pyruvaldehyde has been researched along with Diabetes Mellitus in 117 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Body weight gain, fat deposits, dyslipidemia, hyperglycemia, and fatty liver were ameliorated by dietary genistein in both studies." | 3.91 | Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet. ( Sang, S; Wang, P; Zhao, Y, 2019) |
| "Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisation of blood glucose concentration, the event risk is amplified-an effect called "glycolytic memory"." | 2.82 | Dicarbonyl Stress in Diabetic Vascular Disease. ( Stratmann, B, 2022) |
| " Extensive clinical trials with derivatisation of available antiglycation agents to increase the bioavailability and decrease side effects are warranted further." | 2.72 | Carbonyl stress in diabetics with acute coronary syndrome. ( Bora, S; Shankarrao Adole, P, 2021) |
| "The importance of the dicarbonyls in diabetic kidney disease is clearly demonstrated by the reno-protective benefits of structurally-disparate dicarbonyl scavengers in experimental studies." | 2.66 | Dicarbonyl-mediated AGEing and diabetic kidney disease. ( Dimitropoulos, A; Rosado, CJ; Thomas, MC, 2020) |
| "Glyoxalase-1 (GLO-1) acts as a part of the anti-glycation defense system by carrying out detoxification of GO and MGO." | 2.66 | The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. ( Akhter, A; Kausar, MA; Saeed, M; Siddiqui, AJ; Singh, R, 2020) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "Diabetes mellitus is associated with increased fracture risk despite preservation of bone density and reduced bone turnover." | 1.48 | Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men. ( Alfonso, H; Almeida, OP; Davis, TME; Flicker, L; Forbes, J; Golledge, J; Hankey, GJ; Irrgang, F; Lamb, LS; Müench, G; Norman, PE; Yeap, BB, 2018) |
| " In this study, their levels were measured using a sample preparation procedure based on salting-out assisted liquid-liquid extraction (SALLE) and dispersive liquid-liquid microextraction (DLLME) combined with gas chromatography-mass spectrometry (GC-MS)." | 1.46 | Glyoxal and methylglyoxal as urinary markers of diabetes. Determination using a dispersive liquid-liquid microextraction procedure combined with gas chromatography-mass spectrometry. ( Campillo, N; Fernández-García, AJ; Hernández-Córdoba, M; Motas, M; Pastor-Belda, M; Pérez-Cárceles, MD; Viñas, P, 2017) |
| "Treatment with metformin and glipizide during in vitro albumin glycation significantly reduced the formation of glycation adducts and inhibited structural modifications." | 1.43 | Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes. ( Adeshara, K; Tupe, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (12.82) | 18.2507 |
| 2000's | 27 (23.08) | 29.6817 |
| 2010's | 47 (40.17) | 24.3611 |
| 2020's | 28 (23.93) | 2.80 |
| Authors | Studies |
|---|---|
| Pignalosa, FC | 1 |
| Desiderio, A | 2 |
| Mirra, P | 2 |
| Nigro, C | 4 |
| Perruolo, G | 1 |
| Ulianich, L | 1 |
| Formisano, P | 2 |
| Beguinot, F | 4 |
| Miele, C | 4 |
| Napoli, R | 1 |
| Fiory, F | 2 |
| Cortizo, FG | 1 |
| Pfaff, D | 1 |
| Wirth, A | 1 |
| Schlotterer, A | 1 |
| Medert, R | 1 |
| Morgenstern, J | 1 |
| Weber, T | 1 |
| Hammes, HP | 1 |
| Fleming, T | 3 |
| Nawroth, PP | 4 |
| Freichel, M | 1 |
| Teleman, AA | 1 |
| Rabbani, N | 3 |
| Stratmann, B | 3 |
| Gupta, A | 1 |
| Khursheed, M | 1 |
| Arif, Z | 1 |
| Badar, A | 1 |
| Alam, K | 1 |
| Cho, CH | 1 |
| Lee, CJ | 1 |
| Kim, MG | 1 |
| Ryu, B | 1 |
| Je, JG | 1 |
| Kim, Y | 1 |
| Lee, SH | 1 |
| Betting, F | 1 |
| Schlunck, G | 1 |
| Agostini, HT | 1 |
| Martin, G | 1 |
