pyrrolidonecarboxylic acid has been researched along with Aging in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.15) | 18.7374 |
| 1990's | 14 (42.42) | 18.2507 |
| 2000's | 2 (6.06) | 29.6817 |
| 2010's | 10 (30.30) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Amcoff, M; Liao, S; Nässel, DR | 1 |
| Heier, C; Hofbauer, HF; Kühnlein, RP; Sen Saji, AK | 1 |
| Cao, Y; Chtarbanova, S; Ganetzky, B; Hayne, M; Jayanth, D; Kounatidis, I; Ligoxygakis, P | 1 |
| Boche, D; Gaimster, K; Moro, ML; Mudher, A; Nicoll, JAR; Paul, C; Phillips, AS | 1 |
| Bayer, TA; Härtig, W; Hillmann, A; Pradier, L; Wirths, O | 1 |
| Birras, U; Grönke, S; Hendrich, O; Hinze, Y; Metaxakis, A; Partridge, L; Tain, LS | 1 |
| Alcedo, J; Chung, BY; Harvanek, ZM; Ostojic, I; Pletcher, SD; Waterson, MJ | 1 |
| Deevska, G; Karakashian, C; Morris, AJ; Nikolova-Karakashian, MN; Peppers, B; Sunkara, M | 1 |
| Bayer, TA; Bethge, T; Brody, DL; Esparza, T; Harmeier, A; Ingelsson, M; Jawhar, S; Kalimo, H; Lannfelt, L; Lucassen, PJ; Marcello, A; Multhaup, G; Wirths, O | 1 |
| Orchard, I; Paluzzi, JP | 1 |
| El-Damanhouri, HI; Fassold, K; Lorenz, MW | 1 |
| Eremina, AA; Gorbunova, EN; Khomchenko, TN; Kurganova, IV; Nikolaev, IuA; Pal'tsev, AI; Sharapov, IV; Soldatova, GS | 1 |
| Alexandru, A; Bäuscher, C; Becker, A; Cynis, H; Demuth, HU; Graubner, S; Hartlage-Rübsamen, M; Jagla, W; Kohlmann, S; Osmand, AP; Petrasch-Parwez, E; Raber, KA; Reymann, KG; Rönicke, R; Rossner, S; Schilling, S; Sedlmeier, R; von Hörsten, S; Waniek, A | 1 |
| Kodrík, D; Socha, R; Syrová, Z | 1 |
| Busby, WH; Cottle, C; Kizer, JS; Youngblood, WW | 1 |
| Annoni, G; Arosio, B; Cullurà, D; Gagliano, N; Santambrogio, D; Uslenghi, C | 1 |
| Barbera, N; Bernardini, R; Cantarella, G; Chiarenza, A; Iurato, MP; Lempereur, L; Scapagnini, G; Scapagnini, U | 1 |
| Casis, L; De Gandarias, JM; Fernandez, D; Irazusta, J; Silio, M | 1 |
| Davies, SA; Dow, JA; Huesmann, GR; Maddrell, SH; O'Donnell, MJ; Skaer, NJ; Tublitz, NJ | 1 |
| Barcellini, W; Borghi, MO; Carbonelli, V; Del Papa, N; Fain, C; Gambini, D; La Rosa, L; Meroni, PL; Minonzio, F; Piona, A | 1 |
| Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D | 1 |
| Bundy, R; Jackson, AA; Meakins, TS; Persaud, C | 1 |
| Forrester, T; Jackson, AA; Persaud, C | 1 |
| Calabrese, V; Ragusa, N; Randazzo, G; Rizza, V | 1 |
| Belfiore, F; Iannello, S; Leotta, P; Prestipino, M; Ricciardi, N; Spina, M; Spina, S | 1 |
| Champier, J; Chigr, F; Jodani, D; Kopp, N; Najimi, M; Tabib, A | 1 |
| Aratan-Spire, S; Scharfmann, R | 1 |
| Cockle, SM; Morrell, JM; Thetford, CR | 1 |
| Ashworth, RJ; Cockle, SM; Visser, TJ | 1 |
| Chang, KS; Li, XS; Tanz, RD | 1 |
| Duquesnoy, B; Gilquin, B; Marchandise, X; Pagniez, D; Wemeau, JL; Ythier, H | 1 |
| Bell, RD; Cicero, TJ; Meyer, ER | 1 |
| Schwarz, E | 1 |
2 trial(s) available for pyrrolidonecarboxylic acid and Aging
| Article | Year |
|---|---|
[Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].
