pyruvaldehyde has been researched along with Alloxan Diabetes in 85 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a diabetic pregnancy, an altered maternal metabolism led to increased formation of reactive α-dicarbonyls such as glyoxal (GO) and methylglyoxal (MGO) in the reproductive organs and embryos." | 3.91 | Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits. ( Grybel, KJ; Gürke, J; Haucke, E; Navarrete Santos, A; Pendzialek, SM; Schindler, M; Seeling, T; Simm, A, 2019) |
| " Maternal plasma glucose and methylgyoxal concentrations, as well as embryonic N(ε)-carboxymethyl-lysine (CML) levels were increased to the same extent in diabetic WT and RAGE(-/-) pregnancy." | 3.83 | Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy. ( Brings, S; Ejdesjö, A; Eriksson, UJ; Fleming, T; Fred, RG; Nawroth, PP, 2016) |
| "This study demonstrates that mangiferin can markedly ameliorate diabetes-associated cognitive decline in rats, which is done likely through suppressing methylglyoxal hyperactivity (promoting protein glycation, oxidative stress, and inflammation) mediated noxious effects." | 3.79 | Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. ( Li, HP; Liu, YW; Lu, Q; Wang, JY; Wei, YQ; Yang, QQ; Yin, JL; Yin, XX; Zhu, X, 2013) |
| "Age-related cataracts are a leading cause of blindness." | 1.40 | Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. ( Augusteyn, RC; Ayaki, M; Bidasee, KR; Chan, JY; Palsamy, P; Shinohara, T, 2014) |
| "This hyperalgesia is reflected by increased blood flow in brain regions that are involved in pain processing." | 1.38 | Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. ( Babes, A; Bierhaus, A; Brownlee, M; Cooper, ME; Dehmer, T; Eberhardt, M; Edelstein, D; Elvert, R; Fleming, T; Forbes, J; Haberkorn, U; Humpert, PM; Kichko, TI; Konrade, I; Lasischka, F; Lasitschka, F; Leffler, A; Lukic, IK; Mier, W; Morcos, M; Nau, C; Nawroth, PP; Neacsu, C; Neuhuber, WL; Pirags, V; Rabbani, N; Reeh, PW; Sauer, SK; Schnölzer, M; Schwaninger, M; Stern, DM; Stoyanov, S; Thornalley, PJ; Ziegler, D, 2012) |
| "Ankaflavin (AK) is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects." | 1.38 | Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. ( Chang, YY; Hsu, WH; Hsu, YW; Kuo, HF; Lee, BH; Pan, TM, 2012) |
| "Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by diabetes, resulting in modification of proteins and alterations of their function." | 1.36 | Hyperglycemia impairs proteasome function by methylglyoxal. ( Brownlee, M; Geisler, S; Hammes, HP; Lochnit, G; Preissner, KT; Queisser, MA; Schleicher, ED; Yao, D, 2010) |
