pyruvaldehyde has been researched along with Diabetes Mellitus, Adult-Onset in 112 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated, in individuals with type 2 diabetes, whether irbesartan lowered plasma levels of the dicarbonyls methylglyoxal, glyoxal, 3-deoxyglucosone and their derived advanced glycation end products (AGEs), and increased d-lactate, reflecting greater methylglyoxal flux." | 7.01 | Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. ( Hanssen, NMJ; Hovind, P; Parving, HH; Persson, F; Piazza, M; Rossing, P; Schalkwijk, CG; Scheijen, JL; Stehouwer, CDA; van de Waarenburg, MPH; van Greevenbroek, MMJ, 2021) |
| "Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score." | 5.72 | Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study. ( Berendschot, TTJM; Dagnelie, PC; Eussen, SJPM; Houben, AJHM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Schram, MT; Stehouwer, CDA; van Greevenbroek, MMJ; Webers, CAB, 2022) |
| " Secondary goals examined albuminuria, age, race, sex, and metformin prescription." | 5.20 | Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease. ( Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM, 2015) |
| " Significant beneficial health effects were observed at 16-week with the doubling of ergothioneine from baseline, increases in the antioxidant marker ORAC (oxygen radical absorption capacity) and anti-inflammatory hormone, adiponectin and significant decreases in serum oxidative stress inducing factors, carboxymethyllysine (CML) and methylglyoxal (MG), but no change in the lipid oxidative stress marker 8-isoprostane, leptin or measures of insulin resistance or glucose metabolism." | 3.83 | A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms). ( Beelman, RB; Cai, W; Calvo, MS; Goh, BC; Kalaras, MD; Mehrotra, A; Nadkarni, G; Uribarri, J; Wang, L, 2016) |
| "We investigated, in individuals with type 2 diabetes, whether irbesartan lowered plasma levels of the dicarbonyls methylglyoxal, glyoxal, 3-deoxyglucosone and their derived advanced glycation end products (AGEs), and increased d-lactate, reflecting greater methylglyoxal flux." | 3.01 | Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. ( Hanssen, NMJ; Hovind, P; Parving, HH; Persson, F; Piazza, M; Rossing, P; Schalkwijk, CG; Scheijen, JL; Stehouwer, CDA; van de Waarenburg, MPH; van Greevenbroek, MMJ, 2021) |
| "Pentosidine level changes were unrelated to changes in levels of renal function, inflammation, or cytokines." | 2.79 | The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. ( Barzilay, JI; Fonseca, V; Goldfine, AB; Jablonski, KA; Monnier, VM; Shoelson, SE; Strauch, C, 2014) |
| "In 20 inpatients with type 2 diabetes (mean age: 55." | 2.73 | Leptin decreases postprandially in people with type 2 diabetes, an effect reduced by the cooking method. ( Gawlowski, T; Götting, C; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D, 2008) |
| "Insulin sensitivity was assessed as the Matsuda index." | 1.91 | Habitual Intake of Dietary Dicarbonyls is Associated with Greater Insulin Sensitivity and Lower Prevalence of Type 2 Diabetes: The Maastricht Study. ( Dagnelie, PC; Eussen, SJPM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Stehouwer, CDA; van Greevenbroek, MMJ, 2023) |
| "In total, 53 type 2 diabetes patients with complications, 16 type 2 diabetes patients without complications, and 47 age and gender matched non-diabetic participants underwent the Trier Social Stress Test." | 1.72 | Pronounced cortisol response to acute psychosocial stress in type 2 diabetes patients with and without complications. ( Buckert, M; Fleming, T; Hartmann, M; Henningsen, N; Monzer, N; Nawroth, P; Streibel, C; Wild, B; Wolff, K, 2022) |
| "Tight control of glycemia is a major treatment goal for type 2 diabetes mellitus (T2DM)." | 1.72 | Glyoxalase 1 knockdown induces age-related β-cell dysfunction and glucose intolerance in mice. ( Beguinot, F; Botti, G; Cabaro, S; Collina, F; Formisano, P; Leone, A; Longo, M; Miele, C; Napoli, R; Nicolò, A; Nigro, C; Panarese, I; Prevenzano, I, 2022) |
| "Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score." | 1.72 | Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study. ( Berendschot, TTJM; Dagnelie, PC; Eussen, SJPM; Houben, AJHM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Schram, MT; Stehouwer, CDA; van Greevenbroek, MMJ; Webers, CAB, 2022) |
