pyrroloquinoline has been researched along with Cardiotoxicity* in 1 studies
1 other study(ies) available for pyrroloquinoline and Cardiotoxicity
| Article | Year |
|---|---|
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Many non-nucleoside human cytomegalovirus (HCMV) inhibitors have been reported in patent and scientific literature, however, none have reached commercialization despite the urgent need for new HCMV treatments. Herein we report select compounds from different templates that all had low micromolar human ether-à-go-go (hERG) ion channel IC Topics: Antiviral Agents; Cardiotoxicity; Cytomegalovirus; ERG1 Potassium Channel; Ether; Ether-A-Go-Go Potassium Channels; Ethers; Ethyl Ethers; Humans; Nucleotidyltransferases; Potassium Channel Blockers | 2023 |