| "Pyridoxamine treatment did not restore erythrocyte glutathione (which was reduced by almost half) in diabetic animals, but it enhanced erythrocyte glyoxalase I activity." | 1.31 | Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. ( Biemel, KM; Lederer, MO; Mally, A; Nagaraj, RH; Padayatti, PS; Sarkar, P, 2002) |
| " Following the chronic administration of methylamine, the urinary levels of both formaldehyde and malondialdehyde (a product from lipid peroxidation) are found to be substantially increased." | 1.30 | Simultaneous determination of formaldehyde and methylglyoxal in urine: involvement of semicarbazide-sensitive amine oxidase-mediated deamination in diabetic complications. ( Deng, Y; Yu, PH, 1999) |
| "Glycerol was the best substrate for D-lactate formation via methylglyoxal in rat liver." | 1.29 | Carbon sources for D-lactate formation in rat liver. ( Hirata, M; Kawase, M; Kondoh, Y; Ohmori, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.71) | 18.7374 |
| 1990's | 7 (8.24) | 18.2507 |
| 2000's | 17 (20.00) | 29.6817 |
| 2010's | 48 (56.47) | 24.3611 |
| 2020's | 9 (10.59) | 2.80 |
| Authors | Studies |
|---|---|
| Koivisto, A | 2 |
| Hukkanen, M | 1 |
| Saarnilehto, M | 1 |
| Chapman, H | 2 |
| Kuokkanen, K | 1 |
| Wei, H | 2 |
| Viisanen, H | 2 |
| Akerman, KE | 2 |
| Lindstedt, K | 1 |
| Pertovaara, A | 2 |
| Pignalosa, FC | 1 |
| Desiderio, A | 1 |
| Mirra, P | 1 |
| Nigro, C | 1 |
| Perruolo, G | 1 |
| Ulianich, L | 1 |
| Formisano, P | 1 |
| Beguinot, F | 1 |
| Miele, C | 1 |
| Napoli, R | 1 |
| Fiory, F | 1 |
| Takenokuchi, M | 1 |
| Matsumoto, K | 1 |
| Nitta, Y | 1 |
| Takasugi, R | 1 |
| Inoue, Y | 1 |
| Iwai, M | 1 |
| Kadoyama, K | 1 |
| Yoshida, K | 1 |
| Takano-Ohmuro, H | 1 |
| Taniguchi, T | 1 |
| Xie, Q | 1 |
| Zhan, Y | 1 |
| Guo, L | 1 |
| Hao, H | 1 |
| Shi, X | 1 |
| Yang, J | 1 |
| Luo, F | 1 |
| Qiu, B | 1 |
| Lin, Z | 1 |
| Xiang, X | 1 |
| Chen, J | 1 |
| Jiang, T | 1 |
| Yan, C | 1 |
| Kang, Y | 1 |
| Zhang, M | 1 |
| Xiang, K | 1 |
| Guo, J | 1 |
| Jiang, G | 1 |
| Wang, C | 1 |
| Yang, X | 2 |
| Chen, Z | 2 |
| Seeling, T | 1 |
| Haucke, E | 1 |
| Navarrete Santos, A | 2 |
| Grybel, KJ | 1 |
| Gürke, J | 1 |
| Pendzialek, SM | 1 |
| Schindler, M | 1 |
| Simm, A | 1 |
| Anandan, S | 1 |
| Mahadevamurthy, M | 1 |
| Ansari, MA | 1 |
| Alzohairy, MA | 1 |
| Alomary, MN | 1 |
| Farha Siraj, S | 1 |
| Halugudde Nagaraja, S | 1 |
| Chikkamadaiah, M | 1 |
| Thimappa Ramachandrappa, L | 1 |
| Naguvanahalli Krishnappa, HK | 1 |
| Ledesma, AE | 1 |
| Nagaraj, AK | 1 |
| Urooj, A | 1 |
| Fang, X | 1 |
| Liu, L | 1 |
| Zhou, S | 1 |
| Zhu, M | 1 |
| Wang, B | 2 |
| Jiang, M | 1 |
| Yakupu, A | 1 |
| Guan, H | 1 |
| Dong, J | 1 |
| Liu, Y | 1 |
| Song, F | 1 |
| Tang, J | 1 |
| Tian, M | 1 |
