pyrrolidonecarboxylic acid and Metabolic Acidosis

pyrrolidonecarboxylic acid has been researched along with Metabolic Acidosis in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (12.50)	18.7374
1990's	7 (10.94)	18.2507
2000's	15 (23.44)	29.6817
2010's	26 (40.63)	24.3611
2020's	8 (12.50)	2.80

Authors

Authors	Studies
Baud, FJ; Beaudeux, JL; Deveaux, M; Houzé, P; Lasse, A; Raphalen, JH	1
Elsayed, S; Gohar, A; Omar, M	1
Helmich, F; Mostard, G; van Montfort, P; van Twist, D	1
Ekuni, S; Hirayama, K; Kanno, H; Katayama, Y; Kondo, H; Nagasaka, M; Nakahara, E; Osumi, K; Shimojima Yamamoto, K	1
Barker, PJ; Hoshitsuki, K; Inaba, H; Molinelli, AR; Rubnitz, JE	1
Bromley, A; Hughes, LT; Robson, R; Stewart, GW; Trevor-Jones, E	1
Borchert, G; Craven, B; Gibbons, H; Zand Irani, A	1
Canivet, JL; Charlier, C; Misset, B; Morreale, A	1
Heireman, L; Helbert, M; Mahieu, B; Piqueur, M; Stroobants, J; Uyttenbroeck, W	1
Bursová, M; Čabala, R; Coufal, P; Hložek, T; Křížek, T; Tůma, P	1
Henri, P; Lanot, A; Lobbedez, T; Maucorps, C; Nowoczyn, M; Read, MH; Sassier, M	1
Alhourani, HM; George, LK; Kumar, A; Sarwar, T; Wall, BM	1
Gueta, I; Loebstein, R; Markovits, N; Massalha, E; Mayan, H; Priel, E; Raibman Spector, S; Shafir, Y	1
Bell, M; Brennan, M; Costello, M; Newman, C; O'Shea, P	1
Fratita, M; Owens, R; O’Dwyer, M; Spring, A	1
Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES	1
Emmett, M	1
Dive, A; Galanti, L; Luyasu, S; Wamelink, MM	1
Rastegar, A; Vichot, AA	1
Aloulou, H; Ben Ameur, S; Hachicha, M; Kaabachi, N; Kamoun, T; Nasrallah, F	1
Abkur, TM; Ali, M; Casserly, L; Mohammed, W	1
Hulley, SL; Manning, N; Olpin, S; Perring, J; Yap, S	1
Bellmann, R; Kullak-Ublick, GA; Weiler, S	1
Gündüz, M; Kavurt, S; Mungan, NÖ; Türk, E; Ünal, Ö	1
Bouckaert, Y; Lanoy, C	1
Galitsiou, E; Gifford, F; Hunter, RW; Lawson, C; Neary, JJ	1
Lipman, J; McWhinney, B; Phua, MM; Pretorius, CJ; Reade, MC; Ungerer, JPJ; Warnholtz, C	1
Didden, P; Hoorn, EJ; Rolleman, EJ; Zietse, R	1
Holman, M; ter Maaten, JC	1
Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT	1
Bijlsma, JJ; Green, TJ; Sweet, DD	1
Kunadi, AR; Reddi, AS	1
Marsh, A; Myall, K; Sidney, J	1
El-Zoghby, ZM; Franco, PM; Greene, EL; Muriithi, A; Nelsen, E; Qian, Q; Zand, L	1
Milosevic, S; O'Brien, B; Tran, K	1
Belyaev, S; Mecher, C; Mizock, BA	1
Fuster, D; Moe, OW	1
Kameda, G; Mayatepek, E; Schwahn, B; Wessalowski, R	1
Carey, HB; Carlsson, K; Garganta, CL; Njalsson, R; Raman, T; Ristoff, E; Tailor, P	1
Bazari, H; Forman, JP; Humphreys, BD; Magee, CC; Seifter, J; Zandi-Nejad, K	1
Foot, CL; Fraser, JF; Mullany, DV	1
Gerace, R; Mackay, R; Murty, S; Peake, SL; Peter, JV; Rogers, N	1
Ayling, R; Brooker, G; Jeffery, J; Nataraj, T; Sair, M	1
Emmett, M; Fenves, AZ; Kirkpatrick, HM; Patel, VV; Sweetman, L	1
Cantor, R; Carmel, PM; Hodgman, MJ; Holland, MG; Horn, JF; Marraffa, JM; Stork, CM	1
Christie, E; MacKenzie, SL; Meister, A; Mendelson, IS; Wellner, VP; Zaleski, WA	1
Halpern, B; Hick, LA; Hocart, CH; Wong, CO	1
Crist, WM; Prchal, JT; Roper, M; Wellner, VP	1
Pejaver, RK; Watson, AH	2
Board, P; Carlsson, B; Dahl, N; Gali, R; Larsson, A; Mannervik, B; Pigg, M; Ristoff, E	1
Croal, BL; Glen, AC; Kelly, CJ; Logan, RW	1
Hauser, S; Pitt, JJ	1
Corke, CF; Dempsey, GA; Lyall, HJ; Scheinkestel, CD	1
Mecher, C; Mizock, BA	1
Mazza, JJ; Yale, SH	1
Durrmeyer, X; Larsson, A; Menget, A; Mitanchez, D; Mokhtari, M; Rabier, D; Saudubray, JM	1
Orlowski, M	1
Butler, J; Goodman, SI; Kramer, LI; Quinn, P; Schulman, JD; Spielberg, SP; Tietze, F	1
Ando, T; Kilroy, A; Nyhan, WL; Sweetman, L; Wadlington, WB	1
Borden, M; Fleisher, L; Holm, J; Leslie, J; Lewis, D; Nadler, H; Nyhan, WL; Scott, CR; Sweetman, L	1
Buchanan, DN; Muenzer, J; Robertson, PL	1
Chan, KM; Creer, MH; Jones, JD; Lau, BW	1
Eldjarn, L; Jellum, E; Stokke, O	1

Reviews

9 review(s) available for pyrrolidonecarboxylic acid and Metabolic Acidosis

Article	Year
A Review Article on 5-Oxoproline Induced High Anion Gap Metabolic Acidosis. South Dakota medicine : the journal of the South Dakota State Medical Association, 2021, Volume: 74, Issue:10 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Female; Humans; Pyrrolidonecarboxylic Acid	2021
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:9 Topics: Acetaminophen; Acetylcysteine; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narcotic; Antipyretics; Disease Susceptibility; Free Radical Scavengers; Glutathione Synthase; Humans; Pyrrolidonecarboxylic Acid; Severity of Illness Index	2013
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:1 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Cysteine; Energy Metabolism; Glutathione; Humans; Poisoning; Prognosis; Pyrrolidonecarboxylic Acid; Substrate Cycling	2014
[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis]. Therapeutische Umschau. Revue therapeutique, 2015, Volume: 72, Issue:11-12 Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Biomarkers; Diagnosis, Differential; Humans; Medication Errors; Pyrrolidonecarboxylic Acid; Reproducibility of Results; Sensitivity and Specificity	2015
Recurrent anion gap metabolic acidosis in a woman with vertebral disc disease. The American journal of emergency medicine, 2011, Volume: 29, Issue:8 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Analgesics, Non-Narcotic; Emergency Service, Hospital; Female; Humans; Middle Aged; Pain; Pyrrolidonecarboxylic Acid; Recurrence; Spinal Diseases	2011
A rare cause of high anion gap metabolic acidosis. Internal medicine journal, 2013, Volume: 43, Issue:1 Topics: Abdominal Pain; Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn Errors; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Substitution; Female; Glutathione Synthase; Humans; Liver Function Tests; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Stomach Ulcer; Vomiting	2013
Clinical acid-base pathophysiology: disorders of plasma anion gap. Best practice & research. Clinical endocrinology & metabolism, 2003, Volume: 17, Issue:4 Topics: Acid-Base Equilibrium; Acidosis; Alkalosis, Respiratory; Anions; Cations; Humans; Pyrrolidonecarboxylic Acid	2003
Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen. Clinical journal of the American Society of Nephrology : CJASN, 2006, Volume: 1, Issue:3 Topics: Acetaminophen; Acid-Base Imbalance; Acidosis; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Middle Aged; Pyrrolidonecarboxylic Acid	2006
Possible role of glutathione in transport processes. Advances in experimental medicine and biology, 1976, Volume: 69 Topics: Acidosis; Amino Acids; Animals; Biological Transport, Active; Brain; Capillaries; Cell Membrane; Choroid Plexus; Ciliary Body; Epithelium; gamma-Glutamyltransferase; Glutamine; Glutathione; Humans; Intestinal Mucosa; Kidney; Lens, Crystalline; Liver Diseases; Organ Specificity; Peptide Synthases; Pyrrolidonecarboxylic Acid	1976

Other Studies

55 other study(ies) available for pyrrolidonecarboxylic acid and Metabolic Acidosis

Article	Year
