pyruvaldehyde has been researched along with Aging in 62 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane." | 7.83 | The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016) |
| "Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome." | 4.84 | Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease. ( Thornalley, PJ, 2008) |
| " The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo." | 4.83 | Protein modification in aging: an update. ( Schöneich, C, 2006) |
| "The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane." | 3.83 | The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016) |
| "Protection of mitochondrial proteins from glycation by endogenous dicarbonyl compounds, methylglyoxal and glyoxal, was found recently to prevent increased formation of reactive oxygen species and oxidative and nitrosative damage to the proteome during aging and produce life extension in the nematode Caenorhabditis elegans." | 3.74 | Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress. ( Rabbani, N; Thornalley, PJ, 2008) |
| "We examined 172 young (<45 years old) and older (>60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N(epsilon)-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation." | 3.74 | Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. ( Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H, 2007) |
| "Advanced glycation end-products and glycoxidation products, such as Nepsilon-(carboxymethyl)lysine (CML) and pentosidine, accumulate in long-lived tissue proteins with age and are implicated in the aging of tissue proteins and in the development of pathology in diabetes, atherosclerosis and other diseases." | 3.69 | N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. ( Ahmed, MU; Baynes, JW; Brinkmann Frye, E; Degenhardt, TP; Thorpe, SR, 1997) |
| "The importance of the dicarbonyls in diabetic kidney disease is clearly demonstrated by the reno-protective benefits of structurally-disparate dicarbonyl scavengers in experimental studies." | 2.66 | Dicarbonyl-mediated AGEing and diabetic kidney disease. ( Dimitropoulos, A; Rosado, CJ; Thomas, MC, 2020) |
| "Glyoxalase-1 (GLO-1) acts as a part of the anti-glycation defense system by carrying out detoxification of GO and MGO." | 2.66 | The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. ( Akhter, A; Kausar, MA; Saeed, M; Siddiqui, AJ; Singh, R, 2020) |
| "Glo-1 has a dual role in cancer as a tumour suppressor protein prior to tumour development and mediator of multi-drug resistance in cancer treatment, implicating dicarbonyl glycation of DNA in carcinogenesis and dicarbonyl-driven cytotoxicity in mechanism of action of anticancer drugs." | 2.53 | Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics. ( Rabbani, N; Thornalley, PJ; Xue, M, 2016) |
| "Aging is a Parkinson's disease (PD) risk factor." | 2.50 | Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents. ( Hipkiss, AR, 2014) |
| "Aging is a main risk factor for many diseases including neurodegenerative disorders." | 1.72 | Age-related neuronal damage by advanced glycation end products through altered proteostasis. ( Jakhotia, S; Reddy Addi, U; Reddy, GB; Reddy, SS, 2022) |
