Page last updated: 2024-10-19

pyruvaldehyde and Aging

pyruvaldehyde has been researched along with Aging in 62 studies

Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane."7.83The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016)
"Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome."4.84Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease. ( Thornalley, PJ, 2008)
" The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo."4.83Protein modification in aging: an update. ( Schöneich, C, 2006)
"The purpose of the study is to identify the sites of modification when fibronectin reacts with glycolaldehyde or methylglyoxal as a model system for aging of Bruch's membrane."3.83The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane. ( Gaillard, ER; Thao, MT, 2016)
"Protection of mitochondrial proteins from glycation by endogenous dicarbonyl compounds, methylglyoxal and glyoxal, was found recently to prevent increased formation of reactive oxygen species and oxidative and nitrosative damage to the proteome during aging and produce life extension in the nematode Caenorhabditis elegans."3.74Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress. ( Rabbani, N; Thornalley, PJ, 2008)
"We examined 172 young (<45 years old) and older (>60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N(epsilon)-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation."3.74Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. ( Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H, 2007)
"Advanced glycation end-products and glycoxidation products, such as Nepsilon-(carboxymethyl)lysine (CML) and pentosidine, accumulate in long-lived tissue proteins with age and are implicated in the aging of tissue proteins and in the development of pathology in diabetes, atherosclerosis and other diseases."3.69N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. ( Ahmed, MU; Baynes, JW; Brinkmann Frye, E; Degenhardt, TP; Thorpe, SR, 1997)
"The importance of the dicarbonyls in diabetic kidney disease is clearly demonstrated by the reno-protective benefits of structurally-disparate dicarbonyl scavengers in experimental studies."2.66Dicarbonyl-mediated AGEing and diabetic kidney disease. ( Dimitropoulos, A; Rosado, CJ; Thomas, MC, 2020)
"Glyoxalase-1 (GLO-1) acts as a part of the anti-glycation defense system by carrying out detoxification of GO and MGO."2.66The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders. ( Akhter, A; Kausar, MA; Saeed, M; Siddiqui, AJ; Singh, R, 2020)
"Glo-1 has a dual role in cancer as a tumour suppressor protein prior to tumour development and mediator of multi-drug resistance in cancer treatment, implicating dicarbonyl glycation of DNA in carcinogenesis and dicarbonyl-driven cytotoxicity in mechanism of action of anticancer drugs."2.53Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics. ( Rabbani, N; Thornalley, PJ; Xue, M, 2016)
"Aging is a Parkinson's disease (PD) risk factor."2.50Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents. ( Hipkiss, AR, 2014)
"Aging is a main risk factor for many diseases including neurodegenerative disorders."1.72Age-related neuronal damage by advanced glycation end products through altered proteostasis. ( Jakhotia, S; Reddy Addi, U; Reddy, GB; Reddy, SS, 2022)
"Age-related cataracts are a leading cause of blindness."1.40Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. ( Augusteyn, RC; Ayaki, M; Bidasee, KR; Chan, JY; Palsamy, P; Shinohara, T, 2014)
"To assess the role of dAGE on type 1 diabetes, NOD mice were exposed to a high-AGE diet (H-AGE) and to a nutritionally similar diet with approximate fivefold-lower levels of N(epsilon)-carboxymethyllysine (CML) and methylglyoxal-derivatives (MG) (L-AGE)."1.32Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice. ( Hattori, M; He, C; McEvoy, R; Peppa, M; Vlassara, H; Zheng, F, 2003)

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.61)18.7374
1990's6 (9.68)18.2507
2000's19 (30.65)29.6817
2010's30 (48.39)24.3611
2020's6 (9.68)2.80

