| Thornalley, PJ | 2 |
| Alouffi, S | 1 |
| Khan, MWA | 1 |
| Dimitropoulos, A | 1 |
| Rosado, CJ | 1 |
| Thomas, MC | 1 |
| Mojadami, S | 1 |
| Ahangarpour, A | 1 |
| Mard, SA | 1 |
| Khorsandi, L | 1 |
| Abharzanjani, F | 1 |
| Hemmati, M | 1 |
| Hanssen, NMJ | 2 |
| Scheijen, JLJM | 1 |
| Jorsal, A | 1 |
| Parving, HH | 1 |
| Tarnow, L | 1 |
| Rossing, P | 2 |
| Stehouwer, CDA | 2 |
| Schalkwijk, CG | 2 |
| Do, MH | 1 |
| Hur, J | 1 |
| Choi, J | 1 |
| Kim, M | 1 |
| Kim, MJ | 1 |
| Ha, SK | 1 |
| Pácal, L | 1 |
| Chalásová, K | 1 |
| Pleskačová, A | 1 |
| Řehořová, J | 1 |
| Tomandl, J | 1 |
| Kaňková, K | 1 |
| Tezuka, Y | 1 |
| Nakaya, I | 1 |
| Nakayama, K | 1 |
| Nakayama, M | 1 |
| Yahata, M | 1 |
| Soma, J | 1 |
| Wang, XJ | 1 |
| Ma, SB | 1 |
| Liu, ZF | 1 |
| Li, H | 1 |
| Gao, WY | 1 |
| Beisswenger, PJ | 3 |
| Howell, SK | 2 |
| Russell, GB | 1 |
| Miller, ME | 1 |
| Rich, SS | 1 |
| Mauer, M | 3 |
| Sveen, KA | 1 |
| Karimé, B | 1 |
| Jørum, E | 1 |
| Mellgren, SI | 1 |
| Fagerland, MW | 1 |
| Monnier, VM | 5 |
| Dahl-Jørgensen, K | 1 |
| Hanssen, KF | 1 |
| Rodrigues, L | 1 |
| Matafome, P | 1 |
| Crisóstomo, J | 1 |
| Santos-Silva, D | 1 |
| Sena, C | 1 |
| Pereira, P | 1 |
| Seiça, R | 1 |
| Genuth, S | 1 |
| Sun, W | 1 |
| Cleary, P | 1 |
| Gao, X | 1 |
| Sell, DR | 1 |
| Lachin, J | 1 |
| Zhu, D | 1 |
| Wang, L | 1 |
| Zhou, Q | 1 |
| Yan, S | 1 |
| Li, Z | 1 |
| Sheng, J | 1 |
| Zhang, W | 1 |
| Yubero-Serrano, EM | 1 |
| Woodward, M | 1 |
| Poretsky, L | 1 |
| Vlassara, H | 1 |
| Striker, GE | 1 |
| Sohn, E | 3 |
| Kim, J | 3 |
| Kim, CS | 2 |
| Jo, K | 1 |
| Kim, JS | 3 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| Jensen, TM | 1 |
| Vistisen, D | 1 |
| Fleming, T | 1 |
| Nawroth, PP | 2 |
| Jørgensen, ME | 1 |
| Lauritzen, T | 1 |
| Sandbaek, A | 1 |
| Witte, DR | 1 |
| Saulnier, PJ | 1 |
| Wheelock, KM | 1 |
| Howell, S | 1 |
| Weil, EJ | 1 |
| Tanamas, SK | 1 |
| Knowler, WC | 1 |
| Lemley, KV | 1 |
| Yee, B | 1 |
| Nelson, RG | 2 |
| Singh, J | 1 |
| Chaudhari, BP | 1 |
| Kakkar, P | 1 |
| Yamabe, N | 1 |
| Kang, KS | 1 |
| Park, CH | 1 |
| Tanaka, T | 1 |
| Yokozawa, T | 1 |
| Pozzi, A | 1 |
| Zent, R | 1 |
| Chetyrkin, S | 1 |
| Borza, C | 1 |
| Bulus, N | 1 |
| Chuang, P | 2 |
| Chen, D | 1 |
| Hudson, B | 1 |
| Voziyan, P | 1 |
| Reiniger, N | 1 |
| Lau, K | 1 |
| McCalla, D | 1 |
| Eby, B | 1 |
| Cheng, B | 1 |
| Lu, Y | 1 |
| Qu, W | 1 |
| Quadri, N | 1 |
| Ananthakrishnan, R | 1 |
| Furmansky, M | 1 |
| Rosario, R | 1 |
| Song, F | 1 |
| Rai, V | 1 |
| Weinberg, A | 1 |
| Friedman, R | 1 |
| Ramasamy, R | 1 |
| D'Agati, V | 1 |
