pyrrolidine dithiocarbamate has been researched along with Disease Models, Animal in 91 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (5.49) | 18.2507 |
2000's | 43 (47.25) | 29.6817 |
2010's | 38 (41.76) | 24.3611 |
2020's | 5 (5.49) | 2.80 |
Authors | Studies |
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He, X; Song, Y; Wang, L; Xu, J | 1 |
Huang, Q; Li, F; Song, Y; Xu, Z; Zhang, Z | 1 |
Chen, BB; Cui, PP; Li, YZ; Wang, Y; Yi, S; Zhang, CQ | 1 |
Cai, W; Jiang, N; Jin, X; Li, G; Ma, C; Qian, J; Zheng, J | 1 |
Chen, B; Gong, SL; Shen, ZH; Wu, B; Xu, Z | 1 |
Abdelnour, E; Eckert, P; Francioli, C; Gronchi, F; Krueger, T; Liaudet, L; Lugrin, J; Parapanov, R; Perentes, J; Piquilloud, L; Ris, HB; Wang, X | 1 |
Chao, K; Liu, Q; Ma, N; Sun, R; Sun, X; Wang, J; Yang, H; Yu, L; Zi, P | 1 |
Cai, Y; Fang, XL; Hong, HQ; Liu, PQ; Lu, J; Ye, JT; Yuan, J; Zhang, YH | 1 |
Jang, CG; Jeong, JH; Kim, HC; Lee, YJ; Nabeshima, T; Nah, SY; Park, SJ; Shin, EJ; Tran, HQ; Tran, TV | 1 |
He, X; Lai, K; Liu, Z; Xie, Y; Zhou, X | 1 |
Ding, K; Liu, Z; Xu, Y; Zhang, H; Zhang, W; Zhang, Y; Zhao, Q | 1 |
Baracat, MM; Campanini, MZ; Casagrande, R; Ferreira, VS; Fonseca, MJV; Georgetti, SR; Ivan, ALM; Martinez, RM; Steffen, VS; Vale, DL; Verri, WA; Vicentini, FTMC; Vilela, FMP | 1 |
Chen, J; Kan, S; Mao, J; Ni, L; Wang, M; Zhang, M; Zhang, Q; Zhang, W | 1 |
Comunoglu, C; Macit, A; Silan, C; Uzun, O; Yavuz, O; Yavuz, T; Yildirim, HA; Yuksel, H | 1 |
Arias, SC; Barlette, GP; Borges, RL; Camara, NO; de Almeida, DC; Fanelli, C; Fujihara, CK; Machado, FG; Malheiros, DM; Okabe, C; Zatz, R | 1 |
Chang, XL; Huang, M; Yang, HF; Zhang, P; Zhou, ZJ | 1 |
Abd-El-Fattah, MA; Abdelakader, NF; Zaki, HF | 1 |
Carson, JA; Fayad, R; Hand, GA; Murphy, EA; Puppa, MJ | 1 |
Chen, D; Jiao, XL; Zhang, DL; Zhang, J; Zhang, KJ; Zhang, MS | 1 |
Bhat, OM; Dhawan, V; Giridharan, NV; Kaul, D; Kumar, MJ; Kumar, PU | 1 |
Fan, Z; Han, Y; Li, J; Liu, W; Mao, Y; Wang, H; Wang, M; Xu, L; Zhang, D | 1 |
Chen, W; Cui, W; Jia, LL; Kang, YM; Qi, J; Qin, DN; Song, XA; Tan, H; Yu, XJ; Zhang, DM; Zhu, GQ | 1 |
Cau, SB; Ceron, CS; Gerlach, RF; Guimaraes, DA; Rizzi, E; Tanus-Santos, JE | 1 |
Hu, CY; Lu, LJ; Tang, WH; Xu, GY; Yuan, B; Zhang, HH; Zhou, Y; Zhou, YL; Zhu, HY | 1 |
Al-Dhabi, NA; Chen, S; Cui, Z; Deng, J; Duan, J; Duraipandiyan, V; Li, T; Liao, P; Liu, G; Ren, W; Tan, X; Wu, M; Yin, J; Yulong, Y; Zheng, J | 1 |
Cui, W; Fan, XY; Gao, HL; Kang, YM; Liu, JJ; Qi, J; Shi, XL; Song, XA; Tan, H; Yi, QY; Yu, XJ; Zhang, Y | 1 |
Carson, JA; Enos, RT; Hardee, JP; Murphy, EA; Narsale, AA; Puppa, MJ; VanderVeen, BN | 1 |
Chen, M; Kang, J; Li, B; Shen, S; Song, J; Yang, X | 1 |
Bongartz, LG; Braam, B; Cheng, C; Cramer, MJ; Doevendans, PA; Gaillard, CA; Goldschmeding, R; Joles, JA; Oosterhuis, NR; van Koppen, A; Verhaar, MC; Xu, YJ | 1 |
Kim, SH; Lee, CH; Lee, SM | 1 |
Berge, J; Bledsoe, C; Carlson, CG; Gatti, F; Lavin, J; Millman, G; Palmeiri, B; Rutter, J; Siegel, AL; Turin, E; Winders, WT | 1 |
Chen, CJ; Li, K; Li, XJ; Li, YN; Li, YY; Lu, XY | 1 |
Lei, RQ; Su, JY; Tang, YQ; Wang, YL; Zhang, SD; Zhang, ZP; Zheng, YJ | 1 |
Ban, TT; Chang, XL; Jiang, N; Shao, CF; Wu, QE; Yao, XM; Zhou, ZJ | 1 |
Chang, X; Huang, M; Shao, C; Wu, Q; Zhou, Z | 1 |
O, K; Siow, YL; Wu, N | 1 |
Chen, L; Li, S; Luo, Y; Sun, X; Zeng, K; Zhang, F; Zhong, S | 1 |
Bucher, M; Höcherl, K; Kurt, B; Schmidt, C | 1 |
Coderre, TJ; de Mos, M; Huygen, FJ; Laferrière, A; Millecamps, M; Pilkington, M; Sturkenboom, MC | 1 |
Chen, TK; Liu, NX; Wu, L; Zhang, QY; Zhang, ZW; Zhou, MT; Zhu, YF | 1 |
Gobe, G; Healy, H; Johnson, DW; Morais, C | 1 |
