pyruvaldehyde has been researched along with Acute Confusional Senile Dementia in 30 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse." | 7.88 | Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. ( Dhananjayan, K; Gunawardena, D; Gyengesi, E; Liang, H; Millington, C; Münch, G; Niedermayer, G; Sirijovski, D; Sonego, S; Venigalla, M, 2018) |
| "To test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse." | 3.88 | Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. ( Dhananjayan, K; Gunawardena, D; Gyengesi, E; Liang, H; Millington, C; Münch, G; Niedermayer, G; Sirijovski, D; Sonego, S; Venigalla, M, 2018) |
| "Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression." | 2.61 | Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging. ( Armeni, T; Atlante, A; de Bari, L; Kalapos, MP, 2019) |
| "The major hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein." | 2.50 | Role of methylglyoxal in Alzheimer's disease. ( Angeloni, C; Hrelia, S; Zambonin, L, 2014) |
| "Morin is a common plant-produced flavonoid polyphenol that exhibits the ability to enhance the GP-mediated detoxification of MG." | 1.56 | Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. ( Choi, SR; Frandsen, J; Narayanasamy, P, 2020) |
| "An important part of pathogenesis of Alzheimer's disease (AD) is attributed to the contribution of AGE (Advanced Glycation Endproducts) and ALE (Advanced Lipid peroxidation Endproducts)." | 1.43 | Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease. ( Boullier, A; Lohou, E; Sasaki, NA; Sonnet, P, 2016) |
| "The possible relevance to Alzheimer's disease of the effects of these aldehydes on beta-amyloid deposition is discussed." | 1.33 | Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis. ( Chen, K; Maley, J; Yu, PH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 8 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Pucci, M | 1 |
| Aria, F | 1 |
| Premoli, M | 1 |
| Maccarinelli, G | 1 |
| Mastinu, A | 1 |
| Bonini, S | 1 |
| Memo, M | 1 |
| Uberti, D | 1 |
| Abate, G | 1 |
| Moreira, AP | 1 |
| Vizuete, AFK | 1 |
| Zin, LEF | 1 |
| de Marques, CO | 1 |
| Pacheco, RF | 1 |
| Leal, MB | 1 |
| Gonçalves, CA | 1 |
| Frandsen, J | 2 |
| Narayanasamy, P | 3 |
| Wei, CC | 1 |
| Li, SW | 1 |
| Wu, CT | 1 |
| How, CM | 1 |
| Pan, MH | 1 |
| Liu, Y | 1 |
| Zhuang, D | 1 |
| Wang, J | 2 |
| Huang, H | 1 |
| Li, R | 1 |
| Wu, C | 1 |
| Deng, Y | 1 |
| Hu, G | 1 |
| Guo, B | 1 |
| Haddad, M | 1 |
| Perrotte, M | 1 |
| Khedher, MRB | 1 |
| Demongin, C | 1 |
| Lepage, A | 1 |
| Fülöp, T | 1 |
| Ramassamy, C | 1 |
| Dang, Y | 1 |
| Wang, F | 1 |
| Li, L | 1 |
| Lai, Y | 1 |
| Xu, Z | 1 |
| Xiong, Z | 1 |
| Zhang, A | 1 |
| Tian, Y | 1 |
| Ding, C | 1 |
| Zhang, W | 1 |
| Choi, SR | 1 |
| Shuster, SO | 1 |
| Fica-Contreras, SM | 1 |
| Hedges, JS | 1 |
| Henning, NJ | 1 |
| Choi, S | 1 |
| Dafre, AL | 1 |
| Schmitz, AE | 1 |
| Maher, P | 1 |
| Frandsen, JR | 1 |
| Robertson, DS | 1 |
| Gyengesi, E | 1 |
| Liang, H | 1 |
| Millington, C | 1 |
| Sonego, S | 1 |
| Sirijovski, D | 1 |
| Gunawardena, D | 1 |
| Dhananjayan, K | 1 |
| Venigalla, M | 1 |
| Niedermayer, G | 1 |
| Münch, G | 4 |
| Jiang, L | 1 |
| Wang, Z | 1 |
| Huang, W | 1 |
| Yang, Y | 1 |
| Cai, Z | 1 |
| Li, K | 1 |
| Fleitas, C | 1 |
| Piñol-Ripoll, G | 1 |
| Marfull, P | 1 |
| Rocandio, D | 1 |
| Ferrer, I | 1 |
| Rampon, C | 1 |
| Egea, J | 1 |
| Espinet, C | 1 |
| de Bari, L | 1 |
| Atlante, A | 1 |
| Armeni, T | 1 |
| Kalapos, MP | 1 |
| More, SS | 1 |
| Vartak, AP | 1 |
| Vince, R | 1 |
| Tajes, M | 2 |
| Eraso-Pichot, A | 2 |
| Rubio-Moscardó, F | 2 |
| Guivernau, B | 2 |
| Ramos-Fernández, E | 1 |
| Bosch-Morató, M | 2 |
| Guix, FX | 1 |
| Clarimón, J | 1 |
| Miscione, GP | 1 |
| Boada, M | 1 |
| Gil-Gómez, G | 1 |
| Suzuki, T | 1 |
| Molina, H | 1 |
| Villà-Freixa, J | 1 |
| Vicente, R | 1 |
| Muñoz, FJ | 2 |
| Angeloni, C | 1 |
| Zambonin, L | 1 |
| Hrelia, S | 1 |
| Valls-Comamala, V | 1 |
| Tóth, AE | 1 |
| Tóth, A | 1 |
| Walter, FR | 1 |
| Kiss, L | 1 |
| Veszelka, S | 1 |
| Ózsvári, B | 1 |
| Puskás, LG | 1 |
| Heimesaat, MM | 1 |
| Dohgu, S | 1 |
| Kataoka, Y | 1 |
| Rákhely, G | 1 |
| Deli, MA | 1 |
| Lohou, E | 1 |
| Sasaki, NA | 1 |
| Boullier, A | 1 |
| Sonnet, P | 1 |
| Krautwald, M | 1 |
| Li, XH | 1 |
| Xie, JZ | 1 |
| Jiang, X | 1 |
| Lv, BL | 1 |
| Cheng, XS | 1 |
| Du, LL | 1 |
| Zhang, JY | 1 |
| Wang, JZ | 1 |
| Zhou, XW | 1 |
| Woltjer, RL | 1 |
| Maezawa, I | 1 |
| Ou, JJ | 1 |
| Montine, KS | 1 |
| Montine, TJ | 1 |
| Kuhla, B | 2 |
| Lüth, HJ | 2 |