| Chen, X | 2 |
| Liu, Y | 1 |
| Kong, L | 1 |
| Wen, Z | 1 |
| Wang, W | 3 |
| Wang, C | 1 |
| Sengani, M | 1 |
| Chakraborty, S | 1 |
| Balaji, MP | 1 |
| Govindasamy, R | 1 |
| Alahmadi, TA | 1 |
| Al Obaid, S | 1 |
| Karuppusamy, I | 1 |
| Lan Chi, NT | 1 |
| Brindhadevi, K | 1 |
| V, DR | 1 |
| Alomar, FA | 3 |
| Schalkwijk, CG | 7 |
| Micali, LR | 3 |
| Wouters, K | 3 |
| Waseem, R | 2 |
| Shamsi, A | 2 |
| Khan, T | 2 |
| Anwer, A | 2 |
| Shahid, M | 2 |
| Kazim, SN | 2 |
| Hassan, MI | 2 |
| Islam, A | 2 |
| Adaikalakoteswari, A | 1 |
| Larkin, JR | 1 |
| Panagiotopoulos, S | 1 |
| MacIsaac, RJ | 1 |
| Yue, DK | 1 |
| Fulcher, GR | 1 |
| Roberts, MA | 1 |
| Thomas, M | 1 |
| Ekinci, E | 1 |
| Thornalley, PJ | 10 |
| Zhu, Y | 1 |
| Sang, S | 3 |
| Alzayadneh, EM | 1 |
| Shatanawi, A | 1 |
| Caldwell, RW | 1 |
| Caldwell, RB | 1 |
| Ye, J | 1 |
| Guo, Z | 1 |
| Ma, Y | 1 |
| Yang, Q | 1 |
| Zhong, W | 1 |
| Du, S | 1 |
| Bai, J | 1 |
| Yadav, N | 1 |
| Palkhede, JD | 1 |
| Kim, SY | 1 |
| Leone, A | 3 |
| Nicolò, A | 2 |
| Prevenzano, I | 3 |
| Zatterale, F | 1 |
| Longo, M | 3 |
| Spinelli, R | 2 |
| Campitelli, M | 1 |
| Conza, D | 1 |
| Raciti, GA | 2 |
| Wang, J | 1 |
| Yan, B | 1 |
| Kold-Christensen, R | 1 |
| Johannsen, M | 2 |
| Banerjee, S | 1 |
| Xin, Y | 1 |
| Hertle, E | 1 |
| van der Kallen, CJH | 1 |
| Stehouwer, CDA | 2 |
| van Greevenbroek, MMJ | 1 |
| Dimitropoulos, A | 1 |
| Rosado, CJ | 1 |
| Thomas, MC | 1 |
| Saeed, M | 1 |
| Kausar, MA | 1 |
| Singh, R | 1 |
| Siddiqui, AJ | 1 |
| Akhter, A | 1 |
| Nomiyama, T | 1 |
| Hanssen, NMJ | 1 |
| Teraa, M | 1 |
| Scheijen, JLJM | 1 |
| Van de Waarenburg, M | 1 |
| Gremmels, H | 1 |
| Verhaar, MC | 1 |
| Strom, A | 1 |
| Strassburger, K | 1 |
| Schmuck, M | 1 |
| Shevalye, H | 1 |
| Davidson, E | 1 |
| Zivehe, F | 1 |
| Bönhof, G | 1 |
| Reimer, R | 1 |
| Belgardt, BF | 1 |
| Biermann, B | 1 |
| Burkart, V | 1 |
| Müssig, K | 1 |
| Szendroedi, J | 1 |
| Yorek, MA | 1 |
| Fritsche, E | 1 |
| Roden, M | 1 |
| Ziegler, D | 1 |
| Mojadami, S | 1 |
| Ahangarpour, A | 1 |
| Mard, SA | 1 |
| Khorsandi, L | 1 |
| Bora, S | 1 |
| Shankarrao Adole, P | 1 |
| Pastor-Belda, M | 1 |
| Fernández-García, AJ | 1 |
| Campillo, N | 1 |
| Pérez-Cárceles, MD | 1 |
| Motas, M | 1 |
| Hernández-Córdoba, M | 1 |
| Viñas, P | 1 |
| Salomón, T | 1 |
| Sibbersen, C | 1 |
| Hansen, J | 1 |
| Britz, D | 1 |
| Svart, MV | 1 |
| Voss, TS | 1 |
| Møller, N | 1 |
| Gregersen, N | 1 |
| Jørgensen, KA | 1 |
| Palmfeldt, J | 1 |
| Poulsen, TB | 1 |
| Pácal, L | 1 |
| Chalásová, K | 1 |
| Pleskačová, A | 1 |
| Řehořová, J | 1 |
| Tomandl, J | 1 |
| Kaňková, K | 1 |
| Arcanjo, NMO | 1 |
| Luna, C | 1 |
| Madruga, MS | 1 |
| Estévez, M | 1 |
| Lamb, LS | 1 |
| Alfonso, H | 1 |
| Norman, PE | 1 |
| Davis, TME | 1 |
| Forbes, J | 1 |
| Müench, G | 1 |
| Irrgang, F | 2 |
| Almeida, OP | 1 |
| Golledge, J | 1 |
| Hankey, GJ | 1 |
| Flicker, L | 1 |
| Yeap, BB | 1 |
| Fleming, TH | 1 |
| Parrillo, L | 1 |
| Dhananjayan, K | 1 |
| Raju, R | 1 |
| Harman, DG | 1 |
| Moran, C | 1 |
| Srikanth, V | 1 |
| Münch, G | 1 |
| Ramachandra Bhat, L | 1 |
| Vedantham, S | 1 |
| Krishnan, UM | 1 |
| Rayappan, JBB | 1 |
| Wang, H | 1 |
| Xu, Y | 1 |
| Rao, L | 1 |
| Yang, C | 1 |
| Yuan, H | 1 |
| Gao, T | 1 |
| Sun, H | 1 |
| Xian, M | 1 |
| Liu, C | 2 |
| Zhao, Y | 1 |
| Wang, P | 1 |
| Lee, BH | 1 |
| Hsu, WH | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Engelbrecht, B | 1 |
| Hess, C | 2 |
| Tschoepe, D | 2 |
| Gawlowski, T | 1 |
| Brouwers, O | 1 |
| Niessen, PM | 1 |
| Miyata, T | 2 |
| Østergaard, JA | 1 |
| Flyvbjerg, A | 1 |