| "Age-related cataracts are a leading cause of blindness." | 1.40 | Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. ( Augusteyn, RC; Ayaki, M; Bidasee, KR; Chan, JY; Palsamy, P; Shinohara, T, 2014) |
| "To assess the role of dAGE on type 1 diabetes, NOD mice were exposed to a high-AGE diet (H-AGE) and to a nutritionally similar diet with approximate fivefold-lower levels of N(epsilon)-carboxymethyllysine (CML) and methylglyoxal-derivatives (MG) (L-AGE)." | 1.32 | Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice. ( Hattori, M; He, C; McEvoy, R; Peppa, M; Vlassara, H; Zheng, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.61) | 18.7374 |
| 1990's | 6 (9.68) | 18.2507 |
| 2000's | 19 (30.65) | 29.6817 |
| 2010's | 30 (48.39) | 24.3611 |
| 2020's | 6 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Pucci, M | 1 |
| Aria, F | 1 |
| Premoli, M | 1 |
| Maccarinelli, G | 1 |
| Mastinu, A | 1 |
| Bonini, S | 1 |
| Memo, M | 1 |
| Uberti, D | 1 |
| Abate, G | 1 |
| Reddy Addi, U | 1 |
| Jakhotia, S | 1 |
| Reddy, SS | 1 |
| Reddy, GB | 1 |
| Kold-Christensen, R | 1 |
| Johannsen, M | 1 |
| Dimitropoulos, A | 1 |
| Rosado, CJ | 1 |
| Thomas, MC | 1 |
| Saeed, M | 1 |
| Kausar, MA | 1 |
| Singh, R | 1 |
| Siddiqui, AJ | 1 |
| Akhter, A | 1 |
| Francisco, FA | 1 |
| Saavedra, LPJ | 1 |
| Junior, MDF | 1 |
| Barra, C | 1 |
| Matafome, P | 1 |
| Mathias, PCF | 1 |
| Gomes, RM | 1 |
| Vicente Miranda, H | 1 |
| Szego, ÉM | 1 |
| Oliveira, LMA | 1 |
| Breda, C | 1 |
| Darendelioglu, E | 1 |
| de Oliveira, RM | 1 |
| Ferreira, DG | 1 |
| Gomes, MA | 1 |
| Rott, R | 1 |
| Oliveira, M | 1 |
| Munari, F | 1 |
| Enguita, FJ | 1 |
| Simões, T | 1 |
| Rodrigues, EF | 1 |
| Heinrich, M | 1 |
| Martins, IC | 1 |
| Zamolo, I | 1 |
| Riess, O | 1 |
| Cordeiro, C | 1 |
| Ponces-Freire, A | 1 |
| Lashuel, HA | 1 |
| Santos, NC | 1 |
| Lopes, LV | 1 |
| Xiang, W | 1 |
| Jovin, TM | 1 |
| Penque, D | 1 |
| Engelender, S | 1 |
| Zweckstetter, M | 1 |
| Klucken, J | 1 |
| Giorgini, F | 1 |
| Quintas, A | 1 |
| Outeiro, TF | 1 |
| Frandsen, JR | 1 |
| Narayanasamy, P | 1 |
| Nowotny, K | 1 |
| Castro, JP | 1 |
| Hugo, M | 1 |
| Braune, S | 1 |
| Weber, D | 1 |
| Pignitter, M | 1 |
| Somoza, V | 1 |
| Bornhorst, J | 1 |
| Schwerdtle, T | 1 |
| Grune, T | 1 |
| Jost, T | 1 |
| Zipprich, A | 1 |
| Glomb, MA | 2 |
| Rosenstock, P | 2 |
| Bezold, V | 2 |
| Bork, K | 2 |
| Scheffler, J | 2 |
| Horstkorte, R | 2 |
| Nigro, C | 1 |
| Leone, A | 1 |
| Fiory, F | 1 |
| Prevenzano, I | 1 |
| Nicolò, A | 1 |
| Mirra, P | 1 |
| Beguinot, F | 1 |
| Miele, C | 1 |
| Geyer, H | 1 |
| Fleming, TH | 1 |
| Theilen, TM | 1 |
| Masania, J | 1 |
| Wunderle, M | 1 |
| Karimi, J | 1 |
| Vittas, S | 1 |
| Bernauer, R | 1 |
| Bierhaus, A | 2 |
| Rabbani, N | 6 |
| Thornalley, PJ | 7 |
| Kroll, J | 1 |
| Tyedmers, J | 1 |
| Nawrotzki, R | 1 |
| Herzig, S | 1 |
| Brownlee, M | 1 |
| Nawroth, PP | 2 |
| Hipkiss, AR | 8 |
| Boonkaew, B | 1 |
| Tompkins, K | 1 |
| Manokawinchoke, J | 1 |
| Pavasant, P | 1 |
| Supaphol, P | 1 |
| Palsamy, P | 1 |
| Bidasee, KR | 1 |
| Ayaki, M | 1 |
| Augusteyn, RC | 1 |