| Niu, Y | 1 |
| Lu, S | 1 |
| Tan, SM | 1 |
| Lindblom, RSJ | 1 |
| Ziemann, M | 1 |
| Laskowski, A | 1 |
| Granata, C | 1 |
| Snelson, M | 1 |
| Thallas-Bonke, V | 1 |
| El-Osta, A | 1 |
| Baeza-Garza, CD | 1 |
| Caldwell, ST | 1 |
| Hartley, RC | 1 |
| Krieg, T | 1 |
| Cooper, ME | 3 |
| Murphy, MP | 1 |
| Coughlan, MT | 1 |
| Ahmad, S | 1 |
| Khan, MS | 1 |
| Alouffi, S | 1 |
| Khan, S | 1 |
| Khan, M | 1 |
| Akashah, R | 1 |
| Faisal, M | 1 |
| Shahab, U | 1 |
| Chen, L | 1 |
| Xu, Z | 1 |
| Feng, W | 1 |
| Qi, Z | 1 |
| Aikawa, T | 1 |
| Matsubara, H | 1 |
| Ugaji, S | 1 |
| Shirakawa, J | 1 |
| Nagai, R | 2 |
| Munesue, S | 1 |
| Harashima, A | 1 |
| Yamamoto, Y | 1 |
| Tsuchiya, H | 1 |
| Baig, MH | 1 |
| Jan, AT | 1 |
| Rabbani, G | 1 |
| Ahmad, K | 1 |
| Ashraf, JM | 1 |
| Kim, T | 1 |
| Min, HS | 1 |
| Lee, YH | 1 |
| Cho, WK | 1 |
| Ma, JY | 1 |
| Lee, EJ | 1 |
| Choi, I | 1 |
| Do, MH | 1 |
| Hur, J | 1 |
| Choi, J | 1 |
| Kim, M | 1 |
| Kim, MJ | 1 |
| Kim, Y | 1 |
| Ha, SK | 1 |
| Li, H | 1 |
| Tang, Z | 2 |
| Chu, P | 1 |
| Song, Y | 1 |
| Yang, Y | 1 |
| Sun, B | 1 |
| Niu, M | 1 |
| Qaed, E | 1 |
| Shopit, A | 1 |
| Han, G | 1 |
| Ma, X | 1 |
| Peng, J | 1 |
| Hu, M | 1 |
| Zanotto, C | 1 |
| Hansen, F | 1 |
| Galland, F | 1 |
| Batassini, C | 1 |
| Federhen, BC | 1 |
| da Silva, VF | 1 |
| Leite, MC | 1 |
| Nardin, P | 1 |
| Gonçalves, CA | 1 |
| Barragán-Iglesias, P | 1 |
| Kuhn, J | 1 |
| Vidal-Cantú, GC | 1 |
| Salinas-Abarca, AB | 1 |
| Granados-Soto, V | 1 |
| Dussor, GO | 1 |
| Campbell, ZT | 1 |
| Price, TJ | 1 |
| Schumacher, D | 1 |
| Morgenstern, J | 2 |
| Oguchi, Y | 1 |
| Volk, N | 1 |
| Kopf, S | 1 |
| Groener, JB | 1 |
| Nawroth, PP | 4 |
| Fleming, T | 5 |
| Freichel, M | 1 |
| Schlotterer, A | 2 |
| Kolibabka, M | 2 |
| Lin, J | 1 |
| Acunman, K | 1 |
| Dietrich, N | 1 |
| Sticht, C | 1 |
| Nawroth, P | 1 |
| Hammes, HP | 4 |
| Hajizadeh-Sharafabad, F | 1 |
| Sahebkar, A | 1 |
| Zabetian-Targhi, F | 1 |
| Maleki, V | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Fleming, TH | 1 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Kroll, J | 1 |
| Liu, YW | 1 |
| Zhu, X | 1 |
| Yang, QQ | 1 |
| Lu, Q | 1 |
| Wang, JY | 1 |
| Li, HP | 1 |
| Wei, YQ | 1 |
| Yin, JL | 1 |
| Yin, XX | 1 |
| Lupachyk, S | 1 |
| Watcho, P | 1 |
| Shevalye, H | 1 |
| Vareniuk, I | 1 |
| Obrosov, A | 1 |
| Obrosova, IG | 1 |
| Yorek, MA | 1 |
| Vulesevic, B | 2 |
| McNeill, B | 2 |
| Geoffrion, M | 1 |
| Kuraitis, D | 1 |
| McBane, JE | 1 |
| Lochhead, M | 1 |
| Vanderhyden, BC | 1 |
| Korbutt, GS | 1 |
| Milne, RW | 2 |
| Suuronen, EJ | 2 |
| Palsamy, P | 1 |
| Bidasee, KR | 2 |
| Ayaki, M | 1 |
| Augusteyn, RC | 1 |