| Peutz-Kootstra, CJ | 1 |
| Sieber, J | 1 |
| Mundel, PH | 1 |
| Brownlee, M | 2 |
| Janssen, BJ | 1 |
| De Mey, JG | 1 |
| Stehouwer, CD | 1 |
| Boonkaew, B | 1 |
| Tompkins, K | 1 |
| Manokawinchoke, J | 1 |
| Pavasant, P | 1 |
| Supaphol, P | 1 |
| Vulesevic, B | 1 |
| Milne, RW | 1 |
| Suuronen, EJ | 1 |
| Lankin, V | 1 |
| Konovalova, G | 1 |
| Tikhaze, A | 1 |
| Shumaev, K | 1 |
| Kumskova, E | 1 |
| Viigimaa, M | 2 |
| Mori, K | 1 |
| Kitazawa, R | 1 |
| Kondo, T | 1 |
| Mori, M | 1 |
| Hamada, Y | 2 |
| Nishida, M | 1 |
| Minami, Y | 2 |
| Haraguchi, R | 1 |
| Takahashi, Y | 1 |
| Kitazawa, S | 1 |
| Senda, M | 1 |
| Ogawa, S | 1 |
| Nako, K | 1 |
| Okamura, M | 1 |
| Sakamoto, T | 1 |
| Ito, S | 1 |
| Peters, V | 1 |
| Lanthaler, B | 1 |
| Amberger, A | 1 |
| Forsberg, E | 1 |
| Hecker, M | 1 |
| Wagner, AH | 1 |
| Yue, WW | 1 |
| Hoffmann, GF | 1 |
| Nawroth, P | 1 |
| Zschocke, J | 1 |
| Schmitt, CP | 1 |
| Karumanchi, DK | 1 |
| Karunaratne, N | 1 |
| Lurio, L | 1 |
| Dillon, JP | 1 |
| Gaillard, ER | 1 |
| Engelbertsen, D | 1 |
| Vallejo, J | 1 |
| Quách, TD | 1 |
| Fredrikson, GN | 1 |
| Alm, R | 1 |
| Hedblad, B | 1 |
| Björkbacka, H | 1 |
| Rothstein, TL | 1 |
| Nilsson, J | 1 |
| Bengtsson, E | 1 |
| Hansen, F | 1 |
| Battú, CE | 1 |
| Dutra, MF | 1 |
| Galland, F | 1 |
| Lirio, F | 1 |
| Broetto, N | 1 |
| Nardin, P | 1 |
| Gonçalves, CA | 2 |
| Adeshara, K | 1 |
| Tupe, R | 1 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| Procopio, T | 1 |
| Andreozzi, F | 1 |
| Reztsova, VV | 1 |
| Kovalenko, IG | 1 |
| Bershteĭn, LM | 1 |
| Vander Jagt, DL | 5 |
| Kandhro, AJ | 2 |
| Mirza, MA | 2 |
| Khuhawar, MY | 3 |
| Zardari, LA | 1 |
| Laghari, AJ | 1 |
| Takahashi, K | 1 |
| Tatsunami, R | 1 |
| Tampo, Y | 1 |
| Price, CL | 2 |
| Hassi, HO | 1 |
| English, NR | 1 |
| Blakemore, AI | 1 |
| Stagg, AJ | 1 |
| Knight, SC | 2 |
| Thangarajah, H | 1 |
| Yao, D | 1 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Galvez, MG | 1 |
| Januszyk, M | 1 |
| Gurtner, GC | 1 |
| Nass, N | 1 |
| Vogel, K | 1 |
| Hofmann, B | 1 |
| Presek, P | 1 |
| Silber, RE | 1 |
| Simm, A | 1 |
| Lv, L | 1 |
| Shao, X | 1 |
| Wang, L | 1 |
| Huang, D | 1 |
| Ho, CT | 1 |
| Bento, CF | 1 |
| Fernandes, R | 1 |
| Matafome, P | 1 |
| Sena, C | 1 |
| Seiça, R | 1 |
| Pereira, P | 1 |
| Titov, VN | 2 |
| Dmitriev, LF | 1 |
| Krylin, VA | 1 |
| Dmitriev, VA | 1 |
| Tikhaze, AK | 1 |
| Konovalova, GG | 1 |
| Kumskova, EM | 1 |
| Abina, EA | 1 |
| Zemtsovskaya, G | 1 |
| Yanushevskaya, EV | 1 |
| Vlasik, TN | 1 |
| Lankin, VZ | 1 |
| Boušová, I | 1 |
| Průchová, Z | 1 |
| Trnková, L | 1 |
| Dršata, J | 1 |
| Maher, P | 1 |
| Dargusch, R | 1 |
| Ehren, JL | 1 |
| Okada, S | 1 |
| Sharma, K | 1 |
| Schubert, D | 1 |
| Remor, AP | 1 |
| de Matos, FJ | 1 |
| Ghisoni, K | 1 |
| da Silva, TL | 1 |
| Eidt, G | 1 |
| Búrigo, M | 1 |
| de Bem, AF | 1 |
| Silveira, PC | 1 |
| de León, A | 1 |
| Sanchez, MC | 1 |
| Hohl, A | 1 |
| Glaser, V | 1 |
| Quincozes-Santos, A | 1 |
| Borba Rosa, R | 1 |
| Latini, A | 1 |
| Turk, Z | 2 |
| Cavlović-Naglić, M | 1 |
| Turk, N | 1 |
| Liu, J | 1 |
| Wang, R | 1 |
| Desai, K | 1 |
| Wu, L | 1 |
| Kim, KM | 1 |
| Kim, YS | 1 |
| Jung, DH | 1 |
| Lee, J | 1 |
| Kim, JS | 1 |
| Takagi, T | 1 |
| Naito, Y | 1 |
| Oya-Ito, T | 1 |
| Yoshikawa, T | 1 |
| Shiriaeva, IuK | 1 |
| Min, JZ | 1 |
| Yamamoto, M | 1 |
| Yu, HF | 1 |
| Higashi, T | 1 |
| Toyo'oka, T | 1 |
| Quester, W | 1 |
| Madea, B | 1 |
| Musshoff, F | 1 |
| Liu, H | 1 |
| Yu, S | 1 |
| Zhang, H | 1 |
| Xu, J | 1 |
| Kalapos, MP | 3 |
| Chatterjee, S | 1 |
| Wen, J | 1 |
| Chen, A | 1 |