Gao, Y; Huang, F; Kan, SH; Tang, J; Yu, CL | 1 |
Auwardt, RB; Fraser, SA; Levidiotis, V; Mudge, SJ; Paizis, K; Power, DA | 1 |
Arendt-Nielsen, L; Ding, XL; Ge, HY; Ning, LP; Wang, C; Wang, YH; Yue, SW; Zhang, Y | 1 |
Jiang, CD; Li, WQ; Lü, LX; Song, XQ; Yang, YF; Zhong, ZX | 1 |
Bing, M; Chen, F; Chen, H; Chen, W; Sun, Y; Yang, S | 1 |
Rehni, AK; Singh, N | 1 |
Cheng, M; Feng, D; Kan, M; Li, Z; Xu, H; Yao, S; You, Z | 1 |
Kimura, K; Koyama, M; Matsumura, Y; Ohkita, M | 1 |
Bucher, M; Höcherl, K; Raspé, C; Rath, S; Sauvant, C | 1 |
Jiang, M; Wang, CM; Wang, HJ | 1 |
Fu, J; Mo, B; Wang, X; Xiong, W; Xu, Y; Zhang, Z | 1 |
Starkopf, J; Tähepõld, P; Vaage, J; Valen, G | 1 |
Caputi, AP; Chatterjee, PK; Cuzzocrea, E; Cuzzocrea, S; Di Paola, R; Fulia, F; Genovese, T; Ianaro, A; Patel, NS; Pisano, B; Rossi, A; Sautebin, L; Thiemermann, C | 1 |
Aeed, H; Bruck, R; Genina, O; Hochman, A; Pines, M; Schey, R | 1 |
Goldsteins, G; Koistinaho, J; Nurmi, A; Pihlaja, R; Vartiainen, N; Yrjänheikki, J | 1 |
Masamune, A; Shimosegawa, T | 1 |
Aleksić, A; Bobić, B; Djurković-Djaković, O; Klun, I; Nikolić, A | 1 |
Chen, MS; Fang, IM; Lin, CP; Yang, CH; Yang, CM | 2 |
Bartoli, MA; Ennis, TL; Mao, D; Parodi, FE; Thompson, RW | 1 |
Carlson, CG; Samadi, A; Siegel, A | 1 |
Beck-Schimmer, B; Booy, C; Fuhrer, T; Jamnicki, M; Neff, SB; Pasch, T; Reyes, L; Rosenberger, DS; Schimmer, RC; Schwendener, R; Suter, D | 1 |
Browder, IW; Gao, X; Ha, T; Haddad, GE; Izumo, S; Kao, RL; Kelley, JL; Li, C; Li, Y; McMullen, JR; Shioi, T; Williams, DL; Zhao, A | 1 |
Asai, T; Iwai, T; Kaneda, N; Komiya, T; Kuwabara, N; Miura, K; Nakatani, T; Tamada, S; Teramoto, K; Uchida, J; Yukimura, T | 1 |
Gao, HF; Li, YH; Tian, XF; Wang, ZZ; Yang, CM; Yao, JH; Zheng, SS | 1 |
Akin, M; Aksoy, RT; Ay, S; Aydin, NE; Demirbilek, S; Emre, MH; Gürünlüoğlu, K; Taş, E | 1 |
Ahtoniemi, T; Goldsteins, G; Kanninen, K; Keksa-Goldsteine, V; Koistinaho, J; Malm, T; Salminen, A | 1 |
Chai, JK; Liu, Q; Ma, ZF; Shen, CA; Sheng, ZY; Wu, YQ; Yao, YM; Yin, HN | 1 |
Aydin, C; Aytekin, FO; Kabay, B; Sacar, S; Simsek, NG; Teke, Z; Tekin, K; Yenisey, C | 1 |
Khachigian, L; Murrell, M; Ward, MR | 1 |
Chu, Y; Felder, RB; Kang, YM; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH | 1 |
Li, ST; Wang, LZ; Wang, YT; Wang, ZP | 1 |
Chan, JY; Chan, SH; Chang, AY; Cheng, HL; Dai, KY; Tsai, CY; Wu, CH | 1 |
Hirata, I; Inoue, T; Katsu, K; Murano, M; Murano, N; Nishikawa, T; Toshina, K; Wang, FY; Yasumoto, S | 1 |
Aytekin, FO; Bir, F; Erdem, E; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Yenisey, C | 1 |
Aydin, C; Aytekin, FO; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Tekin, K; Yenisey, C | 1 |
Dong, H; Fan, YH; Wang, HC; Yang, XD; Zhao, LY; Zheng, QS | 1 |
Lee, CZ; Xue, Z; Yang, GY; Young, WL; Zhu, Y | 1 |
Gao, JX; Guo, L; Li, J; Li, YH; Ma, XL; Wu, CZ | 1 |
Duan, ZH; Li, XY; Lu, JW; Ning, H; Wang, H; Wei, W; Xu, DX; Yan-Li, J; Zhang, C; Zhang, H; Zhao, L | 1 |
Chai, WS; Chen, BY; Fan, JX; Zhu, XM | 1 |
Bo, Y; Hongli, L; Mingyan, E; Shufeng, L | 1 |
Bini, R; Castagna, E; Cotogni, P; Olivero, G; Trombetta, A | 1 |
Jiang, XM; Tong, JX; Wang, H; Wang, YW; Xu, J; Xu, JH | 1 |
Liu, SF; Malik, AB; Ye, X | 1 |
Adams, MB; Kalyanaraman, B; Moore-Hilton, G; Nakanishi, AL; Pieper, GM; Roza, AM; Seibel, R | 1 |
Gómez del Arco, P; Lauzurica, P; Marazuela, M; Martínez, C; Martínez-Martínez, S; Redondo, JM; Sánchez-Madrid, F | 1 |
Boyle, EM; Canty, TG; Caps, MT; Farr, AL; Frank, N; Kovacich, JC; Morgan, EN; Pohlman, TH; Verrier, ED | 1 |
Carnuccio, R; D'Acquisto, F; Ialenti, A; Ianaro, A | 1 |
Pahan, K; Schmid, M | 1 |
