Page last updated: 2024-08-23

pyrrolidine and Diabetes Mellitus, Type 2

pyrrolidine has been researched along with Diabetes Mellitus, Type 2 in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (22.22)	29.6817
2010's	7 (77.78)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Deng, G; Feng, Y; Ji, X; Leng, Y; Liu, H; Wang, J	1
Haq, W; Katti, SB; Kushwaha, RN; Mishra, A; Rawat, AK; Srivastava, AK; Srivastava, R	1
Sharma, R; Soman, SS	1
Apedo, A; Cap, M; Chen, SS; Cheng, PT; Chu, C; Devasthale, P; Ding, CZ; Doweyko, AM; Farrelly, D; Flynn, N; Gu, L; Hariharan, N; Harrity, T; Herpin, T; Hosagrahara, V; Kadiyala, P; Kunselman, L; Lai, Z; Li, YX; Lippy, J; Locke, K; Morgan, N; Morton, G; O'Malley, K; Qu, F; Ryono, D; Smirk, R; Wang, T; Wang, W; Wu, S; Xu, C; Ye, XX; Zahler, R; Zhang, H; Zhang, L	1
Paliwal, S; Seth, D; Yadav, D; Yadav, R	1
Jiang, H; Jiang, Z; Pang, J; Wang, W; Xi, B	1
Dai, H; Doran, SD; Piotrowski, DW; Prakash, C; Ryder, TF; Sharma, R; Sun, H	1
Trevillyan, JM; Wiedeman, PE	1
Backes, BJ; Ballaron, SJ; Beno, DW; Black-Schaefer, C; Hamilton, GL; Kempf-Grote, AJ; Kopecka, H; Lai, C; Longenecker, K; Lubben, TH; Madar, DJ; Mika, AK; Pei, Z; Sham, HL; Stashko, MA; Stewart, K; Tian, Z; Trevillyan, JM; von Geldern, TW; Zinker, BA	1

Reviews

1 review(s) available for pyrrolidine and Diabetes Mellitus, Type 2

Article	Year
Dipeptidyl peptidase IV inhibitors for the treatment of impaired glucose tolerance and type 2 diabetes. Current opinion in investigational drugs (London, England : 2000), 2003, Volume: 4, Issue:4 Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Design; Glucose Intolerance; Humans; Hypoglycemic Agents; Protease Inhibitors; Pyrrolidines	2003

Other Studies

8 other study(ies) available for pyrrolidine and Diabetes Mellitus, Type 2

Article	Year
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucose Tolerance Test; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Nitriles; Pyrrolidines; Rats; Rats, Sprague-Dawley	2013
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes. Chemical biology & drug design, 2015, Volume: 85, Issue:4 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Piperazine; Piperazines; Pyrrolidines	2015
Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents. European journal of medicinal chemistry, 2015, Jan-27, Volume: 90 Topics: Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoglycemic Agents; Molecular Docking Simulation; Molecular Structure; Piperidines; Pyrrolidines; Structure-Activity Relationship; Sulfonamides	2015
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists. Bioorganic & medicinal chemistry letters, 2015, Mar-15, Volume: 25, Issue:6 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Design; Female; Hypoglycemic Agents; Ligands; Mice; Mice, Obese; PPAR alpha; PPAR gamma; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Triglycerides	2015
Development of a robust QSAR model to predict the affinity of pyrrolidine analogs for dipeptidyl peptidase IV (DPP- IV). Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:1 Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Least-Squares Analysis; Linear Models; Models, Theoretical; Pyrrolidines; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Software	2011
[Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 inhibitors]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2012, Volume: 32, Issue:2 Topics: Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Humans; Hypoglycemic Agents; Pyrrolidines	2012
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11 Topics: Amides; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Feces; Female; Humans; Hydrolysis; Hydroxylation; Male; Metabolic Detoxication, Phase II; Microsomes, Liver; Molecular Docking Simulation; Piperazine; Piperazines; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley	2012
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit. Bioorganic & medicinal chemistry letters, 2007, Apr-01, Volume: 17, Issue:7 Topics: Animals; Blood Glucose; Chemistry, Pharmaceutical; Cyclohexenes; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Enzyme Inhibitors; Female; Hypoglycemic Agents; Models, Chemical; Molecular Conformation; Phenethylamines; Pyrrolidines; Rats	2007