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pyrrolidine dithiocarbamate and Disease Models, Animal

pyrrolidine dithiocarbamate has been researched along with Disease Models, Animal in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (5.49)18.2507
2000's43 (47.25)29.6817
2010's38 (41.76)24.3611
2020's5 (5.49)2.80

Authors

AuthorsStudies
He, X; Song, Y; Wang, L; Xu, J1
Huang, Q; Li, F; Song, Y; Xu, Z; Zhang, Z1
Chen, BB; Cui, PP; Li, YZ; Wang, Y; Yi, S; Zhang, CQ1
Cai, W; Jiang, N; Jin, X; Li, G; Ma, C; Qian, J; Zheng, J1
Chen, B; Gong, SL; Shen, ZH; Wu, B; Xu, Z1
Abdelnour, E; Eckert, P; Francioli, C; Gronchi, F; Krueger, T; Liaudet, L; Lugrin, J; Parapanov, R; Perentes, J; Piquilloud, L; Ris, HB; Wang, X1
Chao, K; Liu, Q; Ma, N; Sun, R; Sun, X; Wang, J; Yang, H; Yu, L; Zi, P1
Cai, Y; Fang, XL; Hong, HQ; Liu, PQ; Lu, J; Ye, JT; Yuan, J; Zhang, YH1
Jang, CG; Jeong, JH; Kim, HC; Lee, YJ; Nabeshima, T; Nah, SY; Park, SJ; Shin, EJ; Tran, HQ; Tran, TV1
He, X; Lai, K; Liu, Z; Xie, Y; Zhou, X1
Ding, K; Liu, Z; Xu, Y; Zhang, H; Zhang, W; Zhang, Y; Zhao, Q1
Baracat, MM; Campanini, MZ; Casagrande, R; Ferreira, VS; Fonseca, MJV; Georgetti, SR; Ivan, ALM; Martinez, RM; Steffen, VS; Vale, DL; Verri, WA; Vicentini, FTMC; Vilela, FMP1
Chen, J; Kan, S; Mao, J; Ni, L; Wang, M; Zhang, M; Zhang, Q; Zhang, W1
Comunoglu, C; Macit, A; Silan, C; Uzun, O; Yavuz, O; Yavuz, T; Yildirim, HA; Yuksel, H1
Arias, SC; Barlette, GP; Borges, RL; Camara, NO; de Almeida, DC; Fanelli, C; Fujihara, CK; Machado, FG; Malheiros, DM; Okabe, C; Zatz, R1
Chang, XL; Huang, M; Yang, HF; Zhang, P; Zhou, ZJ1
Abd-El-Fattah, MA; Abdelakader, NF; Zaki, HF1
Carson, JA; Fayad, R; Hand, GA; Murphy, EA; Puppa, MJ1
Chen, D; Jiao, XL; Zhang, DL; Zhang, J; Zhang, KJ; Zhang, MS1
Bhat, OM; Dhawan, V; Giridharan, NV; Kaul, D; Kumar, MJ; Kumar, PU1
Fan, Z; Han, Y; Li, J; Liu, W; Mao, Y; Wang, H; Wang, M; Xu, L; Zhang, D1
Chen, W; Cui, W; Jia, LL; Kang, YM; Qi, J; Qin, DN; Song, XA; Tan, H; Yu, XJ; Zhang, DM; Zhu, GQ1
Cau, SB; Ceron, CS; Gerlach, RF; Guimaraes, DA; Rizzi, E; Tanus-Santos, JE1
Hu, CY; Lu, LJ; Tang, WH; Xu, GY; Yuan, B; Zhang, HH; Zhou, Y; Zhou, YL; Zhu, HY1
Al-Dhabi, NA; Chen, S; Cui, Z; Deng, J; Duan, J; Duraipandiyan, V; Li, T; Liao, P; Liu, G; Ren, W; Tan, X; Wu, M; Yin, J; Yulong, Y; Zheng, J1
Cui, W; Fan, XY; Gao, HL; Kang, YM; Liu, JJ; Qi, J; Shi, XL; Song, XA; Tan, H; Yi, QY; Yu, XJ; Zhang, Y1
Carson, JA; Enos, RT; Hardee, JP; Murphy, EA; Narsale, AA; Puppa, MJ; VanderVeen, BN1
Chen, M; Kang, J; Li, B; Shen, S; Song, J; Yang, X1
Bongartz, LG; Braam, B; Cheng, C; Cramer, MJ; Doevendans, PA; Gaillard, CA; Goldschmeding, R; Joles, JA; Oosterhuis, NR; van Koppen, A; Verhaar, MC; Xu, YJ1
Kim, SH; Lee, CH; Lee, SM1
Berge, J; Bledsoe, C; Carlson, CG; Gatti, F; Lavin, J; Millman, G; Palmeiri, B; Rutter, J; Siegel, AL; Turin, E; Winders, WT1
Chen, CJ; Li, K; Li, XJ; Li, YN; Li, YY; Lu, XY1
Lei, RQ; Su, JY; Tang, YQ; Wang, YL; Zhang, SD; Zhang, ZP; Zheng, YJ1
Ban, TT; Chang, XL; Jiang, N; Shao, CF; Wu, QE; Yao, XM; Zhou, ZJ1
Chang, X; Huang, M; Shao, C; Wu, Q; Zhou, Z1
O, K; Siow, YL; Wu, N1
Chen, L; Li, S; Luo, Y; Sun, X; Zeng, K; Zhang, F; Zhong, S1
Bucher, M; Höcherl, K; Kurt, B; Schmidt, C1
Coderre, TJ; de Mos, M; Huygen, FJ; Laferrière, A; Millecamps, M; Pilkington, M; Sturkenboom, MC1
Chen, TK; Liu, NX; Wu, L; Zhang, QY; Zhang, ZW; Zhou, MT; Zhu, YF1