| Haferburg, D | 2 |
| Boeck, K | 1 |
| Arendt, T | 2 |
| Weick, M | 1 |
| Reichenbach, A | 1 |
| Chen, K | 2 |
| Maley, J | 1 |
| Yu, PH | 2 |
| Kazachkov, M | 1 |
| Dmitriev, LF | 1 |
7 reviews available for pyruvaldehyde and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Fluorescence; Fluorescent Dyes; Humans; Peroxynitrous Acid | 2022 |
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Autism Spectrum Disorder; Flavonoids; Humans; Lacto | 2018 |
Role of the Glyoxalase System in Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Glycation End Products, Advanced; Humans; Lactoylglutat | 2018 |
Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging.
Topics: Aging, Premature; Alzheimer Disease; Animals; Energy Metabolism; Glutathione; Glycolysis; Humans; La | 2019 |
Role of methylglyoxal in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Glycation End Products, Advanced; G | 2014 |
Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease?
Topics: Aged; Aging; Alzheimer Disease; Biomarkers; Glycation End Products, Advanced; Humans; Pyruvaldehyde; | 2010 |
The involvement of lipid radical cycles and the adenine nucleotide translocator in neurodegenerative diseases.
Topics: Adenine Nucleotide Translocator 1; Adenosine Triphosphate; alpha-Tocopherol; Alzheimer Disease; Anim | 2007 |
23 other studies available for pyruvaldehyde and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Catalase; Cognition; Cytokines; Diet; Female; Glycation En | 2021 |
The Methylglyoxal/RAGE/NOX-2 Pathway is Persistently Activated in the Hippocampus of Rats with STZ-Induced Sporadic Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Humans; Maze Learning; Pyruvaldehyd | 2022 |
Effect of Cannabidiol on the Neural Glyoxalase Pathway Function and Longevity of Several
Topics: Alzheimer Disease; Animals; Antioxidants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; C | 2022 |
Dietary Methylglyoxal Exposure Induces Alzheimer's Disease by Promoting Amyloid β Accumulation and Disrupting Autophagy in
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Autophagy; Caenorh | 2022 |
Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles.
Topics: Aged; Alzheimer Disease; Biomarkers; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cognitive | 2019 |
An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Fluorescent Dye | 2020 |
Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model.
Topics: Alzheimer Disease; Animals; Antioxidants; Flavonoids; Inflammation; Lactoylglutathione Lyase; Mice, | 2020 |
Comparison of the reaction of methylglyoxal (MGO) with murine and human amyloid beta (Aβ): Insights into a mechanism of Alzheimer's disease (AD).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Humans; Lysine; Mice; Peptide Fragments | 2020 |
Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells.
Topics: Acetyl-CoA Carboxylase; Alzheimer Disease; AMP-Activated Protein Kinase Kinases; Animals; Autophagy; | 2017 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cerebellum; Chronic | 2018 |
proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.
Topics: Adaptor Proteins, Vesicular Transport; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Apoptosi | 2018 |
Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Coenzymes; Disease Model | 2013 |
Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; | 2014 |
Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Lin | 2014 |
Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury.
Topics: Alzheimer Disease; Antioxidants; beta Catenin; Blood-Brain Barrier; Butadienes; Cell Line; Cell Surv | 2014 |
Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Copper; Diamines; Glycation | 2016 |
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Enzyme Activation; Glycation End Products, Advanced; G | 2012 |
Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity.
Topics: Adaptor Proteins, Signal Transducing; alpha-Tocopherol; Alzheimer Disease; Amyloid beta-Protein Prec | 2003 |
Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Female; Glyoxal; Humans; Inactivation, | 2005 |
Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.
Topics: Alzheimer Disease; Apoptosis; Brain; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Enzyme | 2006 |
Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.
Topics: Aldehydes; Alzheimer Disease; Amine Oxidase (Copper-Containing); Amyloid beta-Peptides; Benzothiazol | 2006 |
Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Deamination; Formaldehyde; Humans; Mal | 2007 |