| "The presence of both IGM and type 2 diabetes was significantly associated with higher α-dicarbonyl incremental areas under the curve (iAUCs), as calculated from the OGTT (for IGM, MGO β = 0." | 1.42 | Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. ( Hanssen, NM; Maessen, DE; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM, 2015) |
| " NO bioavailability was significantly attenuated and accompanied by an increase in superoxide anion immunofluorescence." | 1.38 | Methylglyoxal promotes oxidative stress and endothelial dysfunction. ( Crisóstomo, J; Fernandes, R; Matafome, P; Pereira, P; Rodrigues, L; Seiça, RM; Sena, CM, 2012) |
| "Insulin resistance is accompanied by increased activity of carbonic anhydrase which is significantly related to increasing methylglyoxal levels." | 1.38 | Study on the changes of carbonic anhydrase activity in insulin resistance and the effect of methylglyoxal. ( Biswas, UK; Kumar, A, 2012) |
| " We investigated the effects of chronic administration of MG on glucose tolerance and β-cell insulin secreting mechanism in 12-week-old male Sprague-Dawley rats." | 1.37 | Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats. ( Desai, KM; Dhar, A; Dhar, I; Jiang, B; Wu, L, 2011) |
| "In conclusion, progression of diabetic nephropathy is significantly related to elevated dicarbonyl stress and possibly related to oxidative stress in three separate populations, suggesting that these factors play a role in determining individual susceptibility." | 1.33 | Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. ( Beisswenger, PJ; Drummond, KS; Howell, SK; Mauer, M; Nelson, RG; Szwergold, BS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (4.46) | 18.2507 |
| 2000's | 12 (10.71) | 29.6817 |
| 2010's | 66 (58.93) | 24.3611 |
| 2020's | 29 (25.89) | 2.80 |
| Authors | Studies |
|---|---|
| Maasen, K | 3 |
| Eussen, SJPM | 3 |
| Scheijen, JLJM | 3 |
| van der Kallen, CJH | 1 |
| Dagnelie, PC | 3 |
| Opperhuizen, A | 3 |
| Stehouwer, CDA | 7 |
| van Greevenbroek, MMJ | 4 |
| Schalkwijk, CG | 11 |
| Nickel, K | 1 |
| Wensorra, U | 1 |
| Wenck, H | 2 |
| Peters, N | 1 |
| Genth, H | 2 |
| Rehman, S | 3 |
| Song, J | 1 |
| Faisal, M | 2 |
| Alatar, AA | 2 |
| Akhter, F | 2 |
| Ahmad, S | 4 |
| Hu, B | 1 |
| Perween, S | 1 |
| Abidi, M | 1 |
| Faiz Faizy, A | 1 |
| Donnellan, L | 1 |
| Simpson, BS | 1 |
| Dhillon, VS | 1 |
| Costabile, M | 1 |
| Fenech, M | 1 |
| Deo, P | 1 |
| Buckert, M | 1 |
| Hartmann, M | 1 |
| Monzer, N | 1 |
| Wolff, K | 1 |
| Nawroth, P | 3 |
| Fleming, T | 11 |
| Streibel, C | 1 |
| Henningsen, N | 1 |
| Wild, B | 1 |
| Rabbani, N | 2 |
| Thornalley, PJ | 6 |
| Zhang, X | 3 |
| Wouters, K | 2 |
| Xie, Q | 1 |
| Zhan, Y | 1 |
| Guo, L | 1 |
| Hao, H | 1 |
| Shi, X | 1 |
| Yang, J | 1 |
| Luo, F | 1 |
| Qiu, B | 1 |
| Lin, Z | 1 |
| Prevenzano, I | 1 |
| Leone, A | 1 |
| Longo, M | 1 |
| Nicolò, A | 1 |
| Cabaro, S | 1 |
| Collina, F | 1 |
| Panarese, I | 1 |
| Botti, G | 1 |
| Formisano, P | 1 |
| Napoli, R | 1 |
| Beguinot, F | 1 |
| Miele, C | 1 |
| Nigro, C | 1 |
| Cheng, Y | 1 |
| Yao, XM | 1 |
| Zhou, SM | 1 |
| Sun, Y | 1 |
| Meng, XJ | 1 |
| Wang, Y | 1 |
| Xing, YJ | 1 |
| Wan, SJ | 1 |
| Hua, Q | 1 |
| Houben, AJHM | 1 |
| Webers, CAB | 1 |
| Schram, MT | 1 |
| Berendschot, TTJM | 1 |
| Jeevanandam, J | 1 |
| Paramasivam, E | 1 |
| Saraswathi, NT | 1 |
| Matthews, JJ | 1 |
| Turner, MD | 1 |
| Santos, L | 1 |
| Elliott-Sale, KJ | 1 |
| Sale, C | 1 |
| Bora, S | 1 |
| Adole, PS | 1 |
| Vinod, KV | 1 |
| Pillai, AA | 1 |
| Ahmed, S | 1 |
| Kumar, P | 1 |
| Nesakumar, N | 1 |
| Gopal, J | 1 |
| Sivasubramanian, S | 1 |
| Vedantham, S | 1 |
| Rayappan, JBB | 1 |
| Alouffi, S | 3 |
| Khan, MWA | 1 |
| Ahmad, K | 1 |
| Shaikh, S | 1 |
| Lee, EJ | 1 |
| Lee, YH | 1 |
| Choi, I | 1 |
| de la Cruz-Ares, S | 1 |
| Cardelo, MP | 2 |
| Gutiérrez-Mariscal, FM | 2 |
| Torres-Peña, JD | 1 |
| García-Rios, A | 1 |
| Katsiki, N | 1 |
| Malagón, MM | 1 |
| López-Miranda, J | 2 |
| Pérez-Martínez, P | 2 |
| Yubero-Serrano, EM | 3 |
| Khanam, A | 1 |
| Husain, A | 1 |
| Farooqui, A | 1 |
| Yusuf, MA | 1 |
| Khan, MY | 1 |
| Khan, MS | 1 |
| Husain, FM | 1 |
| de la Cruz, S | 1 |
| Alcala-Diaz, JF | 1 |
| Roncero-Ramos, I | 1 |
| Guler, I | 1 |
| Vals-Delgado, C | 1 |
| López-Moreno, A | 1 |
| Luque, RM | 1 |
| Delgado-Lista, J | 1 |
| Esmaeili, F | 1 |
| Maleki, V | 1 |
| Kheirouri, S | 1 |