Gobe, G; Healy, H; Johnson, DW; Morais, C1
Gao, Y; Huang, F; Kan, SH; Tang, J; Yu, CL1
Auwardt, RB; Fraser, SA; Levidiotis, V; Mudge, SJ; Paizis, K; Power, DA1
Arendt-Nielsen, L; Ding, XL; Ge, HY; Ning, LP; Wang, C; Wang, YH; Yue, SW; Zhang, Y1
Jiang, CD; Li, WQ; Lü, LX; Song, XQ; Yang, YF; Zhong, ZX1
Bing, M; Chen, F; Chen, H; Chen, W; Sun, Y; Yang, S1
Rehni, AK; Singh, N1
Cheng, M; Feng, D; Kan, M; Li, Z; Xu, H; Yao, S; You, Z1
Kimura, K; Koyama, M; Matsumura, Y; Ohkita, M1
Bucher, M; Höcherl, K; Raspé, C; Rath, S; Sauvant, C1
Jiang, M; Wang, CM; Wang, HJ1
Fu, J; Mo, B; Wang, X; Xiong, W; Xu, Y; Zhang, Z1
Starkopf, J; Tähepõld, P; Vaage, J; Valen, G1
Caputi, AP; Chatterjee, PK; Cuzzocrea, E; Cuzzocrea, S; Di Paola, R; Fulia, F; Genovese, T; Ianaro, A; Patel, NS; Pisano, B; Rossi, A; Sautebin, L; Thiemermann, C1
Aeed, H; Bruck, R; Genina, O; Hochman, A; Pines, M; Schey, R1
Goldsteins, G; Koistinaho, J; Nurmi, A; Pihlaja, R; Vartiainen, N; Yrjänheikki, J1
Masamune, A; Shimosegawa, T1
Aleksić, A; Bobić, B; Djurković-Djaković, O; Klun, I; Nikolić, A1
Chen, MS; Fang, IM; Lin, CP; Yang, CH; Yang, CM2
Bartoli, MA; Ennis, TL; Mao, D; Parodi, FE; Thompson, RW1
Carlson, CG; Samadi, A; Siegel, A1
Beck-Schimmer, B; Booy, C; Fuhrer, T; Jamnicki, M; Neff, SB; Pasch, T; Reyes, L; Rosenberger, DS; Schimmer, RC; Schwendener, R; Suter, D1
Browder, IW; Gao, X; Ha, T; Haddad, GE; Izumo, S; Kao, RL; Kelley, JL; Li, C; Li, Y; McMullen, JR; Shioi, T; Williams, DL; Zhao, A1
Asai, T; Iwai, T; Kaneda, N; Komiya, T; Kuwabara, N; Miura, K; Nakatani, T; Tamada, S; Teramoto, K; Uchida, J; Yukimura, T1
Gao, HF; Li, YH; Tian, XF; Wang, ZZ; Yang, CM; Yao, JH; Zheng, SS1
Akin, M; Aksoy, RT; Ay, S; Aydin, NE; Demirbilek, S; Emre, MH; Gürünlüoğlu, K; Taş, E1
Ahtoniemi, T; Goldsteins, G; Kanninen, K; Keksa-Goldsteine, V; Koistinaho, J; Malm, T; Salminen, A1
Chai, JK; Liu, Q; Ma, ZF; Shen, CA; Sheng, ZY; Wu, YQ; Yao, YM; Yin, HN1
Aydin, C; Aytekin, FO; Kabay, B; Sacar, S; Simsek, NG; Teke, Z; Tekin, K; Yenisey, C1
Khachigian, L; Murrell, M; Ward, MR1
Chu, Y; Felder, RB; Kang, YM; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH1
Li, ST; Wang, LZ; Wang, YT; Wang, ZP1
Chan, JY; Chan, SH; Chang, AY; Cheng, HL; Dai, KY; Tsai, CY; Wu, CH1
Hirata, I; Inoue, T; Katsu, K; Murano, M; Murano, N; Nishikawa, T; Toshina, K; Wang, FY; Yasumoto, S1
Aytekin, FO; Bir, F; Erdem, E; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Yenisey, C1
Aydin, C; Aytekin, FO; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Tekin, K; Yenisey, C1
Dong, H; Fan, YH; Wang, HC; Yang, XD; Zhao, LY; Zheng, QS1
Lee, CZ; Xue, Z; Yang, GY; Young, WL; Zhu, Y1
Gao, JX; Guo, L; Li, J; Li, YH; Ma, XL; Wu, CZ1
Duan, ZH; Li, XY; Lu, JW; Ning, H; Wang, H; Wei, W; Xu, DX; Yan-Li, J; Zhang, C; Zhang, H; Zhao, L1
Chai, WS; Chen, BY; Fan, JX; Zhu, XM1
Bo, Y; Hongli, L; Mingyan, E; Shufeng, L1
Bini, R; Castagna, E; Cotogni, P; Olivero, G; Trombetta, A1
Jiang, XM; Tong, JX; Wang, H; Wang, YW; Xu, J; Xu, JH1
Liu, SF; Malik, AB; Ye, X1
Adams, MB; Kalyanaraman, B; Moore-Hilton, G; Nakanishi, AL; Pieper, GM; Roza, AM; Seibel, R1
Gómez del Arco, P; Lauzurica, P; Marazuela, M; Martínez, C; Martínez-Martínez, S; Redondo, JM; Sánchez-Madrid, F1
Boyle, EM; Canty, TG; Caps, MT; Farr, AL; Frank, N; Kovacich, JC; Morgan, EN; Pohlman, TH; Verrier, ED1
Carnuccio, R; D'Acquisto, F; Ialenti, A; Ianaro, A1
Pahan, K; Schmid, M1