| Vlassara, H | 2 |
| Cai, W | 2 |
| Crandall, J | 1 |
| Goldberg, T | 2 |
| Oberstein, R | 1 |
| Dardaine, V | 1 |
| Peppa, M | 2 |
| Rayfield, EJ | 1 |
| Aleksandrovski, YA | 2 |
| Hunsaker, LA | 4 |
| Du, J | 1 |
| Cai, S | 1 |
| Suzuki, H | 1 |
| Akhand, AA | 1 |
| Ma, X | 1 |
| Takagi, Y | 1 |
| Nakashima, I | 1 |
| Nagase, F | 1 |
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| Lu, M | 1 |
| Baliga, S | 1 |
| Vassalotti, JA | 1 |
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| Beisswenger, PJ | 2 |
| Howell, SK | 2 |
| Nelson, RG | 1 |
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| Szwergold, BS | 1 |
| Nemet, I | 1 |
| Varga-Defterdarović, L | 1 |
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| Wiernsperger, N | 1 |
| Lagarde, M | 1 |
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| Umeda, T | 1 |
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| Ichijo, H | 1 |
| Memon, SQ | 1 |
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| Westwood, M | 1 |
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| Haik, GM | 1 |
| Benn, J | 2 |
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| Piskorska, D | 1 |
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| Shamsi, FA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients With Chronic Critical Limb Ischemia: a Randomized, Placebo-controlled Clinical Trial[NCT00371371] | Phase 1/Phase 2 | 160 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Time in Glucose Hospital Target (TIGHT) - A Randomized Clinical Trial to Evaluate the Use of CGM to Achieve a Mean Glucose Target of 90 to 130 mg/dL Without Hypoglycemia in Hospitalized Adults With Type 2 Diabetes[NCT05135676] | 150 participants (Anticipated) | Interventional | 2022-05-10 | Recruiting | |||
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| Efficacy and Safety of Metformin Glycinate Compared to Metformin Hydrochloride on the Progression of Type 2 Diabetes[NCT04943692] | Phase 3 | 500 participants (Anticipated) | Interventional | 2021-08-31 | Suspended (stopped due to Administrative decision of the investigation direction) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | m/s (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 7.9 | 8.0 |
| Placebo | 8.3 | 8.5 |
A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | mM h (Mean) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 10.8 | 9.9 |
| Placebo | 11.0 | 10.6 |
After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | number of capillaries per mm2 (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 115 | 125 |
| Placebo | 119 | 128 |
Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | percentage of baseline value (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 0.17 | 0.12 |
| Placebo | 0.18 | 0.26 |
31 reviews available for pyruvaldehyde and Diabetes Mellitus
| Article | Year |
|---|---|
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction.
Topics: Animals; Cognition; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus; Diabetes Melli | 2021 |
Dicarbonyl Stress in Diabetic Vascular Disease.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced; | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Methylglyoxal in COVID-19-induced hyperglycemia and new-onset diabetes.
Topics: COVID-19; Diabetes Mellitus; Humans; Hyperglycemia; Insulin; Magnesium Oxide; Pyruvaldehyde; SARS-Co | 2022 |
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal.
Topics: Atherosclerosis; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Magnesium Oxide; Pyruv | 2023 |
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal.