Authors

AuthorsStudies
Pucci, M1
Aria, F1
Premoli, M1
Maccarinelli, G1
Mastinu, A1
Bonini, S1
Memo, M1
Uberti, D1
Abate, G1
Reddy Addi, U1
Jakhotia, S1
Reddy, SS1
Reddy, GB1
Kold-Christensen, R1
Johannsen, M1
Dimitropoulos, A1
Rosado, CJ1
Thomas, MC1
Saeed, M1
Kausar, MA1
Singh, R1
Siddiqui, AJ1
Akhter, A1
Francisco, FA1
Saavedra, LPJ1
Junior, MDF1
Barra, C1
Matafome, P1
Mathias, PCF1
Gomes, RM1
Vicente Miranda, H1
Szego, ÉM1
Oliveira, LMA1
Breda, C1
Darendelioglu, E1
de Oliveira, RM1
Ferreira, DG1
Gomes, MA1
Rott, R1
Oliveira, M1
Munari, F1
Enguita, FJ1
Simões, T1
Rodrigues, EF1
Heinrich, M1
Martins, IC1
Zamolo, I1
Riess, O1
Cordeiro, C1
Ponces-Freire, A1
Lashuel, HA1
Santos, NC1
Lopes, LV1
Xiang, W1
Jovin, TM1
Penque, D1
Engelender, S1
Zweckstetter, M1
Klucken, J1
Giorgini, F1
Quintas, A1
Outeiro, TF1
Frandsen, JR1
Narayanasamy, P1
Nowotny, K1
Castro, JP1
Hugo, M1
Braune, S1
Weber, D1
Pignitter, M1
Somoza, V1
Bornhorst, J1
Schwerdtle, T1
Grune, T1
Jost, T1
Zipprich, A1
Glomb, MA2
Rosenstock, P2
Bezold, V2
Bork, K2
Scheffler, J2
Horstkorte, R2
Nigro, C1
Leone, A1
Fiory, F1
Prevenzano, I1
Nicolò, A1
Mirra, P1
Beguinot, F1
Miele, C1
Geyer, H1
Fleming, TH1
Theilen, TM1
Masania, J1
Wunderle, M1
Karimi, J1
Vittas, S1
Bernauer, R1
Bierhaus, A2
Rabbani, N6
Thornalley, PJ7
Kroll, J1
Tyedmers, J1
Nawrotzki, R1
Herzig, S1
Brownlee, M1
Nawroth, PP2
Hipkiss, AR8
Boonkaew, B1
Tompkins, K1
Manokawinchoke, J1
Pavasant, P1
Supaphol, P1
Palsamy, P1
Bidasee, KR1
Ayaki, M1
Augusteyn, RC1
Chan, JY1
Shinohara, T1
Illien-Jünger, S1
Lu, Y1
Qureshi, SA1
Hecht, AC1
Cai, W2
Vlassara, H3
Striker, GE1
Iatridis, JC1
Karumanchi, DK1
Karunaratne, N1
Lurio, L1
Dillon, JP1
Gaillard, ER2
Zhou, J1
Ueda, K1
Zhao, J1
Sparrow, JR1
Thao, MT1
Xue, M2
Chaudhuri, J1
Bose, N1
Gong, J1
Hall, D1
Rifkind, A1
Bhaumik, D1
Peiris, TH1
Chamoli, M1
Le, CH1
Liu, J2
Lithgow, GJ1
Ramanathan, A1
Xu, XZS1
Kapahi, P1
Falone, S1
Santini, SJ1
Cordone, V1
Grannonico, M1
Cacchio, M1
Di Emidio, G1
Tatone, C1
Amicarelli, F1
Dmitriev, LF1
Titov, VN1
Schmidt, B1
de Assis, AM1
Battu, CE1
Rieger, DK1
Hansen, F1
Sordi, F1
Longoni, A1
Hoefel, AL1
Farina, M1
Gonçalves, CA1
Souza, DO1
Perry, ML1
Krautwald, M1
Münch, G2
Desai, KM1
Chang, T1
Wang, H1
Banigesh, A1
Dhar, A1
Untereiner, A1
Wu, L1
Boušová, I1
Průchová, Z1
Trnková, L1
Dršata, J1
Srikanth, V1
Westcott, B1
Forbes, J1
Phan, TG1
Beare, R1
Venn, A1
Pearson, S1
Greenaway, T1
Parameswaran, V1
Li, Y1
Fessel, G1
Georgiadis, M1
Snedeker, JG1
Peppa, M2
He, C1
Hattori, M1
McEvoy, R1
Zheng, F1
Li, SY1
Du, M1
Dolence, EK1
Fang, CX1
Mayer, GE1
Ceylan-Isik, AF1
LaCour, KH1
Yang, X1
Wilbert, CJ1
Sreejayan, N1
Ren, J1
Ramasamy, R1
Yan, SF1
Schmidt, AM1
Schöneich, C1
Kalapos, MP1
Ahmad, MS1
Pischetsrieder, M1
Ahmed, N1
Uribarri, J1
Goodman, S1
Ferrucci, L1
Striker, G1
Grillo, MA1
Colombatto, S1
Nagaraj, RH3
Biswas, A1
Miller, A1
Oya-Ito, T1
Bhat, M1
Ahmed, MU1
Brinkmann Frye, E1
Degenhardt, TP3
Thorpe, SR4
Baynes, JW4
Shamsi, FA2
Partal, A1
Sady, C2
Frye, EB1
Lin, K1
Odani, H1
Shinzato, T1
Matsumoto, Y1
Usami, J1
Maeda, K1
Brownson, C2
Schleicher, ED1
Häring, HU1
Lehmann, R1
Carrier, MJ1
Yim, MB1
Yim, HS1
Lee, C1
Kang, SO1
Chock, PB1
Verzijl, N1
DeGroot, J1
Ben, ZC1
Brau-Benjamin, O1
Maroudas, A1
Bank, RA1
Mizrahi, J1
Schalkwijk, CG1
Bijlsma, JW1
Lafeber, FP1
TeKoppele, JM1
Peters, MA1
Hudson, PM1
Jurgelske, W1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dietary Inducers of Glyoxalase-1 for Prevention and Early-stage Alleviation of Age Related Health Disorders Through Functional Foods.[NCT02095873]Phase 1/Phase 232 participants (Actual)Interventional2014-05-31Completed
Carnosine for Peripheral Arterial Disease Patients (Car-PAD)[NCT05371145]Phase 1/Phase 220 participants (Anticipated)Interventional2023-03-01Recruiting
Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy[NCT00967629]Phase 120 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Aortal Pulse Wave Velocity (aPWV)