| Chan, JY | 1 |
| Shinohara, T | 1 |
| Tikellis, C | 1 |
| Pickering, RJ | 1 |
| Tsorotes, D | 1 |
| Huet, O | 1 |
| Jandeleit-Dahm, K | 1 |
| Thomas, MC | 1 |
| Zhu, D | 1 |
| Wang, L | 2 |
| Zhou, Q | 1 |
| Yan, S | 1 |
| Li, Z | 1 |
| Sheng, J | 1 |
| Zhang, W | 1 |
| McVicar, CM | 1 |
| Ward, M | 1 |
| Colhoun, LM | 1 |
| Guduric-Fuchs, J | 1 |
| Bierhaus, A | 2 |
| Chen, M | 1 |
| Stitt, AW | 1 |
| Xie, B | 1 |
| Lin, F | 1 |
| Ullah, K | 1 |
| Peng, L | 1 |
| Ding, W | 1 |
| Dai, R | 1 |
| Qing, H | 1 |
| Deng, Y | 2 |
| Li, W | 2 |
| Maloney, RE | 2 |
| Aw, TY | 3 |
| Zhang, X | 1 |
| Pang, N | 1 |
| Xiao, L | 1 |
| Li, Y | 1 |
| Chen, N | 1 |
| Ren, M | 1 |
| Deng, X | 1 |
| Wu, J | 1 |
| Fang, L | 1 |
| Li, X | 1 |
| Zhong, Y | 1 |
| Yu, J | 1 |
| Yu, L | 1 |
| Dai, H | 1 |
| Yan, M | 1 |
| Sohn, E | 3 |
| Kim, J | 4 |
| Kim, CS | 3 |
| Jo, K | 2 |
| Kim, JS | 4 |
| Giacco, F | 1 |
| Maeda, K | 1 |
| Blackburn, NJ | 1 |
| Brownlee, M | 8 |
| Huang, Q | 1 |
| Chen, Y | 2 |
| Gong, N | 1 |
| Wang, YX | 1 |
| Stokes, KY | 1 |
| Ejdesjö, A | 1 |
| Brings, S | 1 |
| Fred, RG | 1 |
| Eriksson, UJ | 2 |
| Alomar, F | 1 |
| Singh, J | 2 |
| Jang, HS | 1 |
| Rozanzki, GJ | 1 |
| Shao, CH | 1 |
| Padanilam, BJ | 1 |
| Mayhan, WG | 1 |
| Yang, G | 1 |
| Cancino, GI | 1 |
| Zahr, SK | 1 |
| Guskjolen, A | 1 |
| Voronova, A | 1 |
| Gallagher, D | 1 |
| Frankland, PW | 1 |
| Kaplan, DR | 1 |
| Miller, FD | 1 |
| Lasierra Losada, M | 1 |
| Chaudhari, BP | 1 |
| Kakkar, P | 1 |
| Lu, MP | 2 |
| Wang, R | 2 |
| Song, X | 2 |
| Chibbar, R | 1 |
| Wang, X | 2 |
| Wu, L | 2 |
| Meng, QH | 2 |
| Yamabe, N | 1 |
| Kang, KS | 1 |
| Park, CH | 1 |
| Tanaka, T | 1 |
| Yokozawa, T | 1 |
| Thangarajah, H | 1 |
| Yao, D | 4 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Galvez, MG | 1 |
| Januszyk, M | 1 |
| Gurtner, GC | 2 |
| Talukdar, D | 1 |
| Chaudhuri, BS | 1 |
| Ray, M | 1 |
| Ray, S | 1 |
| Queisser, MA | 1 |
| Geisler, S | 1 |
| Lochnit, G | 1 |
| Schleicher, ED | 1 |
| Preissner, KT | 1 |
| Naito, Y | 1 |
| Takagi, T | 1 |
| Oya-Ito, T | 2 |
| Okada, H | 1 |
| Suzuki, T | 1 |
| Hirata, I | 1 |
| Hirai, M | 1 |
| Uchiyama, K | 1 |
| Handa, O | 1 |
| Uchida, K | 1 |
| Yoshikawa, T | 1 |
| Jacobsen, JN | 1 |
| Steffensen, B | 1 |
| Häkkinen, L | 1 |
| Krogfelt, KA | 1 |
| Larjava, HS | 1 |
| Brouwers, O | 1 |
| Niessen, PM | 1 |
| Ferreira, I | 1 |
| Miyata, T | 1 |
| Scheffer, PG | 1 |
| Teerlink, T | 1 |
| Schrauwen, P | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Lin, MH | 1 |
| Chen, HY | 1 |
| Liao, TH | 1 |
| Huang, TC | 1 |
| Chen, CM | 1 |
| Lee, JA | 1 |
| Chetyrkin, S | 1 |
| Mathis, M | 1 |
| Pedchenko, V | 1 |
| Sanchez, OA | 1 |