| Alizadeh, M | 1 |
| Piazza, M | 1 |
| Hanssen, NMJ | 2 |
| Persson, F | 1 |
| Scheijen, JL | 3 |
| van de Waarenburg, MPH | 1 |
| Rossing, P | 2 |
| Hovind, P | 1 |
| Parving, HH | 1 |
| Qahtan, AA | 1 |
| Jiang, M | 1 |
| Yakupu, A | 1 |
| Guan, H | 1 |
| Dong, J | 1 |
| Liu, Y | 1 |
| Song, F | 1 |
| Tang, J | 1 |
| Tian, M | 1 |
| Niu, Y | 1 |
| Lu, S | 1 |
| Groener, JB | 2 |
| Oikonomou, D | 1 |
| Cheko, R | 1 |
| Kender, Z | 3 |
| Zemva, J | 1 |
| Kihm, L | 1 |
| Muckenthaler, M | 1 |
| Peters, V | 1 |
| Kopf, S | 3 |
| Nawroth, PP | 8 |
| Catalán, Ú | 1 |
| Barrubés, L | 1 |
| Valls, RM | 1 |
| Solà, R | 1 |
| Rubió, L | 1 |
| Islam, S | 2 |
| Mir, AR | 3 |
| Arfat, MY | 1 |
| Alam, K | 2 |
| Ali, A | 3 |
| Rodriguez, R | 1 |
| Yoshimura, K | 1 |
| Shibata, Y | 1 |
| Miyamoto, Y | 1 |
| Tanaka, R | 1 |
| Uyama, R | 1 |
| Sasa, K | 1 |
| Suzuki, D | 1 |
| Miyazaki, T | 1 |
| Kamijo, R | 1 |
| Moraru, A | 1 |
| Wiederstein, J | 1 |
| Pfaff, D | 1 |
| Miller, AK | 1 |
| Teleman, AA | 1 |
| Westerink, J | 1 |
| van der Graaf, Y | 1 |
| Domingo-Espín, J | 1 |
| Nilsson, O | 1 |
| Bernfur, K | 1 |
| Del Giudice, R | 1 |
| Lagerstedt, JO | 1 |
| Schumacher, D | 1 |
| Morgenstern, J | 2 |
| Oguchi, Y | 1 |
| Volk, N | 1 |
| Freichel, M | 1 |
| Papadaki, M | 1 |
| Holewinski, RJ | 1 |
| Previs, SB | 1 |
| Martin, TG | 1 |
| Stachowski, MJ | 1 |
| Li, A | 1 |
| Blair, CA | 1 |
| Moravec, CS | 1 |
| Van Eyk, JE | 1 |
| Campbell, KS | 1 |
| Warshaw, DM | 1 |
| Kirk, JA | 1 |
| Fernández-Ruiz, I | 1 |
| Wang, XJ | 2 |
| Ma, SB | 1 |
| Liu, ZF | 1 |
| Li, H | 3 |
| Gao, WY | 2 |
| Tahara, N | 1 |
| Kojima, R | 1 |
| Yoshida, R | 1 |
| Bekki, M | 1 |
| Sugiyama, Y | 1 |
| Tahara, A | 1 |
| Maeda, S | 1 |
| Honda, A | 1 |
| Igata, S | 1 |
| Nakamura, T | 1 |
| Sun, J | 1 |
| Matsui, T | 2 |
| Fukumoto, Y | 1 |
| Yamagishi, SI | 1 |
| Griggs, RB | 1 |
| Santos, DF | 1 |
| Laird, DE | 1 |
| Doolen, S | 1 |
| Donahue, RR | 1 |
| Wessel, CR | 1 |
| Fu, W | 1 |
| Sinha, GP | 1 |
| Wang, P | 1 |
| Zhou, J | 1 |
| Brings, S | 1 |
| Susuki, K | 1 |
| Taylor, BK | 1 |
| O'Meara, M | 1 |
| Zhang, K | 1 |
| Seyoum, B | 1 |
| Yi, Z | 1 |
| Kaufman, RJ | 1 |
| Monks, TJ | 3 |
| Wang, JM | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Fleming, TH | 1 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Kroll, J | 1 |
| Zhang, HX | 1 |
| Zhu, AH | 1 |
| Bezold, V | 1 |
| Rosenstock, P | 1 |
| Scheffler, J | 1 |
| Geyer, H | 1 |
| Horstkorte, R | 1 |
| Bork, K | 1 |
| Crisóstomo, J | 3 |
| Matafome, P | 5 |
| Santos-Silva, D | 2 |
| Rodrigues, L | 3 |
| Sena, CM | 2 |
| Pereira, P | 3 |
| Seiça, R | 4 |
| Dieter, BP | 1 |
| Vella, CA | 1 |
| Sena, C | 3 |
| Barzilay, JI | 1 |
| Jablonski, KA | 1 |
| Fonseca, V | 1 |
| Shoelson, SE | 1 |
| Goldfine, AB | 1 |
| Strauch, C | 1 |
| Monnier, VM | 1 |
| Szwergold, BS | 4 |
| Miller, CB | 1 |
| Torzsa, P | 2 |
| Grolmusz, V | 1 |
| Herzig, S | 1 |
| Schleicher, E | 1 |
| Rácz, K | 2 |
| Reismann, P | 2 |
| Kong, X | 1 |
| Ma, MZ | 1 |
| Huang, K | 1 |
| Qin, L | 1 |
| Zhang, HM | 1 |
| Yang, Z | 1 |
| Li, XY | 1 |
| Su, Q | 1 |
| Bano, B | 1 |
| Abbasi, S | 1 |
| Khan, JA | 1 |
| Hussain, S | 1 |
| Rasheed, S | 1 |
| Perveen, S | 1 |
| Khan, KM | 1 |
| Choudhary, MI | 1 |
| Xie, B | 1 |
| Lin, F | 1 |
| Peng, L | 1 |
| Ullah, K | 1 |
| Wu, H | 1 |
| Qing, H | 1 |
| Deng, Y | 1 |
| Sri Harsha, PS | 1 |
| Mesias, M | 1 |
| Lavelli, V | 1 |
| Morales, FJ | 1 |
| Garrido, D | 1 |
| Rubin, T | 1 |
| Poidevin, M | 1 |
| Maroni, B | 1 |
| Le Rouzic, A | 1 |
| Parvy, JP | 1 |
| Montagne, J | 1 |
| Woodward, M | 1 |
| Poretsky, L | 1 |
| Vlassara, H | 2 |
| Striker, GE | 2 |
| Maessen, DE | 2 |
| Hanssen, NM | 1 |
| van der Kallen, CJ | 1 |
| van Greevenbroek, MM | 1 |
| Stehouwer, CD | 2 |
| Hansen, CS | 1 |
| Jensen, TM | 3 |
| Jensen, JS | 1 |
| Witte, DR | 3 |
| Lauritzen, T | 3 |
| Sandbaek, A | 2 |
| Charles, M | 1 |
| Fleischer, J | 1 |
| Vistisen, D | 3 |
| Jørgensen, ME | 3 |
| Sandbæk, A | 1 |
| Dornadula, S | 1 |
| Elango, B | 1 |
| Balashanmugam, P | 1 |
| Palanisamy, R | 1 |
| Kunka Mohanram, R | 1 |
| Kimzey, MJ | 1 |
| Kinsky, OR | 2 |
| Yassine, HN | 1 |
| Tsaprailis, G | 1 |
| Stump, CS | 1 |
| Lau, SS | 2 |
| Chen, HJ | 1 |
| Chen, YC | 1 |
| Hsiao, CF | 1 |
| Chen, PF | 1 |
| Hargraves, TL | 1 |
| Anumol, T | 1 |
| Jacobsen, NE | 1 |
| Dai, J | 1 |
| Snyder, SA | 1 |
| Habib, S | 1 |