Aortal pulse wave velocity is measured by a non-invasive oscillometric device. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionm/s (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer7.98.0
Placebo8.38.5

Area Under the Curve for Oral Glucose Tolerance Test (oGGT)

A standard 75 g glucose oGTT will be performed, as routinely used in clinical practice. Participants will be instructed to eat carbohydrate rich diet (> 150 g/day) for at least three days before the test, followed by an overnight fast. Participants will be instructed to have comparable macronutrient composition of the dinner before the respective study days in the metabolic unit. During the oGTT both capillary and venous blood samples will be collected after 0, 15, 30, 60, 90 and 120 min. To minimize the inconvenience of repeated blood tests during the oGTT, a venous cannula will be inserted, under sterile conditions, prior to the test, for blood sampling. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
InterventionmM h (Mean)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer10.89.9
Placebo11.010.6

Finger-fold Capillary Density by Capillaroscopy

After 20 min seated at rest, measurements are made with the subject seated and the left hand at heart level. Nail-fold capillaries in the dorsal skin of the third finger are visualized using a stereo microscope linked to a monochrome digital camera. Capillary density is defined as the number of capillaries per mm2 of nail-fold skin and is computed as the mean of 4 measurements. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionnumber of capillaries per mm2 (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer115125
Placebo119128

Flow-mediated Dilatation (FMD)

Brachial artery FMD will be assessed. Ultrasound imaging of the brachial artery will be performed. Percent FMD will be calculated using the averaged minimum mean brachial artery diameter at baseline compared to the largest mean values obtained after either release of the forearm occlusion. (NCT02095873)
Timeframe: Week 0 and Week 8 (first intervention); Week 14 and Week 22 (second intervention)

,
Interventionpercentage of baseline value (Median)
BaselinePost-8 weeks treatment
Glyoxalase 1 Inducer0.170.12
Placebo0.180.26

Reviews

21 reviews available for pyruvaldehyde and Aging

ArticleYear
Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation.
    Trends in endocrinology and metabolism: TEM, 2020, Volume: 31, Issue:2

    Topics: Aging; Animals; Causality; Diabetes Mellitus; Glycation End Products, Advanced; Hormesis; Humans; La

2020
Dicarbonyl-mediated AGEing and diabetic kidney disease.
    Journal of nephrology, 2020, Volume: 33, Issue:5

    Topics: Aging; Diabetes Mellitus; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Lactoylg

2020
The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders.
    Current protein & peptide science, 2020, Volume: 21, Issue:9

    Topics: Aging; Deoxyglucose; Diabetes Mellitus; Gene Expression Regulation; Glycation End Products, Advanced

2020
Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
    Nutrition reviews, 2021, 01-01, Volume: 79, Issue:1

    Topics: Aging; Animals; Female; Fetus; Glycation End Products, Advanced; Humans; Infant; Infant, Newborn; In