| McDonald, WH | 1 |
| Hachey, DL | 1 |
| Madu, H | 1 |
| Stec, D | 1 |
| Hudson, B | 1 |
| Voziyan, P | 1 |
| Lee, YM | 1 |
| Shin, SD | 1 |
| Siewiera, K | 1 |
| Labieniec-Watala, M | 1 |
| Stoyanov, S | 1 |
| Leffler, A | 1 |
| Babes, A | 1 |
| Neacsu, C | 1 |
| Sauer, SK | 1 |
| Eberhardt, M | 1 |
| Schnölzer, M | 1 |
| Lasitschka, F | 1 |
| Lasischka, F | 1 |
| Neuhuber, WL | 1 |
| Kichko, TI | 1 |
| Konrade, I | 1 |
| Elvert, R | 1 |
| Mier, W | 1 |
| Pirags, V | 1 |
| Lukic, IK | 1 |
| Morcos, M | 1 |
| Dehmer, T | 1 |
| Rabbani, N | 2 |
| Thornalley, PJ | 4 |
| Edelstein, D | 3 |
| Nau, C | 1 |
| Forbes, J | 1 |
| Humpert, PM | 1 |
| Schwaninger, M | 1 |
| Ziegler, D | 1 |
| Stern, DM | 1 |
| Haberkorn, U | 1 |
| Reeh, PW | 1 |
| Huang, X | 1 |
| Wang, F | 1 |
| Chen, W | 1 |
| Wang, N | 1 |
| von Maltzan, K | 1 |
| Hu, TY | 1 |
| Liu, CL | 1 |
| Chyau, CC | 1 |
| Hu, ML | 1 |
| Talior-Volodarsky, I | 1 |
| Connelly, KA | 1 |
| Arora, PD | 1 |
| Gullberg, D | 1 |
| McCulloch, CA | 1 |
| Lee, BH | 1 |
| Hsu, WH | 1 |
| Chang, YY | 1 |
| Kuo, HF | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Circu, ML | 1 |
| Alexander, JS | 1 |
| Kim, YS | 1 |
| Jung, DH | 1 |
| Akagawa, M | 1 |
| Sasaki, T | 1 |
| Suyama, K | 1 |
| Padival, AK | 1 |
| Crabb, JW | 1 |
| Nagaraj, RH | 6 |
| Rosca, MG | 1 |
| Mustata, TG | 1 |
| Kinter, MT | 1 |
| Ozdemir, AM | 1 |
| Kern, TS | 1 |
| Szweda, LI | 1 |
| Monnier, VM | 1 |
| Weiss, MF | 1 |
| Bhat, M | 1 |
| Liu, B | 1 |
| Staniszewska, MM | 1 |
| Padival, S | 1 |
| Cantero, AV | 1 |
| Portero-Otín, M | 1 |
| Ayala, V | 1 |
| Auge, N | 1 |
| Sanson, M | 1 |
| Elbaz, M | 1 |
| Thiers, JC | 1 |
| Pamplona, R | 1 |
| Salvayre, R | 1 |
| Nègre-Salvayre, A | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Pestell, R | 1 |
| Giardino, I | 1 |
| Suske, G | 1 |
| Sarthy, VP | 1 |
| Ceradini, DJ | 1 |
| Grogan, RH | 1 |
| Callaghan, MJ | 1 |
| Fujiwara, Y | 1 |
| Mera, K | 1 |
| Yamagata, K | 1 |
| Sakashita, N | 1 |
| Takeya, M | 1 |
| Kondoh, Y | 2 |
| Kawase, M | 5 |
| Hirata, M | 1 |
| Ohmori, S | 5 |
| Phillips, SA | 1 |
| Mirrlees, D | 1 |
| Kalapos, MP | 1 |
| Riba, P | 1 |
| Garzo, T | 1 |
| Mandl, J | 1 |
| Shamsi, FA | 1 |
| Lin, K | 1 |
| Sady, C | 1 |
| Wentzel, P | 1 |
| Minhas, HS | 1 |
| Yu, PH | 1 |
| Sarkar, P | 1 |
| Mally, A | 1 |
| Biemel, KM | 1 |
| Lederer, MO | 1 |
| Padayatti, PS | 1 |
| Kawakami, Y | 1 |
| Mori, M | 3 |
| Shiraha, K | 1 |
| Atkins, TW | 1 |
| Thornally, PJ | 1 |
| Tsuboi, S | 1 |
| Hirota, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvaldehyde and Alloxan Diabetes
| Article | Year |
|---|---|
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction.