| Chan, JY | 1 |
| Shinohara, T | 1 |
| Illien-Jünger, S | 1 |
| Lu, Y | 1 |
| Qureshi, SA | 1 |
| Hecht, AC | 1 |
| Cai, W | 2 |
| Vlassara, H | 3 |
| Striker, GE | 1 |
| Iatridis, JC | 1 |
| Karumanchi, DK | 1 |
| Karunaratne, N | 1 |
| Lurio, L | 1 |
| Dillon, JP | 1 |
| Gaillard, ER | 2 |
| Zhou, J | 1 |
| Ueda, K | 1 |
| Zhao, J | 1 |
| Sparrow, JR | 1 |
| Thao, MT | 1 |
| Xue, M | 2 |
| Chaudhuri, J | 1 |
| Bose, N | 1 |
| Gong, J | 1 |
| Hall, D | 1 |
| Rifkind, A | 1 |
| Bhaumik, D | 1 |
| Peiris, TH | 1 |
| Chamoli, M | 1 |
| Le, CH | 1 |
| Liu, J | 2 |
| Lithgow, GJ | 1 |
| Ramanathan, A | 1 |
| Xu, XZS | 1 |
| Kapahi, P | 1 |
| Falone, S | 1 |
| Santini, SJ | 1 |
| Cordone, V | 1 |
| Grannonico, M | 1 |
| Cacchio, M | 1 |
| Di Emidio, G | 1 |
| Tatone, C | 1 |
| Amicarelli, F | 1 |
| Dmitriev, LF | 1 |
| Titov, VN | 1 |
| Schmidt, B | 1 |
| de Assis, AM | 1 |
| Battu, CE | 1 |
| Rieger, DK | 1 |
| Hansen, F | 1 |
| Sordi, F | 1 |
| Longoni, A | 1 |
| Hoefel, AL | 1 |
| Farina, M | 1 |
| Gonçalves, CA | 1 |
| Souza, DO | 1 |
| Perry, ML | 1 |
| Krautwald, M | 1 |
| Münch, G | 2 |
| Desai, KM | 1 |
| Chang, T | 1 |
| Wang, H | 1 |
| Banigesh, A | 1 |
| Dhar, A | 1 |
| Untereiner, A | 1 |
| Wu, L | 1 |
| Boušová, I | 1 |
| Průchová, Z | 1 |
| Trnková, L | 1 |
| Dršata, J | 1 |
| Srikanth, V | 1 |
| Westcott, B | 1 |
| Forbes, J | 1 |
| Phan, TG | 1 |
| Beare, R | 1 |
| Venn, A | 1 |
| Pearson, S | 1 |
| Greenaway, T | 1 |
| Parameswaran, V | 1 |
| Li, Y | 1 |
| Fessel, G | 1 |
| Georgiadis, M | 1 |
| Snedeker, JG | 1 |
| Peppa, M | 2 |
| He, C | 1 |
| Hattori, M | 1 |
| McEvoy, R | 1 |
| Zheng, F | 1 |
| Li, SY | 1 |
| Du, M | 1 |
| Dolence, EK | 1 |
| Fang, CX | 1 |
| Mayer, GE | 1 |
| Ceylan-Isik, AF | 1 |
| LaCour, KH | 1 |
| Yang, X | 1 |
| Wilbert, CJ | 1 |
| Sreejayan, N | 1 |
| Ren, J | 1 |
| Ramasamy, R | 1 |
| Yan, SF | 1 |
| Schmidt, AM | 1 |
| Schöneich, C | 1 |
| Kalapos, MP | 1 |
| Ahmad, MS | 1 |
| Pischetsrieder, M | 1 |
| Ahmed, N | 1 |
| Uribarri, J | 1 |
| Goodman, S | 1 |
| Ferrucci, L | 1 |
| Striker, G | 1 |
| Grillo, MA | 1 |
| Colombatto, S | 1 |
| Nagaraj, RH | 3 |
| Biswas, A | 1 |
| Miller, A | 1 |
| Oya-Ito, T | 1 |
| Bhat, M | 1 |
| Ahmed, MU | 1 |
| Brinkmann Frye, E | 1 |
| Degenhardt, TP | 3 |
| Thorpe, SR | 4 |
| Baynes, JW | 4 |
| Shamsi, FA | 2 |
| Partal, A | 1 |
| Sady, C | 2 |
| Frye, EB | 1 |
| Lin, K | 1 |
| Odani, H | 1 |
| Shinzato, T | 1 |
| Matsumoto, Y | 1 |
| Usami, J | 1 |
| Maeda, K | 1 |
| Brownson, C | 2 |
| Schleicher, ED | 1 |
| Häring, HU | 1 |
| Lehmann, R | 1 |
| Carrier, MJ | 1 |
| Yim, MB | 1 |
| Yim, HS | 1 |
| Lee, C | 1 |
| Kang, SO | 1 |
| Chock, PB | 1 |
| Verzijl, N | 1 |
| DeGroot, J | 1 |
| Ben, ZC | 1 |
| Brau-Benjamin, O | 1 |
| Maroudas, A | 1 |
| Bank, RA | 1 |
| Mizrahi, J | 1 |
| Schalkwijk, CG | 1 |
| Bijlsma, JW | 1 |
| Lafeber, FP | 1 |
| TeKoppele, JM | 1 |
| Peters, MA | 1 |
| Hudson, PM | 1 |
| Jurgelske, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873] | Phase 1/Phase 2 | 32 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Carnosine for Peripheral Arterial Disease Patients (Car-PAD)[NCT05371145] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2023-03-01 | Recruiting | ||
| Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy[NCT00967629] | Phase 1 | 20 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | m/s (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 7.9 | 8.0 |
| Placebo | 8.3 | 8.5 |
A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | mM h (Mean) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 10.8 | 9.9 |
| Placebo | 11.0 | 10.6 |
After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | number of capillaries per mm2 (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 115 | 125 |
| Placebo | 119 | 128 |
Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)
| Intervention | percentage of baseline value (Median) | |
|---|---|---|
| Baseline | Post-8 weeks treatment | |
| Glyoxalase 1 Inducer | 0.17 | 0.12 |
| Placebo | 0.18 | 0.26 |
21 reviews available for pyruvaldehyde and Aging
| Article | Year |
|---|---|
Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation.
Topics: Aging; Animals; Causality; Diabetes Mellitus; Glycation End Products, Advanced; Hormesis; Humans; La | 2020 |
Dicarbonyl-mediated AGEing and diabetic kidney disease.
Topics: Aging; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Lactoylg | 2020 |
The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Gene Expression Regulation; Glycation End Products, Advanced | 2020 |
Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
Topics: Aging; Animals; Female; Fetus; Glycation End Products, Advanced; Humans; Infant; Infant, Newborn; In | 2021 |
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Autism Spectrum Disorder; Flavonoids; Humans; Lacto | 2018 |
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging.
Topics: Aging; Animals; Cardiovascular Diseases; Cells, Cultured; Cellular Senescence; Glycation End Product | 2019 |
Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents.
Topics: Aging; Animals; Carnosine; Clinical Trials as Topic; Dietary Carbohydrates; Dietary Supplements; Dou | 2014 |
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
Topics: Aging; Aldehydes; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Glyoxal; Humans; Inflamm | 2015 |
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.
Topics: Aging; Animals; Dyslipidemias; Glycation End Products, Advanced; Humans; Lactoylglutathione Lyase; N | 2016 |
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Topics: Aging; Animals; Disease; Drug Therapy; Humans; Lactoylglutathione Lyase; Pyruvaldehyde; Stress, Phys | 2016 |
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.
Topics: Aging; Animals; Drug Resistance, Neoplasm; Glycation End Products, Advanced; Glyoxal; Humans; Lactoy | 2008 |
Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases.
Topics: Aging; Aldehydes; Free Radicals; Humans; Lactoylglutathione Lyase; Lipid Metabolism; Lipid Peroxidat | 2010 |
Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease?
Topics: Aged; Aging; Alzheimer Disease; Biomarkers; Glycation End Products, Advanced; Humans; Pyruvaldehyde; | 2010 |
Oxidative stress and aging: is methylglyoxal the hidden enemy?