Topics: Atherosclerosis; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Magnesium Oxide; Pyruv | 2023 |
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal.
Topics: Atherosclerosis; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Magnesium Oxide; Pyruv | 2023 |
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal.
Topics: Atherosclerosis; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Magnesium Oxide; Pyruv | 2023 |
Anti-Glucotoxicity Effect of Phytoconstituents
Topics: Diabetes Mellitus; Glycation End Products, Advanced; Humans; Magnesium Oxide; Pyruvaldehyde | 2023 |
Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation.
Topics: Aging; Animals; Causality; Diabetes Mellitus; Glycation End Products, Advanced; Hormesis; Humans; La | 2020 |
Dicarbonyl-mediated AGEing and diabetic kidney disease.
Topics: Aging; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Lactoylg | 2020 |
The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Gene Expression Regulation; Glycation End Products, Advanced | 2020 |
Carbonyl stress in diabetics with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Oxida | 2021 |
Methylglyoxal - An emerging biomarker for diabetes mellitus diagnosis and its detection methods.
Topics: Biomarkers; Biosensing Techniques; Diabetes Mellitus; Glycosylation; Humans; Metabolic Detoxication, | 2019 |
Reducing methylglyoxal as a therapeutic target for diabetic heart disease.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Pyruv | 2014 |
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
Topics: Aging; Aldehydes; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Glyoxal; Humans; Inflamm | 2015 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
[Role of methyl glyoxal and glyoxalase in diabetes and tumor growth].
Topics: Adenylate Kinase; Diabetes Mellitus; Humans; Lactoylglutathione Lyase; Neoplasms; Nitric Oxide Synth | 2008 |
Methylglyoxal, diabetes mellitus and diabetic complications.
Topics: Aldehydes; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Insu | 2008 |
The role of methylglyoxal-modified proteins in gastric ulcer healing.
Topics: Animals; Diabetes Mellitus; Glycosylation; Humans; Protein Processing, Post-Translational; Pyruvalde | 2012 |
Where does plasma methylglyoxal originate from?
Topics: Acetone; Diabetes Mellitus; Erythrocytes; Humans; Pyruvaldehyde; Retrospective Studies | 2013 |
Molecular mechanisms of the cross-impact of pathological processes in combined diabetes and cancer. Research and clinical aspects.
Topics: Animals; Cell Division; Diabetes Mellitus; Humans; Hyperglycemia; Neoplasms; Neutrophils; Protein Ki | 2002 |
Metformin inhibition of glycation processes.
Topics: Azepines; Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; | 2003 |
Alpha-oxoaldehyde metabolism and diabetic complications.
Topics: Aldehydes; Diabetes Complications; Diabetes Mellitus; Glyceraldehyde-3-Phosphate Dehydrogenases; Hum | 2003 |
[New aspects of diabetes].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose; Humans; Pyruvaldehyde | 2005 |
Formation of methylglyoxal-modified proteins in vitro and in vivo and their involvement in AGE-related processes.
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Proteins; Pyruvaldehyde | 1995 |
The glyoxalase system in health and disease.
Topics: Amino Acid Sequence; Antineoplastic Agents; Bacterial Infections; Catalysis; Diabetes Mellitus; Glut | 1993 |
[The role of methylglyoxal in the development of diabetic complications].
Topics: Diabetes Mellitus; Humans; Pyruvaldehyde | 1997 |
Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.
Topics: Aldehydes; Animals; Apoptosis; Cell Division; Cytokines; Diabetes Complications; Diabetes Mellitus; | 1998 |
Molecular mechanisms of diabetic complications.
Topics: Diabetes Complications; Diabetes Mellitus; Enzyme Activation; Humans; Neutrophils; Protein Kinase C; | 1998 |
Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications.
Topics: Animals; Bacteria; Diabetes Complications; Diabetes Mellitus; Drug Contamination; Energy Metabolism; | 1999 |
Chemistry and pathobiology of advanced glycation end products.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Gene Expression Regulation; Glucose; | 2001 |
Protein glycation: creation of catalytic sites for free radical generation.
Topics: Aging; Alanine; Amino Acids; Animals; Arteriosclerosis; Catalytic Domain; Cations; Cattle; Cytochrom | 2001 |
[Medical aspects of methylglyoxal metabolism].
Topics: Beriberi; Diabetes Mellitus; Humans; Lactoylglutathione Lyase; Pyruvaldehyde; Thiamine Deficiency | 1992 |
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
Topics: Animals; Cell Division; Diabetes Mellitus; Glutathione; Humans; Lactoylglutathione Lyase; Lyases; Ne | 1990 |
1 trial available for pyruvaldehyde and Diabetes Mellitus
| Article | Year |
|---|---|
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.
Topics: Biomarkers; C-Reactive Protein; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus; Diabe | 2002 |
85 other studies available for pyruvaldehyde and Diabetes Mellitus
| Article | Year |
|---|---|
The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Glucose; Glycation End Products, Advanced; HEK29 | 2022 |
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Humans; Hyperglycemia; Insulin R | 2022 |
Methylglyoxal-induces multiple stable changes in human serum albumin before forming nephrotoxic advanced glycation end-products: Injury demonstration in human embryonic kidney cells.