[Plasmatic and urinary pyroglutamic acid measurement by capillary zone electrophoresis in chronic poisoning with acetaminophen in children]. Annales de biologie clinique, 2021, Dec-01, Volume: 79, Issue:6 Topics: Acetaminophen; Acidosis; Child; Electrophoresis, Capillary; Humans; Pharmaceutical Preparations; Pyrrolidonecarboxylic Acid	2021
5-Oxoproline acidosis caused by acetaminophen and flucloxacillin treatment - a case report. Acute medicine, 2022, Volume: 21, Issue:1 Topics: Acetaminophen; Acidosis; Floxacillin; Humans; Pyrrolidonecarboxylic Acid	2022
Severe Hemolytic Anemia and Metabolic Acidosis at Birth with Glutathione Synthetase Deficiency and Progressive Neurological Symptoms on Follow-Up. The American journal of case reports, 2023, Apr-13, Volume: 24 Topics: Acidosis; Anemia, Hemolytic; Child, Preschool; Follow-Up Studies; Glutathione Synthase; Humans; Infant; Infant, Newborn; Male; Pyrrolidonecarboxylic Acid	2023
Metabolic Acidosis in a Pediatric Patient with Leukemia and Fungal Infection. Clinical chemistry, 2020, 04-01, Volume: 66, Issue:4 Topics: Acetaminophen; Acidosis; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Antipyretics; Candida; Candidiasis; Child; Febrile Neutropenia; Humans; Leukemia, Myeloid, Acute; Male; Pyrrolidonecarboxylic Acid	2020
Lessons of the month: Pyroglutamic acidosis: long-term paracetamol and a high anion gap. Clinical medicine (London, England), 2020, Volume: 20, Issue:5 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Female; Glutathione Synthase; Humans; Pyrrolidonecarboxylic Acid	2020
Flucloxacillin and paracetamol induced pyroglutamic acidosis. BMJ case reports, 2021, Jan-08, Volume: 14, Issue:1 Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Antipyretics; Bacteremia; Female; Floxacillin; Humans; Pyrrolidonecarboxylic Acid; Staphylococcal Infections	2021
[Chronic paracetamol intoxication : under-diagnosed iatrogenic cause of metabolic acidosis with increased anion gap]. Revue medicale de Liege, 2021, Volume: 76, Issue:7-8 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Humans; Iatrogenic Disease; Pyrrolidonecarboxylic Acid	2021
High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. Acta clinica Belgica, 2018, Volume: 73, Issue:4 Topics: Acid-Base Equilibrium; Acidosis; Acute Kidney Injury; Aged; Female; Humans; Insulin; Ketones; Lactic Acid; Pyrrolidonecarboxylic Acid; Sodium Bicarbonate	2018
Quantification of paracetamol and 5-oxoproline in serum by capillary electrophoresis: Implication for clinical toxicology. Journal of pharmaceutical and biomedical analysis, 2017, Oct-25, Volume: 145 Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Electrophoresis, Capillary; Humans; Pyrrolidonecarboxylic Acid	2017
[Acetaminophen induced 5-oxoproline acidosis: An uncommon case of high anion gap metabolic acidosis]. La Revue de medecine interne, 2018, Volume: 39, Issue:2 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narcotic; Glutathione Synthase; Humans; Male; Pyrrolidonecarboxylic Acid	2018
Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen. The American journal of the medical sciences, 2018, Volume: 355, Issue:4 Topics: Acetaminophen; Acidosis; Adult; Female; Humans; Pyrrolidonecarboxylic Acid; Recurrence; Treatment Outcome	2018
Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study. Scientific reports, 2019, 03-05, Volume: 9, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Male; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid	2019