Reviews

2 review(s) available for pyrrolidine dithiocarbamate and Disease Models, Animal

ArticleYear
[Anti-cytokine therapy for severe acute pancreatitis].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:11

    Topics: Acute Disease; Adalimumab; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Disease Models, Animal; Drug Design; Etanercept; Humans; Immunoglobulin G; Inflammation Mediators; Infliximab; Interleukin-1; Macrophage Migration-Inhibitory Factors; Pancreatitis; Pyrrolidines; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Thiocarbamates; Tumor Necrosis Factor-alpha

2004
Molecular mechanisms and therapeutic strategies of chronic renal injury: the role of nuclear factor kappaB activation in the development of renal fibrosis.
    Journal of pharmacological sciences, 2006, Volume: 100, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Carbon; Disease Models, Animal; Fibrosis; Inflammation; Kidney Diseases; NF-kappa B; Oxides; Pyrrolidines; Rats; Renin-Angiotensin System; Thiocarbamates

2006

Other Studies

89 other study(ies) available for pyrrolidine dithiocarbamate and Disease Models, Animal

ArticleYear
Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Humans; Isoniazid; Liver; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats; Rifampin; Thiocarbamates; Tumor Necrosis Factor-alpha

2020
Inhibiting nuclear factor-κB at different stages after intracerebral hemorrhage can influence the hemorrhage-induced brain injury in experimental models in vivo.
    Brain research bulletin, 2020, Volume: 155

    Topics: Animals; Cell Death; Cerebral Hemorrhage; Disease Models, Animal; Male; NF-kappa B; Pyrrolidines; Rats, Wistar; Thiocarbamates

2020
mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats.
    The International journal of neuroscience, 2021, Volume: 131, Issue:10

    Topics: Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Hippocampus; Hypoxia; Male; Neurons; NF-kappa B; Protein Kinase Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Sleep Apnea, Obstructive; Thiocarbamates; TOR Serine-Threonine Kinases

2021
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
    Bioscience reports, 2020, 09-30, Volume: 40, Issue:9

    Topics: Acetic Acid; Acute Lung Injury; Animals; Colon; Disease Models, Animal; Emodin; Humans; Intestinal Mucosa; Ischemia; Lung; Male; NF-kappa B; Pulmonary Surfactant-Associated Protein A; Pyrrolidines; Rats; Signal Transduction; Thiocarbamates; Toll-Like Receptor 4

2020
Small molecule natural compound targets the NF-κB signaling and ameliorates the development of osteoarthritis.
    Journal of cellular physiology, 2021, Volume: 236, Issue:11

    Topics: Animals; Antirheumatic Agents; Cells, Cultured; Chondrocytes; Disease Models, Animal; Extracellular Matrix; Female; Flavones; Interleukin-1beta; Joints; Male; Mice, Inbred C57BL; Molecular Docking Simulation; NF-kappa B; Osteoarthritis; Pyrrolidines; Signal Transduction; Thiocarbamates; Transcription Factor RelA

2021
Pyrrolidine dithiocarbamate administered during ex-vivo lung perfusion promotes rehabilitation of injured donor rat lungs obtained after prolonged warm ischemia.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunity, Innate; In Vitro Techniques; Lung; Lung Injury; Lung Transplantation; Male; NF-kappa B; Perfusion; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thiocarbamates; Tissue and Organ Procurement; Tissue Donors; Transplantation Immunology; Warm Ischemia

2017
Inhibition of nuclear factor-κB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury.
    Oncotarget, 2017, Jul-18, Volume: 8, Issue:29

    Topics: Acute Lung Injury; Animals; Antioxidants; Disease Models, Animal; Female; Immunoglobulin Isotypes; Lipopolysaccharides; Mice; Mitochondria; Myeloid Differentiation Factor 88; NF-kappa B; Oxidative Stress; Protective Agents; Pyrrolidines; Signal Transduction; Thiocarbamates; Toll-Like Receptors

2017
G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:2

    Topics: Animals; Cardiomegaly; Cell Nucleus; Disease Models, Animal; Gene Knockdown Techniques; GTP-Binding Protein Regulators; Isoproterenol; Male; Myocytes, Cardiac; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Rats, Sprague-Dawley; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Thiocarbamates; Transcription Factor RelA

2018
Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.
    Brain research bulletin, 2018, Volume: 137

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Down-Regulation; Ginkgolides; Hippocampus; Lactones; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Phencyclidine; Platelet Membrane Glycoproteins; Prefrontal Cortex; Psychoses, Substance-Induced; Pyrrolidines; Receptors, G-Protein-Coupled; RNA, Messenger; Thiocarbamates

2018
Gli2 Mediated Activation of Hedgehog Signaling Attenuates Acute Pancreatitis via Balancing Inflammatory Cytokines in Mice.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:1

    Topics: Acinar Cells; Acute Disease; Animals; Cell Line; Ceruletide; Cytokines; Disease Models, Animal; Hedgehog Proteins; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pancreatitis; Pyrrolidines; Signal Transduction; Thiocarbamates; Up-Regulation; Zinc Finger Protein Gli2

2018
Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Case-Control Studies; Cell Line; Cell Proliferation; Disease Models, Animal; Female; HMGB2 Protein; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyrrolidines; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Time Factors; Transcription Factor RelA; Young Adult

2018
Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin.
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:11

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Drug Compounding; Emulsions; Inflammation Mediators; Lipid Peroxidation; Mice, Hairless; Oxidative Stress; Pyrrolidines; Skin; Sunburn; Thiocarbamates; Ultraviolet Rays

2018
NF-κB activation contributes to parathyroid cell proliferation in chronic kidney disease.
    Journal of nephrology, 2018, Volume: 31, Issue:6

    Topics: Adult; Animals; Biomarkers; Calcitriol; Cell Proliferation; Disease Models, Animal; Female; Humans; Hyperparathyroidism, Secondary; Hyperplasia; Male; Middle Aged; NF-kappa B; Parathyroid Glands; Phosphorylation; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Calcitriol; Renal Insufficiency, Chronic; Signal Transduction; Thiocarbamates; Transcription Factor RelA

2018
Pyrrolidine dithiocarbamate attenuates the development of monocrotaline-induced pulmonary arterial hypertension.
    Pathology, research and practice, 2013, Volume: 209, Issue:5

    Topics: Animals; Antioxidants; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Familial Primary Pulmonary Hypertension; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Malondialdehyde; Monocrotaline; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates

2013
NF-κB activation mediates crystal translocation and interstitial inflammation in adenine overload nephropathy.
    American journal of physiology. Renal physiology, 2013, Jul-15, Volume: 305, Issue:2

    Topics: Adenine; Animals; Disease Models, Animal; Fibrosis; Granuloma; Inflammation Mediators; Kidney; Male; Nephritis, Interstitial; Nephrosclerosis; NF-kappa B; Pyrrolidines; Rats; Rats, Wistar; Thiocarbamates

2013
[Effects of pyrrolidine dithiocarbamate on expressions of α-smooth muscle actin, integrin α5 and fibronectin in acute paraquat poisoned rats].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2013, Volume: 31, Issue:5

    Topics: Actins; Animals; Disease Models, Animal; Fibronectins; Integrin alpha5; Male; Paraquat; Pulmonary Fibrosis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates

2013
Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Alzheimer Disease; Animals; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dopamine; Glutathione; Hippocampus; Interleukin-10; Interleukin-1beta; Male; Neuroprotective Agents; Norepinephrine; Pyrrolidines; Rats; Rats, Wistar; Scopolamine; Serotonin; Thiocarbamates

2014
Cachectic skeletal muscle response to a novel bout of low-frequency stimulation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2014, Apr-15, Volume: 116, Issue:8

    Topics: AMP-Activated Protein Kinases; Animals; Cachexia; Cytochromes c; Disease Models, Animal; DNA-Binding Proteins; Electric Stimulation Therapy; Gene Expression Regulation; Genes, APC; Hand Strength; High Mobility Group Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Contraction; Muscle, Skeletal; Nuclear Respiratory Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Pyrrolidines; RNA, Messenger; STAT3 Transcription Factor; Thiocarbamates; Transcription Factors

2014
Phospholipases A-II (PLA2-II) induces acute pancreatitis through activation of the transcription factor NF-kappaB.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:8

    Topics: Acute Disease; Animals; Disease Models, Animal; Group II Phospholipases A2; Inflammation Mediators; NF-kappa B; Pancreas; Pancreatitis; Pyrrolidines; Rats, Wistar; RNA Interference; RNA, Small Interfering; Severity of Illness Index; Signal Transduction; Taurocholic Acid; Thiocarbamates; Time Factors

2014
Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E-/- mice.
    Journal of cardiology, 2015, Volume: 66, Issue:1

    Topics: Animals; CD36 Antigens; Coronary Artery Disease; Disease Models, Animal; Down-Regulation; Inflammation; Interleukin-18; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred Strains; Pyrrolidines; RNA, Messenger; Thiocarbamates

2015
Activation of NF-κB signaling pathway in HSV-1-induced mouse facial palsy: Possible relation to therapeutic effect of glucocorticoids.
    Neuroscience, 2015, Mar-19, Volume: 289

    Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Brain Stem; Cyclooxygenase 2; Disease Models, Animal; Facial Paralysis; Glucocorticoids; Herpesvirus 1, Human; Hormone Antagonists; I-kappa B Kinase; Male; Methylprednisolone Hemisuccinate; Mice, Inbred BALB C; Mifepristone; NF-kappa B; Pyrrolidines; Receptors, Glucocorticoid; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha

2015
Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.
    Toxicology and applied pharmacology, 2015, May-01, Volume: 284, Issue:3

    Topics: Animals; Arterial Pressure; Biomarkers; Cardiomegaly; Cytokines; Disease Models, Animal; Hypertension; Inflammation Mediators; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Sympathetic Nervous System; Thiocarbamates; Time Factors; Transcription Factor RelA

2015
The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension.
    Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:4

    Topics: Animals; Blood Pressure; Collagen; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinase 2; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats, Wistar; Thiocarbamates; Time Factors; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling

2015
TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity.
    World journal of gastroenterology, 2015, Jul-28, Volume: 21, Issue:28

    Topics: Animals; Cells, Cultured; Colon; Cystathionine beta-Synthase; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Irritable Bowel Syndrome; Lipopolysaccharides; Male; Neurons; Pain Perception; Pain Threshold; Pyrrolidines; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Toll-Like Receptor 4; Transcription Factor RelA; Up-Regulation; Visceral Pain

2015
Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.
    Applied biochemistry and biotechnology, 2015, Volume: 177, Issue:8

    Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Male; Mice; Mice, Inbred ICR; NF-kappa B; Occludin; Phospholipid Hydroperoxide Glutathione Peroxidase; Pyrrolidines; Signal Transduction; Thiocarbamates; Zonula Occludens-1 Protein

2015
NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
    Cardiovascular toxicology, 2016, Volume: 16, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Biomarkers; Caspase 1; Disease Models, Animal; Epinephrine; Hypertension; I-kappa B Kinase; Infusions, Parenteral; Interleukin-1beta; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Norepinephrine; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Phosphorylation; Pyrrolidines; Rats, Inbred Dahl; Signal Transduction; Sodium Chloride, Dietary; Sympathetic Nervous System; Thiocarbamates; Transcription Factor RelA

2016
Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Adenomatous Polyposis Coli Protein; Animals; Cachexia; Cell Line, Tumor; Disease Models, Animal; Humans; Lipid Metabolism; Liver; Mice; Mice, Mutant Strains; Muscle, Skeletal; Neoplasms, Experimental; Pyrrolidines; Signal Transduction; STAT3 Transcription Factor; Thiocarbamates