Topics: Animals; Cognition; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus; Diabetes Melli | 2021 |
The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review.
Topics: Animals; Antigens, Neoplasm; Antioxidants; Atherosclerosis; Diabetes Mellitus, Experimental; Gene Ex | 2019 |
1 trial available for pyruvaldehyde and Alloxan Diabetes
| Article | Year |
|---|---|
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.
Topics: Aged; Aldo-Keto Reductases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fem | 2018 |
82 other studies available for pyruvaldehyde and Alloxan Diabetes
| Article | Year |
|---|---|
Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.
Topics: Animals; Calcium Channels; Calcium Signaling; Diabetes Mellitus, Experimental; Diabetic Nephropathie | 2012 |
In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract.
Topics: Animals; Arginine; Collagen; Connaraceae; Diabetes Mellitus, Experimental; Glycation End Products, A | 2022 |
A Ratiometric Fluorescence Probe for Selective Detection of ex vivo Methylglyoxal in Diabetic Mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fluorescent Dyes; HeLa Cells; H | 2022 |
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Exosomes; Human Umbilical Vein Endothelial C | 2023 |
Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits.
Topics: Animals; Blastocyst; Cell Line; Diabetes Mellitus, Experimental; Female; Glyoxal; Humans; Hyperglyce | 2019 |
Biosynthesized ZnO-NPs from
Topics: Animals; Cattle; Diabetes Mellitus, Experimental; Erythrocytes; Glycation End Products, Advanced; Hy | 2019 |
N‑acetylcysteine inhibits atherosclerosis by correcting glutathione‑dependent methylglyoxal elimination and dicarbonyl/oxidative stress in the aorta of diabetic mice.
Topics: Acetylcysteine; Animals; Aorta; Atherosclerosis; Diabetes Complications; Diabetes Mellitus, Experime | 2021 |
Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Macrophages; Mice; Pyridoxamine | 2022 |
Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide.
Topics: Animals; Benzamides; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal | 2021 |
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Ani | 2021 |
Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucosides; Kelch-Like ECH-Associated Pro | 2021 |
Contribution of methylglyoxal to delayed healing of bone injury in diabetes.
Topics: Animals; Blood Glucose; Bone and Bones; Cell Line; Diabetes Complications; Diabetes Mellitus, Experi | 2017 |
Methylglyoxal and Advanced Glycation End products: Insight of the regulatory machinery affecting the myogenic program and of its modulation by natural compounds.
Topics: Animals; Biological Products; Catechols; Cell Differentiation; Cell Line; Computer Simulation; Curcu | 2017 |
Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eucommiaceae; Gene | 2018 |
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Topics: Animals; Apoptosis; Cell Respiration; Diabetes Mellitus, Experimental; Heme Oxygenase-1; Male; Mitoc | 2018 |
Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4.
Topics: Animals; Astrocytes; Diabetes Mellitus, Experimental; Disease Models, Animal; Exenatide; Glutamic Ac | 2019 |
Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain.
Topics: Analgesics, Non-Narcotic; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA-Bind | 2019 |
Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats.
Topics: Animals; Behavior, Animal; Cognition Disorders; Diabetes Mellitus, Experimental; Dose-Response Relat | 2013 |
Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.
Topics: Aldehydes; Animals; Arterioles; Behavior, Animal; Blood Glucose; Blotting, Western; Body Weight; Dia | 2013 |
Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice.
Topics: Angiogenic Proteins; Animals; Apoptosis; Blood Glucose; Bone Marrow Cells; Bone Marrow Transplantati | 2014 |
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.
Topics: Aging; Animals; Blotting, Western; Cataract; Cells, Cultured; Diabetes Mellitus, Experimental; DNA M | 2014 |
Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes.