Topics: Adult; Aged; Aging; Drug Combinations; Fatty Liver; Humans; Middle Aged; Pyridoxine; Pyrrolidonecarboxylic Acid; Treatment Outcome | 2009 |
Influence of accompanying anion on intestinal radiocalcium absorption.
Topics: Adult; Aged; Aging; Biological Availability; Calcium Gluconate; Calcium Radioisotopes; Female; Gluconates; Humans; Intestinal Absorption; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Osteoporosis; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Strontium Radioisotopes | 1987 |
31 other study(ies) available for pyrrolidonecarboxylic acid and Aging
| Article | Year |
|---|---|
Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila.
Topics: Aging; Animals; Behavior; Diet, High-Fat; Drosophila melanogaster; Drosophila Proteins; Female; Fertility; Insect Hormones; Longevity; Oligopeptides; Pyrrolidonecarboxylic Acid; Reproduction; Signal Transduction | 2021 |
Lipidome remodeling in aging normal and genetically obese Drosophila males.
Topics: Aging; Animals; Drosophila melanogaster; Drosophila Proteins; Fatty Acids; Insect Hormones; Lipase; Lipid Metabolism; Lipidomics; Longevity; Male; Obesity; Oligopeptides; Pyrrolidonecarboxylic Acid; Triglycerides | 2021 |
NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.
Topics: Aging; Animals; Antimicrobial Cationic Peptides; Brain; Drosophila; Drosophila Proteins; Glycopeptides; Immunity, Innate; Insect Hormones; Insect Proteins; Longevity; Neurodegenerative Diseases; Neuroglia; NF-kappa B; Oligopeptides; Pyrrolidonecarboxylic Acid; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factors | 2017 |
Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Brain; Female; Humans; Isoaspartic Acid; Male; Middle Aged; Neocortex; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Statistics, Nonparametric; Young Adult | 2018 |
Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blood Vessels; Brain; Cerebral Amyloid Angiopathy; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Immunotherapy; Macaca mulatta; Male; Mice; Mice, Transgenic; Microglia; Neurons; Paraffin Embedding; Phagocytosis; Presenilin-1; Pyrrolidonecarboxylic Acid | 2013 |
Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.
Topics: Aging; Animals; Circadian Rhythm; Dopamine; Drosophila; Drosophila Proteins; Female; Forkhead Transcription Factors; Inhibitor of Apoptosis Proteins; Insect Hormones; Insulin; Octopamine; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptor, Insulin; Receptors, Dopamine; Receptors, Glucagon; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Sleep; Sleep Deprivation; Somatomedins; TOR Serine-Threonine Kinases | 2014 |
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.
Topics: Aging; Animals; Animals, Genetically Modified; Drosophila melanogaster; Drosophila Proteins; Epithelial Sodium Channels; Female; Food; Homeostasis; Insect Hormones; Longevity; Male; Neuroendocrine Cells; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glucagon; Signal Transduction; Taste; Water | 2014 |
Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3.
Topics: Aging; Animals; Ceramides; Gene Expression Regulation, Enzymologic; Glutathione; Hep G2 Cells; Humans; Liver; Male; Mice; Pyrrolidonecarboxylic Acid; RNA, Messenger; Sphingomyelin Phosphodiesterase; Thiazolidines | 2014 |
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Mutation; Peptide Fragments; Plaque, Amyloid; Presenilin-1; Protease Nexins; Pyrrolidonecarboxylic Acid; Receptors, Cell Surface | 2010 |
A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.
