pyrrolidine-2,4-dicarboxylic acid has been researched along with Nerve Degeneration in 7 studies
pyrrolidine-2,4-dicarboxylic acid: a glutamate uptake inhibitor
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microgliosis and neuronal death were observed at PDC 10 nmol/h in absence of astrogliosis and calcium precipitation, whereas all four aspects were present at the highest rate." | 1.33 | Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transport. ( de Yebra, L; Kerkerian-Le Goff, L; Liévens, JC; Mahy, N; Malpesa, Y; Pugliese, M; Ursu, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Yebra, L | 1 |
| Malpesa, Y | 1 |
| Ursu, G | 1 |
| Pugliese, M | 1 |
| Liévens, JC | 2 |
| Kerkerian-Le Goff, L | 2 |
| Mahy, N | 1 |
| Massieu, L | 5 |
| Morales-Villagrán, A | 1 |
| Tapia, R | 3 |
| Velasco, I | 1 |
| Dutertre, M | 1 |
| Forni, C | 1 |
| Salin, P | 1 |
| Sánchez-Carbente, MR | 1 |
| Del Río, P | 1 |
| Montiel, T | 1 |
7 other studies available for pyrrolidine-2,4-dicarboxylic acid and Nerve Degeneration
| Article | Year |
|---|---|
Dissociation between hippocampal neuronal loss, astroglial and microglial reactivity after pharmacologically induced reverse glutamate transport.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Calcium; Calcium Signaling; Cell Death; Dicar | 2006 |
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study.
Topics: Animals; Cell Death; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dicarboxylic Acids; Dizo | 1995 |
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; | 1996 |
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hipp | 1997 |
Continuous administration of the glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate produces striatal lesion.
Topics: Animals; Biological Transport; Corpus Striatum; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory | 1997 |
Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.
Topics: Animals; Antihypertensive Agents; Aspartic Acid; Biological Transport; Brain Chemistry; Corpus Stria | 1999 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |