pyrrolidonecarboxylic acid has been researched along with Disease Models, Animal in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.08) | 18.7374 |
| 1990's | 4 (6.15) | 18.2507 |
| 2000's | 14 (21.54) | 29.6817 |
| 2010's | 35 (53.85) | 24.3611 |
| 2020's | 10 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Bayer, TA | 1 |
| Cho, KM; Jo, JK; Kim, EJ; Kim, HW; Kim, JH; Kwon, SJ; Lee, G; Nguyen, CD; Park, SE; Seo, SH; Son, HS | 1 |
| Hook, G; Hook, V; Kindy, M | 1 |
| Acero, G; Díaz, G; Gevorkian, G; Rodriguez-Lopez, A; Torres-Paniagua, AM | 1 |
| Fossati, G; Kapuvári, B; Mező, G; Ranđelović, I; Schuster, S; Steinkühler, C; Tóvári, J | 1 |
| Ando, D; Hokazono, H; Kurihara, T; Maruoka, N; Miyashita, M; Watanabe, B | 1 |
| Attems, J; Beutl, K; Daurer, M; Flunkert, S; Hutter-Paier, B; Loeffler, T; Neddens, J; Walker, L | 1 |
| Delpech, JC; Hu, J; Ikezu, S; Ikezu, T; Ruan, Z; Van Enoo, AA; Venkatesan Kalavai, S | 1 |
| Holubová, K; Horacek, J; Hoschl, C; Kacer, D; Kleteckova, L; Kurtas, O; Muhametaj, F; Mutlu, O; Pinterova, N; Rodriguez, DB; Uygun, I; Vales, K | 1 |
| Antonelli, S; Caldarone, BJ; Hettmann, T; Hoesch, C; Lemere, CA; McDannold, NJ; Power, C; Schenk, M; Schilling, S; Schroeder, MK; Shi, Q; Sun, T; Taudte, N; Zhang, Y | 1 |
| Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP | 1 |
| Lim, YM; Minami, R; Omata, Y; Tsuda, L; Yamasaki, Y | 1 |
| Alcántara-Alonso, V; Alvarez-Salas, E; de Gortari, P; Matamoros-Trejo, G | 1 |
| Erden, F; Holubová, K; Horáček, J; Höschl, C; Mutlu, O; Páleníček, T; Pinterová, N; Šíchová, K; Stuchlík, A; Valeš, K | 1 |
| Bischoff, R; de Boer, RA; Gil, A; Grote Beverborg, N; Hoendermis, ES; Schouten, EM; Silljé, HHW; Tromp, J; van der Meer, P; van der Pol, A; van Veldhuisen, DJ; Voors, AA | 1 |
| Keceli, G; Lindsey, ML; Paolocci, N; Sourdon, J | 1 |
| Bencze, M; Kuneš, J; Maletínská, L; Popelová, A; Železná, B | 1 |
| Borcherding, AF; Heier, C; Kühnlein, RP; Roeder, T; Tian, G; Xu, Y | 1 |
| Akasaka, Y; Ishii, T; Kimura, S; Kuwano, K; Misonoo, Y; Saga, T; Saito, K; Tateda, K; Yamaguchi, K; Yoshizawa, S | 1 |
| Egashira, Y; Furuta, S; Hashimoto, K; Itabashi, M; Kiyono, T; Mochizuki, S; Nagata, M; Nakamura, Y; Ono, S; Park, EY; Sakata, Y; Sanada, H; Sato, K; Shimmura, Y; Suzuki, Y | 1 |
| Cotman, CW; Cynis, H; Demuth, HU; Ekpo, E; Ervin, FR; Frost, JL; Ikezu, T; Kleinschmidt, M; Le, KX; Lemere, CA; Palmour, RM; Saido, TC; Schilling, S; Snigdha, S; St George-Hyslop, P; Vassar, RJ | 1 |
| Huang, B; Huang, S; Kasper, LH; Li, YQ; Lu, F; Lun, ZR; Shen, J; Wang, Y; Zhao, Y; Zheng, H | 1 |
| Arthur, PG; Boyatzis, A; Grounds, MD; Terrill, JR | 1 |
| Aoi, W; Bou, Y; Fujiwara, M; Kiyono, T; Naito, Y; Ohta, R; Park, EY; Sato, K; Takagi, T; Wada, E; Wada, S; Yoshikawa, T | 1 |
| Connolly, B; Marcus, J; Miller, RA; Renger, J; Savage, MJ; Wu, G | 1 |
| Mameli, C; Zuccotti, GV | 1 |
| Arthur, PG; Graves, JA; Grounds, MD; Pinniger, GJ; Terrill, JR | 1 |
| Faucherre, A; Giraldo, J; Gorostiza, P; Goudet, C; Jopling, C; Llebaria, A; Pin, JP; Pittolo, S; Rovira, X; Trapero, A; Zussy, C | 1 |
| Brusco, LI; Cardinali, D; Castaño, EM; Cuello, AC; Do Carmo, S; Galeano, P; Gevorkian, G; Martino Adami, PV; Morelli, L; Olivar, N; Pagano, ES; Quijano, C; Rabossi, A; Radi, R; Reyes Toso, C; Wallinger, ML | 1 |