Topics: Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Diabetes Mellitus, Experimental; Glycatio | 2014 |
(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice.
Topics: Animals; Catechin; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progr | 2014 |
Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Lactoylglutathione Ly | 2015 |
A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease.
Topics: alpha-Synuclein; Animals; Brain; Cell Death; Cell Line; Diabetes Mellitus, Experimental; Dopaminergi | 2015 |
High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature.
Topics: Acetylcysteine; Animals; Brain; Buthionine Sulfoximine; Cell Line; Diabetes Mellitus, Experimental; | 2015 |
Glycation of vitronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2-αvβ3 integrin cross-talk.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Diabetes Complications; Diabetes Mellitus, Ex | 2015 |
Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats.
Topics: Animals; Autophagy; Blood-Brain Barrier; Brain Ischemia; Capillaries; Cell Line; Cell Survival; Diab | 2015 |
Extract of Rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin‑induced diabetic rats and its active compound emodin inhibits methylglyoxal‑mediated glycation of proteins.
Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Emodin; Fall | 2015 |
Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy.
Topics: Angiopoietin-2; Animals; Case-Control Studies; Cell Death; Diabetes Mellitus, Experimental; Diabetic | 2016 |
Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels.
Topics: Analgesics; Aniline Compounds; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neu | 2016 |
The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress.
Topics: Acetylcysteine; Animals; Antioxidants; Blood-Brain Barrier; Brain; Cerebral Infarction; Diabetes Mel | 2016 |
Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dinoprost; Embryo, Mammalian; Embryonic Dev | 2016 |
Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.
Topics: Animals; Arterioles; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2016 |
A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.
Topics: Adult Stem Cells; Animals; Animals, Newborn; Behavior, Animal; Cerebral Cortex; Diabetes Mellitus, E | 2016 |
Pronociceptive effects induced by cutaneous application of a transient receptor potential ankyrin 1 (TRPA1) channel agonist methylglyoxal in diabetic animals: comparison with tunicamycin-induced endoplastic reticulum stress.
Topics: Administration, Cutaneous; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Endoplasmic R | 2016 |
Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation.
Topics: Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy | 2017 |
Dietary soy isoflavones increase insulin secretion and prevent the development of diabetic cataracts in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Diet; Glu | 2008 |
7-O-galloyl-D-sedoheptulose is a novel therapeutic agent against oxidative stress and advanced glycation endproducts in the diabetic kidney.
Topics: Aldehydes; Animals; Antioxidants; Blood Glucose; Blotting, Western; Body Weight; Cornus; Diabetes Me | 2009 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
Critical evaluation of toxic versus beneficial effects of methylglyoxal.
Topics: Animals; Arginine; Cataract; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delive | 2009 |
Hyperglycemia impairs proteasome function by methylglyoxal.
Topics: Albumins; Animals; Cattle; Cell Line; Chymotrypsin; Diabetes Mellitus, Experimental; Endothelial Cel | 2010 |
Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal.
Topics: Animals; Anti-Ulcer Agents; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Mucosa; Glycatio | 2009 |
Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Deoxyguanosine; Diabetes Mellitus, Experimental; Di | 2011 |
Skin wound healing in diabetic β6 integrin-deficient mice.
Topics: Animals; Diabetes Mellitus, Experimental; Fibronectins; Glycation End Products, Advanced; Immunohist | 2010 |
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Gene Expressio | 2011 |
Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Histocyt | 2011 |
Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.
Topics: Amino Acid Motifs; Animals; Arginine; Collagen Type IV; Diabetes Mellitus, Experimental; Glucose; Gl | 2011 |
Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.
Topics: Animals; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Chromatogr | 2012 |
Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes - Objective causes of laboratory misfortune or unpredictable G3 activity?
Topics: Animals; Cell Respiration; Cytoprotection; Dendrimers; Diabetes Mellitus, Experimental; Diabetes Mel | 2012 |
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Topics: Animals; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans | 2012 |
Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal.
Topics: Animals; bcl-2-Associated X Protein; Blood Glucose; Caspase 3; Cells, Cultured; Cognition Disorders; | 2012 |
Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells.
Topics: Animals; Blotting, Western; Cell Proliferation; Cell-Free System; Chromatography, High Pressure Liqu | 2012 |
α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy.
