pyruvaldehyde has been researched along with Degenerative Diseases, Central Nervous System in 10 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo." | 4.83 | Protein modification in aging: an update. ( Schöneich, C, 2006) |
| "Glyoxalase-1 (GLO-1) acts as a part of the anti-glycation defense system by carrying out detoxification of GO and MGO." | 2.66 | The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. ( Akhter, A; Kausar, MA; Saeed, M; Siddiqui, AJ; Singh, R, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, L | 1 |
| Gao, R | 1 |
| Chen, Z | 1 |
| Lin, D | 1 |
| Liu, Z | 1 |
| Wang, L | 1 |
| Lin, L | 1 |
| Liu, X | 2 |
| Liu, L | 1 |
| Saeed, M | 1 |
| Kausar, MA | 1 |
| Singh, R | 1 |
| Siddiqui, AJ | 1 |
| Akhter, A | 1 |
| Vicente Miranda, H | 1 |
| Szego, ÉM | 1 |
| Oliveira, LMA | 1 |
| Breda, C | 1 |
| Darendelioglu, E | 1 |
| de Oliveira, RM | 1 |
| Ferreira, DG | 1 |
| Gomes, MA | 1 |
| Rott, R | 1 |
| Oliveira, M | 1 |
| Munari, F | 1 |
| Enguita, FJ | 1 |
| Simões, T | 1 |
| Rodrigues, EF | 1 |
| Heinrich, M | 1 |
| Martins, IC | 1 |
| Zamolo, I | 1 |
| Riess, O | 1 |
| Cordeiro, C | 1 |
| Ponces-Freire, A | 1 |
| Lashuel, HA | 1 |
| Santos, NC | 1 |
| Lopes, LV | 1 |
| Xiang, W | 1 |
| Jovin, TM | 1 |
| Penque, D | 1 |
| Engelender, S | 1 |
| Zweckstetter, M | 1 |
| Klucken, J | 1 |
| Giorgini, F | 1 |
| Quintas, A | 1 |
| Outeiro, TF | 1 |
| Catalán, Ú | 1 |
| Barrubés, L | 1 |
| Valls, RM | 1 |
| Solà, R | 1 |
| Rubió, L | 1 |
| Frandsen, JR | 1 |
| Narayanasamy, P | 1 |
| Nigro, C | 1 |
| Leone, A | 1 |
| Fiory, F | 1 |
| Prevenzano, I | 1 |
| Nicolò, A | 1 |
| Mirra, P | 1 |
| Beguinot, F | 1 |
| Miele, C | 1 |
| Karumanchi, DK | 1 |
| Karunaratne, N | 1 |
| Lurio, L | 1 |
| Dillon, JP | 1 |
| Gaillard, ER | 1 |
| Kuhla, B | 1 |
| Lüth, HJ | 1 |
| Haferburg, D | 1 |
| Weick, M | 1 |
| Reichenbach, A | 1 |
| Arendt, T | 1 |
| Münch, G | 1 |
| Schöneich, C | 1 |
| Kikuchi, S | 1 |
| Shinpo, K | 1 |
| Moriwaka, F | 1 |
| Makita, Z | 1 |
| Miyata, T | 1 |
| Tashiro, K | 1 |
5 reviews available for pyruvaldehyde and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Gene Expression Regulation; Glycation End Products, Advanced | 2020 |
In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update.
Topics: Catecholamines; Diabetes Mellitus, Type 2; Humans; Melatonin; Metabolomics; Neurodegenerative Diseas | 2017 |
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Autism Spectrum Disorder; Flavonoids; Humans; Lacto | 2018 |
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging.
Topics: Aging; Animals; Cardiovascular Diseases; Cells, Cultured; Cellular Senescence; Glycation End Product | 2019 |
Protein modification in aging: an update.
Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Redu | 2006 |
5 other studies available for pyruvaldehyde and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells.
Topics: Energy Metabolism; Glucose; Humans; Hypoglycemic Agents; Liraglutide; Neuroblastoma; Neurodegenerati | 2022 |
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Topics: Aging; alpha-Synuclein; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Model | 2017 |
Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases.
Topics: Aging; alpha-Crystallins; Animals; Apoptosis; Cataract; Cattle; Diabetes Mellitus; Disease Models, A | 2015 |
Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.
Topics: Alzheimer Disease; Apoptosis; Brain; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Enzyme | 2006 |
Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Deoxyglucose; D | 1999 |