| Schmidt, AM | 1 |
| Lu, J | 1 |
| Randell, E | 1 |
| Han, Y | 1 |
| Adeli, K | 1 |
| Krahn, J | 1 |
| Meng, QH | 1 |
| Zhao, Y | 1 |
| Banerjee, S | 1 |
| LeJeune, WS | 1 |
| Choudhary, S | 1 |
| Tilton, RG | 1 |
| Kim, YS | 1 |
| Jung, DH | 1 |
| Liu, BF | 1 |
| Miyata, S | 1 |
| Hirota, Y | 1 |
| Higo, S | 1 |
| Miyazaki, H | 1 |
| Fukunaga, M | 1 |
| Hamada, Y | 1 |
| Ueyama, S | 1 |
| Muramoto, O | 1 |
| Uriuhara, A | 1 |
| Kasuga, M | 1 |
| Rosca, MG | 2 |
| Mustata, TG | 1 |
| Kinter, MT | 1 |
| Ozdemir, AM | 2 |
| Kern, TS | 1 |
| Szweda, LI | 2 |
| Brownlee, M | 1 |
| Weiss, MF | 3 |
| Pedchenko, VK | 1 |
| Chetyrkin, SV | 1 |
| Ham, AJ | 1 |
| Saleem, MA | 1 |
| Mathieson, PW | 1 |
| Hudson, BG | 1 |
| Voziyan, PA | 1 |
| Drummond, KS | 1 |
| Szwergold, BS | 1 |
| Hopfer, U | 1 |
| Rosca, MV | 1 |
| Fan, XJ | 1 |
| McLellan, AC | 1 |
| Benn, J | 1 |
| Sonksen, PH | 1 |
| Schleicher, ED | 1 |
| Bierhaus, A | 1 |
| Häring, HU | 1 |
| Lehmann, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4: a Protocol of a Randomized, Parallel, Controlled Trial[NCT03596749] | Phase 3 | 80 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pyruvaldehyde and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Dicarbonyls Generation, Toxicities, Detoxifications and Potential Roles in Diabetes Complications.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Ret | 2020 |
Dicarbonyl-mediated AGEing and diabetic kidney disease.
Topics: Aging; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Lactoylg | 2020 |
Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease.
Topics: Diabetic Nephropathies; Humans; Lactoylglutathione Lyase; Pyruvaldehyde; Renal Insufficiency, Chroni | 2019 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
Chemistry and pathobiology of advanced glycation end products.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Gene Expression Regulation; Glucose; | 2001 |
3 trials available for pyruvaldehyde and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic N | 2015 |
Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus.
Topics: Adult; Aged; Albuminuria; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic N | 2016 |
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Glycat | 2016 |
33 other studies available for pyruvaldehyde and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.
Topics: Animals; Calcium Channels; Calcium Signaling; Diabetes Mellitus, Experimental; Diabetic Nephropathie | 2012 |
Content of Carbonyl Compounds and Parameters of Glutathione Metabolism in Men with Type 1 Diabetes Mellitus at Preclinical Stages of Diabetic Nephropathy.
