Page last updated: 2024-10-19

pyruvaldehyde and Cardiovascular Diseases

pyruvaldehyde has been researched along with Cardiovascular Diseases in 25 studies

Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisation of blood glucose concentration, the event risk is amplified-an effect called "glycolytic memory"."2.82Dicarbonyl Stress in Diabetic Vascular Disease. ( Stratmann, B, 2022)
"Candesartan treatment for 4 weeks significantly reduced these parameters."1.39Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. ( Chen, X; Endo, S; Guo, Q; Hu, C; Ito, S; Jiang, Y; Miyata, T; Mori, T; Nakayama, K; Nakayama, M; Ogawa, S; Ohsaki, Y; Yoneki, Y; Zhu, W, 2013)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (8.00)29.6817
2010's16 (64.00)24.3611
2020's7 (28.00)2.80

Authors

AuthorsStudies
Rabbani, N3
Stratmann, B1
Schalkwijk, CG6
Stehouwer, CDA5
Khanam, A1
Ahmad, S1
Husain, A1
Rehman, S1
Farooqui, A1
Yusuf, MA1
Hanssen, NMJ4
Scheijen, JLJM4
Houben, AJHM1
van de Waarenburg, M2
Berendschot, TTJM1
Webers, CAB1
Reesink, KD1
van Greevenbroek, MMJ1
van der Kallen, C1
Schaper, NC1
Schram, MT1
Henry, RMA1
He, Y1
Zhou, C1
Huang, M1
Tang, C1
Liu, X1
Yue, Y1
Diao, Q1
Zheng, Z1
Liu, D1
Teraa, M1
Gremmels, H1
Verhaar, MC1
Jorsal, A1
Parving, HH1
Tarnow, L1
Rossing, P1
Westerink, J1
van der Graaf, Y1
Domingo-Espín, J1
Nilsson, O1
Bernfur, K1
Del Giudice, R1
Lagerstedt, JO1
Sankaralingam, S1
Ibrahim, A1
Rahman, MDM1
Eid, AH1
Munusamy, S1
Tezuka, Y1
Nakaya, I1
Nakayama, K2
Nakayama, M2
Yahata, M1
Soma, J1
Nigro, C1
Leone, A1
Fiory, F1
Prevenzano, I1
Nicolò, A1
Mirra, P1
Beguinot, F1
Miele, C1
Vulesevic, B1
Milne, RW1
Suuronen, EJ1
Thornalley, PJ2
Hansen, CS1
Jensen, TM1
Jensen, JS1
Nawroth, P1
Fleming, T1
Witte, DR1
Lauritzen, T1
Sandbaek, A1
Charles, M1
Fleischer, J1
Vistisen, D1
Jørgensen, ME1
Maessen, DE1
Stehouwer, CD1
Engelbertsen, D1
Vallejo, J1
Quách, TD1
Fredrikson, GN1
Alm, R1
Hedblad, B1
Björkbacka, H1
Rothstein, TL1
Nilsson, J1
Bengtsson, E1
Monnier, VM1
Sun, W1
Gao, X1
Sell, DR1
Cleary, PA1
Lachin, JM1
Genuth, S1
Kilhovd, BK1
Juutilainen, A1
Lehto, S1
Rönnemaa, T1
Torjesen, PA1
Hanssen, KF1
Laakso, M1
Chazov, EI1
Griffin, MD1
Wilson, LM1
Mok, YF1
Januszewski, AS1
Wilson, AM1
Karschimkus, CS1
Romas, E1
Lee, AB1
Godfrey, T1
Wong, M1
Clemens, L1
Jenkins, AJ1
Howlett, GJ1
Godfrey, L1
Xue, M1
Shaheen, F1
Geoffrion, M1
Milne, R1
Dmitriev, VA1
Oshchepkova, EV1
Titov, VN1
Balakhonova, TV1
Tripoten', MI1
Rogoza, AN1
Shiriaeva, IuK1
Chen, X1
Mori, T1
Guo, Q1
Hu, C1
Ohsaki, Y1
Yoneki, Y1
Zhu, W1
Jiang, Y1
Endo, S1
Ogawa, S1
Miyata, T1
Ito, S1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients With Chronic Critical Limb Ischemia: a Randomized, Placebo-controlled Clinical Trial[NCT00371371]Phase 1/Phase 2160 participants (Actual)Interventional2006-09-30Completed
Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873]Phase 1/Phase 232 participants (Actual)Interventional2014-05-31Completed
Diabetes Control and Complications Trial (DCCT)[NCT00360815]1,441 participants Interventional1983-08-31Completed
Epidemiology of Diabetes Interventions and Complications (EDIC)[NCT00360893]1,441 participants (Actual)Observational1994-04-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Aortal Pulse Wave Velocity (aPWV)

Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionm/s (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer7.98.0
Placebo8.38.5

Area Under the Curve for Oral Glucose Tolerance Test (oGGT)

A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
InterventionmM h (Mean)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer10.89.9
Placebo11.010.6

Finger-fold Capillary Density by Capillaroscopy

After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionnumber of capillaries per mm2 (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer115125
Placebo119128

Flow-mediated Dilatation (FMD)

Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionpercentage of baseline value (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer0.170.12
Placebo0.180.26

Reviews

9 reviews available for pyruvaldehyde and Cardiovascular Diseases

ArticleYear
Dicarbonyl Stress in Diabetic Vascular Disease.
    International journal of molecular sciences, 2022, May-31, Volume: 23, Issue:11

    Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Glycation End Products, Advanced;

2022
Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases.
    Physiological reviews, 2020, 01-01, Volume: 100, Issue:1

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Lactoylglutathione Lyase; Neopl

2020
Glycation and Antioxidants: Hand in the Glove of Antiglycation and Natural Antioxidants.
    Current protein & peptide science, 2020, Volume: 21, Issue:9

    Topics: Antigens, Neoplasm; Antioxidants; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus, Type 2;

2020
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Animals; Biological Products; Cardiovascular Diseases; Drug Evaluation, Preclinical; Enzyme Inhibito

2020
Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice.
    Current pharmaceutical design, 2018, Volume: 24, Issue:26

    Topics: Animals; Cardiovascular Diseases; Diabetes Complications; Humans; Kidney Diseases; Pyruvaldehyde

2018
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging.
    Cells, 2019, 07-19, Volume: 8, Issue:7

    Topics: Aging; Animals; Cardiovascular Diseases; Cells, Cultured; Cellular Senescence; Glycation End Product

2019
Reducing methylglyoxal as a therapeutic target for diabetic heart disease.
    Biochemical Society transactions, 2014, Volume: 42, Issue:2

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Pyruv

2014
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
    Biochemical and biophysical research communications, 2015, Mar-06, Volume: 458, Issue:2

    Topics: Aging; Aldehydes; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Glyoxal; Humans; Inflamm

2015
The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
    Clinical science (London, England : 1979), 2015, Volume: 128, Issue:12

    Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Diabetic Angiopathies; D

2015

Trials

2 trials available for pyruvaldehyde and Cardiovascular Diseases

ArticleYear
The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
    Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:6

    Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Denmark; Diabetes Mellitus, Type 2; D

2015
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
    Cardiovascular diabetology, 2015, Sep-05, Volume: 14

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Biopsy; Cardiovascular Diseases; Carotid Artery

2015
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
    Cardiovascular diabetology, 2015, Sep-05, Volume: 14

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Biopsy; Cardiovascular Diseases; Carotid Artery

2015
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
    Cardiovascular diabetology, 2015, Sep-05, Volume: 14

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Biopsy; Cardiovascular Diseases; Carotid Artery

2015
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
    Cardiovascular diabetology, 2015, Sep-05, Volume: 14

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Biopsy; Cardiovascular Diseases; Carotid Artery

2015

Other Studies

14 other studies available for pyruvaldehyde and Cardiovascular Diseases

ArticleYear
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes.
    Clinical science (London, England : 1979), 2022, 06-17, Volume: 136, Issue:11

    Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Humans; Hyperglycemia; Insulin R

2022
Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study.
    Diabetes & metabolism, 2021, Volume: 47, Issue:1

    Topics: Aged; Cardiovascular Diseases; Fasting; Female; Glucose Tolerance Test; Humans; Male; Middle Aged; P

2021
Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes.
    Diabetes care, 2021, Volume: 44, Issue:1

    Topics: Amputation, Surgical; Cardiovascular Diseases; Case-Control Studies; Diabetes Mellitus; Female; Glyc

2021
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study.
    Diabetes, 2017, Volume: 66, Issue:8

    Topics: Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow-Up

2017
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes.
    Diabetes care, 2018, Volume: 41, Issue:8

    Topics: Adult; Aged; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathi

2018
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:9 Pt B

    Topics: Acetaldehyde; Animals; Apolipoprotein A-I; Blood Glucose; Cardiovascular Diseases; Cell Line; Choles

2018
Methylglyoxal as a prognostic factor in patients with chronic kidney disease.
    Nephrology (Carlton, Vic.), 2019, Volume: 24, Issue:9

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Deoxyglucose; Diabetic Nephropathies; Disease P

2019
Low Levels of IgM Antibodies against an Advanced Glycation Endproduct-Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic Subjects.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Oct-01, Volume: 195, Issue:7

    Topics: Aged; Aged, 80 and over; Antibodies; Apolipoprotein B-100; Atherosclerosis; Autoantibodies; B-Lympho

2015
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women.
    Atherosclerosis, 2009, Volume: 205, Issue:2

    Topics: Cardiovascular Diseases; Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Female; Fi

2009
[Progress in fundamental research: perspectives of cardiology].
    Terapevticheskii arkhiv, 2009, Volume: 81, Issue:9

    Topics: Apelin; Biomarkers; Cardiology; Cardiovascular Diseases; Endothelium, Vascular; Humans; Intercellula

2009
Thioflavin T fluorescence in human serum: correlations with vascular health and cardiovascular risk factors.
    Clinical biochemistry, 2010, Volume: 43, Issue:3

    Topics: Adult; Amyloid beta-Peptides; Animals; Benzothiazoles; Biomarkers; Cardiovascular Diseases; Cattle;

2010
Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes.
    Diabetes, 2011, Volume: 60, Issue:7

    Topics: Animals; Aorta; Apolipoprotein B-100; Apolipoproteins E; Atherosclerosis; Cardiovascular Diseases; C

2011
[Nonspecific inflammation and structural changes in the arteries of hypertensive males at high and moderate risk for cardiovascular events].
    Terapevticheskii arkhiv, 2012, Volume: 84, Issue:9

    Topics: Adult; Aged; Ankle Brachial Index; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Elas

2012
Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2013, Volume: 36, Issue:4

    Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; B

2013