2016
Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB.
    Oncotarget, 2016, Dec-20, Volume: 7, Issue:51

    Topics: Administration, Oral; Animals; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescein-5-isothiocyanate; Immunoglobulin E; Male; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Phthalic Acids; Pyrrolidines; Signal Transduction; Skin; STAT Transcription Factors; Th2 Cells; Thiocarbamates; Thymic Stromal Lymphopoietin

2016
Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.
    Acta physiologica (Oxford, England), 2017, Volume: 220, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cardio-Renal Syndrome; Coronary Vessels; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrosis; Heart; Kidney; Kidney Function Tests; Ligation; Losartan; Male; Metoprolol; Molsidomine; Nephrectomy; NF-kappa B; Nitric Oxide Donors; Pyrrolidines; Rats, Inbred Lew; Spin Labels; Sympatholytics; Thiocarbamates

2017
Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion.
    European journal of pharmacology, 2008, Oct-24, Volume: 595, Issue:1-3

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cyclooxygenase 2; Cytoprotection; Disease Models, Animal; Endothelin-1; Gene Expression Regulation; Glutathione; Heme Oxygenase (Decyclizing); Lipid Peroxidation; Liver; Liver Circulation; Male; Microcirculation; NF-kappa B; Nitric Oxide Synthase; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Reperfusion Injury; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2008
Treatment with inhibitors of the NF-kappaB pathway improves whole body tension development in the mdx mouse.
    Neuromuscular disorders : NMD, 2009, Volume: 19, Issue:2

    Topics: Animals; Antioxidants; Cholagogues and Choleretics; Disease Models, Animal; Female; Male; Mice; Mice, Inbred mdx; Muscle Strength; Muscle Stretching Exercises; Muscle Tonus; Muscle Weakness; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NF-kappa B; Pyrrolidines; Recovery of Function; Thiocarbamates; Transcription Factor RelA; Treatment Outcome; Ursodeoxycholic Acid

2009
Intervention of pyrrolidine dithiocarbamate and tetrandrine on cellular calcium overload of pancreatic acinar cells induced by serum and ascitic fluid from rats with acute pancreatitis.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:1

    Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Ascitic Fluid; Benzylisoquinolines; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Deoxycholic Acid; Disease Models, Animal; NF-kappa B; Pancreas, Exocrine; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Time Factors

2009
Effects of gut barrier dysfunction and NF-kappaB activation on aggravating mechanism of severe acute pancreatitis.
    Journal of digestive diseases, 2009, Volume: 10, Issue:1

    Topics: Animals; Antioxidants; Bacterial Translocation; Colon, Ascending; Disease Models, Animal; Intercellular Adhesion Molecule-1; Kidney; Lipopolysaccharides; Liver; Lung; Male; NF-kappa B; Pancreatitis, Acute Necrotizing; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha; Up-Regulation

2009
[Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2008, Volume: 26, Issue:10

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Lung; Male; Matrix Metalloproteinase 2; Paraquat; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1

2008
Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats.
    Journal of biomedicine & biotechnology, 2009, Volume: 2009

    Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Humans; Lung Injury; Male; Paraquat; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiocarbamates; Treatment Outcome

2009
Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:4

    Topics: Animals; Antioxidants; Cell Nucleus; Cyclic N-Oxides; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hepatitis; Homocysteine; Hyperhomocysteinemia; I-kappa B Proteins; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Phosphorylation; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spin Labels; Superoxides; Thiocarbamates; Time Factors

2009
Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats.
    Basic research in cardiology, 2010, Volume: 105, Issue:1

    Topics: Animals; Coronary Thrombosis; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Myocardium; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tumor Necrosis Factor-alpha; Ventricular Dysfunction

2010
Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo.
    American journal of physiology. Renal physiology, 2010, Volume: 298, Issue:1

    Topics: Acute Kidney Injury; Animals; Antioxidants; Aquaporin 2; Cecum; Disease Models, Animal; Down-Regulation; Interleukin-1beta; Ligation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrrolidines; Receptors, Vasopressin; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha; Vasopressins

2010
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).
    The journal of pain, 2009, Volume: 10, Issue:11

    Topics: Animals; Cell Nucleus; Cold Temperature; Complex Regional Pain Syndromes; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Muscle, Skeletal; NF-kappa B; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Rats, Long-Evans; Reperfusion Injury; Spinal Cord; Thiocarbamates; Time Factors

2009
Antioxidant inhibits HMGB1 expression and reduces pancreas injury in rats with severe acute pancreatitis.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:9

    Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Down-Regulation; HMGB1 Protein; Male; NF-kappa B; Pancreas; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha

2010
Inhibition of nuclear factor kappa B attenuates tumour progression in an animal model of renal cell carcinoma.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:5

    Topics: Animals; Apoptosis; bcl-X Protein; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Humans; I-kappa B Kinase; Kidney Neoplasms; Male; Mice; Mice, SCID; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Thiocarbamates; Weight Loss; Xenograft Model Antitumor Assays

2010
Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury.
    Inflammation, 2010, Volume: 33, Issue:5

    Topics: Acute Disease; Amylases; Animals; Biomarkers; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Lung; Lung Injury; Male; NF-kappa B; Nitric Oxide Synthase Type II; Pancreas; Pancreatitis; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Thiocarbamates; Time Factors; Transcription Factor RelA

2010
Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-ĸB in a model of membranous glomerulonephritis.
    Nephron. Experimental nephrology, 2010, Volume: 116, Issue:2

    Topics: Animals; Dexamethasone; Disease Models, Animal; Glomerulonephritis, Membranous; Interleukin-1beta; Kidney Glomerulus; Male; NF-kappa B; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sheep; Signal Transduction; Thiocarbamates