Topics: Diabetes Mellitus; Glycation End Products, Advanced; HEK293 Cells; Humans; Kidney; Pyruvaldehyde; Se | 2022 |
Therapeutic Potential of Phlorotannin-Rich
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Magnesium Oxid | 2022 |
Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues.
Topics: Diabetes Mellitus; Endothelial Cells; Glucose; Humans; Lysine; Magnesium Oxide; Phosphorylation; Pyr | 2022 |
Quantitative Chemoproteomic Profiling of Protein Cross-Links Induced by Methylglyoxal.
Topics: Diabetes Mellitus; Glycolysis; Humans; Magnesium Oxide; Proteome; Pyruvaldehyde | 2022 |
Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle.
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Magnesium Oxide; Nanoparticles; Pyruva | 2023 |
Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches.
Topics: Diabetes Mellitus; Fibronectins; Glycation End Products, Advanced; Humans; Molecular Docking Simulat | 2023 |
Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches.
Topics: Diabetes Mellitus; Fibronectins; Glycation End Products, Advanced; Humans; Molecular Docking Simulat | 2023 |
Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches.
Topics: Diabetes Mellitus; Fibronectins; Glycation End Products, Advanced; Humans; Molecular Docking Simulat | 2023 |
Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches.
Topics: Diabetes Mellitus; Fibronectins; Glycation End Products, Advanced; Humans; Molecular Docking Simulat | 2023 |
Analysis of Serum Advanced Glycation Endproducts Reveals Methylglyoxal-Derived Advanced Glycation MG-H1 Free Adduct Is a Risk Marker in Non-Diabetic and Diabetic Chronic Kidney Disease.
Topics: Cross-Sectional Studies; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced | 2022 |
Barley Phenolamides Effectively Scavenge Harmful Methylglyoxal In Vitro and in Mice.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Hordeum; Mice; | 2023 |
Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function.
Topics: Acetylcholine; Albumins; Animals; Arginase; Arginine; Diabetes Mellitus; Endothelial Cells; Endothel | 2023 |
A novel glycoprotein from earthworm extract PvE-3: Insights of their characteristics for promoting diabetic wound healing and attenuating methylglyoxal-induced cell damage.
Topics: Animals; Diabetes Mellitus; Glycoproteins; Magnesium Oxide; Oligochaeta; Plant Extracts; Pyruvaldehy | 2023 |
Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism.
Topics: Animals; Diabetes Mellitus; Humans; Magnesium Oxide; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated | 2023 |
Improving Covalent Organic Frameworks Fluorescence by Triethylamine Pinpoint Surgery as Selective Biomarker Sensor for Diabetes Mellitus Diagnosis.
Topics: Biomarkers; Diabetes Mellitus; Ethylamines; Fluorescence; Fluorescent Dyes; Humans; Limit of Detecti | 2019 |
Methylglyoxal modification reduces the sensitivity of hen egg white lysozyme to stress-induced aggregation: Insight into the anti-amyloidogenic property of α-dicarbonyl compound.
Topics: Diabetes Mellitus; Egg White; Glycation End Products, Advanced; Maillard Reaction; Muramidase; Prote | 2020 |
Associations of dicarbonyl stress with complement activation: the CODAM study.
Topics: Aged; Cohort Studies; Complement Activation; Diabetes Mellitus; Female; Genotype; Glycation End Prod | 2020 |
Can SGLT2 Inhibitor be Used for Diabetes Mellitus or Vascular Diseases?
Topics: Animals; Atherosclerosis; Blood Glucose; Canagliflozin; Clinical Trials as Topic; Diabetes Mellitus; | 2020 |
Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes.
Topics: Amputation, Surgical; Cardiovascular Diseases; Case-Control Studies; Diabetes Mellitus; Female; Glyc | 2021 |
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Topics: Animals; Cross-Sectional Studies; Diabetes Mellitus; Diabetic Neuropathies; Energy Metabolism; Femal | 2021 |
Diabetic nephropathy induced by methylglyoxal: gallic acid regulates kidney microRNAs and glyoxalase1-Nrf2 in male mice.
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Gallic Acid; Kidney; Male; Mice; Micro | 2023 |
Glyoxal and methylglyoxal as urinary markers of diabetes. Determination using a dispersive liquid-liquid microextraction procedure combined with gas chromatography-mass spectrometry.
Topics: Adult; Diabetes Mellitus; Female; Gas Chromatography-Mass Spectrometry; Glyoxal; Humans; Limit of De | 2017 |
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis.
Topics: Acetoacetates; Alkynes; Amino Acid Sequence; Chromatography, High Pressure Liquid; Diabetes Mellitus | 2017 |
Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology.
Topics: Aged; Case-Control Studies; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Lactoylglutat | 2018 |
Antioxidant and pro-oxidant actions of resveratrol on human serum albumin in the presence of toxic diabetes metabolites: Glyoxal and methyl-glyoxal.