Topics: Aging; Amino Acid Sequence; Animals; Base Sequence; Central Nervous System; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genome; Immunohistochemistry; Larva; Male; Molecular Sequence Data; Neuropeptides; Oligopeptides; Phylogeny; Pyrrolidonecarboxylic Acid; Reverse Transcriptase Polymerase Chain Reaction; Rhodnius; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid | 2010 |
Age-dependent cyclic locomotor activity in the cricket, Gryllus bimaculatus, and the effect of adipokinetic hormone on locomotion and excitability.
Topics: Aging; Animals; Behavior, Animal; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Gryllidae; Insect Hormones; Locomotion; Male; Oligopeptides; Pyrrolidonecarboxylic Acid | 2010 |
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Enzyme-Linked Immunosorbent Assay; Gliosis; Heredodegenerative Disorders, Nervous System; Hippocampus; Humans; Immunohistochemistry; Kinetics; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microscopy, Electron; Neuronal Plasticity; Phenotype; Postural Balance; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Developmental and diel changes of adipokinetic hormone in CNS and haemolymph of the flightless wing-polymorphic bug, Pyrrhocoris apterus (L.).
Topics: Aging; Animals; Circadian Rhythm; Female; Hemiptera; Hemolymph; Immunohistochemistry; Insect Hormones; Lipid Metabolism; Nervous System Physiological Phenomena; Neuropeptides; Oligopeptides; Pyrrolidonecarboxylic Acid | 2003 |
Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone).
Topics: Aging; Animals; Animals, Newborn; Brain; Glycine; Kinetics; Mass Spectrometry; Pituitary Gland; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substrate Specificity; Thyrotropin-Releasing Hormone | 1984 |
Gene expression for interleukin-2 and tumor necrosis factor-alpha in the spleen of old rats under physiological condition and during septic shock. Possible pharmacological modulation.
Topics: Aging; Animals; Blotting, Northern; Gene Expression Regulation; Immunologic Factors; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA; Shock, Septic; Spleen; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1994 |
Effects of pidotimod on the immune and the neuroendocrine system in the aging rat.
Topics: Adjuvants, Immunologic; Adrenocorticotropic Hormone; Aging; Animals; Cytokines; Immune System; Immunologic Factors; Interleukin-1; Lymphocytes; Male; Mitogens; Neurosecretory Systems; Pituitary-Adrenal System; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spleen; Thiazoles; Thiazolidines | 1994 |
Membrane-bound pyroglutamyl-arylamidase activity during the first postnatal month in several rat brain areas.
Topics: Aging; Aminopeptidases; Animals; Animals, Newborn; Brain; Cell Membrane; Cerebral Cortex; Corpus Striatum; Female; Hypothalamus; Male; Pituitary Gland; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley | 1994 |
CAP2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP.
Topics: Aging; Animals; Body Fluids; Cyclic AMP; Cyclic GMP; Drosophila melanogaster; Electrophysiology; Female; Insect Hormones; Malpighian Tubules; Manduca; Oligopeptides; Osmolar Concentration; Pyrrolidonecarboxylic Acid | 1995 |
[Effect of pidotimod on the function of the human immune system: in vitro and ex vivo study].
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Antibody Formation; Chemotaxis, Leukocyte; Humans; Immune System; Interferon-gamma; Interleukin-1; Interleukin-2; Interleukin-6; Lymphocyte Activation; Lymphocyte Subsets; Mitogens; Muromonab-CD3; Neutrophils; Phagocytosis; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1993 |
[Levels of interleukin-2 )IL-2 and tumor necrosis factor alpha (TNF-alpha) mRNA in aged rat spleen under physiological conditions and in septic shock: possible role of pidotimod in gene expression modulation].