Pyroglutamic acidosis. QJM : monthly journal of the Association of Physicians, 2019, Aug-01, Volume: 112, Issue:8 Topics: Acetaminophen; Acidosis; Aged; Analgesics, Non-Narcotic; Humans; Male; Pain Management; Pyrrolidonecarboxylic Acid	2019
An Under-Recognised Cause of Iatrogenic, Severe Metabolic Acidosis Irish medical journal, 2019, 04-11, Volume: 112, Issue:4 Topics: Acetaminophen; Acetylcysteine; Acidosis; Aged, 80 and over; Anti-Bacterial Agents; Antipyretics; Arthroplasty, Replacement, Hip; Blood Gas Analysis; Drug Interactions; Floxacillin; Hip Prosthesis; Humans; Iatrogenic Disease; Male; Prosthesis-Related Infections; Pyrrolidonecarboxylic Acid; Renal Insufficiency, Chronic; Renal Replacement Therapy; Severity of Illness Index; Sodium Bicarbonate; Staphylococcal Infections; Surgical Wound Infection	2019
Pyroglutamic acid-induced metabolic acidosis: a case report. Acta clinica Belgica, 2014, Volume: 69, Issue:3 Topics: Acetaminophen; Acidosis; Anti-Bacterial Agents; Antipyretics; Female; Fever; Floxacillin; Humans; Middle Aged; Pyrrolidonecarboxylic Acid	2014
Use of anion gap in the evaluation of a patient with metabolic acidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014, Volume: 64, Issue:4 Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Bicarbonates; Confusion; Drug Substitution; Female; Free Radical Scavengers; Humans; Pyrrolidonecarboxylic Acid; Serum Albumin; Treatment Outcome	2014
Hemolytic anemia and metabolic acidosis: think about glutathione synthetase deficiency. Fetal and pediatric pathology, 2015, Volume: 34, Issue:1 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Anemia, Hemolytic; Antioxidants; Erythrocytes; Fatal Outcome; Fever; Fibroblasts; Glutathione Synthase; Humans; Infant; Klebsiella Infections; Male; Pyrrolidonecarboxylic Acid; Sepsis; Skin; Treatment Outcome; Tunisia	2015
Acetaminophen-induced anion gap metabolic acidosis secondary to 5-oxoproline: a case report. Journal of medical case reports, 2014, Dec-06, Volume: 8 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Analgesics, Non-Narcotic; Female; Humans; Pyrrolidonecarboxylic Acid	2014
Transient 5-oxoprolinuria: unusually high anion gap acidosis in an infant. European journal of pediatrics, 2015, Volume: 174, Issue:12 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narcotic; Female; Glutathione Synthase; Humans; Infant; Pyrrolidonecarboxylic Acid; Sepsis	2015
Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency. Journal of pediatric endocrinology & metabolism : JPEM, 2016, Volume: 29, Issue:4 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Glutathione Synthase; Humans; Infant, Newborn; Male; Mutation; Prognosis; Pyrrolidonecarboxylic Acid; Sodium Bicarbonate	2016
Metabolic acidosis and 5-oxoprolinuria induced by flucloxacillin and acetaminophen: a case report. Journal of medical case reports, 2016, Jun-23, Volume: 10, Issue:1 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Amino Acid Metabolism, Inborn Errors; Anti-Bacterial Agents; Arthritis, Infectious; Female; Floxacillin; Glutathione Synthase; Humans; Knee Joint; Pyrrolidonecarboxylic Acid; Shock, Septic; Staphylococcal Infections; Treatment Outcome	2016
Pyroglutamic acidosis in association with therapeutic paracetamol use. Clinical medicine (London, England), 2016, Volume: 16, Issue:6 Topics: Acetaminophen; Acidosis; Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Male; Middle Aged; Pyrrolidonecarboxylic Acid	2016
