pyruvaldehyde has been researched along with Diabetic Angiopathies in 28 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisation of blood glucose concentration, the event risk is amplified-an effect called "glycolytic memory"." | 2.82 | Dicarbonyl Stress in Diabetic Vascular Disease. ( Stratmann, B, 2022) |
| "Pentosidine level changes were unrelated to changes in levels of renal function, inflammation, or cytokines." | 2.79 | The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. ( Barzilay, JI; Fonseca, V; Goldfine, AB; Jablonski, KA; Monnier, VM; Shoelson, SE; Strauch, C, 2014) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "The presence of both IGM and type 2 diabetes was significantly associated with higher α-dicarbonyl incremental areas under the curve (iAUCs), as calculated from the OGTT (for IGM, MGO β = 0." | 1.42 | Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. ( Hanssen, NM; Maessen, DE; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 18 (64.29) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Jahan, H | 1 |
| Siddiqui, NN | 1 |
| Iqbal, S | 1 |
| Basha, FZ | 1 |
| Shaikh, S | 1 |
| Pizzi, M | 1 |
| Choudhary, MI | 1 |
| Stratmann, B | 1 |
| Hanssen, NMJ | 1 |
| Westerink, J | 1 |
| Scheijen, JLJM | 1 |
| van der Graaf, Y | 1 |
| Stehouwer, CDA | 1 |
| Schalkwijk, CG | 5 |
| Barzilay, JI | 1 |
| Jablonski, KA | 1 |
| Fonseca, V | 1 |
| Shoelson, SE | 1 |
| Goldfine, AB | 1 |
| Strauch, C | 1 |
| Monnier, VM | 2 |
| Vulesevic, B | 1 |
| McNeill, B | 1 |
| Geoffrion, M | 1 |
| Kuraitis, D | 1 |
| McBane, JE | 1 |
| Lochhead, M | 1 |
| Vanderhyden, BC | 1 |
| Korbutt, GS | 1 |
| Milne, RW | 1 |
| Suuronen, EJ | 1 |
| Genuth, S | 1 |
| Sun, W | 1 |
| Cleary, P | 1 |
| Gao, X | 1 |
| Sell, DR | 1 |
| Lachin, J | 1 |
| Maessen, DE | 2 |
| Hanssen, NM | 1 |
| Scheijen, JL | 1 |
| van der Kallen, CJ | 1 |
| van Greevenbroek, MM | 1 |
| Stehouwer, CD | 3 |
| Hansen, CS | 1 |
| Jensen, TM | 1 |
| Jensen, JS | 1 |
| Nawroth, P | 1 |
| Fleming, T | 1 |
| Witte, DR | 1 |
| Lauritzen, T | 1 |
| Sandbaek, A | 1 |
| Charles, M | 1 |
| Fleischer, J | 1 |
| Vistisen, D | 1 |
| Jørgensen, ME | 1 |
| Fang, L | 1 |
| Li, X | 1 |
| Zhong, Y | 1 |
| Yu, J | 1 |
| Yu, L | 1 |
| Dai, H | 1 |
| Yan, M | 1 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| Boydens, C | 1 |
| Pauwels, B | 1 |
| Vanden Daele, L | 1 |
| Van de Voorde, J | 1 |
| Alomar, F | 1 |
| Singh, J | 1 |
| Jang, HS | 1 |
| Rozanzki, GJ | 1 |
| Shao, CH | 1 |
| Padanilam, BJ | 1 |
| Mayhan, WG | 1 |
| Bidasee, KR | 1 |
| Nobécourt, E | 1 |
| Tabet, F | 1 |
| Lambert, G | 1 |
| Puranik, R | 1 |
| Bao, S | 1 |
| Yan, L | 1 |
| Davies, MJ | 1 |
| Brown, BE | 1 |
| Jenkins, AJ | 1 |
| Dusting, GJ | 1 |
| Bonnet, DJ | 1 |
| Curtiss, LK | 1 |
| Barter, PJ | 1 |
| Rye, KA | 1 |
| Ogawa, S | 1 |
| Nakayama, K | 1 |
| Nakayama, M | 1 |
| Mori, T | 1 |
| Matsushima, M | 1 |
| Okamura, M | 1 |
| Senda, M | 1 |
| Nako, K | 1 |
| Miyata, T | 1 |
| Ito, S | 1 |
| Lund, T | 1 |
| Svindland, A | 1 |
| Pepaj, M | 1 |
| Jensen, AB | 1 |
| Berg, JP | 1 |
| Kilhovd, B | 1 |
| Hanssen, KF | 1 |
| Titov, VN | 1 |
| Shiriaeva, IuK | 1 |
| Mukohda, M | 1 |
| Okada, M | 1 |
| Hara, Y | 1 |
| Yamawaki, H | 1 |
| Kender, Z | 1 |
| Torzsa, P | 1 |
| Grolmusz K, V | 1 |
| Patócs, A | 1 |
| Lichthammer, A | 1 |
| Veresné Bálint, M | 1 |
| Rácz, K | 1 |
| Reismann, P | 1 |
| Mathys, KC | 1 |
| Ponnampalam, SN | 1 |
| Padival, S | 1 |
| Nagaraj, RH | 1 |
| Vlassara, H | 1 |
| Cai, W | 1 |
| Crandall, J | 1 |
| Goldberg, T | 1 |
| Oberstein, R | 1 |
| Dardaine, V | 1 |
| Peppa, M | 1 |
| Rayfield, EJ | 1 |
| Bourajjaj, M | 1 |
| van Hinsbergh, VW | 1 |
| Berlanga, J | 1 |
| Cibrian, D | 1 |
| Guillén, I | 1 |
| Freyre, F | 1 |
| Alba, JS | 1 |
| Lopez-Saura, P | 1 |
| Merino, N | 1 |
| Aldama, A | 1 |
| Quintela, AM | 1 |
| Triana, ME | 1 |
| Montequin, JF | 1 |
| Ajamieh, H | 1 |
| Urquiza, D | 1 |
| Ahmed, N | 1 |
| Thornalley, PJ | 2 |
| Han, Y | 1 |
| Randell, E | 1 |
| Vasdev, S | 1 |
| Gill, V | 1 |
| Gadag, V | 1 |
| Newhook, LA | 1 |
| Grant, M | 1 |
| Hagerty, D | 1 |
| Yao, D | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Pestell, R | 1 |
| Edelstein, D | 1 |
| Giardino, I | 1 |
| Suske, G | 1 |
| Rabbani, N | 1 |
| Sarthy, VP | 1 |
| Hammes, HP | 1 |
| Brownlee, M | 1 |
| Che, W | 1 |
| Asahi, M | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Okado, A | 1 |
| Higashiyama, S | 1 |
| Taniguchi, N | 1 |
| Aleksandrovskii, YA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease: Investigator Initiated Randomized Placebo-controlled Double-blind, Pilot Study[NCT03222206] | Phase 4 | 34 participants (Actual) | Interventional | 2017-11-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for pyruvaldehyde and Diabetic Angiopathies