| Cheng, D; Hong, S; Hu, Y; O'Connor, MB; Perrimon, N; Pissios, P; Sappe, B; Song, W; Wei, N; Zhu, C | 1 |
| Bac, P; Dartevelle, P; El Tawil, Z; German-Fattal, M; Hulin, A; Lecerf, F; Maurois, P; Sabbagh, F | 1 |
| Cynis, H; Demuth, HU; Francke, M; Heiser, U; Hoffmann, T; Holzer, M; Hutter-Paier, B; Jagla, W; Kehlen, A; Lindner, C; Montag, D; Prokesch, M; Reuter, G; Rossner, S; Rudolph, T; Schilling, S; Schlenzig, D; Windisch, M; Zeitschel, U | 1 |
| Chen, JD; Tang, M; Zhang, J | 1 |
| Bayer, TA; Bethge, T; Brody, DL; Esparza, T; Harmeier, A; Ingelsson, M; Jawhar, S; Kalimo, H; Lannfelt, L; Lucassen, PJ; Marcello, A; Multhaup, G; Wirths, O | 1 |
| Bachhawat, AK; Kumar, A | 1 |
| de Moura Coelho, D; de Souza Wyse, AT; Dutra-Filho, CS; Duval Wannmacher, CM; Mescka, CP; Pederzolli, CD; Sgaravatti, AM; Sgarbi, MB; Vargas, CR; Wajner, M; Zandoná, BR | 1 |
| Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M | 1 |
| Fan, X; Guidot, DM; Joshi, PC; Koval, M | 1 |
| Lekic, T; Manaenko, A; Tang, J; Zhang, JH | 1 |
| Bayer, TA; Wirths, O | 1 |
| Harney, JW; Larsen, PR; Lechan, RM; Marsili, A; Sanchez, E; Singru, P; Zavacki, AM | 1 |
| Chan, YS; Chen, LW; Chu, JM; Yung, KK | 1 |
| Bayer, TA; Jawhar, S; Wirths, O | 1 |
| Bayer, TA; Blennow, K; Demuth, HU; Gustavsson, MK; Koch, B; Portelius, E; Schilling, S; Wirths, O; Wittnam, JL; Zetterberg, H | 1 |
| Baik, SH; Hong, HS; Kim, YS; Kook, SY; Lee, J; Mook-Jung, I; Moon, M; Nam, DW; Song, H | 1 |
| Demuth, HU; Frost, JL; Kleinschmidt, M; Lemere, CA; Liu, B; Schilling, S | 1 |
| Higuchi, M; Maeda, J; Mori, T; Shimada, H; Shinotoh, H; Suhara, T; Ueno, S | 1 |
| Deheza, R; Muriel, P | 1 |
| Castejón Castán, LM; Fernández Pérez, C; González Mateos, MJ; Moreno Koch, Mdel C; Olmos, CL; Pérez Cuadrado, S; Pérez Villalobos, C | 1 |
| Baek, SY; Chung, BS; Kang, CD; Kim, JY; Kim, SD; Kim, SH; Park, KH; Park, SW | 1 |
| Choi, IW; Im, MJ; Kim, UH; Lee, HK; Lee, KS; Lee, YC; Lim, JS; Park, HS; Park, KH; Park, SJ | 1 |
| Nies, M; Ro, JY; Zhang, Y | 1 |
| Andreelli, F; Bado, A; Burcelin, R; Cani, PD; Foretz, M; Iglesias, MA; Knauf, C; Mithieux, G; Perrin, C; Pillot, B; Tronche, F; Vaulont, S; Viollet, B | 1 |
| Levine, JE; Schwartz, NB | 1 |
| Brown, LA; Guidot, DM; Otis, JS | 1 |
| de Gortari, P; Jaimes-Hoy, L; Joseph-Bravo, P | 1 |
| Dikalov, S; Guidot, DM; Hart, CM; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Sutliff, RL | 1 |
| Crowley, C; Tucker, EM; Young, JD | 1 |
| Hunter, JF; Rieke, GK; Scarfe, AD | 1 |
| Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D | 1 |
| Dykes-Hoberg, M; Jin, L; Kuncl, RW; Rothstein, JD | 1 |
| Bais, R; Baker, PW; Rofe, AM | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Hori, E; Miyake, N; Nishijo, H; Ono, T; Tamura, R; Uwano, T | 1 |
6 review(s) available for pyrrolidonecarboxylic acid and Disease Models, Animal
| Article | Year |
|---|---|
Pyroglutamate Aβ cascade as drug target in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mice; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2022 |
Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cathepsin B; Disease Models, Animal; Memory Disorders; Mice; Mice, Transgenic; Pyrrolidonecarboxylic Acid | 2023 |
The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology.