Topics: Actins; Animals; Cell Adhesion; Cell Differentiation; Cells, Cultured; Collagen; Diabetes Mellitus, | 2012 |
Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experiment | 2012 |
Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain; Cells, Cultured; Diabetes Mellitus, Experimental; En | 2013 |
Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells.
Topics: Acetophenones; Animals; Axl Receptor Tyrosine Kinase; Benzopyrans; Diabetes Mellitus, Experimental; | 2012 |
Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction.
Topics: 2-Aminoadipic Acid; Animals; Blood Proteins; Carbohydrate Metabolism; Chromatography, High Pressure | 2002 |
Methylglyoxal modifies heat shock protein 27 in glomerular mesangial cells.
Topics: Animals; Cells, Cultured; Cytochrome c Group; Diabetes Mellitus, Experimental; Glomerular Mesangium; | 2003 |
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabe | 2005 |
Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.
Topics: alpha-Crystallin B Chain; Animals; Antioxidants; Apoptosis; Capillaries; Cattle; Diabetes Mellitus, | 2005 |
Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses.
Topics: Animals; Diabetes Mellitus, Experimental; Epithelial Cells; Female; Glucose; Glutathione; Lactoylglu | 2006 |
Pyridoxamine inhibits maillard reactions in diabetic rat lenses.
Topics: Aldehyde Reductase; Animals; Arginine; Chromatography, High Pressure Liquid; Diabetes Complications; | 2006 |
Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Becaplermin; Cell Movement; Cell Proli | 2007 |
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
Topics: Acetylglucosamine; Angiopoietin-2; Animals; Arginine; Cell Line, Transformed; Diabetes Mellitus, Exp | 2007 |
Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Glycine max; Homocysteine; Ins | 2008 |
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.
Topics: Animals; Bone Marrow Transplantation; Diabetes Mellitus, Experimental; Glucose; Hyperglycemia; Hypox | 2008 |
Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.
Topics: Aldehydes; Animals; Antibodies, Monoclonal; Antibody Specificity; Antigen-Antibody Reactions; Cattle | 2008 |
Carbon sources for D-lactate formation in rat liver.
Topics: Acetoacetates; Acetone; Animals; Diabetes Mellitus, Experimental; Glucose; Glycerol; In Vitro Techni | 1994 |
Modification of the glyoxalase system in streptozotocin-induced diabetic rats. Effect of the aldose reductase inhibitor Statil.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Kidney; Lactates; Lacto | 1993 |
Glucose formation from methylglyoxal in hepatocytes from streptozotocin-induced diabetic mice: the effect of insulin.
Topics: Acetone; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; | 1996 |
Methylglyoxal-derived modifications in lens aging and cataract formation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Blotting, Western; Cataract; Cattle; Chi | 1998 |
Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.
Topics: Animals; Deoxyglucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Embryo, Ma | 1998 |
Simultaneous determination of formaldehyde and methylglyoxal in urine: involvement of semicarbazide-sensitive amine oxidase-mediated deamination in diabetic complications.
Topics: Amine Oxidase (Copper-Containing); Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, | 1999 |
Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal.
Topics: Animals; Arginine; Cattle; Chromatography, High Pressure Liquid; Crystallins; Diabetes Mellitus, Exp | 2002 |
Concentrations of D-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats.
Topics: Animals; Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus, Experimental; Enzymes; Food Depr | 1992 |
Biosynthesis and degradation of methylglyoxal in animals.
Topics: Acetoacetates; Aldehydes; Animals; Diabetes Mellitus, Experimental; Kinetics; Liver; Male; Myocardiu | 1989 |
Erythrocyte glyoxalase activity in genetically obese (ob/ob) and streptozotocin diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glutathione; Mice; Mice, Obes | 1989 |
Determination of methylglyoxal as 2-methylquinoxaline by high-performance liquid chromatography and its application to biological samples.
Topics: Aldehydes; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experi | 1987 |
Simple and sensitive determination of methylglyoxal in biological samples by gas chromatography with electron-capture detection.
Topics: Aldehydes; Animals; Chromatography, Gas; Coffee; Diabetes Mellitus, Experimental; Electrochemistry; | 1987 |