Pyroglutamate (5-oxoproline) measured with hydrophilic interaction chromatography (HILIC) tandem mass spectrometry in acutely ill patients. Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 466 Topics: Acidosis; Acute Disease; Chromatography, Liquid; Cohort Studies; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Pyrrolidonecarboxylic Acid; Reference Standards; Severity of Illness Index; Tandem Mass Spectrometry	2017
Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis. The Netherlands journal of medicine, 2008, Volume: 66, Issue:8 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged; Anions; Anti-Bacterial Agents; Cations; Female; Floxacillin; Humans; Pyrrolidonecarboxylic Acid; Risk Factors	2008
[Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use]. Nederlands tijdschrift voor geneeskunde, 2010, Volume: 154 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Female; Humans; Pyrrolidonecarboxylic Acid; Urinalysis	2010
5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose. The Journal of the American Osteopathic Association, 2010, Volume: 110, Issue:9 Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Acute Disease; Adult; Analgesics, Non-Narcotic; Female; Free Radical Scavengers; Humans; Pyrrolidonecarboxylic Acid	2010
Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis. CJEM, 2010, Volume: 12, Issue:5 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Diagnosis, Differential; Female; Humans; Opioid-Related Disorders; Pyrrolidonecarboxylic Acid	2010
Mind the gap! An unusual metabolic acidosis. Lancet (London, England), 2011, Feb-05, Volume: 377, Issue:9764 Topics: Acetaminophen; Acetylcysteine; Acidosis; Anti-Bacterial Agents; Antioxidants; Female; Floxacillin; Humans; Middle Aged; Pyrrolidonecarboxylic Acid; Sepsis; Sodium Bicarbonate	2011
Severe anion gap metabolic acidosis from acetaminophen use secondary to 5-oxoproline (pyroglutamic acid) accumulation. The American journal of the medical sciences, 2012, Volume: 344, Issue:6 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Acute Disease; Aged; Analgesics, Non-Narcotic; Female; Humans; Prescription Drug Misuse; Pyrrolidonecarboxylic Acid; Suicide, Attempted; Young Adult	2012
Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid. Intensive care medicine, 2004, Volume: 30, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Adult; Blood Chemical Analysis; Critical Illness; Humans; Pyrrolidonecarboxylic Acid	2004
Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment. Journal of inherited metabolic disease, 2005, Volume: 28, Issue:1 Topics: Acidosis; Anions; Anti-Infective Agents; Antineoplastic Agents; Child; Female; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Lymphoma, T-Cell; Phenytoin; Polymorphism, Genetic; Pyrrolidonecarboxylic Acid; Time Factors	2005
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid). American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:1 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Amino Acid Metabolism, Inborn Errors; Anorexia; Bicarbonates; Dyspnea; Fatigue; Glutathione Synthase; Humans; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Urinalysis	2005
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:1 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Candidiasis; Chlorides; Cytarabine; Etoposide; Fatal Outcome; Fever; Humans; Ifosfamide; Kidney Tubular Necrosis, Acute; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Male; Mesna; Neutropenia; Polycystic Kidney, Autosomal Dominant; Pyrrolidonecarboxylic Acid; Salvage Therapy; Systemic Inflammatory Response Syndrome	2005