| Siddiqui, SS | 1 |
| Calvo, MS | 1 |
| Mehrotra, A | 1 |
| Beelman, RB | 1 |
| Nadkarni, G | 1 |
| Wang, L | 1 |
| Cai, W | 2 |
| Goh, BC | 1 |
| Kalaras, MD | 1 |
| Uribarri, J | 2 |
| Reichert, O | 1 |
| Neufang, G | 1 |
| Schmelz, M | 1 |
| Kaever, V | 1 |
| Stäb, F | 1 |
| Terstegen, L | 1 |
| Kolbe, L | 1 |
| Roggenkamp, D | 1 |
| Masania, J | 1 |
| Malczewska-Malec, M | 1 |
| Razny, U | 1 |
| Goralska, J | 1 |
| Zdzienicka, A | 1 |
| Kiec-Wilk, B | 1 |
| Gruca, A | 1 |
| Stancel-Mozwillo, J | 1 |
| Dembinska-Kiec, A | 1 |
| Gugliucci, A | 1 |
| Saulnier, PJ | 1 |
| Wheelock, KM | 1 |
| Howell, S | 2 |
| Weil, EJ | 1 |
| Tanamas, SK | 1 |
| Knowler, WC | 1 |
| Lemley, KV | 1 |
| Mauer, M | 2 |
| Yee, B | 1 |
| Nelson, RG | 2 |
| Beisswenger, PJ | 5 |
| Rodrigues, T | 1 |
| Francisco, FA | 1 |
| Barella, LF | 1 |
| Silveira, SDS | 1 |
| Saavedra, LPJ | 1 |
| Prates, KV | 1 |
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| Franco, CCDS | 1 |
| Miranda, RA | 1 |
| Ribeiro, TA | 1 |
| Tófolo, LP | 1 |
| Malta, A | 1 |
| Vieira, E | 1 |
| Palma-Rigo, K | 1 |
| Pavanello, A | 1 |
| Martins, IP | 1 |
| Moreira, VM | 1 |
| de Oliveira, JC | 1 |
| Mathias, PCF | 1 |
| Gomes, RM | 1 |
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| Chang, T | 1 |
| Li, XQ | 1 |
| Wang, R | 1 |
| Wu, L | 3 |
| Raghav, A | 1 |
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| Uddin, M | 1 |
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| Schwenke, DC | 1 |
| Bahn, G | 1 |
| Reaven, PD | 1 |
| Yang, CT | 1 |
| Meng, FH | 1 |
| Chen, L | 1 |
| Li, X | 1 |
| Cen, LJ | 1 |
| Wen, YH | 1 |
| Li, CC | 1 |
| Zhang, H | 1 |
| Stirban, A | 1 |
| Negrean, M | 1 |
| Götting, C | 1 |
| Stratmann, B | 1 |
| Gawlowski, T | 1 |
| Mueller-Roesel, M | 1 |
| Kleesiek, K | 1 |
| Koschinsky, T | 1 |
| Tschoepe, D | 1 |
| Kilhovd, BK | 2 |
| Juutilainen, A | 1 |
| Lehto, S | 1 |
| Rönnemaa, T | 1 |
| Torjesen, PA | 2 |
| Hanssen, KF | 2 |
| Laakso, M | 1 |
| Talukdar, D | 1 |
| Chaudhuri, BS | 1 |
| Ray, M | 1 |
| Ray, S | 1 |
| Nobécourt, E | 1 |
| Tabet, F | 1 |
| Lambert, G | 1 |
| Puranik, R | 1 |
| Bao, S | 1 |
| Yan, L | 1 |
| Davies, MJ | 1 |
| Brown, BE | 1 |
| Jenkins, AJ | 1 |
| Dusting, GJ | 1 |
| Bonnet, DJ | 1 |
| Curtiss, LK | 1 |
| Barter, PJ | 1 |
| Rye, KA | 1 |
| Kim, J | 1 |
| Sohn, E | 1 |
| Kim, CS | 1 |
| Kim, JS | 1 |
| Mericq, V | 1 |
| Piccardo, C | 1 |
| Chen, X | 1 |
| Zhu, L | 1 |
| Ogawa, S | 1 |
| Nakayama, K | 1 |
| Nakayama, M | 1 |
| Mori, T | 1 |
| Matsushima, M | 1 |
| Okamura, M | 1 |
| Senda, M | 1 |
| Nako, K | 1 |
| Miyata, T | 1 |
| Ito, S | 1 |
| Dhar, A | 1 |
| Dhar, I | 1 |
| Jiang, B | 1 |
| Desai, KM | 1 |
| Aćimović, JM | 1 |
| Jovanović, VB | 1 |
| Veselinović, MR | 1 |
| Srećković, VD | 1 |
| Mandić, LM | 1 |
| Engelbertsen, D | 1 |
| Anand, DV | 1 |
| Fredrikson, GN | 1 |
| Hopkins, D | 1 |
| Corder, R | 1 |
| Shah, PK | 1 |
| Lahiri, A | 1 |
| Nilsson, J | 1 |
| Bengtsson, E | 1 |
| Turk, Z | 2 |
| Cavlović-Naglić, M | 1 |
| Turk, N | 1 |
| Cuny, J | 1 |
| Nawroth, G | 1 |
| Djuric, Z | 1 |
| Humpert, PM | 1 |
| Zeier, M | 1 |
| Bierhaus, A | 1 |
| Fernandes, R | 1 |
| Seiça, RM | 1 |
| Grolmusz K, V | 1 |
| Patócs, A | 1 |
| Lichthammer, A | 1 |
| Veresné Bálint, M | 1 |
| Biswas, UK | 1 |
| Kumar, A | 1 |
| Chen, NK | 1 |
| Chong, TW | 1 |
| Loh, HL | 1 |
| Lim, KH | 1 |
| Gan, VH | 1 |
| Wang, M | 1 |
| Kon, OL | 1 |
| Lee, BH | 1 |
| Hsu, WH | 1 |
| Huang, T | 1 |
| Chang, YY | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Howell, SK | 3 |
| Smith, K | 1 |
| Giardino, I | 1 |
| Birkeland, KI | 1 |
| Berg, TJ | 1 |
| Brownlee, M | 1 |
| Lapolla, A | 2 |
| Flamini, R | 1 |
| Dalla Vedova, A | 1 |
| Senesi, A | 1 |
| Reitano, R | 2 |
| Fedele, D | 1 |
| Basso, E | 1 |
| Seraglia, R | 2 |
| Traldi, P | 2 |
| Nemet, I | 1 |
| Duvnjak, L | 1 |
| Car, N | 1 |
| Varga-Defterdarović, L | 1 |
| Sartore, G | 1 |
| Ragazzi, E | 1 |
| Drummond, KS | 1 |
| Potier, P | 1 |
| Sasaki, A | 1 |
| Bakala, J | 1 |
| García-Alvarez, MC | 1 |
| Franck, G | 1 |
| Nhiri, N | 1 |
| Wang, Q | 1 |
| Ermolenko, L | 1 |
| Nguefeu, Y | 1 |
| Calvo, F | 1 |
| Gautier, JF | 1 |
| Wang, H | 1 |
| Meng, QH | 1 |
| Gordon, JR | 1 |
| Khandwala, H | 1 |
| McLellan, AC | 3 |
| Benn, J | 2 |
| Sonksen, PH | 2 |
| Touchette, AD | 1 |
| Lal, S | 1 |
| Odani, H | 1 |
| Shinzato, T | 1 |
| Matsumoto, Y | 1 |