2 review(s) available for pyrrolidine dithiocarbamate and Disease Models, Animal
Article | Year |
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[Anti-cytokine therapy for severe acute pancreatitis].
Topics: Acute Disease; Adalimumab; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Disease Models, Animal; Drug Design; Etanercept; Humans; Immunoglobulin G; Inflammation Mediators; Infliximab; Interleukin-1; Macrophage Migration-Inhibitory Factors; Pancreatitis; Pyrrolidines; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Thiocarbamates; Tumor Necrosis Factor-alpha | 2004 |
Molecular mechanisms and therapeutic strategies of chronic renal injury: the role of nuclear factor kappaB activation in the development of renal fibrosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Carbon; Disease Models, Animal; Fibrosis; Inflammation; Kidney Diseases; NF-kappa B; Oxides; Pyrrolidines; Rats; Renin-Angiotensin System; Thiocarbamates | 2006 |
89 other study(ies) available for pyrrolidine dithiocarbamate and Disease Models, Animal
Article | Year |
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Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Humans; Isoniazid; Liver; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats; Rifampin; Thiocarbamates; Tumor Necrosis Factor-alpha | 2020 |
Inhibiting nuclear factor-κB at different stages after intracerebral hemorrhage can influence the hemorrhage-induced brain injury in experimental models in vivo.
Topics: Animals; Cell Death; Cerebral Hemorrhage; Disease Models, Animal; Male; NF-kappa B; Pyrrolidines; Rats, Wistar; Thiocarbamates | 2020 |
mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats.
Topics: Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Hippocampus; Hypoxia; Male; Neurons; NF-kappa B; Protein Kinase Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Sleep Apnea, Obstructive; Thiocarbamates; TOR Serine-Threonine Kinases | 2021 |
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
Topics: Acetic Acid; Acute Lung Injury; Animals; Colon; Disease Models, Animal; Emodin; Humans; Intestinal Mucosa; Ischemia; Lung; Male; NF-kappa B; Pulmonary Surfactant-Associated Protein A; Pyrrolidines; Rats; Signal Transduction; Thiocarbamates; Toll-Like Receptor 4 | 2020 |
Small molecule natural compound targets the NF-κB signaling and ameliorates the development of osteoarthritis.
Topics: Animals; Antirheumatic Agents; Cells, Cultured; Chondrocytes; Disease Models, Animal; Extracellular Matrix; Female; Flavones; Interleukin-1beta; Joints; Male; Mice, Inbred C57BL; Molecular Docking Simulation; NF-kappa B; Osteoarthritis; Pyrrolidines; Signal Transduction; Thiocarbamates; Transcription Factor RelA | 2021 |
Pyrrolidine dithiocarbamate administered during ex-vivo lung perfusion promotes rehabilitation of injured donor rat lungs obtained after prolonged warm ischemia.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunity, Innate; In Vitro Techniques; Lung; Lung Injury; Lung Transplantation; Male; NF-kappa B; Perfusion; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thiocarbamates; Tissue and Organ Procurement; Tissue Donors; Transplantation Immunology; Warm Ischemia | 2017 |
Inhibition of nuclear factor-κB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Antioxidants; Disease Models, Animal; Female; Immunoglobulin Isotypes; Lipopolysaccharides; Mice; Mitochondria; Myeloid Differentiation Factor 88; NF-kappa B; Oxidative Stress; Protective Agents; Pyrrolidines; Signal Transduction; Thiocarbamates; Toll-Like Receptors | 2017 |
G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.