Topics: Aging; Animals; Glycation End Products, Advanced; Humans; Oxidative Stress; Pyruvaldehyde; Reactive | 2010 |
Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine.
Topics: Aging; Animals; Carnosine; Energy Metabolism; Glycation End Products, Advanced; Glycolysis; Humans; | 2011 |
Methylglyoxal comes of AGE.
Topics: Aging; Animals; Gene Expression Regulation; Genome; Glycation End Products, Advanced; Glycosylation; | 2006 |
Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?
Topics: Aging; Animals; Caloric Restriction; Glycolysis; Pyruvaldehyde | 2006 |
Protein modification in aging: an update.
Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Redu | 2006 |
Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases.
Topics: Aging; Aldehyde Oxidoreductases; Animals; Glycation End Products, Advanced; Glyoxal; Humans; Pyruval | 2008 |
Chemistry and pathobiology of advanced glycation end products.
Topics: Aging; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Gene Expression Regulation; Glucose; | 2001 |
Protein glycation: creation of catalytic sites for free radical generation.
Topics: Aging; Alanine; Amino Acids; Animals; Arteriosclerosis; Catalytic Domain; Cations; Cattle; Cytochrom | 2001 |
41 other studies available for pyruvaldehyde and Aging
| Article | Year |
|---|---|
Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Catalase; Cognition; Cytokines; Diet; Female; Glycation En | 2021 |
Age-related neuronal damage by advanced glycation end products through altered proteostasis.
Topics: Aging; Animals; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Brain; Brain-Derived Neurot | 2022 |
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Topics: Aging; alpha-Synuclein; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Model | 2017 |
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts.
Topics: Aging; Animals; Apoptosis; Collagen; Endoplasmic Reticulum Stress; Fibroblasts; Glycation End Produc | 2018 |
Analysis of Advanced Glycation Endproducts in Rat Tail Collagen and Correlation to Tendon Stiffening.
Topics: Aging; Animals; Collagen; Glycation End Products, Advanced; Male; Mass Spectrometry; Pyruvaldehyde; | 2018 |
Glycation interferes with natural killer cell function.
Topics: Aging; Apoptosis; Cytotoxicity, Immunologic; Glycation End Products, Advanced; Glyoxal; Humans; K562 | 2019 |
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency.
Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glycosylation; Humans | 2019 |
Aging-dependent reduction in glyoxalase 1 delays wound healing.
Topics: Aging; Animals; Cells, Cultured; Down-Regulation; Fibroblasts; Guanidines; Lactoylglutathione Lyase; | 2013 |
Characterization and cytological effects of a novel glycated gelatine substrate.
Topics: Aging; Animals; Biocompatible Materials; Cell Survival; Collagen; Cross-Linking Reagents; Diabetes M | 2014 |
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.
Topics: Aging; Animals; Blotting, Western; Cataract; Cells, Cultured; Diabetes Mellitus, Experimental; DNA M | 2014 |
Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.
Topics: Aging; Animals; Diet; Glycation End Products, Advanced; Histological Techniques; Immunohistochemistr | 2015 |
Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases.
Topics: Aging; alpha-Crystallins; Animals; Apoptosis; Cataract; Cattle; Diabetes Mellitus; Disease Models, A | 2015 |
Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition.
Topics: Aging; Alcohol Oxidoreductases; Animals; ATP-Binding Cassette Transporters; Bruch Membrane; Cell Lin | 2015 |
The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane.
Topics: Acetaldehyde; Aging; Bruch Membrane; Fibronectins; Humans; Models, Biological; Pyruvaldehyde | 2016 |
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Pyruvaldehyde; Signal Trans | 2016 |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice.
Topics: Aging; Animals; Antioxidants; Catalase; Female; Glutathione; Glutathione Peroxidase; Lactoylglutathi | 2016 |
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.
Topics: Aging; Animals; Caenorhabditis elegans; Glycosylation; Glyoxal; Longevity; Mitochondria; Mitochondri | 2008 |
Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats.