| Usami, J | 1 |
| Maeda, K | 1 |
| Takeuchi, M | 1 |
| Makita, Z | 1 |
| Bucala, R | 1 |
| Suzuki, T | 1 |
| Koike, T | 1 |
| Kameda, Y | 1 |
| Phillips, SA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Irbesartan in Patients With Type 2 Diabetes and Microalbuminuria (IRMA 2)[NCT00317915] | Phase 3 | 0 participants | Interventional | Completed | |||
| The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease: Investigator Initiated Randomized Placebo-controlled Double-blind, Pilot Study[NCT03222206] | Phase 4 | 34 participants (Actual) | Interventional | 2017-11-08 | Completed | ||
| The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4: a Protocol of a Randomized, Parallel, Controlled Trial[NCT03596749] | Phase 3 | 80 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | ||
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients[NCT05896878] | 20 participants (Anticipated) | Interventional | 2023-07-10 | Enrolling by invitation | |||
| CSP #465FS - VA Diabetes Trial Long Term Follow-up Study[NCT00756613] | 1,044 participants (Actual) | Observational | 2008-02-01 | Completed | |||
| Effects of Glycooxidative Stress on Human Aging- Study #3[NCT01363141] | 383 participants (Actual) | Interventional | 2010-12-31 | Completed | |||
| The Effects of Metformin on Vascular Structure and Function in Subjects With the Metabolic Syndrome (MET Trial)[NCT00105066] | Phase 2 | 77 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
End-stage renal disease, amputation for either ischemic or non-ischemic gangrene, CV-related death, or nonfatal MI, stroke, or new CHF. (NCT00756613)
Timeframe: 15 years
| Intervention | events (Number) |
|---|---|
| 465 VADT Participants - Standard | 355 |
| 465 VADT Participants -Intensive | 342 |
Self-reported health status using an instrument adapted for type 2 diabetes mellitus patients from the Diabetes Control and Complications Trial (DCCT) (Duckworth, 1998; Saudek 1996). This survey tool has been used since the inception of the VADT and will be continued in the annual survey. The minimum value is 0 and the maximum value is 100. The higher score is a better outcome. (NCT00756613)
Timeframe: 9 years
| Intervention | score on a scale (Mean) |
|---|---|
| 465 VADT Participants - Standard | 62.2 |
| 465 VADT Participants -Intensive | 63.8 |
Major CV events (non-fatal MI resulting in hospitalization, non-fatal stroke, new Congestive Heart Failure (CHF), amputation for ischemic diabetic gangrene, or CV-related death). (NCT00756613)
Timeframe: 15 years
| Intervention | number of events (Number) |
|---|---|
| 465 VADT Participants - Standard | 336 |
| 465 VADT Participants -Intensive | 325 |
The major secondary end-point of total mortality will measure all deaths with data retrieved from VA Information Resource Center (VIREC) Cooperate Data Warehouse (CDW) . Survival analysis will analyzed by time to death. (NCT00756613)
Timeframe: 15 years
| Intervention | Participants (Count of Participants) |
|---|---|
| 465 VADT Participants - Standard | 125 |
| 465 VADT Participants -Intensive | 118 |
The major secondary end-point of cardiovascular (CV) mortality will measure the cause of death (end-stage renal disease, amputation for either ischemic or non-ischemic gangrene, CV-related death, or nonfatal myocardial infarction (MI), stroke, or new congestive heart failure (CHF)) retrieved by the National Death Index (NDI). Survival analysis will analyzed by time of event to death. (NCT00756613)
Timeframe: 15 years
| Intervention | Participants (Count of Participants) |
|---|---|
| 465 VADT Participants - Standard | 366 |
| 465 VADT Participants -Intensive | 376 |
(NCT00105066)
Timeframe: Baseline and 4.5 months
| Intervention | meters / second (Mean) |
|---|---|
| Placebo | -7.2 |
| Metformin | -7.3 |
to evaluate improvement in endothelial function (NCT00105066)
Timeframe: Baseline and 4.5 months
| Intervention | percentage change in diameter (Mean) |
|---|---|
| Placebo | 8.8 |
| Metformin | 10.5 |
Homeostatic Model Assessment of insulin sensitivity (NCT00105066)
Timeframe: 4.5 months
| Intervention | HOMA Score (Mean) |
|---|---|
| Placebo | 57.4 |
| Metformin | 64.5 |
15 reviews available for pyruvaldehyde and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Induction; Glutathione; Glycos | 2022 |
Immunometabolism and the modulation of immune responses and host defense: A role for methylglyoxal?