Topics: Animals; Cardiomegaly; Cell Nucleus; Disease Models, Animal; Gene Knockdown Techniques; GTP-Binding Protein Regulators; Isoproterenol; Male; Myocytes, Cardiac; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Rats, Sprague-Dawley; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Thiocarbamates; Transcription Factor RelA | 2018 |
Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Down-Regulation; Ginkgolides; Hippocampus; Lactones; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Phencyclidine; Platelet Membrane Glycoproteins; Prefrontal Cortex; Psychoses, Substance-Induced; Pyrrolidines; Receptors, G-Protein-Coupled; RNA, Messenger; Thiocarbamates | 2018 |
Gli2 Mediated Activation of Hedgehog Signaling Attenuates Acute Pancreatitis via Balancing Inflammatory Cytokines in Mice.
Topics: Acinar Cells; Acute Disease; Animals; Cell Line; Ceruletide; Cytokines; Disease Models, Animal; Hedgehog Proteins; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pancreatitis; Pyrrolidines; Signal Transduction; Thiocarbamates; Up-Regulation; Zinc Finger Protein Gli2 | 2018 |
Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Case-Control Studies; Cell Line; Cell Proliferation; Disease Models, Animal; Female; HMGB2 Protein; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyrrolidines; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Time Factors; Transcription Factor RelA; Young Adult | 2018 |
Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Drug Compounding; Emulsions; Inflammation Mediators; Lipid Peroxidation; Mice, Hairless; Oxidative Stress; Pyrrolidines; Skin; Sunburn; Thiocarbamates; Ultraviolet Rays | 2018 |
NF-κB activation contributes to parathyroid cell proliferation in chronic kidney disease.
Topics: Adult; Animals; Biomarkers; Calcitriol; Cell Proliferation; Disease Models, Animal; Female; Humans; Hyperparathyroidism, Secondary; Hyperplasia; Male; Middle Aged; NF-kappa B; Parathyroid Glands; Phosphorylation; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Calcitriol; Renal Insufficiency, Chronic; Signal Transduction; Thiocarbamates; Transcription Factor RelA | 2018 |
Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2013 |
NF-κB activation mediates crystal translocation and interstitial inflammation in adenine overload nephropathy.
Topics: Adenine; Animals; Disease Models, Animal; Fibrosis; Granuloma; Inflammation Mediators; Kidney; Male; Nephritis, Interstitial; Nephrosclerosis; NF-kappa B; Pyrrolidines; Rats; Rats, Wistar; Thiocarbamates | 2013 |
[Effects of pyrrolidine dithiocarbamate on expressions of α-smooth muscle actin, integrin α5 and fibronectin in acute paraquat poisoned rats].
Topics: Actins; Animals; Disease Models, Animal; Fibronectins; Integrin alpha5; Male; Paraquat; Pulmonary Fibrosis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2013 |
Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dopamine; Glutathione; Hippocampus; Interleukin-10; Interleukin-1beta; Male; Neuroprotective Agents; Norepinephrine; Pyrrolidines; Rats; Rats, Wistar; Scopolamine; Serotonin; Thiocarbamates | 2014 |
Cachectic skeletal muscle response to a novel bout of low-frequency stimulation.
Topics: AMP-Activated Protein Kinases; Animals; Cachexia; Cytochromes c; Disease Models, Animal; DNA-Binding Proteins; Electric Stimulation Therapy; Gene Expression Regulation; Genes, APC; Hand Strength; High Mobility Group Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Contraction; Muscle, Skeletal; Nuclear Respiratory Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Pyrrolidines; RNA, Messenger; STAT3 Transcription Factor; Thiocarbamates; Transcription Factors | 2014 |
Phospholipases A-II (PLA2-II) induces acute pancreatitis through activation of the transcription factor NF-kappaB.
Topics: Acute Disease; Animals; Disease Models, Animal; Group II Phospholipases A2; Inflammation Mediators; NF-kappa B; Pancreas; Pancreatitis; Pyrrolidines; Rats, Wistar; RNA Interference; RNA, Small Interfering; Severity of Illness Index; Signal Transduction; Taurocholic Acid; Thiocarbamates; Time Factors | 2014 |
Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E-/- mice.
Topics: Animals; CD36 Antigens; Coronary Artery Disease; Disease Models, Animal; Down-Regulation; Inflammation; Interleukin-18; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred Strains; Pyrrolidines; RNA, Messenger; Thiocarbamates | 2015 |
Activation of NF-κB signaling pathway in HSV-1-induced mouse facial palsy: Possible relation to therapeutic effect of glucocorticoids.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Brain Stem; Cyclooxygenase 2; Disease Models, Animal; Facial Paralysis; Glucocorticoids; Herpesvirus 1, Human; Hormone Antagonists; I-kappa B Kinase; Male; Methylprednisolone Hemisuccinate; Mice, Inbred BALB C; Mifepristone; NF-kappa B; Pyrrolidines; Receptors, Glucocorticoid; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.