Topics: Adjuvants, Immunologic; Aging; Animals; Escherichia coli Infections; Gene Expression Regulation; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Septic; Spleen; Stimulation, Chemical; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1993 |
Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased in normal adults consuming vegetarian or low protein diets.
Topics: Adult; Aging; Analysis of Variance; Body Height; Body Mass Index; Body Weight; Circadian Rhythm; Diet, Protein-Restricted; Diet, Vegetarian; Female; Glutamic Acid; Humans; Male; Middle Aged; Nitrogen; Pyrrolidonecarboxylic Acid; Time Factors | 1996 |
Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine.
Topics: Aging; Body Weight; Child, Preschool; Female; Food, Fortified; Glutathione; Glycine; Growth; Humans; Infant; Male; Nutrition Disorders; Pyrrolidonecarboxylic Acid; Weight Gain | 1996 |
Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: protection by metadoxine.
Topics: Aging; Animals; Antioxidants; Brain; Drug Combinations; Ethanol; Glutathione; Glutathione Reductase; Glutathione Transferase; Kidney; Liver; Male; Oxidation-Reduction; Oxidative Stress; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar | 1998 |
Hypomagnesemia and smooth muscle contractility: diffuse esophageal spasm in an old female patient.
Topics: Aged; Aging; Barium; Esophageal Spasm, Diffuse; Female; Humans; Magnesium; Magnesium Deficiency; Muscle Contraction; Muscle, Smooth; Pyrrolidonecarboxylic Acid; Radiography, Thoracic | 1998 |
Autoradiographic distribution of TRH binding sites in the human hypothalamus.
Topics: Adult; Aged; Aging; Autoradiography; Female; Humans; Hypothalamus; Hypothalamus, Anterior; Hypothalamus, Middle; Hypothalamus, Posterior; In Vitro Techniques; Infant, Newborn; Kinetics; Male; Middle Aged; Preoptic Area; Pyrrolidonecarboxylic Acid; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone | 1991 |
Ontogeny of two topologically distinct TRH-degrading pyroglutamate aminopeptidase activities in the rat liver.
Topics: Aging; Aminopeptidases; Animals; Chromatography, Gel; Hydrolysis; Liver; Male; Pyroglutamyl-Peptidase I; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Serine Endopeptidases; Solubility; Thyrotropin-Releasing Hormone | 1991 |
TRH-related peptides in the rabbit prostate complex during development.
Topics: Aging; Amino Acid Sequence; Animals; Chromatography, Gel; Chromatography, Ion Exchange; Male; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Prostate; Pyrrolidonecarboxylic Acid; Rabbits; Sexual Maturation; Thyrotropin-Releasing Hormone; Trypsin | 1992 |
The TRH-like peptide pGlu-Glu-ProNH2 is present in the porcine pituitary but not in reproductive tissues.
Topics: Aging; Amino Acid Sequence; Animals; Chromatography, Gel; Chromatography, Ion Exchange; Female; Molecular Sequence Data; Oligopeptides; Organ Specificity; Ovarian Follicle; Ovary; Pituitary Gland; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Swine; Thyrotropin-Releasing Hormone | 1991 |
Effect of age and methacholine on the rate and coronary flow of isolated hearts of diabetic rats.
Topics: Aging; Animals; Atropine; Blood Glucose; Body Weight; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Heart Rate; In Vitro Techniques; Male; Methacholine Compounds; Organ Size; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Substance P; Time Factors | 1989 |
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Morphine; N-Methylaspartate; Naloxone; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains | 1988 |
[Biochemical stigmas of human skin surface in old age (author's transl)].
Topics: Adult; Aged; Aging; Alanine; Amino Acids; Ammonia; Citrulline; Glutamates; Glycine; Histidine; Humans; Lactates; Pyrrolidonecarboxylic Acid; Skin; Surface Properties; Sweating; Threonine; Urea; Valine | 1974 |