Topics: Diabetes Mellitus, Type 2; Humans; Immunity; Insulin Resistance; Magnesium Oxide; Pyruvaldehyde | 2022 |
Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Lactoylglutathione Lyase; Neopl | 2020 |
Dicarbonyls Generation, Toxicities, Detoxifications and Potential Roles in Diabetes Complications.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Ret | 2020 |
Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Extracellular Matrix Proteins; Gene Expression Regulation; | 2020 |
Glycation and Antioxidants: Hand in the Glove of Antiglycation and Natural Antioxidants.
Topics: Antigens, Neoplasm; Antioxidants; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus, Type 2; | 2020 |
Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links.
Topics: Diabetes Complications; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glycation End Products | 2019 |
In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update.
Topics: Catecholamines; Diabetes Mellitus, Type 2; Humans; Melatonin; Metabolomics; Neurodegenerative Diseas | 2017 |
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Angiopathies; D | 2015 |
Pathophysiological insights of methylglyoxal induced type-2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Pyruvaldehyde | 2015 |
Dicarbonyl stress in clinical obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Lactic Acid; Lactoylglutathione Lyase; Mice; Non-alcohol | 2016 |
Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises.
Topics: Animals; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Humans; Pyruvaldehyde | 2017 |
[The role of methylglyoxal metabolism in type-2 diabetes and its complications].
Topics: Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glycation End Products, Advanced; | 2012 |
Methylglyoxal, obesity, and diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Ob | 2013 |
[New aspects of diabetes].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose; Humans; Pyruvaldehyde | 2005 |
14 trials available for pyruvaldehyde and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study.
Topics: Biomarkers; Carotid Artery Diseases; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitus, T | 2020 |
Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study.
Topics: Antigens, Neoplasm; Coronary Disease; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Diet, Mediter | 2021 |
The Effects of Taurine Supplementation on Metabolic Profiles, Pentosidine, Soluble Receptor of Advanced Glycation End Products and Methylglyoxal in Adults With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Double-B | 2021 |
Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Chromatography, Liquid; Deoxygluco | 2021 |
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.
Topics: Aged; Aldo-Keto Reductases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fem | 2018 |
Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine.
Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Gly | 2019 |
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Diabetes Mellitus, Type 2; Di | 2014 |
Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactoylglutathione Lyase; Mal | 2014 |
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic N | 2015 |
The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Denmark; Diabetes Mellitus, Type 2; D | 2015 |
Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus.
Topics: Adult; Aged; Albuminuria; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic N | 2016 |
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Glycat | 2016 |
Leptin decreases postprandially in people with type 2 diabetes, an effect reduced by the cooking method.
Topics: Blood Glucose; Cooking; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet; Diet, Diabetic; Female; | 2008 |
Metformin reduces systemic methylglyoxal levels in type 2 diabetes.
Topics: Adult; Aged; Deoxyglucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Huma | 1999 |
83 other studies available for pyruvaldehyde and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study.
Topics: Aged; Chromatography, Liquid; Cross-Sectional Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Diet | 2022 |
Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors.
Topics: Dermis; Diabetes Mellitus, Type 2; Female; Fibroblasts; Glucose; Humans; Immunomodulation; Insulin; | 2021 |
The Neoepitopes on Methylglyoxal- (MG-) Glycated Fibrinogen Generate Autoimmune Response: Its Role in Diabetes, Atherosclerosis, and Diabetic Atherosclerosis Subjects.
Topics: Adult; Atherosclerosis; Diabetes Mellitus, Type 2; Female; Fibrinogen; Humans; Male; Middle Aged; Py | 2021 |
Biophysical changes in methylglyoxal modified fibrinogen and its role in the immunopathology of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Fibrinogen; Glycation End Products, Advanced; Glycosylation; Hum | 2022 |
Folic acid deficiency increases sensitivity to DNA damage by glucose and methylglyoxal.
Topics: Diabetes Mellitus, Type 2; DNA Damage; Folic Acid; Folic Acid Deficiency; Glucose; Humans; Pyruvalde | 2022 |
Pronounced cortisol response to acute psychosocial stress in type 2 diabetes patients with and without complications.