Topics: Animals; Arterial Pressure; Biomarkers; Cardiomegaly; Cytokines; Disease Models, Animal; Hypertension; Inflammation Mediators; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Sympathetic Nervous System; Thiocarbamates; Time Factors; Transcription Factor RelA | 2015 |
The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension.
Topics: Animals; Blood Pressure; Collagen; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinase 2; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats, Wistar; Thiocarbamates; Time Factors; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2015 |
TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity.
Topics: Animals; Cells, Cultured; Colon; Cystathionine beta-Synthase; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Neurons; Pain Perception; Pain Threshold; Pyrrolidines; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Toll-Like Receptor 4; Transcription Factor RelA; Up-Regulation; Visceral Pain | 2015 |
Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Male; Mice; Mice, Inbred ICR; NF-kappa B; Occludin; Phospholipid Hydroperoxide Glutathione Peroxidase; Pyrrolidines; Signal Transduction; Thiocarbamates; Zonula Occludens-1 Protein | 2015 |
NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Biomarkers; Caspase 1; Disease Models, Animal; Epinephrine; Hypertension; I-kappa B Kinase; Infusions, Parenteral; Interleukin-1beta; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Norepinephrine; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Phosphorylation; Pyrrolidines; Rats, Inbred Dahl; Signal Transduction; Sodium Chloride, Dietary; Sympathetic Nervous System; Thiocarbamates; Transcription Factor RelA | 2016 |
Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; Cachexia; Cell Line, Tumor; Disease Models, Animal; Humans; Lipid Metabolism; Liver; Mice; Mice, Mutant Strains; Muscle, Skeletal; Neoplasms, Experimental; Pyrrolidines; Signal Transduction; STAT3 Transcription Factor; Thiocarbamates | 2016 |
Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB.
Topics: Administration, Oral; Animals; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescein-5-isothiocyanate; Immunoglobulin E; Male; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Phthalic Acids; Pyrrolidines; Signal Transduction; Skin; STAT Transcription Factors; Th2 Cells; Thiocarbamates; Thymic Stromal Lymphopoietin | 2016 |
Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cardio-Renal Syndrome; Coronary Vessels; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrosis; Heart; Kidney; Kidney Function Tests; Ligation; Losartan; Male; Metoprolol; Molsidomine; Nephrectomy; NF-kappa B; Nitric Oxide Donors; Pyrrolidines; Rats, Inbred Lew; Spin Labels; Sympatholytics; Thiocarbamates | 2017 |
Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cyclooxygenase 2; Cytoprotection; Disease Models, Animal; Endothelin-1; Gene Expression Regulation; Glutathione; Heme Oxygenase (Decyclizing); Lipid Peroxidation; Liver; Liver Circulation; Male; Microcirculation; NF-kappa B; Nitric Oxide Synthase; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Reperfusion Injury; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2008 |
Treatment with inhibitors of the NF-kappaB pathway improves whole body tension development in the mdx mouse.
Topics: Animals; Antioxidants; Cholagogues and Choleretics; Disease Models, Animal; Female; Male; Mice; Mice, Inbred mdx; Muscle Strength; Muscle Stretching Exercises; Muscle Tonus; Muscle Weakness; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NF-kappa B; Pyrrolidines; Recovery of Function; Thiocarbamates; Transcription Factor RelA; Treatment Outcome; Ursodeoxycholic Acid | 2009 |
Intervention of pyrrolidine dithiocarbamate and tetrandrine on cellular calcium overload of pancreatic acinar cells induced by serum and ascitic fluid from rats with acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Ascitic Fluid; Benzylisoquinolines; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Deoxycholic Acid; Disease Models, Animal; NF-kappa B; Pancreas, Exocrine; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Time Factors | 2009 |
Effects of gut barrier dysfunction and NF-kappaB activation on aggravating mechanism of severe acute pancreatitis.
Topics: Animals; Antioxidants; Bacterial Translocation; Colon, Ascending; Disease Models, Animal; Intercellular Adhesion Molecule-1; Kidney; Lipopolysaccharides; Liver; Lung; Male; NF-kappa B; Pancreatitis, Acute Necrotizing; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Lung; Male; Matrix Metalloproteinase 2; Paraquat; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2008 |
Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Humans; Lung Injury; Male; Paraquat; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiocarbamates; Treatment Outcome | 2009 |
Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation.
Topics: Animals; Antioxidants; Cell Nucleus; Cyclic N-Oxides; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hepatitis; Homocysteine; Hyperhomocysteinemia; I-kappa B Proteins; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Phosphorylation; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spin Labels; Superoxides; Thiocarbamates; Time Factors | 2009 |
Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats.
Topics: Animals; Coronary Thrombosis; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Myocardium; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tumor Necrosis Factor-alpha; Ventricular Dysfunction | 2010 |
Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo.
