pyrrolidonecarboxylic acid and Disease Exacerbation

pyrrolidonecarboxylic acid has been researched along with Disease Exacerbation in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80

Authors

Authors	Studies
Andersen, SW; Apostolova, LG; Ardayfio, PA; Brys, M; Duggan Evans, C; Lo, AC; Mintun, MA; Salloway, SP; Shcherbinin, S; Sims, JR; Skovronsky, DM; Sparks, J; Wessels, AM	1
Egan, TM; Han, J; Jin, H; Liu, C; Liu, H; Perlmutter, JS; Tu, Z	1
Blennow, K; Brinet, D; Brinkmalm, G; Guerard, L; Hammarström, P; Hanrieder, J; Kaya, I; Lashley, T; Michno, W; Nilsson, KPR; Nyström, S; Sehlin, D; Syvänen, S; Wehrli, P; Zetterberg, H	1
Abrahamson, EE; DeKosky, ST; Ikonomovic, MD; Leurgans, SE; Mufson, EJ; Pivtoraiko, VN	1
Baik, SH; Hong, HS; Kim, YS; Kook, SY; Lee, J; Mook-Jung, I; Moon, M; Nam, DW; Song, H	1
Foot, CL; Fraser, JF; Mullany, DV	1
Brown, LA; Guidot, DM; Otis, JS	1
Alonso-Varona, A; Bilbao, P; Calle, Y; Castro, B; del Olmo, M; Palomares, T	1

Trials

1 trial(s) available for pyrrolidonecarboxylic acid and Disease Exacerbation

Article	Year
Donanemab in Early Alzheimer's Disease. The New England journal of medicine, 2021, 05-06, Volume: 384, Issue:18 Topics: Activities of Daily Living; Administration, Intravenous; Aged; Alzheimer Disease; Brain Edema; Cognition; Disease Progression; Double-Blind Method; Epitopes; Female; Humans; Male; Mental Status and Dementia Tests; Plaque, Amyloid; Pyrrolidonecarboxylic Acid; Severity of Illness Index	2021

Article

Year

Donanemab in Early Alzheimer's Disease.

The New England journal of medicine, 2021, 05-06, Volume: 384, Issue:18

Topics: Activities of Daily Living; Administration, Intravenous; Aged; Alzheimer Disease; Brain Edema; Cognition; Disease Progression; Double-Blind Method; Epitopes; Female; Humans; Male; Mental Status and Dementia Tests; Plaque, Amyloid; Pyrrolidonecarboxylic Acid; Severity of Illness Index

2021

Other Studies

7 other study(ies) available for pyrrolidonecarboxylic acid and Disease Exacerbation

Article	Year
Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response. Nuclear medicine communications, 2017, Volume: 38, Issue:5 Topics: Animals; Biological Transport; Brain; Carbon Radioisotopes; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; HEK293 Cells; Humans; Ligands; Macaca fascicularis; Male; Mice; Positron-Emission Tomography; Pyrrolidonecarboxylic Acid; Radiochemistry; Rats; Receptors, Purinergic P2X7; Spinal Cord; Substrate Specificity	2017
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology. The Journal of biological chemistry, 2019, 04-26, Volume: 294, Issue:17 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Progression; Humans; Male; Mice; Mice, Transgenic; Models, Animal; Peptide Fragments; Plaque, Amyloid; Protein Conformation; Pyrrolidonecarboxylic Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2019
Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease. Neurobiology of aging, 2015, Volume: 36, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Cognition; Disease Progression; Female; Gyrus Cinguli; Humans; Male; Molecular Targeted Therapy; Peptide Fragments; Pyrrolidonecarboxylic Acid; Solubility	2015
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2012, Volume: 29, Issue:3 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Calcium-Binding Proteins; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation; Hippocampus; Humans; Intracellular Fluid; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Pyrrolidonecarboxylic Acid	2012
Pyroglutamic acidosis in a renal transplant patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:12 Topics: Acidosis; Acute Kidney Injury; Diagnosis, Differential; Disease Progression; Fatal Outcome; Female; Humans; Kidney Transplantation; Medullary Sponge Kidney; Middle Aged; Pyrrolidonecarboxylic Acid	2005
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats. Muscle & nerve, 2007, Volume: 36, Issue:6 Topics: Alcoholism; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models, Animal; Disease Progression; Ethanol; Glutathione; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Oxidants; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazolidines; Transforming Growth Factor beta1; Up-Regulation	2007
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases. Melanoma research, 2000, Volume: 10, Issue:2 Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cell Division; Cyclophosphamide; Cysteine; Disease Progression; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glutathione; Leukopenia; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	2000