Pyroglutamic acidosis in a renal transplant patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:12 Topics: Acidosis; Acute Kidney Injury; Diagnosis, Differential; Disease Progression; Fatal Outcome; Female; Humans; Kidney Transplantation; Medullary Sponge Kidney; Middle Aged; Pyrrolidonecarboxylic Acid	2005
An unusual cause of severe metabolic acidosis. The Medical journal of Australia, 2006, Aug-21, Volume: 185, Issue:4 Topics: Acetaminophen; Acidosis; Acute Kidney Injury; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Floxacillin; Humans; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Sepsis	2006
High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition. Annals of clinical biochemistry, 2007, Volume: 44, Issue:Pt 4 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Female; Humans; Male; Malnutrition; Middle Aged; Pyrrolidonecarboxylic Acid	2007
Profound metabolic acidosis and oxoprolinuria in an adult. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2007, Volume: 3, Issue:3 Topics: Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Critical Illness; Female; Humans; Metabolic Diseases; Middle Aged; Pyrrolidonecarboxylic Acid	2007
Neonatal 5-oxoprolinuria: difficult-to-diagnose? Journal of inherited metabolic disease, 1983, Volume: 6, Issue:1 Topics: Acidosis; Diagnosis, Differential; Erythrocytes; Glutathione; Glutathione Synthase; Humans; Infant, Newborn; Male; Metabolic Diseases; Peptide Synthases; Pyrrolidinones; Pyrrolidonecarboxylic Acid	1983
Hawkinsinuria--identification of quinolacetic acid and pyroglutamic acid during an acidotic phase. Journal of chromatography, 1983, Jul-08, Volume: 275, Issue:2 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids, Sulfur; Australia; Cyclohexenes; Gas Chromatography-Mass Spectrometry; Humans; Infant; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Quinones	1983
Hemolytic anemia, recurrent metabolic acidosis, and incomplete albinism associated with glutathione synthetase deficiency. Blood, 1983, Volume: 62, Issue:4 Topics: Acidosis; Albinism; Anemia, Hemolytic; Cells, Cultured; Erythrocytes; Fibroblasts; Glucosephosphate Dehydrogenase; Glutathione Synthase; Granulocytes; Humans; Infant; Male; Peptide Synthases; Pyrrolidonecarboxylic Acid	1983
Glutathione synthetase deficiency: a family report. Journal of the Royal Society of Medicine, 1994, Volume: 87, Issue:3 Topics: Acidosis; Adult; Child; Child, Preschool; Erythrocytes; Female; Fibroblasts; Follow-Up Studies; Glutathione Synthase; Hemolysis; Humans; Infant, Newborn; Male; Pyrrolidonecarboxylic Acid	1994
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Human molecular genetics, 1997, Volume: 6, Issue:7 Topics: Acidosis; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Anemia, Hemolytic; Animals; Blotting, Southern; Child, Preschool; Glutathione Synthase; Humans; Infant, Newborn; Molecular Sequence Data; Mutation; Nervous System Diseases; Phenotype; Point Mutation; Polymerase Chain Reaction; Pyrrolidonecarboxylic Acid; Rats; Recombinant Proteins; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Xenopus	1997
Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy. Clinical chemistry, 1998, Volume: 44, Issue:2 Topics: Acidosis; Adult; Anti-Bacterial Agents; Female; Floxacillin; Gentamicins; Glutathione; Humans; Netilmicin; Penicillins; Pneumonia, Staphylococcal; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid	1998
Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects. Clinical chemistry, 1998, Volume: 44, Issue:7 Topics: 3-Hydroxybutyric Acid; Acetaminophen; Acidosis; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Humans; Hydroxybutyrates; Infant; Lactic Acid; Male; Middle Aged; Phenylpropionates; Pregnancy; Pyrrolidonecarboxylic Acid	1998
Pyroglutamic acidemia: a cause of high anion gap metabolic acidosis. Critical care medicine, 2000, Volume: 28, Issue:6 Topics: Acidosis; Aged; Aged, 80 and over; Female; Humans; Middle Aged; Pyrrolidonecarboxylic Acid	2000
Pyroglutamic acid and high anion gap: looking through the keyhole? Critical care medicine, 2000, Volume: 28, Issue:6 Topics: Acid-Base Equilibrium; Acidosis; Humans; Pyrrolidonecarboxylic Acid	2000
Anion gap acidosis associated with acetaminophen. Annals of internal medicine, 2000, Nov-07, Volume: 133, Issue:9 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Female; Humans; Pyrrolidonecarboxylic Acid	2000
5-Oxoprolinuria: a cause of neonatal metabolic acidosis. Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:7 Topics: Acidosis; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pyrrolidonecarboxylic Acid; Severity of Illness Index	2001
5-oxoprolinuria: biochemical observations and case report. The Journal of pediatrics, 1977, Volume: 91, Issue:2 Topics: Acidosis; Chromosome Aberrations; Chromosome Disorders; Erythrocytes; Fibroblasts; Glutathione; Glutathione Synthase; Humans; Infant; Infant, Newborn; Jaundice, Neonatal; Leukocytes; Male; Mutation; Peptide Synthases; Pyrrolidinones; Pyrrolidonecarboxylic Acid	1977
Hyperglycinemia and propionyl coA carboxylase deficiency and episodic severe illness without consistent ketosis. The Journal of pediatrics, 1975, Volume: 86, Issue:5 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids; Citrates; Coenzyme A; Creatinine; Crotonates; Glutamates; Glutamine; Glycine; Humans; Infant; Ketone Bodies; Ketosis; Ligases; Male; Propionates; Pyrrolidonecarboxylic Acid	1975
5-Oxoprolinuria due to glutathione synthetase deficiency. Journal of inherited metabolic disease, 1992, Volume: 15, Issue:6 Topics: Acidosis; Erythrocytes; Female; Fibroblasts; Glutathione Synthase; Humans; Infant, Newborn; Pyrrolidonecarboxylic Acid; Respiratory Mechanics	1992
Hawkinsinuria in two families. American journal of medical genetics, 1992, Sep-01, Volume: 44, Issue:1 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids, Sulfur; Cyclohexanecarboxylic Acids; Cyclohexenes; Electrophoresis; Failure to Thrive; Female; Genes, Dominant; Humans; Infant; Male; Pedigree; Phenylpyruvic Acids; Pyrrolidonecarboxylic Acid; Tyrosine	1992
5-Oxoprolinuria in an adolescent with chronic metabolic acidosis, mental retardation, and psychosis. The Journal of pediatrics, 1991, Volume: 118, Issue:1 Topics: Acidosis; Child; Chronic Disease; Female; Glutathione Synthase; Humans; Intellectual Disability; Metabolism, Inborn Errors; Neurocognitive Disorders; Pyrrolidonecarboxylic Acid	1991
Pyroglutamic acidemia in an adult patient. Clinical chemistry, 1989, Volume: 35, Issue:4 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Female; Gas Chromatography-Mass Spectrometry; Humans; Middle Aged; Pyrrolidinones; Pyrrolidonecarboxylic Acid	1989
Pyroglutamic aciduria: rate of formation and degradation of pyroglutamate. Clinica chimica acta; international journal of clinical chemistry, 1973, Dec-27, Volume: 49, Issue:3 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Dogs; Glutamates; Humans; Kidney; Kinetics; Mathematics; Nephrectomy; Proline; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Time Factors	1973