2021
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.
    Redox biology, 2018, Volume: 14

    Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Autism Spectrum Disorder; Flavonoids; Humans; Lacto

2018
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging.
    Cells, 2019, 07-19, Volume: 8, Issue:7

    Topics: Aging; Animals; Cardiovascular Diseases; Cells, Cultured; Cellular Senescence; Glycation End Product

2019
Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents.
    Neurobiology of aging, 2014, Volume: 35, Issue:6

    Topics: Aging; Animals; Carnosine; Clinical Trials as Topic; Dietary Carbohydrates; Dietary Supplements; Dou

2014
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
    Biochemical and biophysical research communications, 2015, Mar-06, Volume: 458, Issue:2

    Topics: Aging; Aldehydes; Cardiovascular Diseases; Deoxyglucose; Diabetes Mellitus; Glyoxal; Humans; Inflamm

2015
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.
    Glycoconjugate journal, 2016, Volume: 33, Issue:4

    Topics: Aging; Animals; Dyslipidemias; Glycation End Products, Advanced; Humans; Lactoylglutathione Lyase; N

2016
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
    Clinical science (London, England : 1979), 2016, 10-01, Volume: 130, Issue:19

    Topics: Aging; Animals; Disease; Drug Therapy; Humans; Lactoylglutathione Lyase; Pyruvaldehyde; Stress, Phys

2016
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.
    Drug metabolism and drug interactions, 2008, Volume: 23, Issue:1-2

    Topics: Aging; Animals; Drug Resistance, Neoplasm; Glycation End Products, Advanced; Glyoxal; Humans; Lactoy

2008
Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases.
    Ageing research reviews, 2010, Volume: 9, Issue:2

    Topics: Aging; Aldehydes; Free Radicals; Humans; Lactoylglutathione Lyase; Lipid Metabolism; Lipid Peroxidat

2010
Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease?
    Experimental gerontology, 2010, Volume: 45, Issue:10

    Topics: Aged; Aging; Alzheimer Disease; Biomarkers; Glycation End Products, Advanced; Humans; Pyruvaldehyde;

2010
Oxidative stress and aging: is methylglyoxal the hidden enemy?
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:3

    Topics: Aging; Animals; Glycation End Products, Advanced; Humans; Oxidative Stress; Pyruvaldehyde; Reactive

2010
Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine.
    Molecular aspects of medicine, 2011, Volume: 32, Issue:4-6

    Topics: Aging; Animals; Carnosine; Energy Metabolism; Glycation End Products, Advanced; Glycolysis; Humans;

2011
Methylglyoxal comes of AGE.
    Cell, 2006, Jan-27, Volume: 124, Issue:2

    Topics: Aging; Animals; Gene Expression Regulation; Genome; Glycation End Products, Advanced; Glycosylation;

2006
Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?
    Annals of the New York Academy of Sciences, 2006, Volume: 1067

    Topics: Aging; Animals; Caloric Restriction; Glycolysis; Pyruvaldehyde

2006
Protein modification in aging: an update.
    Experimental gerontology, 2006, Volume: 41, Issue:9

    Topics: Aging; Histidine; Humans; Lamin Type A; Neurodegenerative Diseases; Nuclear Proteins; Oxidation-Redu

2006
Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases.
    Amino acids, 2008, Volume: 35, Issue:1

    Topics: Aging; Aldehyde Oxidoreductases; Animals; Glycation End Products, Advanced; Glyoxal; Humans; Pyruval

2008
Chemistry and pathobiology of advanced glycation end products.
    Contributions to nephrology, 2001, Issue:131

    Topics: Aging; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Gene Expression Regulation; Glucose;

2001
Protein glycation: creation of catalytic sites for free radical generation.
    Annals of the New York Academy of Sciences, 2001, Volume: 928

    Topics: Aging; Alanine; Amino Acids; Animals; Arteriosclerosis; Catalytic Domain; Cations; Cattle; Cytochrom

2001

Other Studies

41 other studies available for pyruvaldehyde and Aging

ArticleYear
Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 158

    Topics: Aging; Alzheimer Disease; Animals; Brain; Catalase; Cognition; Cytokines; Diet; Female; Glycation En

2021
Age-related neuronal damage by advanced glycation end products through altered proteostasis.
    Chemico-biological interactions, 2022, Mar-01, Volume: 355

    Topics: Aging; Animals; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Brain; Brain-Derived Neurot

