pyruvaldehyde has been researched along with Cognition Disorders in 5 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrates that mangiferin can markedly ameliorate diabetes-associated cognitive decline in rats, which is done likely through suppressing methylglyoxal hyperactivity (promoting protein glycation, oxidative stress, and inflammation) mediated noxious effects." | 3.79 | Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. ( Li, HP; Liu, YW; Lu, Q; Wang, JY; Wei, YQ; Yang, QQ; Yin, JL; Yin, XX; Zhu, X, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, YW | 1 |
| Zhu, X | 1 |
| Yang, QQ | 1 |
| Lu, Q | 1 |
| Wang, JY | 1 |
| Li, HP | 1 |
| Wei, YQ | 1 |
| Yin, JL | 1 |
| Yin, XX | 1 |
| Watanabe, K | 1 |
| Okada, K | 1 |
| Fukabori, R | 1 |
| Hayashi, Y | 1 |
| Asahi, K | 1 |
| Terawaki, H | 1 |
| Kobayashi, K | 1 |
| Watanabe, T | 1 |
| Nakayama, M | 1 |
| West, RK | 1 |
| Moshier, E | 1 |
| Lubitz, I | 1 |
| Schmeidler, J | 1 |
| Godbold, J | 1 |
| Cai, W | 1 |
| Uribarri, J | 1 |
| Vlassara, H | 1 |
| Silverman, JM | 1 |
| Beeri, MS | 1 |
| Hansen, F | 1 |
| Pandolfo, P | 1 |
| Galland, F | 1 |
| Torres, FV | 1 |
| Dutra, MF | 1 |
| Batassini, C | 1 |
| Guerra, MC | 1 |
| Leite, MC | 1 |
| Gonçalves, CA | 1 |
| Huang, X | 1 |
| Wang, F | 1 |
| Chen, W | 1 |
| Chen, Y | 1 |
| Wang, N | 1 |
| von Maltzan, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dietary Reduction of Advanced Glycation End Products to Prevent Cognitive Decline in Elderly Diabetics - a Randomized Pilot Trial[NCT02739971] | 75 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for pyruvaldehyde and Cognition Disorders
| Article | Year |
|---|---|
Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats.
Topics: Animals; Behavior, Animal; Cognition Disorders; Diabetes Mellitus, Experimental; Dose-Response Relat | 2013 |
Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?
Topics: Administration, Oral; Angiotensinogen; Animals; Antioxidants; Cognition; Cognition Disorders; Glutat | 2014 |
Dietary advanced glycation end products are associated with decline in memory in young elderly.
Topics: Aged; Cognition Disorders; Diet; Female; Glycation End Products, Advanced; Humans; Male; Memory Diso | 2014 |
Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Cognition Disorders; Disease Models, Animal; Glial Fi | 2016 |
Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal.
Topics: Animals; bcl-2-Associated X Protein; Blood Glucose; Caspase 3; Cells, Cultured; Cognition Disorders; | 2012 |