2010
Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
    Behavioural brain research, 2011, Aug-01, Volume: 221, Issue:1

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Hyperalgesia; I-kappa B Proteins; Male; Nerve Compression Syndromes; Neuralgia; NF-kappa B; Nitric Oxide; Nitriles; Phorbols; Pyrrolidines; Rats; Rats, Wistar; Signal Transduction; Sulfones; Thiocarbamates; TRPV Cation Channels

2011
[Effect of pyrrolidinedithiocarbamate on neural developmental disorder of adult offspring with maternal systemic exposure to Poly(I:C) during pregnancy].
    Zhonghua yi xue za zhi, 2011, Feb-22, Volume: 91, Issue:7

    Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Female; Inhibition, Psychological; Interleukin-10; Maternal Exposure; NF-kappa B; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha

2011
Autophagy regulation by the nuclear factor κB signal axis in acute pancreatitis.
    Pancreas, 2012, Volume: 41, Issue:3

    Topics: Amylases; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomarkers; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; NF-kappa B; Oligopeptides; Pancreas; Pancreatitis, Acute Necrotizing; Pyrrolidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurocholic Acid; Thiocarbamates; Time Factors; Tumor Necrosis Factor-alpha

2012
Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro.
    Psychopharmacology, 2012, Volume: 220, Issue:2

    Topics: Animals; Benzoxazines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Ileum; Male; Mice; Morphine; Naloxone; NF-kappa B; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, CCR2; Substance Withdrawal Syndrome; Thiocarbamates

2012
Nuclear factor-kappa B mediates one-lung ventilation-induced acute lung injury in rabbits.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2012, Volume: 25, Issue:2

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation Mediators; Interleukin-8; Male; NF-kappa B; Oxygen; Pyrrolidines; Rabbits; Respiration, Artificial; Thiocarbamates; Tumor Necrosis Factor-alpha

2012
Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats.
    Life sciences, 2012, Oct-15, Volume: 91, Issue:13-14

    Topics: Animals; Atrasentan; Desoxycorticosterone; Disease Models, Animal; Disease Susceptibility; Endothelin-1; Hypertension; Kidney Diseases; Male; NF-kappa B; Nitric Oxide; Nitroarginine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Severity of Illness Index; Sodium Chloride, Dietary; Thiocarbamates

2012
NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis.
    Cytokine, 2013, Volume: 61, Issue:1

    Topics: Animals; Cecum; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; Down-Regulation; Interferon-gamma; Interleukin-1beta; Interleukin-6; Ligation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Punctures; Pyrrolidines; Receptors, Chemokine; RNA, Messenger; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha

2013
Effect of NF‑κB inhibitor on high‑mobility group protein B1 expression in a COPD rat model.
    Molecular medicine reports, 2013, Volume: 7, Issue:2

    Topics: Animals; Disease Models, Animal; Gene Expression; HMGB1 Protein; Lung; Male; NF-kappa B; Pulmonary Disease, Chronic Obstructive; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Thiocarbamates

2013
Nuclear factor-kappa B in signal conduction of protein kinase C in T lymphocytes from an asthmatic guinea pig model.
    Chinese medical journal, 2002, Volume: 115, Issue:5

    Topics: Animals; Apoptosis; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Cell Nucleus; Disease Models, Animal; Guinea Pigs; Immunohistochemistry; In Situ Hybridization; Interleukin-4; Interleukin-5; Male; NF-kappa B; Protein Kinase C; Pyrrolidines; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiocarbamates

2002
Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heart.
    The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:3

    Topics: Analysis of Variance; Animals; Antioxidants; Coronary Circulation; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Hyperoxia; I-kappa B Proteins; Immunoblotting; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Reperfusion Injury; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Oxygen Inhalation Therapy; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Recovery of Function; Thiocarbamates; Time Factors; Transcriptional Activation; Ventricular Pressure

2003
Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice.
    Intensive care medicine, 2003, Volume: 29, Issue:11

    Topics: Animals; Antioxidants; Blotting, Western; Chemotaxis, Leukocyte; Disease Models, Animal; Drug Evaluation, Preclinical; Immunohistochemistry; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Multiple Organ Failure; Neutrophils; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Poly(ADP-ribose) Polymerases; Pyrrolidines; Random Allocation; Thiocarbamates; Time Factors; Tyrosine; Zymosan

2003
A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis.
    Liver international : official journal of the International Association for the Study of the Liver, 2004, Volume: 24, Issue:2

    Topics: Animals; Antioxidants; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyproline; Immunohistochemistry; In Situ Hybridization; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Experimental; Male; NF-kappa B; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Thioacetamide; Thiobarbituric Acid Reactive Substances; Thiocarbamates

2004
Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window.
    Journal of neurochemistry, 2004, Volume: 91, Issue:3

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Microglia; Neurons; Neuroprotective Agents; Neurotoxins; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Wistar; Thiocarbamates; Time Factors; Treatment Outcome

2004
Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate.
    Microbes and infection, 2005, Volume: 7, Issue:1

    Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Female; Mice; Naphthoquinones; Oocysts; Pyrrolidines; Thiocarbamates; Toxoplasma; Toxoplasmosis

2005
Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:4

    Topics: Animals; Aqueous Humor; Autoimmune Diseases; Chemokines; Ciliary Body; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression; Injections, Intraperitoneal; Iris; Leukocyte Count; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Uveitis, Anterior

2005
Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB.
    Journal of vascular surgery, 2005, Volume: 41, Issue:3

    Topics: Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Electrophoretic Mobility Shift Assay; Interleukin-1; Interleukin-6; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrrolidines; Thiocarbamates; Transcription Factor AP-1

2005
Effects of pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, on cytokine expression and ocular inflammation in experimental autoimmune anterior uveitis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2005, Volume: 21, Issue:2