2022
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
    Brain : a journal of neurology, 2017, May-01, Volume: 140, Issue:5

    Topics: Aging; alpha-Synuclein; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Model

2017
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts.
    Free radical biology & medicine, 2018, 05-20, Volume: 120

    Topics: Aging; Animals; Apoptosis; Collagen; Endoplasmic Reticulum Stress; Fibroblasts; Glycation End Produc

2018
Analysis of Advanced Glycation Endproducts in Rat Tail Collagen and Correlation to Tendon Stiffening.
    Journal of agricultural and food chemistry, 2018, Apr-18, Volume: 66, Issue:15

    Topics: Aging; Animals; Collagen; Glycation End Products, Advanced; Male; Mass Spectrometry; Pyruvaldehyde;

2018
Glycation interferes with natural killer cell function.
    Mechanisms of ageing and development, 2019, Volume: 178

    Topics: Aging; Apoptosis; Cytotoxicity, Immunologic; Glycation End Products, Advanced; Glyoxal; Humans; K562

2019
Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency.
    Aging, 2019, 07-29, Volume: 11, Issue:14

    Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glycosylation; Humans

2019
Aging-dependent reduction in glyoxalase 1 delays wound healing.
    Gerontology, 2013, Volume: 59, Issue:5

    Topics: Aging; Animals; Cells, Cultured; Down-Regulation; Fibroblasts; Guanidines; Lactoylglutathione Lyase;

2013
Characterization and cytological effects of a novel glycated gelatine substrate.
    Biomedical materials (Bristol, England), 2014, Volume: 9, Issue:2

    Topics: Aging; Animals; Biocompatible Materials; Cell Survival; Collagen; Cross-Linking Reagents; Diabetes M

2014
Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.
    Free radical biology & medicine, 2014, Volume: 72

    Topics: Aging; Animals; Blotting, Western; Cataract; Cells, Cultured; Diabetes Mellitus, Experimental; DNA M

2014
Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Aging; Animals; Diet; Glycation End Products, Advanced; Histological Techniques; Immunohistochemistr

2015
Non-enzymatic glycation of α-crystallin as an in vitro model for aging, diabetes and degenerative diseases.
    Amino acids, 2015, Volume: 47, Issue:12

    Topics: Aging; alpha-Crystallins; Animals; Apoptosis; Cataract; Cattle; Diabetes Mellitus; Disease Models, A

2015
Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition.
    The Journal of biological chemistry, 2015, Nov-06, Volume: 290, Issue:45

    Topics: Aging; Alcohol Oxidoreductases; Animals; ATP-Binding Cassette Transporters; Bruch Membrane; Cell Lin

2015
The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch's membrane.
    Amino acids, 2016, Volume: 48, Issue:7

    Topics: Acetaldehyde; Aging; Bruch Membrane; Fibronectins; Humans; Models, Biological; Pyruvaldehyde

2016
A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.
    Current biology : CB, 2016, 11-21, Volume: 26, Issue:22

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Pyruvaldehyde; Signal Trans

2016
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Aging; Animals; Antioxidants; Catalase; Female; Glutathione; Glutathione Peroxidase; Lactoylglutathi

2016
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.
    Biochemical Society transactions, 2008, Volume: 36, Issue:Pt 5

    Topics: Aging; Animals; Caenorhabditis elegans; Glycosylation; Glyoxal; Longevity; Mitochondria; Mitochondri

2008
Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats.
    Brain research, 2010, Feb-22, Volume: 1315

    Topics: Acetates; Aging; Amino Acids; Animals; Carbon Dioxide; Central Nervous System Agents; Cerebral Corte

2010
NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?
    Experimental gerontology, 2010, Volume: 45, Issue:6

    Topics: Aging; Animals; Caenorhabditis elegans; Carnosine; Cell Survival; Gene Expression Regulation; Glycat

2010
Comparison of glycation of glutathione S-transferase by methylglyoxal, glucose or fructose.
    Molecular and cellular biochemistry, 2011, Volume: 357, Issue:1-2

    Topics: Aging; Animals; Catalysis; Diabetes Mellitus; Fructose; Glucose; Glutathione Transferase; Glycation

2011
Methylglyoxal, cognitive function and cerebral atrophy in older people.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2013, Volume: 68, Issue:1

    Topics: Aged; Aging; Atrophy; Brain; Cognition; Female; Glycation End Products, Advanced; Humans; Magnetic R