Topics: Acute Kidney Injury; Animals; Antioxidants; Aquaporin 2; Cecum; Disease Models, Animal; Down-Regulation; Interleukin-1beta; Ligation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrrolidines; Receptors, Vasopressin; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha; Vasopressins | 2010 |
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).
Topics: Animals; Cell Nucleus; Cold Temperature; Complex Regional Pain Syndromes; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Muscle, Skeletal; NF-kappa B; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Rats, Long-Evans; Reperfusion Injury; Spinal Cord; Thiocarbamates; Time Factors | 2009 |
Antioxidant inhibits HMGB1 expression and reduces pancreas injury in rats with severe acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Down-Regulation; HMGB1 Protein; Male; NF-kappa B; Pancreas; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
Inhibition of nuclear factor kappa B attenuates tumour progression in an animal model of renal cell carcinoma.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Humans; I-kappa B Kinase; Kidney Neoplasms; Male; Mice; Mice, SCID; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Thiocarbamates; Weight Loss; Xenograft Model Antitumor Assays | 2010 |
Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury.
Topics: Acute Disease; Amylases; Animals; Biomarkers; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Lung; Lung Injury; Male; NF-kappa B; Nitric Oxide Synthase Type II; Pancreas; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Thiocarbamates; Time Factors; Transcription Factor RelA | 2010 |
Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-ĸB in a model of membranous glomerulonephritis.
Topics: Animals; Dexamethasone; Disease Models, Animal; Glomerulonephritis, Membranous; Interleukin-1beta; Kidney Glomerulus; Male; NF-kappa B; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sheep; Signal Transduction; Thiocarbamates | 2010 |
Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Hyperalgesia; I-kappa B Proteins; Male; Nerve Compression Syndromes; Neuralgia; NF-kappa B; Nitric Oxide; Nitriles; Phorbols; Pyrrolidines; Rats; Rats, Wistar; Signal Transduction; Sulfones; Thiocarbamates; TRPV Cation Channels | 2011 |
[Effect of pyrrolidinedithiocarbamate on neural developmental disorder of adult offspring with maternal systemic exposure to Poly(I:C) during pregnancy].
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Female; Inhibition, Psychological; Interleukin-10; Maternal Exposure; NF-kappa B; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha | 2011 |
Autophagy regulation by the nuclear factor κB signal axis in acute pancreatitis.
Topics: Amylases; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomarkers; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; NF-kappa B; Oligopeptides; Pancreas; Pancreatitis, Acute Necrotizing; Pyrrolidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurocholic Acid; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro.
Topics: Animals; Benzoxazines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Ileum; Male; Mice; Morphine; Naloxone; NF-kappa B; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, CCR2; Substance Withdrawal Syndrome; Thiocarbamates | 2012 |
Nuclear factor-kappa B mediates one-lung ventilation-induced acute lung injury in rabbits.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation Mediators; Interleukin-8; Male; NF-kappa B; Oxygen; Pyrrolidines; Rabbits; Respiration, Artificial; Thiocarbamates; Tumor Necrosis Factor-alpha | 2012 |
Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats.
Topics: Animals; Atrasentan; Desoxycorticosterone; Disease Models, Animal; Disease Susceptibility; Endothelin-1; Hypertension; Kidney Diseases; Male; NF-kappa B; Nitric Oxide; Nitroarginine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Severity of Illness Index; Sodium Chloride, Dietary; Thiocarbamates | 2012 |
NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis.
Topics: Animals; Cecum; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; Down-Regulation; Interferon-gamma; Interleukin-1beta; Interleukin-6; Ligation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Punctures; Pyrrolidines; Receptors, Chemokine; RNA, Messenger; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha | 2013 |
Effect of NF‑κB inhibitor on high‑mobility group protein B1 expression in a COPD rat model.
Topics: Animals; Disease Models, Animal; Gene Expression; HMGB1 Protein; Lung; Male; NF-kappa B; Pulmonary Disease, Chronic Obstructive; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Thiocarbamates | 2013 |
Nuclear factor-kappa B in signal conduction of protein kinase C in T lymphocytes from an asthmatic guinea pig model.
Topics: Animals; Apoptosis; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Cell Nucleus; Disease Models, Animal; Guinea Pigs; Immunohistochemistry; In Situ Hybridization; Interleukin-4; Interleukin-5; Male; NF-kappa B; Protein Kinase C; Pyrrolidines; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiocarbamates | 2002 |
Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heart.
Topics: Analysis of Variance; Animals; Antioxidants; Coronary Circulation; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Hyperoxia; I-kappa B Proteins; Immunoblotting; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Reperfusion Injury; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Oxygen Inhalation Therapy; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Recovery of Function; Thiocarbamates; Time Factors; Transcriptional Activation; Ventricular Pressure | 2003 |
Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice.
Topics: Animals; Antioxidants; Blotting, Western; Chemotaxis, Leukocyte; Disease Models, Animal; Drug Evaluation, Preclinical; Immunohistochemistry; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Multiple Organ Failure; Neutrophils; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Poly(ADP-ribose) Polymerases; Pyrrolidines; Random Allocation; Thiocarbamates; Time Factors; Tyrosine; Zymosan | 2003 |
A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis.