    Topics: Animals; Aqueous Humor; Autoimmune Diseases; Ciliary Body; Cytokines; Disease Models, Animal; Injections, Intraperitoneal; Iris; Leukocyte Count; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Thiocarbamates; Uveitis, Anterior

2005
Chronic treatment with agents that stabilize cytosolic IkappaB-alpha enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch.
    Neurobiology of disease, 2005, Volume: 20, Issue:3

    Topics: Animals; Antioxidants; Calcium Channel Blockers; Calcium Signaling; Cell Survival; Cytosol; Disease Models, Animal; Drug Administration Schedule; Female; Gadolinium; I-kappa B Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Sarcolemma; Thiocarbamates

2005
Pulmonary aspiration: new therapeutic approaches in the experimental model.
    Anesthesiology, 2005, Volume: 103, Issue:3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokine CCL2; Disease Models, Animal; Inflammation Mediators; Macrophages, Alveolar; Male; NF-kappa B; Pneumonia, Aspiration; Pyrrolidines; Rats; Rats, Wistar; Respiratory Distress Syndrome; Thiocarbamates; Tumor Necrosis Factor-alpha

2005
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
    Free radical biology & medicine, 2005, Dec-15, Volume: 39, Issue:12

    Topics: Animals; Antioxidants; Body Weight; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Transgenic; NF-kappa B; Organ Size; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrrolidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thiocarbamates; TOR Serine-Threonine Kinases

2005
Protective effect of pyrrolidine dithiocarbamate on liver injury induced by intestinal ischemia-reperfusion in rats.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2006, Volume: 5, Issue:1

    Topics: Animals; Antioxidants; Biomarkers; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestine, Small; Liver Diseases; Male; NF-kappa B; Nitric Oxide; Pyrrolidines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Thiocarbamates; Tumor Necrosis Factor-alpha

2006
The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
    Pediatric surgery international, 2006, Volume: 22, Issue:8

    Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Female; Ligation; Lipid Peroxidation; Liver; Liver Diseases; Liver Function Tests; NF-kappa B; Oxidative Stress; Peroxidase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sulfasalazine; Superoxide Dismutase; Thiocarbamates; Tumor Necrosis Factor-alpha

2006
Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis.
    Molecular pharmacology, 2007, Volume: 71, Issue:1

    Topics: Animals; Animals, Genetically Modified; Antioxidants; Death; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Humans; Motor Neuron Disease; Neuroglia; Pyrrolidines; Rats; Superoxide Dismutase; Survival Rate; Thiocarbamates

2007
[Effect of ubiquitin-proteasome pathway on inflammatory reaction in intestine and its barrier function in rats with postburn sepsis].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:11

    Topics: Amine Oxidase (Copper-Containing); Animals; Burns; Cysteine Proteinase Inhibitors; Disease Models, Animal; Intestinal Mucosa; Intestines; Leupeptins; Male; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Sepsis; Thiocarbamates; Tumor Necrosis Factor-alpha; Ubiquitin

2006
Effects of pyrrolidine dithiocarbamate on healing of colonic anastomoses in the cecal ligation and puncture model of intraperitoneal sepsis in rats.
    World journal of surgery, 2007, Volume: 31, Issue:1

    Topics: Anastomosis, Surgical; Animals; Antioxidants; Cecum; Disease Models, Animal; Glutathione; Ligation; Lipid Peroxidation; Male; Peritoneal Diseases; Punctures; Pyrrolidines; Rats; Rats, Wistar; Sepsis; Thiocarbamates; Wound Healing

2007
The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting.
    Atherosclerosis, 2007, Volume: 194, Issue:2

    Topics: Angioplasty, Balloon; Animals; Antioxidants; Blood Flow Velocity; Carotid Artery, Common; Carotid Stenosis; Coronary Restenosis; Diet, Atherogenic; Disease Models, Animal; DNA, Catalytic; Gene Expression Regulation; Genes, jun; Proto-Oncogene Proteins c-jun; Pyrrolidines; Rabbits; Stents; Thiocarbamates

2007
Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eplerenone; Heart Failure; Male; NF-kappa B; Paraventricular Hypothalamic Nucleus; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spironolactone; Thiocarbamates

2007
Antioxidant attenuates acute lung injury after cardiopulmonary bypass in rats.
    Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:1

    Topics: Animals; Antioxidants; Cardiopulmonary Bypass; Disease Models, Animal; Female; Male; Models, Cardiovascular; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Thiocarbamates

2007
Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death.
    The Journal of physiology, 2007, Jun-15, Volume: 581, Issue:Pt 3

    Topics: Animals; Blood Pressure; Brain Death; Cyclic GMP-Dependent Protein Kinases; Diamines; Disease Models, Animal; Ditiocarb; Enzyme Induction; Heart Rate; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Reproducibility of Results; Thiocarbamates; Time Factors; Transcription, Genetic; Tropicamide; Tyrosine

2007
Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis.
    World journal of gastroenterology, 2007, Mar-21, Volume: 13, Issue:11

    Topics: Animals; Antioxidants; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Indicators and Reagents; Inflammation; Injections, Intraperitoneal; Interleukin-1beta; Mice; Mice, Inbred BALB C; NF-kappa B; Pyrrolidines; Severity of Illness Index; Thiocarbamates; Tumor Necrosis Factor-alpha

2007
Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model.
    World journal of surgery, 2007, Volume: 31, Issue:8

    Topics: Animals; Antioxidants; Capillary Permeability; Disease Models, Animal; Glutathione; Lung; Malondialdehyde; Mesenteric Vascular Occlusion; Neutrophil Activation; Neutrophils; Nitrates; Nitrites; Pulmonary Edema; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Thiocarbamates

2007
Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia/reperfusion injury on healing of colonic anastomoses in rats.
    World journal of surgery, 2007, Volume: 31, Issue:9