Topics: Adrenocorticotropic Hormone; Diabetes Mellitus, Type 2; Humans; Hydrocortisone; Hypothalamo-Hypophys | 2022 |
A Ratiometric Fluorescence Probe for Selective Detection of ex vivo Methylglyoxal in Diabetic Mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fluorescent Dyes; HeLa Cells; H | 2022 |
Glyoxalase 1 knockdown induces age-related β-cell dysfunction and glucose intolerance in mice.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Glucose Intolerance; Lactoylglutathione Lyase; Magnesiu | 2022 |
The m
Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Insulin Secretion; Insulin-Secreting Cells; Maf Transcri | 2022 |
Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Female; Glycation End Pr | 2022 |
Glycation restrains open-closed conformation of Insulin.
Topics: Diabetes Mellitus, Type 2; Humans; Insulin; Maillard Reaction; Pyruvaldehyde; Receptor, Insulin | 2023 |
Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells.
Topics: beta-Alanine; Carnosine; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Resistance; Ma | 2023 |
Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Glycation End Products, Advance | 2023 |
Habitual Intake of Dietary Dicarbonyls is Associated with Greater Insulin Sensitivity and Lower Prevalence of Type 2 Diabetes: The Maastricht Study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glyoxal; Humans; Insulin Resistance; Mag | 2023 |
The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.
Topics: Acute Coronary Syndrome; Case-Control Studies; Diabetes Mellitus, Type 2; Genetic Predisposition to | 2023 |
Clinical validation of electrochemical biosensor for the detection of methylglyoxal in subjects with type-2 diabetes mellitus.
Topics: Biosensing Techniques; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycation End Products, Advan | 2024 |
The neoepitopes on methylglyoxal (MG) glycated LDL create autoimmune response; autoimmunity detection in T2DM patients with varying disease duration.
Topics: Adult; Aged; Autoantibodies; Autoantigens; Autoimmunity; Diabetes Mellitus, Type 2; Epitopes, B-Lymp | 2020 |
Methylglyoxal mediated glycation leads to neo-epitopes generation in fibrinogen: Role in the induction of adaptive immune response.
Topics: Adaptive Immunity; Animals; Autoantibodies; Cross Reactions; Diabetes Mellitus, Type 2; Enzyme-Linke | 2021 |
Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Macrophages; Mice; Pyridoxamine | 2022 |
Studies on glycoxidatively modified human IgG: Implications in immuno-pathology of type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; DNA Damage; Glycation End Products, Advanced; Healthy Volunteers; Humans; | 2017 |
Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules.
Topics: Bone and Bones; Calcinosis; Cell Line; Cell Proliferation; Diabetes Mellitus, Type 2; Glycation End | 2017 |
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Drosophila melanogaster; Hyperglycemia; Insulin | 2018 |
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes.
Topics: Adult; Aged; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathi | 2018 |
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.
Topics: Acetaldehyde; Animals; Apolipoprotein A-I; Blood Glucose; Cardiovascular Diseases; Cell Line; Choles | 2018 |
Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function.
Topics: Actins; Adult; Animals; Arginine; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Disease Models | 2018 |
A new link for heart failure and diabetes.
Topics: Diabetes Mellitus, Type 2; Heart Failure; Humans; Pyruvaldehyde; Sarcomeres | 2019 |
Elevated levels of α-dicarbonyl compounds in the plasma of type II diabetics and their relevance with diabetic nephropathy.
Topics: Aged; Biomarkers; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; Dia | 2019 |
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Topics: Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Cyclic AMP-Dependent Protein Kinas | 2019 |
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
Topics: Animals; Bone Marrow Cells; Cell- and Tissue-Based Therapy; Diabetes Mellitus, Type 2; Disease Model | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
Measurement of α-dicarbonyl compounds in human saliva by pre-column derivatization HPLC.
Topics: Adult; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; Female; Glyoxa | 2019 |
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency.
Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glycosylation; Humans | 2019 |
Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen.
Topics: Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes M | 2014 |
Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats.
Topics: Animals; Apoptosis; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Heart; Male; Myocar | 2013 |
A proposed mechanism for exercise attenuated methylglyoxal accumulation: activation of the ARE-Nrf pathway and increased glutathione biosynthesis.
Topics: Antioxidant Response Elements; Diabetes Mellitus, Type 2; Exercise; Glutathione; Humans; Models, Bio | 2013 |
Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.
Topics: Angiotensin II; Animals; Apoptosis; Apoptosis Regulatory Proteins; Diabetes Mellitus, Type 2; Diabet | 2014 |
Potential of birds to serve as pathology-free models of type 2 diabetes, part 2: do high levels of carbonyl-scavenging amino acids (e.g., taurine) and low concentrations of methylglyoxal limit the production of advanced glycation end-products?
Topics: Albumins; Animals; Arginine; Birds; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructosamine; | 2014 |
Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 2.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; M | 2014 |
Antiglycation activity of quinoline derivatives- a new therapeutic class for the management of type 2 diabetes complications.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cattle; Diabetes Mellitus, Type 2; Glycation End Products | 2014 |
Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells.
Topics: Cell Line; Diabetes Mellitus, Type 2; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamin | 2014 |
Grape skin extracts from winemaking by-products as a source of trapping agents for reactive carbonyl species.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Flavonoids; Food-Processing Industry; Fruit; Glycation End | 2016 |
Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.
Topics: Animals; Diabetes Mellitus, Type 2; Dietary Sucrose; Drosophila; Fatty Acid Synthase, Type I; Glycat | 2015 |
Post-Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study.
Topics: Atherosclerosis; Blood Glucose; Chromatography, Liquid; Cross-Sectional Studies; Deoxyglucose; Diabe | 2015 |
Impact of intensive treatment on serum methylglyoxal levels among individuals with screen-detected type 2 diabetes: the ADDITION-Denmark study.