Topics: Antioxidants; Diabetes Mellitus; Glyoxal; Humans; Oxidants; Oxidation-Reduction; Oxidative Stress; P | 2018 |
Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men.
Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Bone Density; Bone Remodeling; Diab | 2018 |
Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.
Topics: Angiogenesis Inducing Agents; Animals; Aorta; Cell Movement; Diabetes Mellitus; Endothelial Cells; G | 2019 |
Determination of glyoxal and methylglyoxal in serum by UHPLC coupled with fluorescence detection.
Topics: Aged; Aged, 80 and over; Animals; Calibration; Chromatography, High Pressure Liquid; Diabetes Mellit | 2019 |
Ratiometric Fluorescent Probe for Monitoring Endogenous Methylglyoxal in Living Cells and Diabetic Blood Samples.
Topics: Case-Control Studies; Cell Survival; Diabetes Complications; Diabetes Mellitus; Fluorescent Dyes; Hu | 2019 |
Dietary Genistein Inhibits Methylglyoxal-Induced Advanced Glycation End Product Formation in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue; Aldehyde Reductase; Animals; Diabetes Mellitus; Diet, High-Fat; Dietary Fats; Dyslip | 2019 |
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus; Diketopiperazines; Glucose; Glycation End Products, Advanc | 2013 |
Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.
Topics: Animals; Apoptosis; Cell Line; Diabetes Mellitus; Gene Knockdown Techniques; Glucose; Glucose Transp | 2013 |
Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
Topics: Animals; Diabetes Mellitus; Immunohistochemistry; Lactoylglutathione Lyase; Male; Pyruvaldehyde; Rat | 2014 |
Characterization and cytological effects of a novel glycated gelatine substrate.
Topics: Aging; Animals; Biocompatible Materials; Cell Survival; Collagen; Cross-Linking Reagents; Diabetes M | 2014 |
The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes.
Topics: Adult; Aged; Coronary Artery Disease; Diabetes Mellitus; Female; Glucose; Humans; Lipid Peroxidation | 2014 |
Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.
Topics: Animals; beta Catenin; Bone Diseases, Metabolic; Cell Line; Diabetes Mellitus; DNA Methylation; Down | 2014 |
The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Lunch; | 2015 |
Vascular AGE-ing by methylglyoxal: the past, the present and the future.
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced; Humans; Lactoyl | 2015 |
Carnosine metabolism in diabetes is altered by reactive metabolites.
Topics: Animals; Carnosine; Diabetes Mellitus; Dipeptidases; Humans; Hydrogen Peroxide; Iron; Mice; Mice, Mu | 2015 |
Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases.
Topics: Aging; alpha-Crystallins; Animals; Apoptosis; Cataract; Cattle; Diabetes Mellitus; Disease Models, A | 2015 |
Low Levels of IgM Antibodies against an Advanced Glycation Endproduct-Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic Subjects.
Topics: Aged; Aged, 80 and over; Antibodies; Apolipoprotein B-100; Atherosclerosis; Autoantibodies; B-Lympho | 2015 |
Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation.
Topics: Animals; Astrocytes; Biological Transport; Diabetes Mellitus; Energy Metabolism; Glucose; Glutamate- | 2016 |
Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes.
Topics: Antioxidants; Cytoprotection; Diabetes Mellitus; Erythrocytes; Glipizide; Glycated Serum Albumin; Gl | 2016 |
The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells.
Topics: Animals; Cell Line; Diabetes Mellitus; Down-Regulation; Endothelial Cells; Glycolysis; Human Umbilic | 2017 |
Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization using meso-stilbenediamine as derivatizing reagent.
Topics: Adult; Case-Control Studies; Chromatography, Gas; Diabetes Mellitus; Female; Humans; Indicators and | 2008 |
Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization with 1,2-diamonopropane.
Topics: Chromatography, Gas; Diabetes Mellitus; Diamines; Humans; Pyruvaldehyde; Uncertainty | 2008 |
[Methylglyoxal-induced apoptosis of endothelial cells].
Topics: Animals; Apoptosis; Caspase 3; Cattle; Cells, Cultured; Diabetes Complications; Diabetes Mellitus; D | 2008 |
Methylglyoxal modulates immune responses: relevance to diabetes.
Topics: Antigens, CD; Apoptosis; CD83 Antigen; Cell Proliferation; Cytokines; Diabetes Mellitus; Gene Expres | 2010 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
Methylglyoxal: possible link between hyperglycaemia and immune suppression?
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Immunologic Fac | 2009 |
Glycation of PDGF results in decreased biological activity.
Topics: Animals; Becaplermin; Blood Platelets; Cell Line; Cell Proliferation; Diabetes Mellitus; Extracellul | 2010 |
Stilbene glucoside from Polygonum multiflorum Thunb.: a novel natural inhibitor of advanced glycation end product formation by trapping of methylglyoxal.
Topics: Chromatography, Liquid; Diabetes Complications; Diabetes Mellitus; Glucosides; Glycation End Product | 2010 |
Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.
Topics: Amino Acid Sequence; Angiopoietin-2; Animals; Apoptosis; Cell Line; Cell Proliferation; Culture Medi | 2010 |
[Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)].