    Topics: Anastomosis, Surgical; Animals; Antioxidants; Colon; Colonic Diseases; Disease Models, Animal; Glutathione; Hydroxyproline; Male; Malondialdehyde; Peroxidase; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Thiocarbamates; Wound Healing

2007
Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis.
    Life sciences, 2007, Jul-04, Volume: 81, Issue:4

    Topics: Animals; Arginine Vasopressin; Cardiomyopathies; Cells, Cultured; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; Fibrosis; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Myocardium; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spectrophotometry; Thiocarbamates

2007
Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage.
    Stroke, 2007, Volume: 38, Issue:9

    Topics: Adenoviridae; Animals; Anti-Bacterial Agents; Antioxidants; Brain; Cerebral Hemorrhage; Disease Models, Animal; Humans; Intracranial Arteriovenous Malformations; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Minocycline; Pyrrolidines; Thiocarbamates; Vascular Endothelial Growth Factor A

2007
Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:7 Pt 2

    Topics: Active Transport, Cell Nucleus; Alanine Transaminase; Animals; Concanavalin A; Disease Models, Animal; Enzyme Induction; Hepatitis; I-kappa B Proteins; Liver; Male; Mice; Mice, Inbred BALB C; Necrosis; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrrolidines; Severity of Illness Index; Thiocarbamates; Time Factors; Transcription Factor RelA; Up-Regulation

2008
Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis.
    Journal of hepatology, 2008, Volume: 48, Issue:3

    Topics: Animals; Antioxidants; Disease Models, Animal; Female; Galactosamine; Glutathione; Hepatitis; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liver; Liver Failure, Acute; Mice; Mice, Inbred Strains; Mycobacterium bovis; NF-kappa B; Nitric Oxide; Pyrrolidines; Thiocarbamates; Tumor Necrosis Factor-alpha

2008
[Expression of nuclear factor-kappa B and effect of pyrrolidine dithiocarbamate in Pseudomonas aeruginosa pneumonia rat model].
    Zhonghua nei ke za zhi, 2007, Volume: 46, Issue:10

    Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Lung; Male; NF-kappa B; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Tumor Necrosis Factor-alpha

2007
Effects of pyrrolidine dithiocarbamate on antioxidant enzymes in cardiomyopathy induced by adriamycin in rats.
    Cardiology, 2008, Volume: 111, Issue:2

    Topics: Animals; Antioxidants; Biopsy, Needle; Cardiomyopathies; Disease Models, Animal; Doxorubicin; Enzyme Activation; Glutathione Peroxidase; Immunohistochemistry; Male; Myocardium; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reference Values; Sensitivity and Specificity; Superoxide Dismutase; Thiocarbamates

2008
Effects of dimethyl sulfoxide, pyrrolidine dithiocarbamate, and methylprednisolone on nuclear factor-kappaB and heat shock protein 70 in a rat model of hemorrhagic shock.
    The Journal of trauma, 2008, Volume: 64, Issue:4

    Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; HSP70 Heat-Shock Proteins; Inflammation Mediators; Male; Methylprednisolone; NF-kappa B; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Shock, Hemorrhagic; Thiocarbamates; Up-Regulation

2008
The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis.
    Clinical and experimental immunology, 2008, Volume: 152, Issue:3

    Topics: Actins; Animals; Collagen Type IV; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Glomerulonephritis, Membranoproliferative; Interleukin-1beta; Interleukin-6; Isoantibodies; Kidney Glomerulus; NF-kappa B; Proliferating Cell Nuclear Antigen; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thy-1 Antigens

2008
In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock.
    Journal of immunology (Baltimore, Md. : 1950), 1997, Oct-15, Volume: 159, Issue:8

    Topics: Animals; Calcium; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Hypotension; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Shock, Septic; Thiocarbamates; Time Factors

1997
Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate.
    Free radical biology & medicine, 1998, Jul-15, Volume: 25, Issue:2

    Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Graft Rejection; Graft Survival; Guanidines; Heart Transplantation; Injections, Subcutaneous; Iron-Sulfur Proteins; Macromolecular Substances; Male; Myocardium; Myoglobin; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Pyrrolidines; Rats; Rats, Inbred Lew; Rats, Inbred WF; Thiocarbamates; Transplantation, Heterotopic

1998
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.
    European journal of immunology, 1999, Volume: 29, Issue:6

    Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; DNA-Binding Proteins; Female; I-kappa B Proteins; Lipopolysaccharides; Liver; Lung; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Pyrrolidines; Shock, Septic; Thiocarbamates; Tumor Necrosis Factor-alpha

1999
Inhibition of the transcriptional activator protein nuclear factor kappaB prevents hemodynamic instability associated with the whole-body inflammatory response syndrome.
    The Journal of thoracic and cardiovascular surgery, 1999, Volume: 118, Issue:1

    Topics: Acidosis; Animals; Antioxidants; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypotension; Infusions, Intravenous; Interleukin-1; NF-kappa B; Proline; Pyrrolidines; Rabbits; Random Allocation; Systemic Inflammatory Response Syndrome; Thiocarbamates

1999
Nuclear factor-kappaB activation mediates inducible nitric oxide synthase expression in carrageenin-induced rat pleurisy.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6

    Topics: Animals; Antioxidants; Carrageenan; Cell Movement; Cell Nucleus; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exudates and Transudates; Leukocyte Count; Leukocytes; Male; NF-kappa B; NF-kappa B p50 Subunit; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pleural Effusion; Pleurisy; Pyrrolidines; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Thiocarbamates; Tosyllysine Chloromethyl Ketone; Transcription Factor RelA

1999
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis.
    Neuroscience letters, 2000, Jun-16, Volume: 287, Issue:1

    Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Multiple Sclerosis; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Lew; Spinal Cord; Thiocarbamates

2000