Topics: Adolescent; Adult; Albuminuria; Asymptomatic Diseases; Case-Control Studies; Diabetes Mellitus, Type | 2021 |
Therapeutic Potential of Phlorotannin-Rich
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Magnesium Oxid | 2022 |
Mineralocorticoid interaction with glycated albumin downregulates NRF - 2 signaling pathway in renal cells: Insights into diabetic nephropathy.
Topics: Aldehyde Reductase; Aldosterone; Antioxidants; Catalase; Diabetic Nephropathies; Glutathione; Glutat | 2022 |
Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease.
Topics: Cross-Sectional Studies; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced | 2022 |
Diabetic nephropathy induced by methylglyoxal: gallic acid regulates kidney microRNAs and glyoxalase1-Nrf2 in male mice.
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Gallic Acid; Kidney; Male; Mice; Micro | 2023 |
Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: in vivo and in vitro analysis.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Calcium-Binding Proteins; Carboxylic Ester Hydrola | 2021 |
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study.
Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow-Up | 2017 |
Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eucommiaceae; Gene | 2018 |
Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology.
Topics: Aged; Case-Control Studies; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Lactoylglutat | 2018 |
Methylglyoxal as a prognostic factor in patients with chronic kidney disease.
Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Deoxyglucose; Diabetic Nephropathies; Disease P | 2019 |
Elevated levels of α-dicarbonyl compounds in the plasma of type II diabetics and their relevance with diabetic nephropathy.
Topics: Aged; Biomarkers; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; Dia | 2019 |
Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products.
Topics: Adolescent; Adult; Child; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; | 2013 |
Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow- | 2013 |
Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.
Topics: Angiotensin II; Animals; Apoptosis; Apoptosis Regulatory Proteins; Diabetes Mellitus, Type 2; Diabet | 2014 |
Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopath | 2015 |
(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice.
Topics: Animals; Catechin; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progr | 2014 |
Extract of Rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin‑induced diabetic rats and its active compound emodin inhibits methylglyoxal‑mediated glycation of proteins.
Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Emodin; Fall | 2015 |
Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation.
Topics: Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy | 2017 |
7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney.
Topics: Aldehydes; Animals; Antioxidants; Blood Glucose; Blotting, Western; Body Weight; Cornus; Diabetes Me | 2009 |
Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type IV; Diabetic Nephropathie | 2009 |
Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Diabetes Mellitus, Experimental; Di | 2011 |
Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse.
Topics: Animals; Blood Glucose; Chickens; Diabetic Nephropathies; Disease Models, Animal; Gene Deletion; Glo | 2010 |
Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.
Topics: Albumins; Biomarkers; Blood Glucose; Case-Control Studies; Cell Adhesion Molecules; Creatinine; Diab | 2011 |
NF-κB-inducing kinase increases renal tubule epithelial inflammation associated with diabetes.
Topics: Animals; Cells, Cultured; Diabetic Nephropathies; Gene Expression Regulation; Humans; Inflammation; | 2011 |
Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells.
Topics: Acetophenones; Animals; Axl Receptor Tyrosine Kinase; Benzopyrans; Diabetes Mellitus, Experimental; | 2012 |
Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diabetic Nephropathies; DNA Fragmentation; En | 2003 |
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabe | 2005 |
Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy.
Topics: Aldehydes; Arginine; Binding Sites; Cell Adhesion; Cell Physiological Phenomena; Collagen Type IV; D | 2005 |
Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress.
Topics: Adolescent; Adult; Cohort Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2005 |
Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin.
Topics: Cell Line, Transformed; Diabetic Nephropathies; Epithelial Cells; Fluorescein-5-isothiocyanate; Fluo | 2008 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal.
Topics: Adenosine Diphosphate; Animals; Diabetic Nephropathies; Electron Transport; Kidney; Mitochondria; Mi | 2002 |