Topics: Alzheimer Disease; Animals; Appetite Depressants; Disease Models, Animal; Energy Metabolism; Homeostasis; Humans; Leptin; Neuroprotective Agents; Oligopeptides; Pyrrolidonecarboxylic Acid | 2019 |
Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Neurons; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2011 |
Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Brain; Brain Chemistry; Disease Models, Animal; Humans; Mice; Pyrrolidonecarboxylic Acid | 2011 |
Molecular imaging of dementia.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Humans; Immunization; Lewy Body Disease; Mice; Molecular Imaging; Parkinson Disease; Positron-Emission Tomography; Pyrrolidonecarboxylic Acid; tau Proteins | 2012 |
59 other study(ies) available for pyrrolidonecarboxylic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Gastrointestinal Microbiome; Glutamic Acid; Glycerol; Hypoxanthines; Inosine; Mice; Oxalates; Phenylalanine; Pyrrolidonecarboxylic Acid; Xylose | 2022 |
Increased TSPO expression, pyroglutamate-modified amyloid beta (AβN3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Amyloid Angiopathy; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Microglia; Pyrrolidonecarboxylic Acid; Thalamus | 2023 |
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Daunorubicin; Disease Models, Animal; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Molecular Structure; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface; RNA, Messenger; Toxicity Tests; Xenograft Model Antitumor Assays | 2019 |
Effects of a pyroglutamyl pentapeptide isolated from fermented barley extract on atopic dermatitis-like skin lesions in hairless mouse.
Topics: Animals; Complex Mixtures; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Fermentation; Hordeum; Hypodermoclysis; Male; Mice; Mice, Hairless; Oligopeptides; Picryl Chloride; Pyrrolidonecarboxylic Acid; Treatment Outcome | 2020 |
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Female; Humans; Male; Mice; Middle Aged; Phosphorylation; Pyrrolidonecarboxylic Acid; Species Specificity; tau Proteins | 2020 |
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Topics: Animals; Disease Models, Animal; Exosomes; Mice; Mice, Transgenic; Microglia; Phenotype; Pyrrolidonecarboxylic Acid; Receptors, Purinergic P2X7; Tauopathies | 2020 |
Effects of adipokinetic hormone/red pigment-concentrating hormone family of peptides in olfactory bulbectomy model and posttraumatic stress disorder model of rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Insect Hormones; Male; Neuropeptides; Olfactory Bulb; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Stress Disorders, Post-Traumatic | 2020 |
Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2021 |
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma.
Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Down-Regulation; Eosinophils; Female; Hypersensitivity; Immunoglobulin E; Intercellular Signaling Peptides and Proteins; Lung; Metaplasia; Mice, Inbred C57BL; Mucus; Ovalbumin; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Th2 Cells; Thiazolidines | 2017 |
Pyroglutamate-amyloid-β peptide expression in Drosophila leads to caspase-dependent and endoplasmic reticulum stress-related progressive neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Caspases; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Endoplasmic Reticulum Stress; Neurodegenerative Diseases; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid | 2017 |
Intrauterine Zn Deficiency Favors Thyrotropin-Releasing Hormone-Increasing Effects on Thyrotropin Serum Levels and Induces Subclinical Hypothyroidism in Weaned Rats.
Topics: Aminopeptidases; Animal Nutritional Physiological Phenomena; Animals; Asymptomatic Diseases; Biomarkers; Deficiency Diseases; Disease Models, Animal; Female; Gestational Age; Hypothalamus; Hypothyroidism; Maternal Nutritional Physiological Phenomena; Nutritional Status; Pituitary Gland, Anterior; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidonecarboxylic Acid; Rats, Wistar; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone; Up-Regulation; Weaning; Zinc | 2017 |
Effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on MK-801-induced schizophrenia models.
Topics: Animals; Anti-Anxiety Agents; Disease Models, Animal; Dizocilpine Maleate; Insect Hormones; Male; Memory; Memory Disorders; Neuropeptides; Neuroprotective Agents; Oligopeptides; Peptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Long-Evans; Rats, Wistar; Schizophrenia | 2018 |
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.
Topics: Aged; Aged, 80 and over; Animals; Case-Control Studies; Disease Models, Animal; Female; Fibrosis; Genetic Predisposition to Disease; Heart Failure; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phenotype; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Randomized Controlled Trials as Topic; Signal Transduction; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2018 |
Death of an antioxidant brings heart failure with preserved ejection fraction to life: 5-oxoproline and post-ischaemic cardio-renal dysfunction.
Topics: Animals; Antioxidants; Disease Models, Animal; Fibrosis; Heart Failure; Kidney Diseases; Mice; Oxidative Stress; Pyrrolidonecarboxylic Acid; Stroke Volume | 2018 |
Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.
Topics: Adipose Tissue; Animals; Aspartate Aminotransferase, Cytoplasmic; Calcium; Calcium Signaling; Calcium-Binding Proteins; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Energy Metabolism; Female; Gene Expression Regulation; Homeostasis; Humans; Hyperphagia; Insect Hormones; Ion Transport; Isoenzymes; Lipid Metabolism; Malate Dehydrogenase; Male; Obesity; Oligopeptides; Pyrrolidonecarboxylic Acid; RNA, Small Interfering; Stromal Interaction Molecule 1 | 2019 |
Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions.
Topics: Acinetobacter Infections; Administration, Intranasal; Animals; Antioxidants; Bacterial Load; Cytokines; Disease Models, Animal; Female; Histocytochemistry; Lung; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Phagocytosis; Pneumonia, Ventilator-Associated; Pyrrolidonecarboxylic Acid; Thiazolidines; Treatment Outcome | 2013 |
Identification of a hepatoprotective peptide in wheat gluten hydrolysate against D-galactosamine-induced acute hepatitis in rats.
Topics: Animals; Biomarkers; Dipeptides; Disease Models, Animal; Galactosamine; Glutens; Hepatitis; Peptide Fragments; Protective Agents; Protein Hydrolysates; Pyrrolidonecarboxylic Acid; Rats; Triticum | 2013 |
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebral Amyloid Angiopathy; Chlorocebus aethiops; Disease Models, Animal; Dogs; Down Syndrome; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Middle Aged; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2013 |
Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin G; Injections, Intraperitoneal; Liver; Mice; Protozoan Proteins; Protozoan Vaccines; Pyrrolidonecarboxylic Acid; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasma; Toxoplasmosis; Ultraviolet Rays; Vaccination; Vaccines, Attenuated | 2013 |
Treatment with the cysteine precursor l-2-oxothiazolidine-4-carboxylate (OTC) implicates taurine deficiency in severity of dystropathology in mdx mice.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Duchenne; Oxidative Stress; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2013 |
Ingestion of low dose pyroglutamyl leucine improves dextran sulfate sodium-induced colitis and intestinal microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Dextran Sulfate; Dipeptides; Disease Models, Animal; Humans; Intestines; Male; Mice; Mice, Inbred C57BL; Microbiota; Pyrrolidonecarboxylic Acid | 2013 |
Pyroglutamate-modified amyloid-β protein demonstrates similar properties in an Alzheimer's disease familial mutant knock-in mouse and Alzheimer's disease brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Knock-In Techniques; Humans; Mice; Mice, Transgenic; Presenilin-1; Pyrrolidonecarboxylic Acid | 2014 |
Pidotimod: the past and the present.
Topics: Acute Disease; Adaptive Immunity; Adjuvants, Immunologic; Animals; Child; Child, Preschool; Cohort Studies; Disease Models, Animal; Female; Forecasting; Humans; Immunity, Innate; Incidence; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Secondary Prevention; Thiazolidines; Treatment Outcome | 2013 |
Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2016 |
OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.