Topics: Acetates; Aging; Amino Acids; Animals; Carbon Dioxide; Central Nervous System Agents; Cerebral Corte | 2010 |
NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?
Topics: Aging; Animals; Caenorhabditis elegans; Carnosine; Cell Survival; Gene Expression Regulation; Glycat | 2010 |
Comparison of glycation of glutathione S-transferase by methylglyoxal, glucose or fructose.
Topics: Aging; Animals; Catalysis; Diabetes Mellitus; Fructose; Glucose; Glutathione Transferase; Glycation | 2011 |
Methylglyoxal, cognitive function and cerebral atrophy in older people.
Topics: Aged; Aging; Atrophy; Brain; Cognition; Female; Glycation End Products, Advanced; Humans; Magnetic R | 2013 |
Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
Topics: Aging; Animals; Carbohydrate Metabolism; Dihydroxyacetone Phosphate; Foods, Specialized; Glyceraldeh | 2012 |
Advanced glycation end-products diminish tendon collagen fiber sliding.
Topics: Aging; Animals; Biomechanical Phenomena; Elastic Modulus; Extracellular Matrix; Fibrillar Collagens; | 2013 |
Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.
Topics: Administration, Oral; Aging; Albuminuria; Animals; Animals, Newborn; Blood Glucose; Creatinine; Cros | 2003 |
Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification.
Topics: Aging; Animals; Cellular Senescence; Diastole; Enzyme Activation; Glutathione; Glutathione Disulfide | 2005 |
Dietary restriction, glycolysis, hormesis and ageing.
Topics: Aging; Animals; Caloric Restriction; Cellular Senescence; Dose-Response Relationship, Drug; Fasting; | 2007 |
Can ageing be prevented by dietary restriction?
Topics: Acetone; Acetyl Coenzyme A; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Cytochrome P-45 | 2007 |
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.
Topics: Aging; Antioxidants; Cysteine; Diabetes Complications; Electrophoresis, Polyacrylamide Gel; Free Rad | 2007 |
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; G | 2007 |
The other side of the Maillard reaction.
Topics: Aging; Cataract; Glycation End Products, Advanced; Humans; Lens, Crystalline; Maillard Reaction; Pyr | 2008 |
The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.
Topics: Aging; Disease; Glyoxal; Health; Humans; Lactoylglutathione Lyase; Protein Carbonylation; Proteome; | 2008 |
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbohydrate Metabolism; Child; Collagen; Crystal | 1997 |
Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.
Topics: Adult; Aged; Aging; Animals; Blood Proteins; Diabetes Mellitus; Epitopes; Glycation End Products, Ad | 1998 |
Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins.
Topics: Aging; Chromatography, High Pressure Liquid; Collagen; Cross-Linking Reagents; Crystallins; Dimeriza | 1998 |
Methylglyoxal-derived modifications in lens aging and cataract formation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Blotting, Western; Cataract; Cattle; Chi | 1998 |
Chemical modification of proteins by methylglyoxal.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Aorta; Arginine; Child; Collagen; Crysta | 1998 |
Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction.
Topics: 2-Naphthylamine; Aging; Arginine; Chromatography, Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; G | 1999 |
Carnosine reacts with a glycated protein.
Topics: Aging; Animals; Carnosine; Glycoproteins; Glycosylation; Humans; In Vitro Techniques; Lysine; Ovalbu | 2000 |
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.
Topics: Aging; Animals; Antioxidants; Carnosine; Male; Ovalbumin; Pyruvaldehyde; Rats; Rats, Wistar | 2001 |
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
Topics: Adult; Aging; Arginine; Cartilage, Articular; Collagen; Cross-Linking Reagents; Glycation End Produc | 2002 |
The acute toxicity of methylglyoxal in rats: the influence of age, sex, and pregnancy.
Topics: Aging; Aldehydes; Animals; Animals, Newborn; Female; Gestational Age; Intubation, Gastrointestinal; | 1978 |