2013
Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
    Biogerontology, 2012, Volume: 13, Issue:6

    Topics: Aging; Animals; Carbohydrate Metabolism; Dihydroxyacetone Phosphate; Foods, Specialized; Glyceraldeh

2012
Advanced glycation end-products diminish tendon collagen fiber sliding.
    Matrix biology : journal of the International Society for Matrix Biology, 2013, Apr-24, Volume: 32, Issue:3-4

    Topics: Aging; Animals; Biomechanical Phenomena; Elastic Modulus; Extracellular Matrix; Fibrillar Collagens;

2013
Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.
    Diabetes, 2003, Volume: 52, Issue:6

    Topics: Administration, Oral; Aging; Albuminuria; Animals; Animals, Newborn; Blood Glucose; Creatinine; Cros

2003
Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification.
    Aging cell, 2005, Volume: 4, Issue:2

    Topics: Aging; Animals; Cellular Senescence; Diastole; Enzyme Activation; Glutathione; Glutathione Disulfide

2005
Dietary restriction, glycolysis, hormesis and ageing.
    Biogerontology, 2007, Volume: 8, Issue:2

    Topics: Aging; Animals; Caloric Restriction; Cellular Senescence; Dose-Response Relationship, Drug; Fasting;

2007
Can ageing be prevented by dietary restriction?
    Mechanisms of ageing and development, 2007, Volume: 128, Issue:2

    Topics: Acetone; Acetyl Coenzyme A; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Cytochrome P-45

2007
Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts.
    European journal of pharmacology, 2007, Apr-30, Volume: 561, Issue:1-3

    Topics: Aging; Antioxidants; Cysteine; Diabetes Complications; Electrophoresis, Polyacrylamide Gel; Free Rad

2007
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; G

2007
The other side of the Maillard reaction.
    Annals of the New York Academy of Sciences, 2008, Volume: 1126

    Topics: Aging; Cataract; Glycation End Products, Advanced; Humans; Lens, Crystalline; Maillard Reaction; Pyr

2008
The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.
    Annals of the New York Academy of Sciences, 2008, Volume: 1126

    Topics: Aging; Disease; Glyoxal; Health; Humans; Lactoylglutathione Lyase; Protein Carbonylation; Proteome;

2008
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
    The Biochemical journal, 1997, Jun-01, Volume: 324 ( Pt 2)

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbohydrate Metabolism; Child; Collagen; Crystal

1997
Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes.
    The Journal of biological chemistry, 1998, Mar-20, Volume: 273, Issue:12

    Topics: Adult; Aged; Aging; Animals; Blood Proteins; Diabetes Mellitus; Epitopes; Glycation End Products, Ad

1998
Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins.
    The Journal of biological chemistry, 1998, Jul-24, Volume: 273, Issue:30

    Topics: Aging; Chromatography, High Pressure Liquid; Collagen; Cross-Linking Reagents; Crystallins; Dimeriza

1998
Methylglyoxal-derived modifications in lens aging and cataract formation.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Blotting, Western; Cataract; Cattle; Chi

1998
Chemical modification of proteins by methylglyoxal.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Aorta; Arginine; Child; Collagen; Crysta

1998
Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction.
    Biochemical and biophysical research communications, 1999, Mar-05, Volume: 256, Issue:1

    Topics: 2-Naphthylamine; Aging; Arginine; Chromatography, Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; G

1999
Carnosine reacts with a glycated protein.
    Free radical biology & medicine, 2000, May-15, Volume: 28, Issue:10

    Topics: Aging; Animals; Carnosine; Glycoproteins; Glycosylation; Humans; In Vitro Techniques; Lysine; Ovalbu

2000
Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.
    Mechanisms of ageing and development, 2001, Sep-15, Volume: 122, Issue:13

    Topics: Aging; Animals; Antioxidants; Carnosine; Male; Ovalbumin; Pyruvaldehyde; Rats; Rats, Wistar

2001
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:1

    Topics: Adult; Aging; Arginine; Cartilage, Articular; Collagen; Cross-Linking Reagents; Glycation End Produc

2002
The acute toxicity of methylglyoxal in rats: the influence of age, sex, and pregnancy.
    Ecotoxicology and environmental safety, 1978, Volume: 2, Issue:3-4

    Topics: Aging; Aldehydes; Animals; Animals, Newborn; Female; Gestational Age; Intubation, Gastrointestinal;

1978