Topics: Allosteric Regulation; Animals; Azo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Light; Mice; Mice, Inbred C57BL; Pain Threshold; Pyrrolidonecarboxylic Acid; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Time Factors; Zebrafish | 2016 |
Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation.
Topics: Adiposity; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Diet, Western; Disease Models, Animal; Energy Metabolism; Gene Deletion; Hippocampus; Humans; Inflammation; Male; Memory Disorders; Pyrrolidonecarboxylic Acid; Rats; Rats, Transgenic | 2017 |
Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
Topics: Activin Receptors; Activins; Animals; Carbohydrate Metabolism; Carrier Proteins; Dietary Carbohydrates; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enteroendocrine Cells; Fat Body; Gastrointestinal Tract; Glucagon; Hepatocytes; Hyperglycemia; Insect Hormones; Larva; Mice; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glucagon; RNA Interference; RNA, Messenger; Signal Transduction | 2017 |
Impact of cyclosporine A on magnesium homeostasis: clinical observation in lung transplant recipients and experimental study in mice.
Topics: Administration, Oral; Adolescent; Adult; Animals; Creatinine; Cyclosporine; Dietary Supplements; Disease Models, Animal; Female; Homeostasis; Humans; Immunosuppressive Agents; Kidney Diseases; Lung Transplantation; Magnesium; Magnesium Deficiency; Male; Mice; Mice, Inbred C57BL; Middle Aged; Pyrrolidonecarboxylic Acid; Retrospective Studies; Time Factors; Treatment Failure | 2008 |
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Topics: Alzheimer Disease; Aminoacyltransferases; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Memory; Mice; Mice, Transgenic; Pyrrolidonecarboxylic Acid | 2008 |
Gastric electrical stimulation for obesity: the need for a new device using wider pulses.
Topics: Animals; Disease Models, Animal; Eating; Electric Stimulation Therapy; Equipment and Supplies; Female; Male; Neurons; Obesity; Oligopeptides; Oxytocin; Paraventricular Hypothalamic Nucleus; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stomach; Weight Loss | 2009 |
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Mutation; Peptide Fragments; Plaque, Amyloid; Presenilin-1; Protease Nexins; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface | 2010 |
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
Topics: Adenosine Triphosphate; Amino Acid Transport Systems, Neutral; Animals; Cysteine; Cystinosis; Disease Models, Animal; Glutamate-Cysteine Ligase; Glutamic Acid; Humans; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid | 2010 |
Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.
Topics: Age Factors; Animals; Antioxidants; Brain Diseases, Metabolic, Inborn; Cerebellum; Cerebrum; Disease Models, Animal; Glutathione Synthase; Lipid Peroxidation; Nerve Tissue Proteins; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 2010 |
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cysteine; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Stomach Ulcer; Thiazolidines | 2012 |
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Topics: Alcoholism; Animals; Antioxidants; Central Nervous System Depressants; Comorbidity; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial Cells; Epithelium; Ethanol; Glutathione; HIV Envelope Protein gp120; HIV Infections; HIV-1; Lung; Lung Diseases; Male; Membrane Proteins; NF-E2-Related Factor 2; Occludin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Rats, Transgenic; Thiazolidines; Tight Junctions; Time Factors | 2011 |
NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.
Topics: Analysis of Variance; Animals; Aquaporin 4; Arginine Vasopressin; Basal Ganglia; Brain Edema; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Exploratory Behavior; Functional Laterality; Gait Disorders, Neurologic; Male; Mice; Movement Disorders; Oligopeptides; Pyrrolidonecarboxylic Acid; Time Factors | 2011 |
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
Topics: Aminopeptidases; Animals; Antithyroid Agents; Disease Models, Animal; Hypothyroidism; Injections, Intraperitoneal; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Mice; Mice, Inbred C57BL; Mice, Knockout; Paraventricular Hypothalamic Nucleus; Pyrrolidonecarboxylic Acid; RNA, Messenger; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine | 2011 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; Peptide Fragments; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Rotarod Performance Test; Signal Transduction; Substance P; Sympatholytics; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Mice; Mice, Transgenic; Pyrrolidonecarboxylic Acid | 2012 |
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Calcium-Binding Proteins; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation; Hippocampus; Humans; Intracellular Fluid; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Pyrrolidonecarboxylic Acid | 2012 |
Passive immunization against pyroglutamate-3 amyloid-β reduces plaque burden in Alzheimer-like transgenic mice: a pilot study.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Antibodies; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gliosis; Humans; Immunization, Passive; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Peptide Fragments; Pilot Projects; Plaque, Amyloid; Presenilin-1; Pyrrolidonecarboxylic Acid; Statistics, Nonparametric; Time Factors | 2012 |
Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.