Topics: Animals; Antioxidants; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyproline; Immunohistochemistry; In Situ Hybridization; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Experimental; Male; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Thioacetamide; Thiobarbituric Acid Reactive Substances; Thiocarbamates | 2004 |
Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Microglia; Neurons; Neuroprotective Agents; Neurotoxins; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Wistar; Thiocarbamates; Time Factors; Treatment Outcome | 2004 |
Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate.
Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Female; Mice; Naphthoquinones; Oocysts; Pyrrolidines; Thiocarbamates; Toxoplasma; Toxoplasmosis | 2005 |
Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis.
Topics: Animals; Aqueous Humor; Autoimmune Diseases; Chemokines; Ciliary Body; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression; Injections, Intraperitoneal; Iris; Leukocyte Count; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Uveitis, Anterior | 2005 |
Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB.
Topics: Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Electrophoretic Mobility Shift Assay; Interleukin-1; Interleukin-6; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrrolidines; Thiocarbamates; Transcription Factor AP-1 | 2005 |
Effects of pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, on cytokine expression and ocular inflammation in experimental autoimmune anterior uveitis.
Topics: Animals; Aqueous Humor; Autoimmune Diseases; Ciliary Body; Cytokines; Disease Models, Animal; Injections, Intraperitoneal; Iris; Leukocyte Count; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Thiocarbamates; Uveitis, Anterior | 2005 |
Chronic treatment with agents that stabilize cytosolic IkappaB-alpha enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch.
Topics: Animals; Antioxidants; Calcium Channel Blockers; Calcium Signaling; Cell Survival; Cytosol; Disease Models, Animal; Drug Administration Schedule; Female; Gadolinium; I-kappa B Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Sarcolemma; Thiocarbamates | 2005 |
Pulmonary aspiration: new therapeutic approaches in the experimental model.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokine CCL2; Disease Models, Animal; Inflammation Mediators; Macrophages, Alveolar; Male; NF-kappa B; Pneumonia, Aspiration; Pyrrolidines; Rats; Rats, Wistar; Respiratory Distress Syndrome; Thiocarbamates; Tumor Necrosis Factor-alpha | 2005 |
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
Topics: Animals; Antioxidants; Body Weight; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Transgenic; NF-kappa B; Organ Size; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrrolidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thiocarbamates; TOR Serine-Threonine Kinases | 2005 |
Protective effect of pyrrolidine dithiocarbamate on liver injury induced by intestinal ischemia-reperfusion in rats.
Topics: Animals; Antioxidants; Biomarkers; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestine, Small; Liver Diseases; Male; NF-kappa B; Nitric Oxide; Pyrrolidines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Thiocarbamates; Tumor Necrosis Factor-alpha | 2006 |
The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Female; Ligation; Lipid Peroxidation; Liver; Liver Diseases; Liver Function Tests; NF-kappa B; Oxidative Stress; Peroxidase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sulfasalazine; Superoxide Dismutase; Thiocarbamates; Tumor Necrosis Factor-alpha | 2006 |
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis.
Topics: Animals; Animals, Genetically Modified; Antioxidants; Death; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Humans; Motor Neuron Disease; Neuroglia; Pyrrolidines; Rats; Superoxide Dismutase; Survival Rate; Thiocarbamates | 2007 |
[Effect of ubiquitin-proteasome pathway on inflammatory reaction in intestine and its barrier function in rats with postburn sepsis].
Topics: Amine Oxidase (Copper-Containing); Animals; Burns; Cysteine Proteinase Inhibitors; Disease Models, Animal; Intestinal Mucosa; Intestines; Leupeptins; Male; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha; Ubiquitin | 2006 |
Effects of pyrrolidine dithiocarbamate on healing of colonic anastomoses in the cecal ligation and puncture model of intraperitoneal sepsis in rats.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Cecum; Disease Models, Animal; Glutathione; Ligation; Lipid Peroxidation; Male; Peritoneal Diseases; Punctures; Pyrrolidines; Rats; Rats, Wistar; Sepsis; Thiocarbamates; Wound Healing | 2007 |
The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting.
Topics: Angioplasty, Balloon; Animals; Antioxidants; Blood Flow Velocity; Carotid Artery, Common; Carotid Stenosis; Coronary Restenosis; Diet, Atherogenic; Disease Models, Animal; DNA, Catalytic; Gene Expression Regulation; Genes, jun; Proto-Oncogene Proteins c-jun; Pyrrolidines; Rabbits; Stents; Thiocarbamates | 2007 |
Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eplerenone; Heart Failure; Male; NF-kappa B; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spironolactone; Thiocarbamates | 2007 |
Antioxidant attenuates acute lung injury after cardiopulmonary bypass in rats.
Topics: Animals; Antioxidants; Cardiopulmonary Bypass; Disease Models, Animal; Female; Male; Models, Cardiovascular; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Thiocarbamates | 2007 |
Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death.
Topics: Animals; Blood Pressure; Brain Death; Cyclic GMP-Dependent Protein Kinases; Diamines; Disease Models, Animal; Ditiocarb; Enzyme Induction; Heart Rate; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Reproducibility of Results; Thiocarbamates; Time Factors; Transcription, Genetic; Tropicamide; Tyrosine | 2007 |
Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Indicators and Reagents; Inflammation; Injections, Intraperitoneal; Interleukin-1beta; Mice; Mice, Inbred BALB C; NF-kappa B; Pyrrolidines; Severity of Illness Index; Thiocarbamates; Tumor Necrosis Factor-alpha | 2007 |
Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model.