| Article | Year |
|---|---|
Dicarbonyl Stress in Diabetic Vascular Disease.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced; | 2022 |
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Angiopathies; D | 2015 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility.
Topics: Animals; Arteries; Diabetic Angiopathies; Glucose; Humans; Pyruvaldehyde; Vasoconstriction | 2012 |
[The role of methylglyoxal metabolism in type-2 diabetes and its complications].
Topics: Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glycation End Products, Advanced; | 2012 |
Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus.
Topics: Diabetic Angiopathies; Humans; Imidazoles; Pyruvaldehyde | 2003 |
3 trials available for pyruvaldehyde and Diabetic Angiopathies
| Article | Year |
|---|---|
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Diabetes Mellitus, Type 2; Di | 2014 |
The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Denmark; Diabetes Mellitus, Type 2; D | 2015 |
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.
Topics: Biomarkers; C-Reactive Protein; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus; Diabe | 2002 |
19 other studies available for pyruvaldehyde and Diabetic Angiopathies
| Article | Year |
|---|---|
Suppression of COX-2/PGE
Topics: Carbazoles; Cyclooxygenase 2; Diabetic Angiopathies; Dinoprostone; Glucose; Glycation End Products, | 2022 |
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes.
Topics: Adult; Aged; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathi | 2018 |
Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice.
Topics: Angiogenic Proteins; Animals; Apoptosis; Blood Glucose; Bone Marrow Cells; Bone Marrow Transplantati | 2014 |
Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes.
Topics: Adult; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopath | 2015 |
Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study.
Topics: Atherosclerosis; Blood Glucose; Chromatography, Liquid; Cross-Sectional Studies; Deoxyglucose; Diabe | 2015 |
Vascular AGE-ing by methylglyoxal: the past, the present and the future.
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced; Humans; Lactoyl | 2015 |
Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats.
Topics: Animals; Autophagy; Blood-Brain Barrier; Brain Ischemia; Capillaries; Cell Line; Cell Survival; Diab | 2015 |
Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum.
Topics: Acetylcholine; Animals; Arteries; Biological Factors; Cytoprotection; Diabetic Angiopathies; Dose-Re | 2016 |
Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.
Topics: Animals; Arterioles; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2016 |
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apolipoprotein A-I; Carotid Arter | 2010 |
Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.
Topics: Biomarkers; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; H | 2010 |
Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans.
Topics: Aged; Aged, 80 and over; Amino Acid Sequence; Aorta; Blotting, Western; Carotid Artery, Common; Case | 2011 |
[The glucose, glycotoxins and glycation products: the involvement into pathogenesis of microangiopathies, arteriolosclerosis and atherosclerosis].
Topics: Arteriolosclerosis; Atherosclerosis; Diabetes Mellitus; Diabetic Angiopathies; Glucose; Glutamic Aci | 2011 |
Semicarbazide-sensitive amine oxidase in aortic smooth muscle cells mediates synthesis of a methylglyoxal-AGE: implications for vascular complications in diabetes.
Topics: Amine Oxidase (Copper-Containing); Animals; Aorta; Cattle; Cells, Cultured; Diabetic Angiopathies; G | 2002 |
Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.
Topics: Animals; Blood Glucose; Cholesterol; Diabetic Angiopathies; Disease Models, Animal; Fructosamine; In | 2005 |
Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes.
Topics: Adolescent; Adult; Cell Membrane; Child; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease P | 2007 |
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
Topics: Acetylglucosamine; Angiopoietin-2; Animals; Arginine; Cell Line, Transformed; Diabetes Mellitus, Exp | 2007 |
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Cell Nucleus; Cells, Cultured; Cyclohexi | 1997 |
Antithrombin III, C1 inhibitor, methylglyoxal, and polymorphonuclear leukocytes in the development of vascular complications in diabetes mellitus.
Topics: Acetoacetates; Antithrombin III; Complement C1 Inactivator Proteins; Diabetic Angiopathies; Humans; | 1992 |