Topics: Administration, Oral; Alanine Transaminase; Alcohol Deterrents; Animals; Bilirubin; Cholestasis, Extrahepatic; Colchicine; Collagen; Disease Models, Animal; Drug Combinations; gamma-Glutamyltransferase; Hydroxyproline; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Liver Glycogen; Male; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 2003 |
Immunomodulation in established murine tumors: response and survival rate enhancement by blood leukocyte-augmenting substance 236 (Cl-), a novel synthetic compound.
Topics: Adjuvants, Immunologic; Animals; Cell Division; Cell Survival; Chemotherapy, Adjuvant; Cyclophosphamide; Disease Models, Animal; Female; Male; Mice; Neoplasms, Experimental; Placebos; Pyridines; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds | 2003 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cell Adhesion Molecules; Chemokines; Disease Models, Animal; Eosinophil Cationic Protein; Interleukins; Lung; Mice; NF-kappa B; Ovalbumin; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2004 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Catalysis; Disease Models, Animal; Gene Deletion; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Glucose-6-Phosphatase; Hyperglycemia; Insect Hormones; Insulin; Leptin; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Genetic; Models, Statistical; Multienzyme Complexes; Oligopeptides; Phosphoenolpyruvate Carboxykinase (ATP); Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyrrolidonecarboxylic Acid; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription, Genetic; Transcriptional Activation | 2006 |
Ontogeny of gonadotropin-releasing hormone neurons: fishing for clues in medaka.
Topics: Animals; Animals, Genetically Modified; Brain; Disease Models, Animal; Gene Expression Regulation, Developmental; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Neurons; Oligopeptides; Oryzias; Protein Precursors; Pyrrolidonecarboxylic Acid | 2006 |
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.
Topics: Alcoholism; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models, Animal; Disease Progression; Ethanol; Glutathione; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Oxidants; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazolidines; Transforming Growth Factor beta1; Up-Regulation | 2007 |
Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.
Topics: Adaptation, Physiological; Aminopeptidases; Animals; Anorexia; Anxiety; Appetite Regulation; Body Composition; Cold Temperature; Corticosterone; Dehydration; Disease Models, Animal; Female; Food Deprivation; Hypothalamo-Hypophyseal System; Matched-Pair Analysis; Neurons; Paraventricular Hypothalamic Nucleus; Pituitary Gland, Anterior; Protein Precursors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Thyrotropin-Releasing Hormone; RNA, Messenger; Sex Factors; Stress, Physiological; Thyroid Gland; Thyroid Hormones; Thyrotropin-Releasing Hormone | 2008 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2008 |
Red cell glutathione deficiency: clinical and biochemical investigations using sheep as an experimental model system.
Topics: Anemia; Animals; Cysteine; Disease Models, Animal; Erythrocyte Aging; Erythrocytes; Glutamate-Cysteine Ligase; Glutathione; Nitrites; Phenylhydrazines; Pyrrolidonecarboxylic Acid; Sheep; Sulfoxides | 1981 |
L-pyroglutamate: an alternate neurotoxin for a rodent model of Huntington's disease.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Corpus Striatum; Disease Models, Animal; Huntington Disease; Kainic Acid; Male; Mice; Microscopy, Electron; Pyrrolidinones; Pyrrolidonecarboxylic Acid | 1984 |
Changes in expression of the albumin, fibronectin and type I procollagen genes in CCl4-induced liver fibrosis: effect of pyridoxol L,2-pyrrolidon-5 carboxylate.
Topics: Albumins; Animals; Blotting, Northern; Carbon Tetrachloride; Disease Models, Animal; Drug Combinations; Female; Fibronectins; Gene Expression Regulation; Liver Cirrhosis, Experimental; Procollagen; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA | 1993 |
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biological Transport, Active; Choline O-Acetyltransferase; Disease Models, Animal; Glutamates; Lumbosacral Region; Motor Neurons; Organ Culture Techniques; Pyrrolidonecarboxylic Acid; Rats; Receptors, Glutamate; Spinal Cord; Synaptic Transmission | 1993 |
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi | 1998 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia.
Topics: Amnesia; Animals; Brain Ischemia; Disease Models, Animal; Hippocampus; Learning; Male; Memory Disorders; Oligopeptides; Prosencephalon; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Vasopressins | 2002 |