Topics: Aged; Blood Glucose; Cholesterol, LDL; Cohort Studies; Denmark; Diabetes Mellitus, Type 2; Female; F | 2015 |
Site specific modification of the human plasma proteome by methylglyoxal.
Topics: Arginine; Binding Sites; Biomarkers; Blood Proteins; Chromatography, High Pressure Liquid; Diabetes | 2015 |
Mass Spectrometric Analysis of Glyoxal and Methylglyoxal-Induced Modifications in Human Hemoglobin from Poorly Controlled Type 2 Diabetes Mellitus Patients.
Topics: Diabetes Mellitus, Type 2; Female; Glyoxal; Hemoglobins; Humans; Male; Middle Aged; Peptides; Pyruva | 2015 |
Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Diabet | 2016 |
Neo-epitopes on methylglyoxal modified human serum albumin lead to aggressive autoimmune response in diabetes.
Topics: Autoimmunity; Case-Control Studies; Diabetes Mellitus, Type 2; Epitopes; Female; Humans; Hydrophobic | 2016 |
A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms).
Topics: Adiponectin; Adult; Agaricus; Antioxidants; beta-Glucans; Biomarkers; Body Mass Index; Chitin; Chole | 2016 |
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.
Topics: Adult; Aged; Animals; Diabetes Mellitus, Type 2; Female; Fibroblasts; Gene Silencing; Glucose; Healt | 2017 |
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance.
Topics: Adenosine Monophosphate; Adenylate Kinase; Allosteric Site; AMP-Activated Protein Kinases; Animals; | 2016 |
Methylglyoxal treatment in lactating mothers leads to type 2 diabetes phenotype in male rat offspring at adulthood.
Topics: Adiposity; Administration, Oral; Animals; Diabetes Mellitus, Type 2; Dyslipidemias; Environmental Po | 2018 |
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Topics: Adult; Aged; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Proliferatio | 2017 |
Neo-Epitopes Generated on Hydroxyl Radical Modified GlycatedIgG Have Role in Immunopathology of Diabetes Type 2.
Topics: Antioxidants; Autoantibodies; Case-Control Studies; Diabetes Mellitus, Type 2; Epitopes; Erythrocyte | 2017 |
Advanced Glycation End Products, Oxidation Products, and the Extent of Atherosclerosis During the VA Diabetes Trial and Follow-up Study.
Topics: Aged; Atherosclerosis; Blood Glucose; Carotid Intima-Media Thickness; Cholesterol; Deoxyglucose; Dia | 2017 |
Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine.
Topics: Acetylcysteine; Aged; Case-Control Studies; Cell Adhesion; Cell Line; Cell Movement; Cell Survival; | 2017 |
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women.
Topics: Cardiovascular Diseases; Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Female; Fi | 2009 |
Critical evaluation of toxic versus beneficial effects of methylglyoxal.
Topics: Animals; Arginine; Cataract; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delive | 2009 |
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Apolipoprotein A-I; Carotid Arter | 2010 |
Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Diabetes Mellitus, Experimental; Di | 2011 |
Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?
Topics: Adiponectin; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glycat | 2010 |
Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.
Topics: Biomarkers; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; H | 2010 |
Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.
Topics: Adipose Tissue; Animals; Apoptosis; Blotting, Western; Diabetes Mellitus, Type 2; Glucose; Glucose T | 2011 |
Method for monitoring of the protein amino group changes during carbonylation.
Topics: Benzoquinones; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Protein Carbon | 2011 |
High levels of IgM against methylglyoxal-modified apolipoprotein B100 are associated with less coronary artery calcification in patients with type 2 diabetes.
Topics: Apolipoprotein B-100; Autoantibodies; Coronary Artery Disease; Diabetes Complications; Diabetes Mell | 2012 |
Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics.
Topics: Adult; Aged; Aged, 80 and over; Cholesterol, LDL; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diab | 2011 |
Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Erythrocytes; Fema | 2012 |
Methylglyoxal promotes oxidative stress and endothelial dysfunction.
Topics: Animals; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glycation End Pr | 2012 |
Study on the changes of carbonic anhydrase activity in insulin resistance and the effect of methylglyoxal.
Topics: Adult; Blood Glucose; Body Mass Index; Carbonic Anhydrases; Case-Control Studies; Diabetes Mellitus, | 2012 |
Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus.
Topics: Antioxidants; Cytokines; Diabetes Mellitus, Type 2; Epithelial Cells; Female; Gene Expression Regula | 2013 |
Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Diabetes Mellitus, Type 2; Glycation End Products, Adv | 2013 |
Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes.
Topics: Adult; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Ery | 2003 |
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Humans; Imidazoles; Immunoassay; Lysine; Pyruvaldehyde; Sensitivity and S | 2003 |
Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method.
Topics: Diabetes Mellitus, Type 2; Female; Gas Chromatography-Mass Spectrometry; Glyoxal; Humans; Male; Midd | 2003 |
Humoral methylglyoxal level reflects glycemic fluctuation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Case-Control Studies; Chromatography, Hig | 2005 |
Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress.
Topics: Aged; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Dialysis Solutions; Glycated Hemoglobin; G | 2005 |
Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress.
Topics: Adolescent; Adult; Cohort Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2005 |
Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus.
Topics: Aged; Albuminuria; Anti-Inflammatory Agents; Apoptosis; Blood Glucose; Caspase 3; Creatine; Cytokine | 2007 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Modification of the glyoxalase system in clinical diabetes mellitus.
Topics: Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Lactoylglutathione | 1993 |
Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction.
Topics: 2-Naphthylamine; Aging; Arginine; Chromatography, Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; G | 1999 |
Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo.
Topics: Animals; Antibodies; Cattle; Chromatography, Affinity; Cross Reactions; Diabetes Mellitus, Type 2; E | 2000 |
The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene.
Topics: Calibration; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 1992 |