Topics: Animals; Antioxidants; Capillary Permeability; Disease Models, Animal; Glutathione; Lung; Malondialdehyde; Mesenteric Vascular Occlusion; Neutrophil Activation; Neutrophils; Nitrates; Nitrites; Pulmonary Edema; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Thiocarbamates | 2007 |
Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia/reperfusion injury on healing of colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Colon; Colonic Diseases; Disease Models, Animal; Glutathione; Hydroxyproline; Male; Malondialdehyde; Peroxidase; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Thiocarbamates; Wound Healing | 2007 |
Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis.
Topics: Animals; Arginine Vasopressin; Cardiomyopathies; Cells, Cultured; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; Fibrosis; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Myocardium; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spectrophotometry; Thiocarbamates | 2007 |
Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage.
Topics: Adenoviridae; Animals; Anti-Bacterial Agents; Antioxidants; Brain; Cerebral Hemorrhage; Disease Models, Animal; Humans; Intracranial Arteriovenous Malformations; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Minocycline; Pyrrolidines; Thiocarbamates; Vascular Endothelial Growth Factor A | 2007 |
Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis.
Topics: Active Transport, Cell Nucleus; Alanine Transaminase; Animals; Concanavalin A; Disease Models, Animal; Enzyme Induction; Hepatitis; I-kappa B Proteins; Liver; Male; Mice; Mice, Inbred BALB C; Necrosis; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrrolidines; Severity of Illness Index; Thiocarbamates; Time Factors; Transcription Factor RelA; Up-Regulation | 2008 |
Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Galactosamine; Glutathione; Hepatitis; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Mice, Inbred Strains; Mycobacterium bovis; NF-kappa B; Nitric Oxide; Pyrrolidines; Thiocarbamates; Tumor Necrosis Factor-alpha | 2008 |
[Expression of nuclear factor-kappa B and effect of pyrrolidine dithiocarbamate in Pseudomonas aeruginosa pneumonia rat model].
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Lung; Male; NF-kappa B; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Tumor Necrosis Factor-alpha | 2007 |
Effects of pyrrolidine dithiocarbamate on antioxidant enzymes in cardiomyopathy induced by adriamycin in rats.
Topics: Animals; Antioxidants; Biopsy, Needle; Cardiomyopathies; Disease Models, Animal; Doxorubicin; Enzyme Activation; Glutathione Peroxidase; Immunohistochemistry; Male; Myocardium; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reference Values; Sensitivity and Specificity; Superoxide Dismutase; Thiocarbamates | 2008 |
Effects of dimethyl sulfoxide, pyrrolidine dithiocarbamate, and methylprednisolone on nuclear factor-kappaB and heat shock protein 70 in a rat model of hemorrhagic shock.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; HSP70 Heat-Shock Proteins; Inflammation Mediators; Male; Methylprednisolone; NF-kappa B; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Shock, Hemorrhagic; Thiocarbamates; Up-Regulation | 2008 |
The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis.
Topics: Actins; Animals; Collagen Type IV; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Glomerulonephritis, Membranoproliferative; Interleukin-1beta; Interleukin-6; Isoantibodies; Kidney Glomerulus; NF-kappa B; Proliferating Cell Nuclear Antigen; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thy-1 Antigens | 2008 |
In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock.
Topics: Animals; Calcium; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Hypotension; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Shock, Septic; Thiocarbamates; Time Factors | 1997 |
Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate.
Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Graft Rejection; Graft Survival; Guanidines; Heart Transplantation; Injections, Subcutaneous; Iron-Sulfur Proteins; Macromolecular Substances; Male; Myocardium; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Pyrrolidines; Rats; Rats, Inbred Lew; Rats, Inbred WF; Thiocarbamates; Transplantation, Heterotopic | 1998 |
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.
Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; DNA-Binding Proteins; Female; I-kappa B Proteins; Lipopolysaccharides; Liver; Lung; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Shock, Septic; Thiocarbamates; Tumor Necrosis Factor-alpha | 1999 |
Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome.
Topics: Acidosis; Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypotension; Infusions, Intravenous; Interleukin-1; NF-kappa B; Proline; Pyrrolidines; Rabbits; Random Allocation; Systemic Inflammatory Response Syndrome; Thiocarbamates | 1999 |
Nuclear factor-kappaB activation mediates inducible nitric oxide synthase expression in carrageenin-induced rat pleurisy.
Topics: Animals; Antioxidants; Carrageenan; Cell Movement; Cell Nucleus; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exudates and Transudates; Leukocyte Count; Leukocytes; Male; NF-kappa B; NF-kappa B p50 Subunit; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pleural Effusion; Pleurisy; Pyrrolidines; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Thiocarbamates; Tosyllysine Chloromethyl Ketone; Transcription Factor RelA | 1999 |
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Multiple Sclerosis; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Spinal Cord; Thiocarbamates | 2000 |