Topics: Animals; Cytosol; Diabetes Mellitus; Diabetic Ketoacidosis; Energy Metabolism; Fatty Acids; Gluconeo | 2010 |
Interrelation between malonyl dialdehyde-dependent modification and cholesterol content in low-density lipoproteins.
Topics: Adult; Atherosclerosis; Biomarkers; Blood Glucose; Cholesterol; Cholesterol, LDL; Diabetes Mellitus; | 2010 |
Comparison of glycation of glutathione S-transferase by methylglyoxal, glucose or fructose.
Topics: Aging; Animals; Catalysis; Diabetes Mellitus; Fructose; Glucose; Glutathione Transferase; Glycation | 2011 |
Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.
Topics: Animals; Anxiety; Cell Line; Diabetes Complications; Diabetes Mellitus; Flavonoids; Flavonols; Glyco | 2011 |
Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: involvement of advanced glycosylated end products.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antibiotics, Antineoplastic; Blood Glucose; Case-Control St | 2011 |
Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics.
Topics: Adult; Aged; Aged, 80 and over; Cholesterol, LDL; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diab | 2011 |
Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Topics: Aldehyde Reductase; Amine Oxidase (Copper-Containing); Animals; Aorta; Cells, Cultured; Cytochrome P | 2011 |
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Apoptosis; Caspase 3; Cell Line; Cells, Cultured; D | 2012 |
[The glucose, glycotoxins and glycation products: the involvement into pathogenesis of microangiopathies, arteriolosclerosis and atherosclerosis].
Topics: Arteriolosclerosis; Atherosclerosis; Diabetes Mellitus; Diabetic Angiopathies; Glucose; Glutamic Aci | 2011 |
Rapid and sensitive determination of the intermediates of advanced glycation end products in the human nail by ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry.
Topics: Adult; Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mell | 2012 |
Clinical and forensic examinations of glycaemic marker methylglyoxal by means of high performance liquid chromatography-tandem mass spectrometry.
Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, Liquid; Diabetes Mellitus; Diabetic Coma; F | 2013 |
Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cattle; Cell Line; C | 2012 |
Electrochemical determination of methylglyoxal as a biomarker in human plasma.
Topics: Biomarkers; Biosensing Techniques; Diabetes Mellitus; Electrochemical Techniques; Humans; Limit of D | 2013 |
Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.
Topics: Aldehyde Oxidoreductases; Aldehyde Reductase; Betaine-Aldehyde Dehydrogenase; Diabetes Complications | 2003 |
Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal.
Topics: 3T3 Cells; Animals; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diabetes Mellit | 2003 |
Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.
Topics: Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Diet; Diet Records; Food Analysi | 2003 |
Preparation and quantification of methylglyoxal in human plasma using reverse-phase high-performance liquid chromatography.
Topics: Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus; Humans; | 2004 |
Albumin antioxidant capacity is modified by methylglyoxal.
Topics: Animals; Antioxidants; Cattle; Diabetes Mellitus; Humans; Pyruvaldehyde; Reference Values; Serum Alb | 2005 |
Methylglyoxal can modify GAPDH activity and structure.
Topics: Diabetes Mellitus; Fibroblasts; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Kinetics | 2005 |
The sour side of sweet.
Topics: Angiopoietin-2; Blindness; Diabetes Mellitus; DNA Damage; Gene Expression Regulation; Glucose; Glyca | 2006 |
Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; De | 2007 |
Determination of glyoxal and methylglyoxal in the serum of diabetic patients by MEKC using stilbenediamine as derivatizing reagent.
Topics: Calibration; Chromatography, Micellar Electrokinetic Capillary; Diabetes Mellitus; Glyoxal; Humans; | 2007 |
Methylglyoxal concentration and glyoxalase activities in the human lens.
Topics: Age Factors; Aged; Cataract; Diabetes Mellitus; Female; Humans; Lactoylglutathione Lyase; Lens, Crys | 1994 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Modification of the glyoxalase system in clinical diabetes mellitus.
Topics: Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Lactoylglutathione | 1993 |
Substrate specificity of reduced and oxidized forms of human aldose reductase.
Topics: Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Humans; In Vitro Techniques; Kinetics | 1993 |
Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.
Topics: Adult; Aged; Aging; Animals; Blood Proteins; Diabetes Mellitus; Epitopes; Glycation End Products, Ad | 1998 |
Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts.
Topics: Animals; Antibodies, Monoclonal; Arginine; Brain Chemistry; Chromatography, High Pressure Liquid; Di | 1999 |
Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Arginine; Blood Proteins; Diabetes Mellitus; Humans; | 2001 |
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans; | 2001 |
Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.
Topics: Aldehyde Reductase; Binding Sites; Diabetes Complications; Diabetes Mellitus; Glutathione; Humans; I | 2001 |
Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.
Topics: Aldehyde Reductase; Animals; Cell Survival; Diabetes Mellitus; Enzyme Activation; Mitogen-Activated | 2002 |
Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.
Topics: Acetone; Aldehyde Reductase; Diabetes Complications; Diabetes Mellitus; Female; Glucose; Humans; Kin | 1992 |